CN1240430C - 预防和治疗慢性疲劳综合症的药物 - Google Patents
预防和治疗慢性疲劳综合症的药物 Download PDFInfo
- Publication number
- CN1240430C CN1240430C CNB031469671A CN03146967A CN1240430C CN 1240430 C CN1240430 C CN 1240430C CN B031469671 A CNB031469671 A CN B031469671A CN 03146967 A CN03146967 A CN 03146967A CN 1240430 C CN1240430 C CN 1240430C
- Authority
- CN
- China
- Prior art keywords
- medicine
- colla
- chronic fatigue
- fatigue syndrome
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 39
- 229940079593 drug Drugs 0.000 title description 7
- 208000011580 syndromic disease Diseases 0.000 title description 3
- 230000001684 chronic effect Effects 0.000 title description 2
- 208000016253 exhaustion Diseases 0.000 title 1
- 239000007788 liquid Substances 0.000 claims abstract description 39
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims abstract description 20
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims abstract description 20
- 241000005787 Cistanche Species 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000003826 tablet Substances 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 241001550206 Colla Species 0.000 claims description 24
- 108010052008 colla corii asini Proteins 0.000 claims description 18
- 241000208340 Araliaceae Species 0.000 claims description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 15
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 15
- 235000008434 ginseng Nutrition 0.000 claims description 15
- 241000209020 Cornus Species 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 11
- 206010012735 Diarrhoea Diseases 0.000 abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 7
- 208000031975 Yang Deficiency Diseases 0.000 abstract description 6
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract description 5
- 206010022437 insomnia Diseases 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 206010046543 Urinary incontinence Diseases 0.000 abstract description 4
- 210000003414 extremity Anatomy 0.000 abstract description 4
- 201000001881 impotence Diseases 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000003292 glue Substances 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 108010010803 Gelatin Proteins 0.000 abstract description 2
- 206010003549 asthenia Diseases 0.000 abstract description 2
- 229920000159 gelatin Polymers 0.000 abstract description 2
- 239000008273 gelatin Substances 0.000 abstract description 2
- 235000019322 gelatine Nutrition 0.000 abstract description 2
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 239000003390 Chinese drug Substances 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 240000002624 Mespilus germanica Species 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 abstract 1
- 235000000560 Mimusops elengi Nutrition 0.000 abstract 1
- 206010030124 Oedema peripheral Diseases 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 241000270708 Testudinidae Species 0.000 abstract 1
- 235000007837 Vangueria infausta Nutrition 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 11
- 210000003734 kidney Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 9
- 230000007812 deficiency Effects 0.000 description 9
- 206010016256 fatigue Diseases 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 230000009182 swimming Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 108010002350 Interleukin-2 Proteins 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 239000011800 void material Substances 0.000 description 4
- 206010063659 Aversion Diseases 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 3
- 208000019914 Mental Fatigue Diseases 0.000 description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 230000002180 anti-stress Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 210000000629 knee joint Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 206010027175 memory impairment Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 208000012201 sexual and gender identity disease Diseases 0.000 description 3
- 208000015891 sexual disease Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000711404 Avian avulavirus 1 Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000001773 anti-convulsant effect Effects 0.000 description 2
- 230000002929 anti-fatigue Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000000147 hypnotic effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000036299 sexual function Effects 0.000 description 2
- 208000011726 slow pulse Diseases 0.000 description 2
- 230000008925 spontaneous activity Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- PCGVPMHGSJFFTI-ZEYGOCRCSA-N (4ar,5as,8ar,13as,15as,15br)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2h-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one;nitric acid Chemical compound O[N+]([O-])=O.O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 PCGVPMHGSJFFTI-ZEYGOCRCSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010053156 Musculoskeletal discomfort Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000002920 convulsive effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000607 neurosecretory system Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940059935 strychnine nitrate Drugs 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000019590 thick flavour Nutrition 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
分组 | 显效 | 有效 | 无效 | X2值 | P值 |
复方阿胶浆 | 9 | 33 | 22 | 13.63 | <0.01 |
SFS口服液 | 35 | 64 | 15 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031469671A CN1240430C (zh) | 2003-09-27 | 2003-09-27 | 预防和治疗慢性疲劳综合症的药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB031469671A CN1240430C (zh) | 2003-09-27 | 2003-09-27 | 预防和治疗慢性疲劳综合症的药物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1528381A CN1528381A (zh) | 2004-09-15 |
CN1240430C true CN1240430C (zh) | 2006-02-08 |
Family
ID=34286702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031469671A Expired - Fee Related CN1240430C (zh) | 2003-09-27 | 2003-09-27 | 预防和治疗慢性疲劳综合症的药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1240430C (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103893577B (zh) * | 2014-04-04 | 2017-04-05 | 重庆市中药研究院 | 一种复方乌天麻片剂、制备方法及其应用 |
CN104083404B (zh) * | 2014-08-01 | 2015-07-29 | 李江红 | 一种抗衰老的中药组合物 |
CN106074974A (zh) * | 2016-07-19 | 2016-11-09 | 成都嘉宝祥生物科技有限公司 | 一种提高免疫力的组合物 |
-
2003
- 2003-09-27 CN CNB031469671A patent/CN1240430C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1528381A (zh) | 2004-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1596914A (zh) | 一种治疗由脏腑病所致眼病的药物 | |
CN1814167A (zh) | 一种用于糖尿病的保健品 | |
CN101590168B (zh) | 一种用于治疗痛风的中药组合物及其制备方法 | |
CN101053621A (zh) | 一种治疗肥胖症的中药组合物及其制备方法 | |
CN101744924A (zh) | 大菱鲆细菌性疾病的多效中草药复方 | |
CN1679909A (zh) | 治疗失眠症的中药组合物及其生产方法 | |
CN100586465C (zh) | 治疗抑郁症的中药组合物及其制备方法 | |
CN1240430C (zh) | 预防和治疗慢性疲劳综合症的药物 | |
CN101590169B (zh) | 一种用于治疗痛风的中药组合物及其制备方法 | |
CN101590167B (zh) | 一种用于治疗痛风的中药组合物及其制备方法 | |
CN101045110A (zh) | 一种治疗肾虚的药物组合物及其制备方法 | |
CN1422636A (zh) | 一种治疗妇女更年期综合征的中药制剂 | |
CN101647985B (zh) | 一种治疗银屑病的药物组合物 | |
CN1234404C (zh) | 一种预防和治疗慢性疲劳综合症的药物 | |
CN101590166B (zh) | 一种用于治疗痛风的中药组合物及其制备方法 | |
CN101991757B (zh) | 一种补肾助阳的中药组合物及其制备方法 | |
CN1242766C (zh) | 一种预防和治疗慢性疲劳综合症的药物及其制备方法 | |
CN1259095C (zh) | 一种安脑降压药物及其制备方法和应用 | |
CN1313112C (zh) | 一种具有养神镇静作用的药物组合物 | |
CN1105557A (zh) | 减肥药的制造方法及产品 | |
CN113332327A (zh) | 西洋参黄芪制剂在制备提高免疫力的产品中的应用 | |
CN102824414A (zh) | 一种用于治疗便秘的药茶 | |
CN102274428B (zh) | 一种具有治疗肠易激综合症作用的药物组合物及其制备方法和应用 | |
CN102727730B (zh) | 治疗男性不育的复方中药制剂及其制备方法 | |
CN1231196A (zh) | 一种治疗男性性功能减退的胶囊及制作方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDIC Free format text: FORMER OWNER: SHI SHIDE Effective date: 20081017 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081017 Address after: No. 232 East Ring Road, Panyu District University, Guangzhou, Guangdong Patentee after: Guangzhou University of Chinese Medicine Address before: Guangzhou City, Guangdong province Liuhua Road No. 111, Genenral Hospital of PLA Guangzhou Military Area, Department of Medical Laboratory Patentee before: Shi Shide |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060208 Termination date: 20100927 |