CN1244594C - 人参皂甙Rg1制备工艺 - Google Patents
人参皂甙Rg1制备工艺 Download PDFInfo
- Publication number
- CN1244594C CN1244594C CN 03148804 CN03148804A CN1244594C CN 1244594 C CN1244594 C CN 1244594C CN 03148804 CN03148804 CN 03148804 CN 03148804 A CN03148804 A CN 03148804A CN 1244594 C CN1244594 C CN 1244594C
- Authority
- CN
- China
- Prior art keywords
- silica gel
- panaxoside
- saponin
- ethanol
- enthanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 7
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 title abstract 4
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 title 1
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000741 silica gel Substances 0.000 claims abstract description 22
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 22
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 12
- 229930182490 saponin Natural products 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000012043 crude product Substances 0.000 claims abstract description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000011347 resin Substances 0.000 claims abstract description 7
- 229920005989 resin Polymers 0.000 claims abstract description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 4
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 4
- 229960001866 silicon dioxide Drugs 0.000 claims description 17
- 238000005516 engineering process Methods 0.000 claims description 8
- -1 Panaxatriol saponin Chemical class 0.000 claims description 7
- VIXIMKLMEZTTTC-UHFFFAOYSA-N Panaxatriol Natural products CC1(C)CCCC(O1)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(O)CC34C VIXIMKLMEZTTTC-UHFFFAOYSA-N 0.000 claims description 6
- 238000004587 chromatography analysis Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 230000000274 adsorptive effect Effects 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 238000010828 elution Methods 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 abstract description 6
- SIHHLZPXQLFPMC-UHFFFAOYSA-N chloroform;methanol;hydrate Chemical compound O.OC.ClC(Cl)Cl SIHHLZPXQLFPMC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000178 monomer Substances 0.000 abstract description 3
- 238000004809 thin layer chromatography Methods 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 238000005227 gel permeation chromatography Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229910052710 silicon Inorganic materials 0.000 abstract 1
- 239000010703 silicon Substances 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Landscapes
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03148804 CN1244594C (zh) | 2003-06-12 | 2003-06-12 | 人参皂甙Rg1制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 03148804 CN1244594C (zh) | 2003-06-12 | 2003-06-12 | 人参皂甙Rg1制备工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1566138A CN1566138A (zh) | 2005-01-19 |
CN1244594C true CN1244594C (zh) | 2006-03-08 |
Family
ID=34472376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 03148804 Expired - Lifetime CN1244594C (zh) | 2003-06-12 | 2003-06-12 | 人参皂甙Rg1制备工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1244594C (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104011748A (zh) * | 2011-12-27 | 2014-08-27 | 吉列公司 | 用于提供产品信息的设备和方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101463061B (zh) * | 2007-12-21 | 2013-09-18 | 中国医学科学院药物研究所 | 三七中人参皂苷Rg1、Rb1及其总皂苷的制备方法 |
CN101829170A (zh) * | 2010-05-13 | 2010-09-15 | 北京中海康医药科技发展有限公司 | 一种三七总皂苷提取物及其制备方法 |
CN102453072A (zh) * | 2010-10-26 | 2012-05-16 | 中国医学科学院药物研究所 | 人参皂苷Rg1的制备方法 |
CN102532234A (zh) * | 2010-12-10 | 2012-07-04 | 北京本草天源药物研究院 | 一种人参皂苷Rg1的提取纯化方法 |
-
2003
- 2003-06-12 CN CN 03148804 patent/CN1244594C/zh not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104011748A (zh) * | 2011-12-27 | 2014-08-27 | 吉列公司 | 用于提供产品信息的设备和方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1566138A (zh) | 2005-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: DAPHNE PHARMACEUTICAL (GROUP) CO.,LTD. YUNNAN Assignor: Tang Xiuwen Contract fulfillment period: 2009.10.10 to 2015.10.9 Contract record no.: 2009530000040 Denomination of invention: Ginsenoside Rg preparation process Granted publication date: 20060308 License type: Exclusive license Record date: 20091013 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.10.10 TO 2015.10.9; CHANGE OF CONTRACT Name of requester: DAPHNE PHARMACEUTICAL (GROUP) CO., LTD.YUNNAN Effective date: 20091013 |
|
ASS | Succession or assignment of patent right |
Owner name: YUNNAN DAPHNE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: TANG XIUWEN Effective date: 20140416 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 650236 YUXI, YUNNAN PROVINCE TO: 663000 YUXI, YUNNAN PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140416 Address after: 663000 37 pharmaceutical industry park, Yunnan, Wenshan Patentee after: DAPHNE PHARMACEUTICAL (GROUP) CO.,LTD. YUNNAN Address before: Panzhihua 650236, Yunnan province Wenshan County Township Gordon pharmaceutical factory Patentee before: Tang Xiuwen |
|
CX01 | Expiry of patent term |
Granted publication date: 20060308 |
|
CX01 | Expiry of patent term |