JP6551642B2 - Composition for disinfectant solution for shoe sole disinfecting mat and method for disinfecting salmonella attached to shoe sole - Google Patents
Composition for disinfectant solution for shoe sole disinfecting mat and method for disinfecting salmonella attached to shoe sole Download PDFInfo
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- JP6551642B2 JP6551642B2 JP2014153896A JP2014153896A JP6551642B2 JP 6551642 B2 JP6551642 B2 JP 6551642B2 JP 2014153896 A JP2014153896 A JP 2014153896A JP 2014153896 A JP2014153896 A JP 2014153896A JP 6551642 B2 JP6551642 B2 JP 6551642B2
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- 230000000249 desinfective effect Effects 0.000 title claims description 52
- 239000000203 mixture Substances 0.000 title claims description 50
- 239000000645 desinfectant Substances 0.000 title claims description 48
- 241000607142 Salmonella Species 0.000 title claims description 20
- 238000000034 method Methods 0.000 title claims description 17
- 230000001954 sterilising effect Effects 0.000 claims description 42
- 125000000217 alkyl group Chemical group 0.000 claims description 38
- -1 alkyl quaternary ammonium salt Chemical class 0.000 claims description 25
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 21
- 229940123208 Biguanide Drugs 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 19
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 16
- 239000002736 nonionic surfactant Substances 0.000 claims description 16
- 239000002280 amphoteric surfactant Substances 0.000 claims description 15
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 15
- 239000000417 fungicide Substances 0.000 claims description 14
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 229920002413 Polyhexanide Polymers 0.000 claims description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims description 10
- 230000000855 fungicidal effect Effects 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 150000005215 alkyl ethers Chemical class 0.000 claims description 6
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 6
- JGFDZZLUDWMUQH-UHFFFAOYSA-N Didecyldimethylammonium Chemical group CCCCCCCCCC[N+](C)(C)CCCCCCCCCC JGFDZZLUDWMUQH-UHFFFAOYSA-N 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 230000003641 microbiacidal effect Effects 0.000 claims description 4
- 229940124561 microbicide Drugs 0.000 claims description 4
- 239000002855 microbicide agent Substances 0.000 claims description 4
- 239000005416 organic matter Substances 0.000 claims description 4
- 239000003899 bactericide agent Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 description 41
- 239000003921 oil Substances 0.000 description 14
- 235000019198 oils Nutrition 0.000 description 14
- 239000012895 dilution Substances 0.000 description 13
- 238000010790 dilution Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 11
- 230000002421 anti-septic effect Effects 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 3
- 238000007865 diluting Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 235000019484 Rapeseed oil Nutrition 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000003021 water soluble solvent Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- QQJDHWMADUVRDL-UHFFFAOYSA-N didodecyl(dimethyl)azanium Chemical class CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC QQJDHWMADUVRDL-UHFFFAOYSA-N 0.000 description 1
- MELGLHXCBHKVJG-UHFFFAOYSA-N dimethyl(dioctyl)azanium Chemical class CCCCCCCC[N+](C)(C)CCCCCCCC MELGLHXCBHKVJG-UHFFFAOYSA-N 0.000 description 1
- CJBMLKNLJXFFGD-UHFFFAOYSA-N dimethyl-di(tetradecyl)azanium Chemical class CCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCC CJBMLKNLJXFFGD-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000010813 municipal solid waste Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
本発明は、特に靴底に付着したサルモネラの殺菌消毒に有効な靴底消毒マット用殺菌消毒液組成物及び靴底に付着したサルモネラの殺菌消毒方法に関する。 The present invention relates to a sterilizing liquid composition for a shoe sole disinfecting mat that is particularly effective for sterilizing salmonella adhered to a shoe sole, and a method for sterilizing and disinfecting salmonella adhered to a shoe sole.
ビグアナイド系殺菌剤や第4級アンモニウム塩系殺菌剤は、手指、患部、医療機器、台所周りや浴室、繊維材料などの殺菌消毒のための種々の殺菌消毒剤の主成分として使用されており、用途に応じた種々の改良が行われている。例えば、特許文献1には、優れた殺菌消毒力を保持したまま、使用時の皮膚刺激を減少し、使用後の触感を著しく改良した第四級アンモニウム塩系殺菌消毒剤又はビグアナイド系殺菌消毒剤を含有する殺菌消毒剤組成物が開示されている。この殺菌消毒剤組成物は、第四級アンモニウム塩系殺菌消毒剤又はビグアナイド系殺菌消毒剤の低級アルコール溶液に対して、凝固点が35℃以上のポリアルキレングリコール又は凝固点が35℃以上のアルキレングリコールの誘導体を0.01〜2重量%配合してなるものである。
又、特許文献2には、基布への吸着を防止して有効に殺菌消毒効果を発揮することができる殺菌消毒液と、この殺菌消毒液を基布に浸漬させた殺菌消毒剤が開示されている。この殺菌消毒液が、正電荷を帯びた殺菌消毒成分と、リシン、アルギニン、ヒスチジンおよびそれらの塩酸塩の中から選択される少なくとも1種以上のアミノ酸と、ノニオン系界面活性剤とを含有し、pH4〜9に調整されてなる殺菌消毒液である。
Biguanide fungicides and quaternary ammonium salt fungicides are used as the main components of various fungicides for disinfecting fingers, affected areas, medical devices, kitchens, bathrooms, textile materials, etc. Various improvements have been made depending on the application. For example, Patent Document 1 discloses a quaternary ammonium salt-based disinfectant or a biguanide-based disinfectant that reduces skin irritation during use and significantly improves the feel after use while maintaining excellent disinfectant power. Disinfectant compositions containing the same are disclosed. This disinfectant composition is composed of a polyalkylene glycol having a freezing point of 35 ° C. or higher or an alkylene glycol having a freezing point of 35 ° C. or higher, relative to a lower alcohol solution of quaternary ammonium salt based disinfectant or biguanide disinfectant. A derivative is blended in an amount of 0.01 to 2% by weight.
Further, Patent Document 2 discloses a sterilizing / disinfecting solution capable of effectively exerting a sterilizing effect by preventing adsorption to the base cloth, and a sterilizing / disinfecting agent in which the sterilizing / disinfecting liquid is immersed in the base cloth. ing. The disinfectant contains a positively-charged disinfectant component, at least one or more amino acids selected from lysine, arginine, histidine and their hydrochloride salts, and a nonionic surfactant. It is a sterilizing / disinfecting liquid adjusted to pH 4-9.
一方、なたねや大豆などの油糧種子から油脂を採取し、油粕が生じる油脂工場、油糧種子・油粕・油糧種子や油粕から製造される蛋白含有固形物を使用する食品工場や飼料工場では、作業員の靴底に付着した油粕や蛋白含有固形物が栄養源となりサルモネラが繁殖するため、工場への入退出時に靴底に付着したサルモネラを殺菌し、靴底を消毒する必要がある。しかしながら、このような用途に市販の消毒液を用いると、使用の度に消毒液中に油粕や蛋白含有固形物などの有機物が溜まり、これらの有機物が消毒液と反応して、消毒液の殺菌力が著しく低下するとの問題が生じている。さらに、これら有機物が油脂を含有するものであると油脂により消毒液が有機物へ浸透し難く、有機物中において十分な殺菌作用を発揮できない問題点も発生する。特に、食品工場の出入り口の靴底消毒マットに市販の塩化ベンザルコニウムの1%溶液がよく使用されているが、希釈して用いると十分な効果を得ることができないとの問題があった。なお、殺菌消毒剤に洗浄剤(界面活性剤)を含有させると、靴底消毒マットでよくゴミが落ち、また、工場内で靴底に付着した汚れも除去しやすいものの、消毒液中に油粕や蛋白含有固形物などの有機物が混入することによる消毒液の殺菌力の著しい低下の問題は解決しない。 On the other hand, in oil and fat factories where oils and fats are collected from oilseed such as rapeseed and soybeans, oil factories that produce oil lees, food factories and feed factories that use protein-containing solids produced from oil seeds, oil lees, oil seeds and oil lees Since salmonella is propagated as a source of nutrients and oil-containing solids attached to the shoe sole of workers, it is necessary to sterilize the salmonella attached to the shoe sole when entering and leaving the factory and disinfect the shoe sole. However, when a commercially available disinfectant is used for such applications, organic matter such as oil cake and protein-containing solids accumulates in the disinfectant each time it is used, and these organic matter reacts with the disinfectant to disinfect the disinfectant. There is a problem that the power is significantly reduced. Furthermore, if these organic substances contain fats and oils, it is difficult for the antiseptic solution to penetrate the organic substances due to the fats and oils, and there is also a problem that the sufficient bactericidal action can not be exhibited in the organic substances. In particular, a commercially available 1% solution of benzalkonium chloride is often used for shoe sole disinfection mats at the entrances and exits of food factories, but there is a problem that sufficient effects cannot be obtained when diluted. If a disinfectant contains a cleaning agent (surfactant), the shoe sole disinfecting mat will remove trash and the dirt on the shoe sole in the factory can be easily removed. It does not solve the problem of a marked decline in the bactericidal power of the disinfectant solution due to the contamination of organic matter such as protein solids and solid matter.
本発明は、消毒液中に油粕や蛋白含有固形物などの有機物が混入しても殺菌力の著しい低下を抑制できる、特に靴底に付着したサルモネラの殺菌消毒に有効な靴底消毒マット用殺菌消毒液組成物を提供することを目的とする。
本発明は、又、靴底に付着したサルモネラの効率的な殺菌消毒方法を提供することを目的とする。
The present invention is capable of suppressing a significant decrease in sterilizing power even when organic substances such as oil cake and protein-containing solids are mixed in the disinfectant, and is particularly effective for sterilization of salmonella attached to the shoe sole. An object is to provide a disinfectant composition.
Another object of the present invention is to provide an efficient method for sterilizing and disinfecting salmonella attached to soles.
本発明は、ビグアナイド系殺菌剤に特定の第4級アンモニウム塩を併用すると、上記課題を解決できるとの知見に基づいてなされたものである。
すなわち、本発明は、[1]〜[13]を提供する。
[1]ビグアナイド系殺菌剤とジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩(長鎖アルキルは炭素数8〜14のアルキル基であり、短鎖アルキルは炭素数1〜3のアルキル基である)を含有することを特徴とする靴底消毒マット用殺菌消毒液組成物。
[2]さらに、塩化ベンザルコニウムを含有する[1]の殺菌消毒液組成物。
[3]ビグアナイド系殺菌剤:ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩と塩化ベンザルコニウムの合計量の質量比が、0.1/1〜1.2/1である[2]の殺菌消毒液組成物。
[4]さらに、非イオン界面活性剤及び/又は両性界面活性剤を含有する[1]〜[3]のいずれかの殺菌消毒液組成物。
[5]ビグアナイド系殺菌剤がポリヘキサメチレンビグアナイド塩酸塩(PHMB)である[1]〜[4]のいずれかの殺菌消毒液組成物。
The present invention has been made based on the finding that the above-mentioned problems can be solved by using a specific quaternary ammonium salt in combination with a biguanide-based microbicide.
That is, the present invention provides [1] to [13].
[1] Biguanide fungicide and dilong chain alkyldishort chain alkyl quaternary ammonium salt (long chain alkyl is an alkyl group having 8 to 14 carbon atoms, and short chain alkyl is an alkyl group having 1 to 3 carbon atoms) ) A sterilizing liquid composition for shoe sole disinfecting mats.
[2] The disinfectant composition according to [1], further containing benzalkonium chloride.
[3] Biguanide fungicide: The mass ratio of the total amount of dilong chain alkyldishort chain alkyl quaternary ammonium salt and benzalkonium chloride is 0.1 / 1 to 1.2 / 1. Bactericidal disinfectant composition.
[4] The sterilizing liquid composition of any of [1] to [3], further comprising a nonionic surfactant and / or an amphoteric surfactant.
[5] The disinfectant solution composition according to any one of [1] to [4], wherein the biguanide-based microbicide is polyhexamethylene biguanide hydrochloride (PHMB).
[6]ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩が、ジデシルジメチルアンモニウム塩(DDAC)である[1]〜[5]のいずれかの殺菌消毒液組成物。
[7]靴底に付着したサルモネラの殺菌消毒用である[1]〜[6]のいずれかの殺菌消毒液組成物。
[8]水性液体吸収性の靴底消毒マットに、[1]〜[7]のいずれかの殺菌消毒液組成物又はその希釈液を吸収又は含浸させ、靴底消毒マット中の殺菌消毒液組成物に、油脂を含有する有機物とサルモネラが付着した靴底を接触させることを特徴とする靴底に付着したサルモネラの殺菌消毒方法。
[9]殺菌消毒液組成物が、ビグアナイド系殺菌剤を0.005〜1質量%、ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩を0.05〜1.5質量%含有する[8]の殺菌消毒方法。
[10]殺菌消毒液組成物が、さらに、塩化ベンザルコニウムの含有量は、0.005〜1質量%含有する[9]の殺菌消毒方法。
[11]殺菌消毒液組成物が、さらに、非イオン界面活性剤及び/又は両性界面活性剤を0.05〜1.5質量%含有する[9]又は[10]の殺菌消毒方法。
[12]殺菌消毒液組成物又はその希釈液を、靴底消毒マットの重量の0.5〜10倍量で靴底消毒マットに吸収又は含浸させる[8]〜[11]のいずれかの殺菌消毒方法。
[13]殺菌消毒液組成物又はその希釈液を、靴底消毒マットに1週間に1回以上供給する[8]〜[12]のいずれかの殺菌消毒方法。
[6] The disinfectant solution composition according to any one of [1] to [5], wherein the di-long chain alkyl di short chain alkyl quaternary ammonium salt is a didecyldimethyl ammonium salt (DDAC).
[7] The disinfectant solution composition according to any one of [1] to [6], which is for disinfecting salmonella attached to shoe soles.
[8] A disinfectant solution composition in a shoe sole disinfecting mat by absorbing or impregnating a sterilizing disinfectant composition according to any one of [1] to [7] or a dilution thereof in an aqueous liquid-absorbent shoe sole disinfecting mat A method of sterilizing and disinfecting salmonella attached to a shoe sole, comprising contacting the object with an organic substance containing fat and oil and a shoe sole to which the salmonella adheres.
[9] The disinfectant composition contains 0.005 to 1% by mass of a biguanide fungicide and 0.05 to 1.5% by mass of a dilong chain alkyldishort chain alkyl quaternary ammonium salt. [8] Sterilization method.
[10] The sterilizing method of [9], wherein the sterilizing / disinfecting liquid composition further contains 0.005 to 1% by mass of benzalkonium chloride.
[11] The sterilizing method of [9] or [10], wherein the sterilizing / disinfecting liquid composition further contains 0.05 to 1.5% by mass of a nonionic surfactant and / or an amphoteric surfactant.
[12] The sterilization according to any one of [8] to [11], wherein the disinfectant solution composition or its diluted solution is absorbed or impregnated into the shoe sole disinfecting mat in an amount of 0.5 to 10 times the weight of the shoe sole disinfecting mat Disinfection method.
[13] The sterilizing method according to any one of [8] to [12], wherein the sterilizing solution composition or its diluted solution is supplied to a shoe sole disinfecting mat at least once a week.
本発明で用いるビグアナイド系殺菌剤としては、ポリヘキサメチレンビグアナイド塩酸塩(PHMB)、グルコン酸クロルヘキシジン、クロルヘキシジン、クロルヘキシジン塩酸塩などの1種又は2種以上の混合物を用いることができる。
本発明で用いるジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩としては、長鎖アルキルが炭素数8〜14のアルキル基であり、短鎖アルキルが炭素数1〜3のアルキル基であるものが好ましい。より好ましくは、長鎖アルキルが炭素数8〜12のアルキル基であり、短鎖アルキルがメチル基である第4級アンモニウム塩である。具体的には、ジオクチルジメチルアンモニウム塩、ジデシルジメチルアンモニウム塩(DDAC)、ジドデシルジメチルアンモニウム塩、ジテトラデシルジメチルアンモニウム塩などの1種又は2種以上の混合物を用いることができる。ここで、塩としては、塩酸塩、メチル硫酸塩などがあげられる。
本発明の靴底消毒マット用殺菌消毒液組成物の残部は水であるのが好ましいが、エタノールなどの水溶性溶剤を含有していてもよい。引火性の点から、水溶性溶剤を用いる場合は、引火点、爆発限界などが低いものが好ましい。液のpHは、弱酸性〜弱アルカリ性、例えば、pH5〜9であるのが好ましく、より好ましくはpH5.5〜8.5である。液のpHは、酸やアルカリ、塩などを用いて調整することができる。
本発明の靴底消毒マット用殺菌消毒液組成物の原液(濃厚液)中、ビグアナイド系殺菌剤の含有量は、0.5〜20質量%であるのが好ましく、より好ましくは1〜15質量%である。又、ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩の量は、5〜25質量%であるのが好ましく、より好ましくは、7〜20質量%である。
As the biguanide fungicide used in the present invention, one or a mixture of two or more of polyhexamethylene biguanide hydrochloride (PHMB), chlorhexidine gluconate, chlorhexidine, chlorhexidine hydrochloride and the like can be used.
As the long-chain alkyl di-short-chain alkyl quaternary ammonium salt used in the present invention, those in which long-chain alkyl is an alkyl group having 8 to 14 carbon atoms and short-chain alkyl is an alkyl group having 1 to 3 carbon atoms preferable. More preferably, it is a quaternary ammonium salt in which the long chain alkyl is an alkyl group having 8 to 12 carbon atoms and the short chain alkyl is a methyl group. Specifically, one or a mixture of two or more of dioctyldimethyl ammonium salt, didecyl dimethyl ammonium salt (DDAC), didodecyl dimethyl ammonium salt, and ditetradecyl dimethyl ammonium salt can be used. Here, examples of the salt include hydrochloride and methyl sulfate.
The remainder of the disinfectant solution composition for a shoe sole disinfecting mat of the present invention is preferably water, but may contain a water-soluble solvent such as ethanol. In the case of using a water-soluble solvent, those having a low flash point, explosion limit and the like are preferable from the point of flammable. The pH of the solution is preferably weakly acidic to weakly alkaline, for example, pH 5 to 9, more preferably pH 5.5 to 8.5. The pH of the solution can be adjusted using an acid, an alkali, a salt or the like.
In the stock solution (concentrated solution) of the disinfectant solution composition for shoe sole disinfecting mat of the present invention, the content of the biguanide-based disinfectant is preferably 0.5 to 20% by mass, more preferably 1 to 15 wt. %. The amount of di-long chain alkyl di short chain alkyl quaternary ammonium salt is preferably 5 to 25% by mass, more preferably 7 to 20% by mass.
本発明の靴底消毒マット用殺菌消毒液組成物には、さらに、塩化ベンザルコニウムを配合するのが好ましい。本発明の靴底消毒マット用殺菌消毒液組成物の原液(濃厚液)中、塩化ベンザルコニウムの含有量は、0.5〜20質量%であるのが好ましく、より好ましくは1〜15質量%である。
本発明では、特に、ビグアナイド系殺菌剤:ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩と塩化ベンザルコニウムの合計量の質量比が、0.1/1〜1.2/1であるのが好ましく、0.1/1〜1.0/1がより好ましい。
本発明の靴底消毒マット用殺菌消毒液組成物には、さらに、非イオン界面活性剤及び/又は両性界面活性剤を配合するのが好ましい。非イオン界面活性剤としては、HLBが12〜15のものが好ましく、特にポリオキシエチレンアルキルエーテルであるのが好ましい。又、両性界面活性剤としては、各種グリシン型両性界面活性剤やベタイン型両性界面活性剤などがあげられる。本発明の靴底消毒マット用殺菌消毒液組成物の原液(濃厚液)中、非イオン界面活性剤及び/又は両性界面活性剤の量は、5〜25質量%であるのが好ましく、より好ましくは、7〜25質量%である。又、脂肪酸アルカノールアミドやアルキルグルコシドを併用することができる。
It is preferable to further add benzalkonium chloride to the disinfectant solution composition for shoe sole disinfecting mat of the present invention. In the stock solution (concentrated solution) of the sterilizing and disinfecting liquid composition for shoe sole disinfecting mat of the present invention, the content of benzalkonium chloride is preferably 0.5 to 20% by mass, more preferably 1 to 15% by mass. %.
In the present invention, in particular, the mass ratio of the total amount of biguanide fungicide: dilong chain alkyldishort chain alkyl quaternary ammonium salt and benzalkonium chloride is 0.1 / 1 to 1.2 / 1. Is preferable, and 0.1 / 1 to 1.0 / 1 is more preferable.
It is preferable to further add a nonionic surfactant and / or an amphoteric surfactant to the disinfectant solution composition for shoe sole disinfecting mat of the present invention. The nonionic surfactant preferably has an HLB of 12 to 15, and particularly preferably a polyoxyethylene alkyl ether. The amphoteric surfactant includes various glycine type amphoteric surfactants and betaine type amphoteric surfactants. In the stock solution (concentrated solution) of the sterilizing and disinfecting liquid composition for shoe sole disinfecting mat of the present invention, the amount of the nonionic surfactant and / or the amphoteric surfactant is preferably 5 to 25% by mass, more preferably. Is 7-25 mass%. Moreover, fatty acid alkanolamide and alkyl glucoside can be used together.
本発明の靴底消毒マット用殺菌消毒液組成物には、さらに、香料、着色剤など通常の消毒液に添加できる成分を配合することができる。
本発明の靴底消毒マット用殺菌消毒液組成物は、原液自体を使用することができるが、希釈して用いることが好ましい。希釈する液としては水以外に、アルコール水溶液、バッファー水溶液等を用いることができるが、防火の点から好ましくは水で希釈するのが好ましく、100倍以下に水で希釈して用いるのが好ましく、さらに好ましくは80倍以下、特に好ましくは50倍以下に希釈して用いるのが好ましい。特に、希釈後の各成分の濃度として、ビグアナイド系殺菌剤を0.005〜1質量%含有することが好ましく、より好ましくは0.01〜1質量%含有することであり、最も好ましくは0.09〜1質量%含有することである。希釈後の各成分の濃度として、ジ長鎖アルキルジ短鎖アルキル第4級アンモニウム塩を0.05〜1.5質量%含有するのが好ましく、より好ましくは、0.1〜1.5質量%含有することであり、最も好ましくは、0.3〜1.5質量%含有することである。さらに、塩化ベンザルコニウムの含有量は、0.005〜1質量%含有するのが好ましく、より好ましくは塩化ベンザルコニウムを0.1〜1質量%含有することである。塩化ベンザルコニウムに代えて、又は塩化ベンザルコニウムに加えて、非イオン界面活性剤及び/又は両性界面活性剤を0.05〜1.5質量%含有するのが好ましい。
The disinfectant solution composition for a shoe sole disinfecting mat of the present invention may further contain ingredients that can be added to a normal disinfecting solution such as a fragrance and a coloring agent.
Although the stock solution itself can be used as the disinfectant solution composition for a shoe sole disinfecting mat of the present invention, it is preferable to use it diluted. As the solution to be diluted, an aqueous alcohol solution, an aqueous buffer solution, etc. can be used in addition to water, but from the viewpoint of fire protection, it is preferable to dilute with water, preferably 100 times or less with water. More preferably, it is preferably used by diluting it to 80 times or less, particularly preferably 50 times or less. In particular, the concentration of each component after dilution preferably contains a biguanide-based microbicide of 0.005 to 1% by mass, more preferably 0.01 to 1% by mass, and most preferably 0. It is 09-1 mass% containing. As the concentration of each component after dilution, it is preferable to contain 0.05 to 1.5% by mass of di-long-chain alkyl di-short-chain alkyl quaternary ammonium salt, more preferably 0.1 to 1.5% by mass It is contained, Most preferably, it is containing 0.3-1.5 mass%. Furthermore, the content of benzalkonium chloride is preferably 0.005 to 1% by mass, and more preferably 0.1 to 1% by mass of benzalkonium chloride. It is preferable to contain 0.05-1.5 mass% of nonionic surfactant and / or amphoteric surfactant instead of benzalkonium chloride or in addition to benzalkonium chloride.
本発明は、又、水性液体吸収性の靴底消毒マットに、上記殺菌消毒液組成物又はその希釈液を吸収又は含浸させ、靴底消毒マット中の殺菌消毒液組成物に、蛋白を含有する固形物とサルモネラが付着した靴底を接触させることを特徴とする靴底に付着したサルモネラの殺菌消毒方法を提供する。ここで、水性液体吸収性の靴底消毒マットとしては、繊維材料や発泡体材料でできたものがあげられる。殺菌消毒液組成物又はその希釈液を、靴底消毒マットの重量の0.5〜10倍量で靴底消毒マットに吸収又は含浸させるのが好ましく、より好ましくは1〜7倍量である。又、靴底消毒マットに1週間に1回以上供給するのが好ましく、より好ましくは1〜3回である。 In the present invention, an aqueous liquid-absorbing shoe sole disinfecting mat absorbs or impregnates the above-mentioned disinfecting disinfecting liquid composition or a diluted liquid thereof, and the disinfecting disinfecting liquid composition in the shoe sole disinfecting mat contains a protein. There is provided a method of sterilizing and attaching salmonella attached to a shoe sole, the method comprising bringing a solid into contact with a shoe sole attached with salmonella. Here, as an aqueous liquid-absorbent shoe-bottom disinfecting mat, mention may be made of those made of a fiber material or a foam material. It is preferable to absorb or impregnate the antiseptic solution composition or the diluted solution thereof in the amount of 0.5 to 10 times the weight of the antiseptic mat, or more preferably 1 to 7 times the amount of the antiseptic mat. Moreover, it is preferable to supply a shoe sole disinfecting mat once or more once a week, more preferably 1 to 3 times.
次に本発明を実施例及び比較例により具体的に説明する。
実施例1〜3及び比較例1〜4
表1に示した処方の通り、水に、ポリヘキサメチレンビグアナイド塩酸塩(PHMB)、ジデシルジメチルアンモニウム塩(DDAC)、塩化ベンザルコニウム、界面活性剤を配合して、殺菌消毒液を製造した。尚、比較例1、3及び実施例1〜3で用いた界面活性剤は以下の通りである。
比較例1:ポリオキシエチレンアルキルエーテル(HLB12-15)
比較例3、実施例1及び3:ポリオキシエチレンアルキルエーテル(HLB13)と脂肪酸アルカノールアミドの混合物
実施例2:ポリオキシエチレンアルキルエーテル(HLB13)とアルキルグルコシドの混合物
Next, the present invention will be specifically described with reference to examples and comparative examples.
Examples 1-3 and Comparative Examples 1-4
According to the formulation shown in Table 1, a disinfectant solution was prepared by blending polyhexamethylene biguanide hydrochloride (PHMB), didecyldimethylammonium salt (DDAC), benzalkonium chloride, and a surfactant in water. . The surfactants used in Comparative Examples 1 and 3 and Examples 1 to 3 are as follows.
Comparative Example 1: Polyoxyethylene alkyl ether (HLB12-15)
Comparative Example 3, Examples 1 and 3: Mixture of Polyoxyethylene Alkyl Ether (HLB 13) and Fatty Acid Alkanolamide Example 2: Mixture of Polyoxyethylene Alkyl Ether (HLB 13) and Alkyl Glucoside
表1
Table 1
実施例1〜3及び比較例1〜4の殺菌消毒液の殺菌特性を以下の方法で評価した。
<評価方法>
消毒剤を下記のように希釈し、菜種搾油粕を添加したものを常温に保管し、スタート時 (START) 、一日 (1day) および一週間 (1week) 経過時の殺菌力を確認した。
(1)消毒液 100 mL に対し菜種搾油粕5g (5 %)を添加して試験液を調製した。
(2)(1)で調製した試験液 5mL に対しサルモネラの菌液(108cfu/ml)5mL 添加 (10分放置)した。
(3)ハートインフュジョンブイヨン培地 (HIB培地) 3mL に(2)で調製した試験液を30 μL 添加して35℃で24hr培養した。
(4)DHL 寒天培地に(3)で培養した培養液を、画線し、35℃で24時間培養した。
(5)培養液に生じたコロニーの有無でサルモネラ陰性(-)、サルモネラ陽性(+)を判定した。
結果をまとめて、表2と3に示す。
The sterilizing properties of the sterilizing and disinfecting solutions of Examples 1 to 3 and Comparative Examples 1 to 4 were evaluated by the following method.
<Evaluation method>
The disinfectants were diluted as follows, and those to which the rapeseed oil syrup was added were stored at room temperature, and the bactericidal activity at start (START), one day (1 day) and one week (1 week) was confirmed.
(1) A test solution was prepared by adding 5 g (5%) of rapeseed oil bath to 100 mL of antiseptic solution.
(2) To 5 mL of the test solution prepared in (1), 5 mL of a bacterial solution of salmonella (10 8 cfu / ml) was added (left for 10 minutes).
(3) 30 μL of the test solution prepared in (2) was added to 3 mL of heart infusion broth medium (HIB medium) and cultured at 35 ° C. for 24 hours.
(4) The culture broth cultured in (3) was streaked on a DHL agar medium and cultured at 35 ° C. for 24 hours.
(5) Salmonella-negative (-) and Salmonella-positive (+) were judged by the presence or absence of the colony which arose in the culture solution.
The results are summarized and shown in Tables 2 and 3.
表2<比較例>
表2の比較例2と3の結果から明らかなように、塩化ベンザルコニウム単独、DDACと界面活性剤の併用並びにPHMB単独での使用は、0.33%(10%→30倍希釈)以上の高濃度で効果があるものの、0.2%(10%→50倍希釈)では、効果が期待できないことがわかる。
Table 2 <Comparative example>
As is clear from the results of Comparative Examples 2 and 3 in Table 2, benzalkonium chloride alone, combined use of DDAC and surfactant, and use of PHMB alone are 0.33% (10% → 30 times dilution) or more. The effect is high at a concentration of 0.2% (10% → 50 times dilution), but it can be seen that no effect can be expected.
表3<実施例1〜3>
Table 3 <Examples 1-3>
表3の結果から、実施例1のPHMB0.08%(4%×50倍希釈)、DDAC0.2%(10%×50倍希釈)を含有する殺菌消毒液は、優れた殺菌効果があることがわかる。
又、実施例2の80倍希釈濃度<PHMB0.04%(3%×80倍希釈)、DDAC0.15%(12%×80倍希釈)、塩化ベンザルコニウム0.08%(6%×80倍希釈)>を含有する殺菌消毒液は、優れた殺菌効果があることが認められ、50倍希釈濃度では、かなりの効果がみられることがわかる。
実施例3の100倍希釈濃度<PHMB0.09%(9%×100倍希釈)、DDAC0.11%(11%×100倍希釈)>を含有する殺菌消毒液は、優れた殺菌効果が認められ、50倍希釈濃度では、かなりの効果がみられることがわかる。
From the results of Table 3, the sterilizing liquid containing 0.08% (4% × 50 times dilution) and DDAC 0.2% (10% × 50 times dilution) of Example 1 has an excellent sterilizing effect. I understand.
Further, 80-fold dilution concentration of Example 2 <PHMB 0.04% (3% x 80-fold dilution), DDAC 0.15% (12% x 80-fold dilution), benzalkonium chloride 0.08% (6% x 80) It is found that the sterilizing and disinfecting solution containing double dilution) has an excellent bactericidal effect, and a considerable effect is observed at the 50-fold dilution concentration.
The bactericidal antiseptic solution containing 100-fold diluted concentration <PHMB 0.09% (9% × 100-fold diluted) and DDAC 0.11% (11% × 100-fold diluted)> of Example 3 has an excellent bactericidal effect. It can be seen that a considerable effect is observed at a 50-fold dilution concentration.
実施例4
実施例3の消毒液を30倍に水で希釈し、食品工場の出入口に設置してある靴底消毒マット(消毒マット:山崎産業株式会社製マット(#6)F-38-6:サイズ:600×900mm:材質PP 85%、ナイロン 15%:重量0.7 kg)に希釈した消毒液を約3リットル注入した。希釈した消毒液を毎日補充し、1週間ごとにサンプリングを行いサルモネラの検出の有無を確認した。サルモネラは、遺伝子増幅法(PCR)を用いた自動検出システムおよび飼料安全基準に準じた方法により判定した。
比較例5
比較例1の消毒液を希釈せずに、実施例4と同様の試験を行った。
実施例4と比較例5の結果をまとめて表4に示す。
Example 4
The shoe disinfection mat (disinfection mat: mat (# 6) F-38-6 manufactured by Yamazaki Sangyo Co., Ltd.) installed at the entrance of the food factory after diluting the disinfectant solution of Example 3 with water 30 times. About 3 liters of a disinfectant diluted in 600 × 900 mm: material PP 85%, nylon 15%: weight 0.7 kg) was injected. The diluted antiseptic solution was replenished daily and sampled weekly to confirm the presence or absence of salmonella detection. Salmonella was determined by an automatic detection system using gene amplification method (PCR) and a method according to the feed safety standard.
Comparative example 5
The same test as in Example 4 was performed without diluting the disinfectant solution of Comparative Example 1.
Table 4 summarizes the results of Example 4 and Comparative Example 5.
表4
このように、本発明によれば、消毒液中に靴底に付着した油粕や蛋白を含有する固形物などの有機物が混入しても殺菌力の著しい低下を抑制でき、特に靴底に付着したサルモネラを有効に殺菌消毒できることがわかる。
Table 4
Thus, according to the present invention, even if organic substances such as oil cakes and solid substances containing protein attached to shoe soles are mixed in the antiseptic solution, it is possible to suppress a marked decrease in bactericidal activity, and in particular to stick to shoe soles. It can be seen that Salmonella can be effectively sterilized.
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