CN1243476C - Bactericide compsn. - Google Patents
Bactericide compsn. Download PDFInfo
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- CN1243476C CN1243476C CNB028084721A CN02808472A CN1243476C CN 1243476 C CN1243476 C CN 1243476C CN B028084721 A CNB028084721 A CN B028084721A CN 02808472 A CN02808472 A CN 02808472A CN 1243476 C CN1243476 C CN 1243476C
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
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Abstract
This invention provides an easily handled bactericide composition necessitating no rinsing step after treatment and exhibiting a safe and excellent bactericidal effect on surfaces which may be brought into direct contact with foods, such as hard surfaces in a house other than dishes and cooking devices. The bactericide composition of this invention comprises (a) polylysine, (b) plant essential oil, (c) organic solvent and (d) water in a specified ratio.
Description
Technical field
The present invention relates to be suitable as the crust in the room, for example dining table, tank, wall, such as the floor on ground, and the microbicide compositions of the bactericide on the surface of furniture.
Background technology
Along with the variation of living environment in recent years, also changing for the consideration mode that cleans.Particularly, increase day by day for the interest of sterilizing, the people of the influence of a large amount of microorganisms that exist on dining table, tank, wall, floor and the furniture surface in the worry room also increases day by day.Wiping is the effective ways that suppress these microorganisms, but for the growth of abundant inhibition microorganism, preferably will be used in combination by the method for inhibition microorganisms such as sterilization, sterilization or inhibition growth of microorganism.
Find various materials, no matter be organic matter or inorganic matter, all can be used as bactericide, and occurring in nature has also produced a large amount of bactericide.Wherein natural bactericide polylysine can be used as food preservative, thereby also can advise the desinfactant detergent as food and tableware.
JP-A No.9-176689 has described and has been used for tableware or such as the desinfactant detergent of the food of vegetables and fruit, it contains polylysine/chelating agent/surfactant/solubilizer.In addition, among JP-A No.2000-26885,2000-26886,2000-26887,2000-26889 and the 7-188696 food sterilization washing agent is disclosed also.JP-A No.2-107174 and 8-319208 disclose and have contained the aerosol type food bactericide that mixes as the polylysine in the ethanol of matrix.For not directly at the purposes of food, JP-A No.7-166200 has described the washing washing agent that contains polylysine.Yet mixing ethanol in a large number is disadvantageous as bactericide for fire prevention, thereby need have safe and outstanding bactericidal action and easy to handle bactericide.
The invention summary
The purpose of this invention is to provide a kind of easy to handle microbicide compositions, it can with the rigid surface of Food Contact, for example show safe and outstanding bactericidal effect on rigid surface, the especially dining table of the dining table of the household except that tableware and cooker, tank, wall, floor, furniture and electrical equipment and refrigerator or the surface around it.
The invention provides and contain (a) 0.0001-1% (quality) polylysine [component (a) hereinafter referred to as], (b) 0.0001-1% (quality) plants essential oil [component (b) hereinafter referred to as], (c) 0.1-18% (quality) organic solvent [component (c) hereinafter referred to as] and (d) microbicide compositions of 80-99% (quality) water [component (d) hereinafter referred to as].
In addition, the invention provides and contain (a) 0.0001-1% (quality) polylysine, (b1) 0.0001-1% (quality) is selected from thymol, geraniol, Japanese cypress phenol (hinokithiol), carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1,8-ramie alcohol (cineol), citronellal, citronellol, linalool, anethole, menthol, menthones, carvol, at least a compound [component (b1) hereinafter referred to as] of camphor and peaceful alkene, (c) 0.1-18% (quality) organic solvent and (d) microbicide compositions of 80-99% (quality) water.
And the invention provides to comprise and contain said components (a) to the microbicide compositions of (d), and the content of surfactant is no more than 0.1% (quality), and charges into the bactericide that is equipped with such as the packing of the band in the container of the non-aerosol sprayer of manual operation sprayer.
In addition, the invention provides with contain said components (a) to the composition of (d) to the crust disinfectant method.
In the present invention, the content of surfactant is no more than 0.1% (quality).
In the present invention, sterilization has implication widely, not only comprises sterilization, also comprises bacteria growing inhibiting.
The present invention also provides the purposes of the composition of above definition as disinfectant, and the sterilization method of crust, comprises that the composition with above-mentioned definition is administered on the crust, wipes said composition from crust then.
Detailed Description Of The Invention
＜component (a) 〉
Being used for polylysine of the present invention as component (a) is the bactericide component, can be α-polylysine or epsilon-polylysine, but in the present invention, for safety factor, preferably uses epsilon-polylysine.By cultivating polylysine that the streptomyces microorganism obtains is by the polypeptide as the condensation reaction preparation of the lysine of human body primary amino acid.Polylysine can itself or use as its organic or inorganic salt.Also can adopt the polylysine of admixing with excipient or filler in order to handle easily.
The inventor finds, in order by wiping contaminated crust effectively to be sterilized, below what time is very important:
1) mixed solution can suitably be diffused on the surface to be cleaned, the while wetting surface,
2) surplus that contains the mixed solution of dirt is reduced to minimumly when wiping, reduce thereby make as bacteriotrophic residual dirt, with bacteria growing inhibiting and
3) after the wiping, its bactericide remains with enough amounts to surface sterilization.
The inventor also finds, when mixed solution can be adsorbed on the crust, and makes crust become suitably hydrophobic by absorption, can satisfy these requirements effectively.From this point, the microbicide compositions of the present invention that polylysine has been mixed in inventor's discovery is effective.
By mixing polylysine, the present composition that is sprayed on the pending surface can provide suitable wettability from the teeth outwards, thereby to having sprayed the evenly sterilization of surface of said composition.After the said composition spraying, polylysine is adsorbed on the pending surface, thereby gives suitable repellency for this surface, to repel the water in the composition, make the water that contains dirt be easy to transfer on the rag by wiping, the amount that makes the surface go up the residual water that contains dirt reduces after wiping.In addition, because the hydrophobicity that provides from the teeth outwards of the present composition is not strong, make composition with seldom but be enough to the amount of this surface sterilization is remained.As mentioned above, the inventor finds that the present composition that contains polylysine satisfies by wiping goes up the performance of contradiction to necessary those regulations of surface sterilization, thereby has caused outstanding especially effect.
In the present composition, the component that further improves the anti-microbial property of polylysine should have following performance:
1) this component to polylysine on pending surface, provide the influence of suitable hydrophobic ability very little and
2) this component does not influence the anti-microbial property of polylysine.The inventor finds that as the matrix with this performance, specific plants essential oil and component thereof are effective.By these components are combined with polylysine, can give polylysine higher disinfecting power, and not destroy its above-mentioned performance.
When composition did not contain polylysine, the bactericidal action of said composition was with regard to variation, and the water that contains dirt is easy to stay on the surface when wiping, so just destroyed the outward appearance on pending surface, and significantly reduced the effect of handling the back antibacterial agent.
Microbicide compositions of the present invention contains polylysine as component (a) in order to obtain antiseptic property with the amount of 0.0001-1% (quality), in order to obtain good wiping ability, and 0.0005-0.05% (quality) preferably.
＜component (b) 〉
Component (b) is a plants essential oil, promptly such as the plants essential oil of setting essential oil, careless essential oil and fruit oils.
Many plants essential oils as component (b) show bactericidal action, but preferred for the present invention is anise oil, wild marjoram (wild marjoram) oil, orange oil, lemon oil, lime oil, grapefruit oil, mandarin oil, citronella oil, cassia oil, chamomile oil, mustard oil, garlic oil, caraway seed oil, cumin, clove tree, coriander, cinnamon oil, peppermint oil, sage oil, sage clary oil, geranium oil, thyme linaloe oil, basil, peppermint oil, birch (white birch) oil, palmarosa oil, Japanese Thuja or Japanese cypress (arbor-vitae) oil, allspice (Jamaica) oil, laurel, petit grain oil, peppermint oil, bergamot oil, bitter orange flower oil, eucalyptus oil, lavandin oil, lavender oil, lemon oil, lemongrass oil, rosemary oil, oreodaphene, and Japanese horse radish oil, they can use separately or as mixture.Preferably with containing thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1, the plants essential oil of 8-ramie alcohol, linalool, anethole, menthol, menthones, carvol, camphor, peaceful alkene, australene, nopinene, citronellal, citronellol, benzyl carbinol and benzylalcohol is as the component that is used for plants essential oil of the present invention, and they can use separately or as mixture.
As contained component (b1) in the plants essential oil among the present invention, can adopt and be selected from thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1,8-ramie alcohol, citronellal, citronellol, linalool, anethole, menthol, menthones, carvol, camphor and peaceful alkene, the preferred thymol that is selected from, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1,8-ramie alcohol, the especially preferred thymol that is selected from, geraniol, citral and 1, at least a compound of 8-ramie alcohol.
In the present invention, also can be used in combination with plants essential oil as the plants essential oil of component (b) as component (b1).
(b) and/or content (b1) they are 0.0001-1% (quality) in the microbicide compositions of the present invention, for antiseptic property 0.0001-0.5% (quality) preferably, or for the ability of wiping 0.0001-0.1% (quality) preferably.
＜component (c) 〉
Composition of the present invention also contains organic solvent as component (c), with the solubilization plants essential oil and promote the drying of pending crust.Organic solvent preferably has 100 ℃ or the organic solvent of low temperature boiling point more, and it can form azeotrope with water under boiling point, for example can mention ethanol, propyl alcohol, isopropyl alcohol etc., and especially preferred is ethanol.Consider that from rate of drying, wiping ability and safety aspect the content as the organic solvent of component (c) in the microbicide compositions is 0.1-18% (quality), preferred 1-10% (quality), preferred 1-8% (quality).When adopting ethanol, also can adopt the ethanol of modification, modification ethanol comprises the ethanol of the acetylizad sucrose modification of 8-, the ethanol of polyoxyethylene alkyl ether modification, and the ethanol of flavorant modification.
In order to obtain the good stability of solution among the present invention, the ratio (weight ratio) of component in the composition (b) and/or component (b1) and component (c), promptly [component (b) and/or component (b1)]/component (c) is not more than 1/50, preferably is not more than 1/100.
＜other components 〉
Microbicide compositions of the present invention can further contain low quantity of surfactant, improving antiseptic property, or component (b) stably is dispersed in the composition.
The example of surfactant comprises anion surfactant, non-ionic surface active agent, amphoteric surfactant or cationic surfactant.
As anion surfactant, can adopt among the JP-A 9-310091 9 pages in the 8th page of 0045 paragraph to the, those that describe in 0054 paragraph, wherein can mention having and contain 8-22 carbon atom, those of the alkyl of preferred 10-18 carbon atom, the example comprises the alkyl benzene sulphonate of straight chain, alkyl sulfate, the polyoxyethylene alkyl ether sulfate salt that has about 1-10 moles of ethylene oxide (hereinafter referred to as EO), the polyoxyethylene alkyl ether carboxylic acid that has about 1-10 mole EO, with the polyoxyethylene alkylamide ether carboxylic acid or the fatty acid that have about 1-10 mole EO, and their sylvite, sodium salt, magnesium salts and alkanol amine salt.
As non-ionic surface active agent, can mention among the JP-A 9-310091 those that describe in 8 pages in the 6th page of 0028 paragraph to the, 0043 paragraph, wherein can mention following compound: have and contain 8-22 carbon atom, the alkyl chain of preferred 10-18 carbon atom also contains the 1-30 mole of having an appointment, especially the polyoxyethylene alkyl ether of 4-20 mole EO; Contain the 1-30 mole of having an appointment, preferred 1-20 mole EO and about 1-10 mole, especially the polyoxyethylene oxypropylene alkyl ether of 1-5 mole expoxy propane (hereinafter referred to as PO); The Marlamid that has about 8-22 a carbon atom, an especially 10-18 carbon atom wherein can add about 1-3 mole EO (or PO); And about 1.0-10 sugar, especially 1.0-2.0 the sugared alkyl polyglucoside that had the alkyl chain that contains 8-22 carbon atom, an especially 10-18 carbon atom and condensation therein.In addition, contain 8-22 carbon atom, especially the fatty acid of 10-18 carbon atom and have the alkyl that contains 2-10 carbon atom and the polyalcohol of 2-8 hydroxyl between ester also can use, particularly fatty acid glyceride, polyglyceryl fatty acid ester, fatty acid esters of sorbitan, sucrose fatty ester and methyl glycol fatty acid ester can be used as preferred compound.
Amphoteric surfactant comprises among the JP-A 9-310091 the 6th page; those that describe in the 0023-0027 section; wherein can mention those that have the alkyl that contains 8-22 carbon atom; the example comprises alkyl amido propyl group-N; N-dimethyl acetic acid ester betain (N-alkanoyl aminopropyl-N; N-dimethyl-N-carboxymethyl ammonium carbonyl betain); alkyl amido propyl group-N; N-dimethyl-2-hydroxypropyl sulfobetaines (N-alkanoyl aminopropyl-N; N-dimethyl-N-(2-hydroxyl-3-sulfo group propyl group) ammonium sulfobetaines); alkyl-N; N-dimethyl acetic acid ester betain (N-alkyl-N; N-dimethyl-N-carboxymethyl ammonium carbonyl betain); alkyl amido propyl group-N; N-dimethyl-2-propyl group sulfobetaines (N-alkanoyl aminopropyl-N; N-dimethyl-N-(2-sulfo group propyl group) ammonium sulfobetaines); lauryl-N; N-dimethyl-hydroxypropyl sulfobetaines (N-lauryl-N; and alkyl amine oxide N-dimethyl-N-(2-hydroxyl-3-sulfo group propyl group) ammonium sulfobetaines).Preferably following compound aspect detergency wherein: lauric acid acyl aminopropyl-N; N-dimethyl acetic acid ester betain (N-lauroyl aminopropyl-N; N-dimethyl-N-carboxymethyl ammonium carbonyl betain); myristic acid acyl aminopropyl-N; N-dimethyl acetic acid ester betain (N-myristoyl aminopropyl-N; N-dimethyl-N-carboxymethyl ammonium carbonyl betain); coconut oleoyl amine amido propyl-N; N-dimethyl acetic acid ester betain (N-cocounut oil matter alkanoyl aminopropyl-N; N-dimethyl-N-carboxymethyl ammonium carbonyl betain); lauryl-N; N-dimethyl-2-hydroxypropyl sulfobetaines (N-lauryl-N; N-dimethyl-N-(2-hydroxyl-3-sulfo group propyl group) ammonium sulfobetaines); lauric amide propyl group-N; N-dimethyl-2-hydroxypropyl betain (N-lauroyl aminopropyl-N; and have two alkyl that contain 2 or carbon atom still less and a chain alkyl that contains 8-22 carbon atom and can have the alkyl amine oxide of amido link N-dimethyl-N-(2-hydroxyl-3-sulfo group propyl group) ammonium sulfobetaines).
Spendable cationic surfactant comprises those that describe in the 3rd page 0012 section to the 5th page the 0022nd section among the JP-A 9-310091, especially preferred adopt those comprise having and contain 6-24 carbon atom, long-chain dialkyl dimethyl ammonium salt, the long-chain one alkyl one benzyl dimethyl ammonium salt of the long alkyl chain of preferred 6-18 carbon atom, with an alkyl trimethyl ammonium salt, described long alkyl chain can be with acid amides or ester bond at interval, and counter ion counterionsl gegenions are halide ion, sulfate ion or contain the alkyl sulfate ion of 1-3 carbon atom preferably.The amine cation surfactant comprises the long-chain dialkyl group monomethyl amine salt with the available acid amides that contains 8-24 carbon atom or ester bond long alkyl chain at interval, and preferred examples is hydrochloride, sulphate or phosphate.
Except that above-mentioned surfactant, composition of the present invention can comprise and is selected from following at least a surfactant on a small quantity:
(1) contain the fatty acid of 10-18 carbon atom, or their salt,
(2) contain the fatty acid of 10-18 carbon atom and have the alkyl that contains 2-8 carbon atom and the polyalcohol of 2-6 hydroxyl between ester,
(3) have the alkyl chain that contains 8-22 carbon atom, and condensation therein about 1.0-2.0 sugar alkyl polyglucoside,
(4) have two contain 2 or still less carbon atom alkyl and contain the chain alkyl of 8-22 carbon atom and can have amido link alkyl amine oxide and
(5) have the dialkyl dimethyl ammonium salt of the length of the alkyl chain that contains 6-18 carbon atom, a long alkyl one benzyl dimethyl ammonium salt, or an alkyl trimethyl ammonium salt.
Especially preferred is surfactant (2), (3) and (5).
A large amount of surfactants that add, especially ionic surfactant is not preferred, because it can significantly suppress the feature of polylysine, in order to be issued to better effect in the lower situation of polylysine concentration, for the ability of wiping, preferably 1% (quality) or lower, more preferably 0.5% (quality) or lower, most preferably 0.1% (quality) or lower of the content of surfactant in the microbicide compositions.Because anion surfactant can influence bactericidal property, the concentration of anion surfactant is preferably 0.1% (quality) or lower in the composition, more preferably 0.01% (quality) or lower.
Unless the performance that requires is destroyed, microbicide compositions of the present invention can with such as coloring material, mineral salt, comprise the pH value conditioning agent of polybasic carboxylic acid, and the various additives of the spices except that plants essential oil mix use, but surface to be sterilized for direct and Food Contact, these additives preferably can be used for those in the food, and the consumption of this additive should be reduced to minimum.When with polybasic carboxylic acid (succinic acid, citric acid etc.) during as pH value conditioning agent, the content of polybasic carboxylic acid is preferably 0.9% (quality) or still less in the composition, more preferably 0.01-0.9% (quality) or still less, most preferably 0.01-0.5% (quality).
Bactericide of the present invention prepares as component (d) by add entry in above-mentioned solvent and optional components.Therefore, water is the surplus after component in the composition (a) to (c) adds optional components, and the content of water is specially 80-99% (quality) in the composition, preferred 80-98% (quality), more preferably 91-95% (quality).For display security and excellent bactericidal property, the pH value of composition under 20 ℃ is preferably 6.0-9.0, more preferably 6.0-8.0.
The using method of microbicide compositions of the present invention preferably (1) injects directly on pending surface with the manual operation sprayer with composition, the method of wiping then with towel or paper handkerchief, (2) composition is applied to pending surface from squeezable container, the method of wiping then with towel or paper handkerchief, or (3) use the towel of said composition pre-soaked or the method on the pending surface of paper handkerchief wiping.
The manual operation sprayer preferably has the sprayer of manual operation trigger or manual operation pump, the especially preferred sprayer that has the manual operation trigger.Microbicide compositions of the present invention most preferably uses after charging into the container that this manual operation sprayer is housed.This sprayer preferably once sprays 0.1-1.5g, preferred 0.2-1.0g, the sprayer of especially preferred 0.25-0.8g inorganic agent.As the manual operation trigger, not only can adopt direct hydraulic trigger commonly used, also can adopt disclosed hydraulic reservoir D-flip flop among JP-U 4-37554 and the JP-A 9-122547.
Optimal mode of the present invention is as follows.
Microbicide compositions comprises:
Component (a): 0.0001-0.05% (quality) epsilon-polylysine,
Component (b): 0.0001-0.1% (quality) is selected from thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1, at least a compound of 8-ramie alcohol, citronellal, citronellol, linalool, anethole, menthol, menthones, carvol, camphor and peaceful alkene, or contain the plants essential oil of above-mentioned at least a compound
Component (c): 1-8% (quality) be selected from least a of ethanol, propyl alcohol and isopropyl alcohol and
Component (d): 91-98% (quality) water,
Wherein component (b)/component (c) is not more than 1/50, and surfactant concentrations is not higher than 0.1% (quality), and other components contents are not higher than 1% (quality),
And the bactericide that comprises the band packing that charges into the microbicide compositions in the container that the manual operation sprayer is housed.
Embodiment
Embodiment 1 to 10 and comparative example 1 to 6
Microbicide compositions shown in the preparation table 1, and estimate (1) antiseptic property, the use feeling during taste between (2) operating period and wiping and the cleaning and (3) storage stability with the following methods.The results are shown in table 1.
(1) antiseptic property
" Boukin Boubai Handbook " (Handbook ofAntimicrobial Antifungal Agents) is (by The Society forAntibacterial and Antifungal Agents for the antiseptic property basis, the Japan compilation, Gihodo ShuppanCo., Ltd. publishes) middle suspension test method (detection by quantitative) test of describing.Be about to 10 of 50 μ l
8-10
10The cfu/ml microbial suspension adds shown in the 2ml table 1 in every kind of composition, and is fully mixed and placed 5 minutes.Collect 10 μ l mixtures then and add in the 150 μ l SCDLP liquid nutrient mediums and abundant mixing, cultivated 48 hours down at 30 ℃.Week, bore hole checked the turbidity of medium and according to following criterion evaluation.Adopt two kinds of microorganisms, promptly Escherichia coli and staphylococcus aureus are as microorganism.
Zero: this medium is not muddy for Escherichia coli and staphylococcus aureus.
△: this medium is for Escherichia coli and staphylococcus aureus slight haze all.
*: this medium is all obviously muddy for Escherichia coli and staphylococcus aureus.
(2) use feeling during taste between the operating period and wiping and the cleaning
Triggering type sprayer with " Kantan My Pet " usefulness, it is the universal liquid cleaner that Kao Corporation makes, (1m * 1m plank) goes up and sprays microbicide compositions 5 times on pending surface, use the cotton towel wiping of 20cm * 20cm then, during estimate wetability and diffusibility, wiping ability and the residual solution of composition according to following criterion:
(taste between the operating period)
Zero: taste is slight, and the ethanol taste is not obvious.
*: unpleasant strong ethanol taste.
(the wetting and diffusion of mixed solution)
Zero: wetting uniformly and diffusion are gone up in the surface of using.
*: the solution thickness, can not fully wetting and diffusion.
(the wiping ability of mixed solution)
Zero: used lip-deep solution can fully be wiped.
△: solution wiping ability is poor slightly, has slight striped to take place during wiping.
* A: solution can not fully be wiped because during wiping with regard to rapid draing.
* B: solution can not fully be wiped, and produces striped during wiping.
(having wiped lip-deep residual solution)
Zero: all even solution that keeps right quantity does not thinly think thickness after the drying.
△: kept relatively large solution, the slight thickness of dry after sensation.
* A: residual solution is inhomogeneous, and its quantity very little.
* B: solution wipe poor ability, and its quantity is too many.
(3) storage stability
Microbicide compositions packed into be with in the vial of vinyl cover, and placed 20 days down, observe with bore hole then and according to following criterion evaluation at 50 ℃.Any microbicide compositions all is a clear solution after preparation just.
Zero: clear solution
△: slight haze.
*: separate.
Table 1
| Embodiment | Comparative example | |||||||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 1 | 2 | 3 | 4 | 5 | 6 | |||
| Composition (% by weight) | Composition (a) | Epsilon-polylysine | 0.01 | 0.02 | 0.01 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.1 | 0.02 | 0.01 | 0.01 | 0.02 | |||
| Composition (b) | Thyme linaloe oil | 0.01 | 0.01 | 0.01 | 0.005 | 0.01 | 0.1 | 0.01 | 0.01 | 0.01 | 0.005 | |||||||
| Rosemary oil | 0.01 | 0.01 | 0.01 | 0.005 | 0.005 | |||||||||||||
| Eucalyptus oil | 0.01 | |||||||||||||||||
| Composition (c) | Ethanol | 5 | 8 | 5 | 5 | 8 | 5 | 5 | 5 | 5 | 3 | 30 | 5 | 5 | 5 | 5 | 8 | |
| Composition (d) | Water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | |
| Alkyl (C12) polyglucoside (average sugared condensation degree: 1.3) | 0.5 | 0.5 | 0.05 | 1.5 | ||||||||||||||
| Citric acid | 0.02 | |||||||||||||||||
| Total amount | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
| PH value (20 ℃) | 7.2 | 7.6 | 7.2 | 7.9 | 7.6 | 7.8 | 7.8 | 7.7 | 6.8 | 7.7 | 7.2 | 6.8 | 7.2 | 6.8 | 6.8 | 7.6 | ||
| Disinfection Effect | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | × | △ | × | × | △ | ||
| Taste in the use | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | × | ○ | ○ | ○ | ○ | ○ | ||
| The gentle diffusion effect of the profit of mixed solution | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | × | ○ | ○ | ○ | ○ | ||
| The wiping ability of mixed solution | ○ | ○ | ○ | △ | ○ | △ | ○ | ○ | ○ | ○ | ×A | ○ | ○ | ×B | ×B | ○ | ||
| Residual solution on the wipe surfaces | ○ | ○ | ○ | △ | ○ | △ | ○ | ○ | ○ | ○ | ○ | ×A | ○ | ×B | ×B | ○ | ||
| Storage stability | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | △ | ○ | ○ | ○ | ○ | ○ | ○ | ||
Main antibacterial components in the plants essential oil in the table 1 is as follows:
● thyme linaloe oil: 37% (quality) carvacrol and 16% (quality) thymol.
● rosemary oil: 45% (quality) 1,8-ramie pure and mild 10% (quality) camphor
● eucalyptus oil: 81% (quality) 1, the peaceful alkene of pure and mild 13% (quality) of 8-ramie
Used epsilon-polylysine is the product of Chisso Corporation.
Embodiment 11 to 18
With with embodiment 1 table 1 in identical component prepare composition (embodiment 11 to 18), different is the thyme linaloe oil that replaces among the embodiment 1, mix thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol or 1 with the amount of 0.005% (quality), 8-ramie alcohol is as component (b), the any composition that obtains all shows good bactericidal effect and storage stability, and the use feeling aspect during taste during use and wiping and the cleaning can preferably be used.
Claims (6)
1. microbicide compositions, it contains the polylysine of (a) 0.0001-1 quality %, (b) plants essential oil of 0.0001-1 quality %, wherein plants essential oil contains and is selected from thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1, at least a compound of 8-ramie alcohol, citronellal, citronellol, linalool, anethole, menthol, menthones, carvol, camphor He limonene, (c) organic solvent of 0.1-18 quality % and (d) water of 80-99 quality %.
2. microbicide compositions, it contains the polylysine of (a) 0.0001-1 quality %, (b1) 0.0001-1 quality %'s is selected from thymol, geraniol, Japanese cypress phenol, carvacrol, citral, eugenol, terpinene (terpinene)-4-alcohol, 1, at least a compound of 8-ramie alcohol, citronellal, citronellol, linalool, anethole, menthol, menthones, carvol, camphor He limonene, (c) organic solvent of 0.1-18 quality % and (d) water of 80-99 quality %.
3. according to the microbicide compositions of claim 1 or 2, wherein also comprise the surfactant that is not higher than 0.1 quality %.
4. bactericide with packing, it contains the claim 1 that charges in the container that the non-aerosol sprayer is housed or 2 microbicide compositions.
5. claim 1 or 2 composition are as the purposes of disinfectant.
6. the sterilization method of a crust comprises that the composition with claim 1 or 2 is applied on the crust, and wipes said composition from this crust.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001117961 | 2001-04-17 | ||
| JP117961/2001 | 2001-04-17 | ||
| JP2002049079A JP4342761B2 (en) | 2001-04-17 | 2002-02-26 | Disinfectant composition |
| JP49079/2002 | 2002-02-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1520258A CN1520258A (en) | 2004-08-11 |
| CN1243476C true CN1243476C (en) | 2006-03-01 |
Family
ID=26613691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028084721A Expired - Fee Related CN1243476C (en) | 2001-04-17 | 2002-04-15 | Bactericide compsn. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6921745B2 (en) |
| EP (1) | EP1406494B1 (en) |
| JP (1) | JP4342761B2 (en) |
| CN (1) | CN1243476C (en) |
| DE (1) | DE60226606D1 (en) |
| WO (1) | WO2002085109A2 (en) |
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| JP2000026886A (en) * | 1998-07-07 | 2000-01-25 | Kao Corp | Detergent composition |
| JP3269030B2 (en) * | 1998-07-07 | 2002-03-25 | 花王株式会社 | Detergent composition |
| WO2000011956A1 (en) * | 1998-08-27 | 2000-03-09 | Bio Venture Bank Co., Ltd. | Bacteriostatic and bactericidal compositions and method for utilization thereof |
-
2002
- 2002-02-26 JP JP2002049079A patent/JP4342761B2/en not_active Expired - Fee Related
- 2002-04-15 WO PCT/JP2002/003734 patent/WO2002085109A2/en active IP Right Grant
- 2002-04-15 DE DE60226606T patent/DE60226606D1/en not_active Expired - Lifetime
- 2002-04-15 EP EP02718585A patent/EP1406494B1/en not_active Expired - Fee Related
- 2002-04-15 CN CNB028084721A patent/CN1243476C/en not_active Expired - Fee Related
- 2002-04-15 US US10/473,447 patent/US6921745B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4342761B2 (en) | 2009-10-14 |
| CN1520258A (en) | 2004-08-11 |
| JP2003002809A (en) | 2003-01-08 |
| EP1406494B1 (en) | 2008-05-14 |
| EP1406494A2 (en) | 2004-04-14 |
| US6921745B2 (en) | 2005-07-26 |
| US20040132630A1 (en) | 2004-07-08 |
| WO2002085109A3 (en) | 2003-12-31 |
| WO2002085109A2 (en) | 2002-10-31 |
| DE60226606D1 (en) | 2008-06-26 |
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