CN113694149A - Traditional Chinese medicine composition, preparation method and application - Google Patents

Traditional Chinese medicine composition, preparation method and application Download PDF

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CN113694149A
CN113694149A CN202111102424.5A CN202111102424A CN113694149A CN 113694149 A CN113694149 A CN 113694149A CN 202111102424 A CN202111102424 A CN 202111102424A CN 113694149 A CN113694149 A CN 113694149A
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traditional chinese
chinese medicine
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谢亮
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
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Abstract

The invention discloses a traditional Chinese medicine composition, which comprises 1 to 5 parts of rhizoma atractylodis, 1 to 5 parts of salvia miltiorrhiza, 1 to 5 parts of frankincense, 1 to 5 parts of myrrh, 1 to 5 parts of rhizoma anemarrhenae, 1 to 5 parts of eupatorium japonicum, 1 to 5 parts of notopterygium root, 1 to 5 parts of angelica, 1 to 5 parts of brass and 5 to 10 parts of lemongrass, and also comprises 100 parts of ethanol or 150 parts of sesame oil; the method comprises the following steps: grinding the raw materials in the composition into powder respectively, and proportionally placing the powder into ethanol for sealed soaking; filtering the soaked composition, and collecting filtrate to obtain the Chinese medicinal composition; the traditional Chinese medicine composition is applied to preparing medicines for treating shoulder and neck pain, gout, rheumatism, rheumatoid, migraine and sprain; the raw materials are matched to play a synergistic effect, the advantages are complementary, the traditional Chinese medicine is taken according to symptoms, the medicinal materials are scientifically and reasonably matched, and the traditional Chinese medicine is high in treatment efficiency, can be obviously improved and is quick in effect; the Chinese medicinal composition is applied externally, and has the advantages of convenient administration, convenient carrying, and no adverse side effect.

Description

Traditional Chinese medicine composition, preparation method and application
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition, a preparation method and application.
Background
Gout is a recurrent inflammatory disease caused by increased purine biosynthesis, excessive uric acid production or elevated blood uric acid due to inadequate uric acid excretion, and deposit of urate crystals in joint synovium, bursa, cartilage and other tissues. Migraine (Migraine) is a primary central nervous system dysfunction disease with unilateral or bilateral throbbing headache, the etiology is complex, and the current mainstream trigeminal neurovascular theory considers that after trigeminal nerve endings around cerebral vessels are stimulated, certain neuropeptides such as CGRP and the like are released, so that the vessel walls of adjacent intracranial vessels are excessively expanded to generate fluctuating headache. Simultaneously, the vascular permeability is changed, plasma components leak out, platelets are activated, mast cells generate degranulation change, aseptic inflammation is generated, and malignant circulation is formed. Studies of trigeminal cells have shown that under conditions of neurogenic inflammation, CGRP release from trigeminal cells is increased. At the same time, activation of TRPV1 in the trigeminal ganglion may also cause the release of CGRP and substance P, leading to migraine.
At present, the medicines for treating gout, migraine, rheumatism, shoulder and neck and other diseases in the market are very many, but the medicines can not meet the expectations and requirements of patients, the time consumption is long, and the effect is not obvious, so that the development of a product capable of solving the problems is very necessary.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition, a preparation method and application, and solves the problems that most of medicines for treating gout, migraine, rheumatism, shoulder and neck and other diseases in the current market are far from meeting the expectations and requirements of patients, the time consumption is long, and the effect is not obvious.
The invention relates to a traditional Chinese medicine composition which comprises traditional Chinese medicinal materials and a soaking solution, wherein the traditional Chinese medicinal materials comprise 1 to 5 parts of rhizoma atractylodis, 1 to 5 parts of salvia miltiorrhiza, 1 to 5 parts of frankincense, 1 to 5 parts of myrrh, 1 to 5 parts of rhizoma anemarrhenae, 1 to 5 parts of eupatorium, 1 to 5 parts of notopterygium root, 1 to 5 parts of angelica, 1 to 5 parts of brass and 5 to 10 parts of lemongrass, and the soaking solution is 100 to 150 parts of ethanol or 100 to 150 parts of sesame oil.
A method of preparing a traditional Chinese medicine composition, the method comprising the steps of:
the method comprises the following steps: grinding the raw materials in the traditional Chinese medicinal materials into powder respectively, and putting the powder into a soaking solution according to a proportion for sealed soaking;
step two: filtering the soaked composition, and collecting the filtrate to obtain the traditional Chinese medicine composition.
The further technical scheme of the invention is as follows: and in the step one, the sealing and soaking time is more than 10 months.
The further technical scheme of the invention is as follows: and filtering in the second step by using a 200-mesh filter screen.
The application of the traditional Chinese medicine composition in preparing medicines for treating shoulder and neck pain, gout, rheumatism, rheumatoid diseases, migraine and traumatic injury and sprain is disclosed.
Rhizoma atractylodis: used for eliminating dampness, treating arthralgia syndrome with predominant dampness, and dispelling pathogenic wind and dampness, and treating wind-cold exterior syndrome with dampness;
red sage root: promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and eliminating carbuncle;
frankincense: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease;
myrrh: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatalgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease;
rhizoma anemarrhenae: feverish dysphoria with thirst, cough due to lung heat, hectic fever due to yin deficiency, internal heat, diabetes, constipation due to intestinal dryness;
herba lycopi: promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis, and relieving swelling;
notopterygium root: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain;
yellow wood: traumatic injury;
chinese angelica: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation;
ethanol: the skin-care product can be soaked out of the skin-care product, is easy to store and not easy to deteriorate, can better permeate the skin to achieve a drug effect, and increases the fragrance;
and (3) lemongrass: antibacterial and aroma-enhancing;
the invention has the beneficial effects that: the raw materials are matched with each other to play a synergistic effect, and the advantages are complementary, the traditional Chinese medicine is taken according to symptoms, the medicinal materials are scientifically and reasonably matched, the treatment efficiency of the obtained traditional Chinese medicine is high, the traditional Chinese medicine has good treatment effects on shoulder and neck pain, gout, rheumatism, rheumatoid, migraine and bruise and sprain, the traditional Chinese medicine is obviously improved, and the effect is quick; the Chinese medicinal composition is applied externally, can be used at any time, is convenient to use and carry, and has no side effect.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
The first embodiment is as follows:
the embodiment provides a traditional Chinese medicine composition, which comprises traditional Chinese medicinal materials and a soaking solution, wherein the traditional Chinese medicinal materials comprise 3 parts of rhizoma atractylodis, 3 parts of salvia miltiorrhiza, 3 parts of frankincense, 2 parts of myrrh, 4 parts of rhizoma anemarrhenae, 3 parts of lycopi, 2 parts of notopterygium root, 2 parts of angelica, 3 parts of brass and 8 parts of lemongrass, and the soaking solution is 120 parts of ethanol.
The preparation method comprises the following steps:
the method comprises the following steps: grinding the raw materials in the traditional Chinese medicinal materials into powder respectively, and putting the powder into ethanol according to a certain proportion for sealed soaking;
step two: filtering the soaked composition, and collecting the filtrate to obtain the traditional Chinese medicine composition.
And in the step one, the sealing and soaking time is 12 months.
And filtering in the second step by using a 200-mesh filter screen.
Example two:
the embodiment provides a traditional Chinese medicine composition, which comprises traditional Chinese medicinal materials and a soaking solution, wherein the traditional Chinese medicinal materials comprise 4 parts of rhizoma atractylodis, 4 parts of salvia miltiorrhiza, 5 parts of frankincense, 3 parts of myrrh, 2 parts of rhizoma anemarrhenae, 2 parts of eupatorium japonicum, 3 parts of notopterygium root, 4 parts of angelica sinensis, 2 parts of brass and 9 parts of lemongrass, and the soaking solution comprises 140 parts of ethanol.
A preparation method of a traditional Chinese medicine composition comprises the following steps:
the method comprises the following steps: grinding the raw materials in the traditional Chinese medicinal materials into powder respectively, and putting the powder into ethanol according to a certain proportion for sealed soaking;
step two: filtering the soaked composition, and collecting the filtrate to obtain the traditional Chinese medicine composition.
And in the step one, the sealing and soaking time is 13 months.
And filtering in the second step by using a 200-mesh filter screen.
Collecting the filtered filtrate, and directly applying or spraying the filtrate on the corresponding focus position on the epidermis for 3-5 times per day, wherein the effect is obvious in 3-7 days; severe patients take effect for about 15 days, but are ineffective for adult diseases and injuries to bones.
The primary patients can be smeared once according to different conditions, the shoulder and neck pain is 50% effective, the effect can reach 95% three to five times a day and three days, and the primary patients can be cured basically in 5 days.
Patients with gout: the product can be applied twice continuously, and then the effect of more than 60 percent can be achieved, 3 times per day, the patient can be cured by paying attention to diet slightly and taking three days.
Rheumatism and rheumatoid diseases: 3-5 times per day, the duration of the disease is different according to different constitutions and different rheumatism of patients, and one cure can be achieved in 15-90 days.
Migraine: the ointment is applied to the pain part, and generally takes effect obviously in 7 days according to the individual condition.
Fall injury and sprain: the bone can be cured in three days without damaging the bone.
Safety: belongs to an external product, is forbidden to be used by ethanol allergic patients, and is forbidden to be taken by pregnant women.
By adopting the product in the first embodiment, the dosage is 1-2 ml according to different use amounts of pain parts of patients, and the clinical improvement data is as follows after spraying for 1-3 times per day:
Figure BDA0003271318950000051
rhizoma atractylodis: used for eliminating dampness, treating arthralgia syndrome with predominant dampness, and dispelling pathogenic wind and dampness, and treating wind-cold exterior syndrome with dampness;
red sage root: promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and eliminating carbuncle;
frankincense: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease;
myrrh: can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal mass, rheumatalgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease;
rhizoma anemarrhenae: feverish dysphoria with thirst, cough due to lung heat, hectic fever due to yin deficiency, internal heat, diabetes, constipation due to intestinal dryness;
herba lycopi: promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis, and relieving swelling;
notopterygium root: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain;
yellow wood: traumatic injury;
chinese angelica: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation;
ethanol: the skin-care product can be soaked out of the skin-care product, is easy to store and not easy to deteriorate, can better permeate the skin to achieve a drug effect, and increases the fragrance;
and (3) lemongrass: antibacterial and aroma-enhancing;
the raw materials are matched with each other to play a synergistic effect, and the advantages are complementary, the traditional Chinese medicine is taken according to symptoms, the medicinal materials are scientifically and reasonably matched, the treatment efficiency of the obtained traditional Chinese medicine is high, the traditional Chinese medicine has good treatment effects on shoulder and neck pain, gout, rheumatism, rheumatoid, migraine and bruise and sprain, the traditional Chinese medicine is obviously improved, and the effect is quick; the Chinese medicinal composition is applied externally, can be used at any time, is convenient to use and carry, and has no side effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (5)

1. A traditional Chinese medicine composition is characterized in that: the composition comprises traditional Chinese medicinal materials and a soaking solution, wherein the traditional Chinese medicinal materials comprise 1-5 parts of rhizoma atractylodis, 1-5 parts of salvia miltiorrhiza, 1-5 parts of frankincense, 1-5 parts of myrrh, 1-5 parts of rhizoma anemarrhenae, 1-5 parts of eupatorium japonicum, 1-5 parts of notopterygium root, 1-5 parts of angelica, 1-5 parts of brass and 5-10 parts of lemongrass, and the soaking solution is 100-150 parts of ethanol or 100-150 parts of sesame oil.
2. The method for preparing a Chinese medicinal composition according to claim 1, wherein the method comprises the following steps:
the method comprises the following steps: grinding the raw materials in the traditional Chinese medicinal materials into powder respectively, and putting the powder into a soaking solution according to a proportion for sealed soaking;
step two: filtering the soaked composition, and collecting the filtrate to obtain the traditional Chinese medicine composition.
3. The method for preparing a Chinese medicinal composition according to claim 2, wherein the sealed soaking time in the first step is more than 10 months.
4. The method for preparing a Chinese medicinal composition according to claim 2, wherein the filtration in step two is performed by a 200 mesh filter screen.
5. The use of a Chinese medicinal composition according to claim 1, wherein the use of the Chinese medicinal composition is in the preparation of medicaments for treating shoulder and neck pain, gout, rheumatism, rheumatoid arthritis, migraine and sprain caused by falling injury.
CN202111102424.5A 2021-09-19 2021-09-19 Traditional Chinese medicine composition, preparation method and application Pending CN113694149A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1483452A (en) * 2003-07-21 2004-03-24 沈阳海慧科技投资有限公司 Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof
CN106266339A (en) * 2015-06-04 2017-01-04 华阴市超群药业有限公司 A kind of rheumatism patch and preparation thereof
CN108671114A (en) * 2018-06-28 2018-10-19 黄建平 A kind of drug and preparation method thereof for treating gout

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1483452A (en) * 2003-07-21 2004-03-24 沈阳海慧科技投资有限公司 Compound traditional Chinese and western medicine for treating rheumatism and osteoarthritis and productive method thereof
CN106266339A (en) * 2015-06-04 2017-01-04 华阴市超群药业有限公司 A kind of rheumatism patch and preparation thereof
CN108671114A (en) * 2018-06-28 2018-10-19 黄建平 A kind of drug and preparation method thereof for treating gout

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
罗婵清等: "中西医结合治疗痛风的护理", 《现代中西医结合杂志》 *

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Application publication date: 20211126