CN1194702C - 治疗***肥大的淫羊藿提取物及其在制备药物中的应用 - Google Patents
治疗***肥大的淫羊藿提取物及其在制备药物中的应用 Download PDFInfo
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- CN1194702C CN1194702C CNB021485712A CN02148571A CN1194702C CN 1194702 C CN1194702 C CN 1194702C CN B021485712 A CNB021485712 A CN B021485712A CN 02148571 A CN02148571 A CN 02148571A CN 1194702 C CN1194702 C CN 1194702C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
种名 | 产地 | 含量(%) | |||
淫羊藿甙 | 淫羊藿甙I | 总黄酮 | 总多糖 | ||
淫羊藿 | 陕西 | 1.193 | 0.445 | 12.3 | 20.7 |
四川 | 1.088 | 0.794 | 11.6 | 19.0 | |
箭叶淫羊藿 | 湖南 | 0.961 | 0.190 | 7.2 | 15.9 |
湖北 | 0.735 | 0.110 | 6.4 | 13.4 |
贵州 | 3.098 | 0.084 | 18.3 | 26.1 | |
乌山淫羊藿 | 四川 | 3.343 | 0.094 | 20.1 | 25.6 |
贵州 | 2.882 | 0.030 | 8.9 | 20.1 | |
柔毛淫羊藿 | 四川 | 1.140 | 0.067 | 10.2 | 18.6 |
朝鲜淫羊藿 | 辽宁 | 0.890 | 0.104 | 16.9 | 22.5 |
种名 | 产地 | A部分得率 | B部分得率 |
淫羊藿 | 陕西 | 20g,4% | 37g,7.4% |
四川 | 10g,3% | 29g,5.8% | |
箭叶淫羊藿 | 湖南 | 12g,2.4% | 20g,4.0% |
湖北 | 8g,1.6% | 30g,6.0% | |
贵州 | 27g,5.8% | 39g.7.8% | |
乌山淫羊藿 | 四川 | 23g,4.6% | 42g,8.4% |
贵州 | 16g,3.2% | 32g,6.4% | |
柔毛淫羊藿 | 四川 | 9g,1.8% | 25g,5.0% |
朝鲜淫羊藿 | 辽宁 | 18g,3.6% | 28g,5.6% |
组别 | 例数 | 年龄(岁) | 病程(年) | 合并性功能障碍例数 |
良性***肥大* | 32 | 64.90±7.8 | 11.5+8.7 | |
***肥大伴慢性***炎** | 24 | 42.42±12.1 | 3.5±3.3 | 24 |
分组 | 治前积分 | 治后积分 | P值 |
良性***肥大 | 12.16±2.42 | 6.26±1.98 | P<0.01 |
良性***肥大伴炎症 | 10.42±2.54 | 4.88±2.82 | P<0.01 |
分组 | 治前 | 治后积分 | P值 |
良性***肥大 | 65.93±60.19 | 37.19±43.05 | P<0.05 |
良性***肥大伴炎症 | 45.83±53.48 | 25.41±34.38 | P<0.05 |
分组 | 治前 | 治后积分 | P值 |
良性***肥大 | 4.41±1.44 | 7.74±3.33 | P<0.01 |
良性***肥大伴炎症 | 7.02±3.29 | 10.91±5.46 | P<0.01 |
分组 | 治前 | 治后积分 | P值 |
良性***肥大 | 3.31±3.68 | 3.03±3.84 | P>0.05 |
良性***肥大伴炎症 | 4.41±5.28 | 1.84±1.07 | P<0.01 |
分组 | 例数 | 控制 | 显效 | 有效 | 无效 | 总有效 | 总有效率 |
肥大组 | 32 | 2 | 12 | 16 | 2 | 30 | 93.8% |
肥大兼炎症组 | 24 | 1 | 6 | 11 | 6 | 18 | 75.0% |
Claims (6)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021485712A CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗***肥大的淫羊藿提取物及其在制备药物中的应用 |
US10/539,497 US7205005B2 (en) | 2002-12-18 | 2003-11-24 | Medicament containing epidemium extract for treatment of prostatic hyperplasia and prostatitis |
EP03779644A EP1574218B1 (en) | 2002-12-18 | 2003-11-24 | A medicament containing epimedium extract for treatment of prostatic hyperplasia and prostatitis |
JP2004559564A JP4448034B2 (ja) | 2002-12-18 | 2003-11-24 | 淫羊霍抽出物の薬物調製上における応用 |
DE60333586T DE60333586D1 (de) | 2002-12-18 | 2003-11-24 | Medikament mit epimedium-extrakt zur behandlung vo |
KR1020057011420A KR100713088B1 (ko) | 2002-12-18 | 2003-11-24 | 전립선 비대증 및 전립선염 치료용 음양곽 추출물을포함하는 약학적 조성물 |
PCT/CN2003/000994 WO2004054596A1 (fr) | 2002-12-18 | 2003-11-24 | Medicament contenant un extrait d'epimedium et destine au traitement de l'hyperplasie prostatique et de la prostatite |
AU2003289644A AU2003289644A1 (en) | 2002-12-18 | 2003-11-24 | A medicament containing epidemium extract for treatment of prostatic hyperplasia and prostatitis |
AT03779644T ATE475455T1 (de) | 2002-12-18 | 2003-11-24 | Medikament mit epimedium-extrakt zur behandlung von prostatahyperplasie und prostatitis |
US11/476,458 US7250182B2 (en) | 2002-12-18 | 2006-06-28 | Medicament containing Epimedium extract for treatment of prostatic hyperplasia and prostatitis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021485712A CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗***肥大的淫羊藿提取物及其在制备药物中的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410034456 Division CN1254260C (zh) | 2002-12-18 | 2002-12-18 | 含淫羊藿提取物的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1422622A CN1422622A (zh) | 2003-06-11 |
CN1194702C true CN1194702C (zh) | 2005-03-30 |
Family
ID=4751485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021485712A Expired - Lifetime CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗***肥大的淫羊藿提取物及其在制备药物中的应用 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7205005B2 (zh) |
EP (1) | EP1574218B1 (zh) |
JP (1) | JP4448034B2 (zh) |
KR (1) | KR100713088B1 (zh) |
CN (1) | CN1194702C (zh) |
AT (1) | ATE475455T1 (zh) |
AU (1) | AU2003289644A1 (zh) |
DE (1) | DE60333586D1 (zh) |
WO (1) | WO2004054596A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1295224C (zh) * | 2004-11-11 | 2007-01-17 | 中国药科大学 | 注射用淫羊藿总黄酮苷的制备方法 |
KR100803577B1 (ko) * | 2005-11-30 | 2008-02-15 | (주)아모레퍼시픽 | 이카린의 가수분해물을 함유하는 화장료용 조성물 |
EP1952816A1 (en) * | 2007-01-26 | 2008-08-06 | The Jordanian Pharmaceutical Manufacturing Co. | Multi-component herbal composition for the treatment of male erectile dysfunction |
KR101040477B1 (ko) | 2008-06-03 | 2011-06-09 | 고려대학교 산학협력단 | 항안드로겐 조성물 |
KR101144991B1 (ko) * | 2009-12-29 | 2012-06-27 | 대한민국 | 인삼 추출물을 포함하는 전립선비대증을 예방 또는 치료하기 위한 약학적 조성물 및 건강 기능성식품 조성물 |
CN103613675B (zh) * | 2010-11-05 | 2016-08-17 | 北京中安佐际生物科技有限公司 | 淫羊藿多糖及其组分和它们用于疫苗佐剂的用途 |
JP6034293B2 (ja) * | 2010-11-05 | 2016-11-30 | ベイジン チョンアン アジュバント バイオテクノロジー カンパニー,リミティド | イカリソウの多糖、その画分、及びワクチンアジュバントとしてのその使用 |
TWI492754B (zh) | 2012-06-27 | 2015-07-21 | Jin Xin Biotechnology Co Ltd | 台灣山蘇萃取物之用途 |
CA2912438A1 (en) * | 2013-04-10 | 2014-10-16 | Glycobiosciences, Inc. | Topical nutraceutical composition |
CN103565993B (zh) * | 2013-11-11 | 2014-12-10 | 王纯治 | 一种治疗***炎的中药方剂 |
KR20210054481A (ko) | 2019-11-05 | 2021-05-13 | 경희대학교 산학협력단 | 금은화 추출물을 포함하는 전립선비대증 예방 또는 치료용 조성물 |
CN111920858B (zh) * | 2020-09-02 | 2021-10-15 | 毛蕴衡 | 一种组合物及其在制备辅助治疗***炎药物中的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3116695C2 (de) * | 1980-04-30 | 1985-03-07 | Zenyaku Kogyo K.K., Tokio/Tokyo | Neuer Pflanzenextrakt, Verfahren zu seiner Herstellung und ein ihn enthaltendes Arzneimittel |
CN1093600A (zh) | 1993-04-10 | 1994-10-19 | 河南省三门峡市九九三神力保健品厂 | ***保健品及其制造方法 |
US5587167A (en) * | 1993-09-14 | 1996-12-24 | Choi; Hyung K. | Pharmaceutical composition for prophylaxis and treatment of premature ejaculation |
CN1113802A (zh) * | 1994-05-27 | 1995-12-27 | 四川省遂宁市医药研究所 | 前列宁冲剂 |
CA2137219C (en) * | 1994-12-02 | 1997-10-21 | Salva Gideon | Extract for improving male sperm count and use as anti-microbial or anti-inflammatory agent |
CN1219408A (zh) * | 1997-12-07 | 1999-06-16 | 孙树春 | 安神通神胶囊 |
CN1058902C (zh) | 1998-02-25 | 2000-11-29 | 荆延有 | 壮肾助阳液 |
US6123944A (en) * | 1998-03-19 | 2000-09-26 | Phytoceutica, Inc. | Icariin preparations |
CN1245194C (zh) * | 2000-04-28 | 2006-03-15 | 韩富生 | 治疗老年性***肥大的口服液 |
US6750248B2 (en) * | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
US6476203B1 (en) * | 2002-03-14 | 2002-11-05 | Xinxian Zhao | Safe pharmaceutical composition for treating and preventing infertility and increasing immune function |
-
2002
- 2002-12-18 CN CNB021485712A patent/CN1194702C/zh not_active Expired - Lifetime
-
2003
- 2003-11-24 WO PCT/CN2003/000994 patent/WO2004054596A1/zh active Application Filing
- 2003-11-24 AU AU2003289644A patent/AU2003289644A1/en not_active Abandoned
- 2003-11-24 DE DE60333586T patent/DE60333586D1/de not_active Expired - Lifetime
- 2003-11-24 AT AT03779644T patent/ATE475455T1/de not_active IP Right Cessation
- 2003-11-24 EP EP03779644A patent/EP1574218B1/en not_active Expired - Lifetime
- 2003-11-24 KR KR1020057011420A patent/KR100713088B1/ko active IP Right Grant
- 2003-11-24 JP JP2004559564A patent/JP4448034B2/ja not_active Expired - Lifetime
- 2003-11-24 US US10/539,497 patent/US7205005B2/en not_active Expired - Lifetime
-
2006
- 2006-06-28 US US11/476,458 patent/US7250182B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60333586D1 (de) | 2010-09-09 |
KR20050084420A (ko) | 2005-08-26 |
EP1574218A4 (en) | 2007-06-06 |
US7205005B2 (en) | 2007-04-17 |
EP1574218A1 (en) | 2005-09-14 |
US20060105067A1 (en) | 2006-05-18 |
ATE475455T1 (de) | 2010-08-15 |
JP2006510678A (ja) | 2006-03-30 |
JP4448034B2 (ja) | 2010-04-07 |
KR100713088B1 (ko) | 2007-05-02 |
CN1422622A (zh) | 2003-06-11 |
US7250182B2 (en) | 2007-07-31 |
US20060246164A1 (en) | 2006-11-02 |
AU2003289644A1 (en) | 2004-07-09 |
WO2004054596A1 (fr) | 2004-07-01 |
EP1574218B1 (en) | 2010-07-28 |
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