CN1221425A - 朊病毒的色谱分离方法 - Google Patents
朊病毒的色谱分离方法 Download PDFInfo
- Publication number
- CN1221425A CN1221425A CN97195343A CN97195343A CN1221425A CN 1221425 A CN1221425 A CN 1221425A CN 97195343 A CN97195343 A CN 97195343A CN 97195343 A CN97195343 A CN 97195343A CN 1221425 A CN1221425 A CN 1221425A
- Authority
- CN
- China
- Prior art keywords
- protein
- solution
- oxyphorase
- protein virus
- gradient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- General Preparation And Processing Of Foods (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
样品 | 稀释 | 存活/接种 | 表现临床特征的个体数/死亡数或杀死数 | 病理学确认羊痢疾的数/被评价的数 |
感染材料 | 10-8 | 9/10 | 0/1 | 0/1 |
感染材料 | 10-7 | 9/10 | 0/1 | 0/1 |
感染材料 | 10-6 | 9/10 | 1/1 | 1/1 |
感染材料 | 10-5 | 8/10 | 2/2 | 2/2 |
感染材料 | 10-4 | 0/10 | 10/10 | 10/10 |
感染材料 | 10-3 | 1/10 | 9/9 | 9/9 |
对照 | 无 | 12/15 | 0/3 | 0/3 |
载体对照 | 无 | 15/15 | 0/0 | 0/0 |
A’ | 未稀释 | 0/5 | 1/5 | 1/1 |
A’ | 澄清的未稀释 | 0/5 | 5/5 | 5/5 |
A’ | 澄清的1∶10 | 0/5 | 5/5 | 4/5 |
A” | 10-5 | 14/15 | 0/1 | 0/1 |
A” | 10-4 | 14/15 | 0/1 | 0/1 |
A” | 10-3 | 14/15 | 0/1 | 0/1 |
A” | 10-2 | 14/15 | 0/1 | 0/1 |
A” | 10-1 | 15/15 | 0/0 | 0/0 |
A” | 未稀释 | 15/15 | 0/0 | 0/0 |
B’ | 未稀释 | 0/5 | 4/5 | 4/5 |
B” | 10-5 | 13/15 | 0/2 | 0/2 |
B” | 10-4 | 13/15 | 0/2 | 0/2 |
B” | 10-3 | 15/15 | 0/0 | 0/0 |
B” | 10-2 | 14/15 | 0/1 | 0/1 |
B” | 10-1 | 14/15 | 0/1 | 0/1 |
B” | 未稀释 | 15/15 | 0/0 | 0/0 |
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/673,147 | 1996-07-01 | ||
US08/673,147 US5808011A (en) | 1996-07-01 | 1996-07-01 | Method for chromatographic removal of prions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005100039089A Division CN1743340A (zh) | 1996-07-01 | 1997-06-26 | 朊病毒的色谱分离方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1221425A true CN1221425A (zh) | 1999-06-30 |
CN1283660C CN1283660C (zh) | 2006-11-08 |
Family
ID=24701495
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971953430A Expired - Fee Related CN1283660C (zh) | 1996-07-01 | 1997-06-26 | 朊病毒的色谱分离方法 |
CNA2005100039089A Pending CN1743340A (zh) | 1996-07-01 | 1997-06-26 | 朊病毒的色谱分离方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005100039089A Pending CN1743340A (zh) | 1996-07-01 | 1997-06-26 | 朊病毒的色谱分离方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5808011A (zh) |
EP (1) | EP0954528B2 (zh) |
JP (1) | JP4031833B2 (zh) |
CN (2) | CN1283660C (zh) |
AT (1) | ATE267212T1 (zh) |
AU (1) | AU718557B2 (zh) |
BR (1) | BR9710035A (zh) |
CA (1) | CA2259632C (zh) |
DE (1) | DE69729217T3 (zh) |
ES (1) | ES2221957T5 (zh) |
HK (1) | HK1019151A1 (zh) |
TW (1) | TW390887B (zh) |
WO (1) | WO1998000441A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012119558A1 (zh) * | 2011-03-08 | 2012-09-13 | 上海天伟生物制药有限公司 | 糖蛋白中去除/灭活朊病毒的方法 |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040053208A1 (en) * | 1995-08-29 | 2004-03-18 | V. I. TECHNOLOGIES, Inc. | Methods to selectively inactivate parasites in biological compositions |
US6221614B1 (en) | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
US6617119B2 (en) | 1997-02-21 | 2003-09-09 | The Regents Of The University Of California | Assay for specific strains of multiple disease related conformations of a protein |
US6720355B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Sodium dodecyl sulfate compositions for inactivating prions |
US20060008494A1 (en) * | 1997-02-21 | 2006-01-12 | The Regents Of The University Of California | Complete inactivation of infectious proteins |
US6719988B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Antiseptic compositions for inactivating prions |
US6620629B1 (en) | 1997-02-21 | 2003-09-16 | The Regents Of The University Of California | Method for detecting prions |
DE69811628T2 (de) * | 1998-02-11 | 2003-12-18 | Zlb Bioplasma Ag, Bern | Verfahren zur Entfernung von Erregern übertragbarer spongiformer Encephalophatien aus Proteinlösungen |
US6139878A (en) * | 1998-04-27 | 2000-10-31 | Aventis Behring, Llc | Method for preparing a diafiltered stabilized blood product |
US6150172A (en) * | 1999-01-08 | 2000-11-21 | The United States Of America As Represented By The Secretary Of Agriculture | Method and kit for extracting prion protein |
US6605445B1 (en) * | 1999-02-22 | 2003-08-12 | Bayer Corporation | Rapid method of determining clearance of prion protein |
US6166187A (en) | 1999-03-05 | 2000-12-26 | The Regents Of The University Of California | Method of concentrating prion proteins in blood samples |
US6437102B1 (en) * | 1999-11-24 | 2002-08-20 | Bayer Corporation | Method of separating prions from biological materials |
EP1272509A2 (en) * | 2000-04-05 | 2003-01-08 | V.I. Technologies, Inc. | Prion-binding peptidic ligands and methods of using same |
US20030050276A1 (en) * | 2001-08-15 | 2003-03-13 | Cunanan Crystal M. | Treatment of tissue, instruments and work surfaces to remove infectious agents |
US20040140265A1 (en) * | 2000-12-29 | 2004-07-22 | Lihme Allan Otto Fog | Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids |
US20020131958A1 (en) * | 2001-01-22 | 2002-09-19 | John Chapman | Method for purifying a biological composition |
US7577577B2 (en) * | 2001-01-31 | 2009-08-18 | Dell Products L.P. | Pull to customer order demand fulfillment system and method |
US6518010B2 (en) * | 2001-02-28 | 2003-02-11 | Biopure Corporation | Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier |
US6613505B2 (en) | 2001-04-12 | 2003-09-02 | Bioresource International, Inc. | Composition and method for destruction of infetious prion proteins |
WO2003073185A2 (en) * | 2002-02-28 | 2003-09-04 | Zetacon Corporation | Predictive control system and method |
ES2564293T5 (es) * | 2002-02-28 | 2019-04-04 | Microsens Biophage Ltd | Enlazamiento de formas patológicas de proteínas priónicas |
US7001715B2 (en) * | 2002-02-28 | 2006-02-21 | Biopure Corporation | Purification of red blood cells by separation and diafiltration |
GB0214007D0 (en) * | 2002-06-18 | 2002-07-31 | Common Services Agency | Removal of prion infectivity |
EP1953551B1 (en) * | 2002-12-03 | 2014-02-19 | Pathogen Removal and Diagnostic Technologies, Inc. | Prion protein ligands and methods of use |
SG187269A1 (en) | 2003-04-04 | 2013-02-28 | Univ North Carolina State | Prion protein binding materials and methods of use |
US7510848B2 (en) * | 2003-04-04 | 2009-03-31 | North Carolina State University | Prion protein binding materials and methods of use |
US20050054003A1 (en) * | 2003-09-10 | 2005-03-10 | Stenland Christopher J. | Prion clearance using particulate metal oxides |
ES2407380T5 (es) | 2004-02-27 | 2017-07-07 | Octapharma Ag | Procedimiento para proporcionar una preparación de anticuerpos purificada, sin riesgo respecto a virus |
GB0416699D0 (en) * | 2004-07-27 | 2004-09-01 | Prometic Biosciences Ltd | Prion protein ligands and methods of use |
WO2006108047A2 (en) * | 2005-04-05 | 2006-10-12 | Biopure Corporation | Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization |
WO2006131768A2 (en) * | 2005-06-10 | 2006-12-14 | Prometic Biosciences Limited | Triazines as protein binding ligands |
US20070128693A1 (en) * | 2005-12-06 | 2007-06-07 | Advantek Serum Laboratories Limited3/F | Method for the inactivation and removal of dengue virus from biological samples |
RU2410128C2 (ru) * | 2006-07-12 | 2011-01-27 | Асахи Касеи Медикал Ко., Лтд. | Способ удаления патологического прионного белка из продуктов крови |
EP2125041A1 (en) * | 2006-12-29 | 2009-12-02 | Texas Tech University | Orthogonal method for the removal of transmissible spongiform encephalopathy agents from biological fluids |
EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
TWI626057B (zh) | 2009-06-09 | 2018-06-11 | 普龍製藥有限責任公司 | 血紅素組成物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU605901B2 (en) * | 1987-09-11 | 1991-01-24 | Ares Trading S.A. | Purification process |
EP0391934A1 (en) * | 1987-10-23 | 1990-10-17 | Schering Corporation | Method of purifying protein |
ATE326234T1 (de) * | 1993-08-26 | 2006-06-15 | Genetics Inst Llc | Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration |
DE4429558A1 (de) * | 1994-08-19 | 1996-02-22 | Sanorell Pharma Gmbh & Co | Verfahren zur Herstellung von infektionsfreien pharmazeutischen Präparaten und/oder Nahrungsmitteln aus infektiösem Material |
-
1996
- 1996-07-01 US US08/673,147 patent/US5808011A/en not_active Expired - Lifetime
-
1997
- 1997-06-26 CN CNB971953430A patent/CN1283660C/zh not_active Expired - Fee Related
- 1997-06-26 BR BR9710035A patent/BR9710035A/pt not_active Application Discontinuation
- 1997-06-26 JP JP50429698A patent/JP4031833B2/ja not_active Expired - Fee Related
- 1997-06-26 WO PCT/US1997/011149 patent/WO1998000441A1/en active IP Right Grant
- 1997-06-26 CN CNA2005100039089A patent/CN1743340A/zh active Pending
- 1997-06-26 ES ES97932311T patent/ES2221957T5/es not_active Expired - Lifetime
- 1997-06-26 EP EP97932311A patent/EP0954528B2/en not_active Expired - Lifetime
- 1997-06-26 AT AT97932311T patent/ATE267212T1/de not_active IP Right Cessation
- 1997-06-26 DE DE69729217T patent/DE69729217T3/de not_active Expired - Lifetime
- 1997-06-26 AU AU35802/97A patent/AU718557B2/en not_active Ceased
- 1997-06-26 CA CA002259632A patent/CA2259632C/en not_active Expired - Fee Related
- 1997-06-26 TW TW086108949A patent/TW390887B/zh not_active IP Right Cessation
-
1999
- 1999-10-05 HK HK99104337A patent/HK1019151A1/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012119558A1 (zh) * | 2011-03-08 | 2012-09-13 | 上海天伟生物制药有限公司 | 糖蛋白中去除/灭活朊病毒的方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2259632A1 (en) | 1998-01-08 |
BR9710035A (pt) | 1999-08-10 |
DE69729217T3 (de) | 2012-03-15 |
JP4031833B2 (ja) | 2008-01-09 |
JP2000513377A (ja) | 2000-10-10 |
TW390887B (en) | 2000-05-21 |
ATE267212T1 (de) | 2004-06-15 |
ES2221957T3 (es) | 2005-01-16 |
CA2259632C (en) | 2008-04-08 |
HK1019151A1 (en) | 2000-01-14 |
EP0954528A1 (en) | 1999-11-10 |
AU3580297A (en) | 1998-01-21 |
ES2221957T5 (es) | 2012-01-27 |
US5808011A (en) | 1998-09-15 |
DE69729217T2 (de) | 2005-05-04 |
WO1998000441A1 (en) | 1998-01-08 |
AU718557B2 (en) | 2000-04-13 |
CN1283660C (zh) | 2006-11-08 |
EP0954528B1 (en) | 2004-05-19 |
DE69729217D1 (de) | 2004-06-24 |
CN1743340A (zh) | 2006-03-08 |
EP0954528B2 (en) | 2011-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CI01 | Publication of corrected invention patent application |
Correction item: Inventor Correct: Marie S Gabriel False: First inventor Marie S plus Switzerland Number: 26 Volume: 15 |
|
CI02 | Correction of invention patent application |
Correction item: Inventor Correct: Marie S Gabriel False: First inventor Marie S plus Switzerland Number: 26 Page: The title page Volume: 15 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: THE FIRST INVENTOR S, MALI· TO: MARY S GARREL |
|
ERR | Gazette correction |
Free format text: CORRECT: INVENTOR; FROM: THE FIRST INVENTOR S, MALI· TO: MARY S GARREL |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: OPK BIOTECHNOLOGY LLC Free format text: FORMER OWNER: BIOPURE CORP Effective date: 20100629 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20100629 Address after: Massachusetts, USA Patentee after: OPK Biological Technology Co., Ltd. Address before: Massachusetts, USA Patentee before: Biopure Corp. |
|
ASS | Succession or assignment of patent right |
Owner name: HEMOGLOBIN OXYGEN THERAPY LLC Free format text: FORMER OWNER: OPK BIOTECH LLC Effective date: 20150327 |
|
TR01 | Transfer of patent right |
Effective date of registration: 20150327 Address after: American Pennsylvania Patentee after: Hemoglobin oxygen therapy Co Ltd Address before: Massachusetts, USA Patentee before: OPK Biological Technology Co., Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061108 Termination date: 20160626 |
|
CF01 | Termination of patent right due to non-payment of annual fee |