CN117883335A - Skin oil control composition, oil control hair washing composition, and preparation method and application thereof - Google Patents
Skin oil control composition, oil control hair washing composition, and preparation method and application thereof Download PDFInfo
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- 239000000284 extract Substances 0.000 claims abstract description 90
- 229940105022 spearmint extract Drugs 0.000 claims abstract description 28
- 241000501743 Gentiana macrophylla Species 0.000 claims abstract description 23
- 244000193174 agave Species 0.000 claims abstract description 21
- 229940084038 salix alba bark extract Drugs 0.000 claims abstract description 17
- 201000004384 Alopecia Diseases 0.000 claims abstract description 11
- 241001071795 Gentiana Species 0.000 claims description 36
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- 238000000605 extraction Methods 0.000 claims description 24
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- 238000001035 drying Methods 0.000 claims description 14
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- 238000000926 separation method Methods 0.000 claims description 7
- 230000003750 conditioning effect Effects 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 208000024963 hair loss Diseases 0.000 claims description 3
- 230000003676 hair loss Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
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- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
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- 210000000434 stratum corneum Anatomy 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 1
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a skin oil control composition comprising: spearmint extract, white willow bark extract, agave stem extract and gentiana macrophylla extract. The skin oil control composition provided by the invention can effectively control oil on facial skin and head skin, and can effectively face different oil outlet conditions of different areas of facial skin, so that accurate regulation and control are realized; the product is applied to the head washing and caring product, realizes effective oil control, can permeate the skin with effective components, improves the oil outlet condition in the skin, has an effect on the target point of seborrheic oil outlet, and can slow down dermatitis and alopecia caused by seborrheic oil outlet.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a skin oil control composition, an oil control hair washing composition, a preparation method and application thereof.
Background
The daily life has high pressure and high brain consumption energy, and stimulates the body to adaptively regulate autonomic nerves and endocrine so as to maintain physiological balance of metabolism, immune function and the like, secrete more male hormone and the like, thereby ensuring that sebaceous glands secrete vigorously. Meanwhile, the sebaceous gland secretion is vigorous, and the culture condition is very good for the lipotropic bacteria.
Meanwhile, more daily necessities in the market use surfactants to make oil on the surface or add a small amount of skin conditioning agents to make skin conditioning, so that the oil control time can be prolonged.
Similarly, unlike skin care products, which have a long residence time on the skin surface and ingredients that can slowly penetrate into the skin, shampoo is used daily, but the residence time of shampoo on the scalp is not long and scalp care is rarely performed daily.
In addition, facial skin is not all the places with vigorous sebaceous gland secretion, for example, the oil outlet condition of the skin around the T-shaped area and eyes is different, and how to realize accurate oil control is also a great difficulty at present.
In the market, no oil control product capable of simultaneously meeting the requirements of facial skin and head skin exists at present, and aiming at the situation, the invention provides a natural plant extract composition which has an oil control effect on facial skin and head skin.
Disclosure of Invention
The present invention provides a skin oil control composition comprising: spearmint extract, white willow bark extract, agave stem extract and gentiana macrophylla extract.
Preferably, the composition further comprises: centella asiatica extract and swertia japonica extract.
Preferably, the composition further comprises: gentian extract.
Preferably, the preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature and acetone entrainer 2 Extracting.
Preferably, the preparation method of the gentian extract comprises the following steps: the preparation method of the gentian extract comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
Preferably, the weight ratio of spearmint extract to agave stem extract is 1:2.
In another aspect the present invention provides a skin oil control composition as described for protecting or enhancing the skin barrier function.
In another aspect, the invention provides the skin oil control composition for hair oil control.
In another aspect, the present invention provides the skin oil control composition for use in the field of hair loss due to seborrheic dermatitis.
In another aspect, the present invention provides an oil control hair cleansing composition comprising the skin oil control composition, a humectant, a surfactant, and a conditioning agent.
By adopting the technical scheme, the invention has the following beneficial effects:
1. the skin oil control composition provided by the invention can effectively control oil on facial skin and head skin, and can effectively face different oil outlet conditions of different areas of facial skin, so that accurate regulation and control are realized;
2. the product is applied to the head washing and caring product, realizes effective oil control, can permeate the skin with effective components, improves the oil outlet condition in the skin, has an effect on the target point of seborrheic oil outlet, and can slow down dermatitis and alopecia caused by seborrheic oil outlet.
Detailed Description
The following description of the present invention will be made clearly and fully, and it is apparent that the embodiments described are some, but not all, of the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The present invention provides a skin oil control composition comprising: spearmint extract, white willow bark extract, agave stem extract and gentiana macrophylla extract.
Preferably, the composition further comprises: centella asiatica extract and swertia japonica extract.
Preferably, the composition further comprises: gentian extract.
Spearmint extract: spearmint (MENTHA VIRIDIS) extract, spearmint (Mentha spicata L.) is a perennial herb of the genus Mentha of the family Labiatae.
In the invention, the preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature and acetone entrainer 2 Extracting. Wherein, the dosage of the acetone is 75mL.
There are many methods for extracting spearmint, in which supercritical CO is used in consideration of low polarity of its extract components 2 The extraction is carried out in the mode of (2) and the extraction rate is also improved; however, supercritical CO 2 The inventor of the application finds that the acetone is used as the entrainer and can be obviously improved when the preparation efficiency is high and the impurities are also much higherThe volatile oil component in the spearmint is extracted, and meanwhile, acetone is selected as an entrainer, so that a supercritical fluid extraction pipeline is not easy to be blocked compared with ethanol; and face an increase in extraction pressure, CO 2 Too high a pressure, the mass transfer rate is also slowed down and it was found that this can be slowed down after the addition of acetone as entrainer.
White willow bark extract: white willow (Salix ALBA L.) bark extract is tree of Salix of Salicaceae. The white willow bark extract of the present invention is purchased from Shaanxi da biotechnology Co.
Agave stem extract: agave (AGAVE AMERICANA) stem extract, which is purchased from Sesambac chemical Co., ltd.
In the invention, when the using amount of the agave stem extract is small, a certain amount of alopecia prevention is found, but the maintenance time is not long enough; in addition, after the addition amount is increased, partial alopecia exists in the initial use, and the effect of preventing alopecia can be achieved in the later use. The inventors have found that the addition of spearmint extract to the formulation can ameliorate the above-mentioned drawbacks associated with high levels of addition.
Gentiana macrophylla extract: gentiana macrophylla (GENTIANA MACROPHYLLA) extract purchased from hen six-disc rhyme biotechnology limited.
Centella asiatica extract: centella asiatica (CENTELLA ASIATICA) extract purchased from shanxi da biotechnology limited.
Swertia extract: swertia (SWERTIA BIMACULATA) extract purchased from the biological sciences company of Murphy, shaanxi.
Gentian extract: GENTIANA SCABRA (GENTIANA scanra) extract. The preparation method of the gentian extract in the invention comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
In another aspect the present invention provides a skin oil control composition as described for protecting or enhancing the skin barrier function.
In another aspect, the invention provides the skin oil control composition for hair oil control.
In another aspect, the present invention provides the skin oil control composition for use in the field of hair loss due to seborrheic dermatitis.
In another aspect, the present invention provides an oil control hair cleansing composition comprising the skin oil control composition, a humectant, a surfactant, and a conditioning agent.
Wherein the humectant is selected from one or more of small molecule polyalcohol and polysaccharide humectant.
The surfactant may be any surfactant suitable for the daily chemical field, and more preferably is a low-irritation surfactant such as a plant-type surfactant.
The conditioner can be one or more selected from hydroxyacetophenone, panthenol, allantoin, polyglycerol-10 oleate, hydrogenated lecithin, dipotassium glycyrrhizinate and creatine;
the invention is further illustrated with reference to specific embodiments.
Example 1:
the embodiment provides a skin oil control composition, which comprises the following components in parts by weight: 1 part of spearmint extract, 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 0.2 part of centella asiatica extract, 0.5 part of swertia japonica extract and 0.1 part of gentiana macrophylla extract.
The preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature and acetone entrainer 2 Extracting. Which is a kind ofThe amount of acetone used was 75mL.
The preparation method of the gentian extract comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
The white willow bark extract was purchased from Shaanxi Dada biotechnology Co.
The agave stem extract was purchased from the western union chemical company, inc.
The gentiana macrophylla extract is purchased from six-disc rhyme biotechnology company of Bao-ji.
The centella asiatica extract was purchased from Shaanxi da biotechnology Co.
The swertia extract is purchased from Shaanxi Mufei biotechnology limited company.
Example 2:
the embodiment provides a skin oil control composition, which comprises the following components in parts by weight: 1 part of spearmint extract, 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 0.2 part of centella asiatica extract, 0.5 part of swertia japonica extract and 0.1 part of gentiana macrophylla extract.
The preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature and acetone entrainer 2 Extracting. Wherein, the dosage of the acetone is 75mL.
The gentian extract was purchased from Shaanxi Sida Biotechnology Inc.
The white willow bark extract was purchased from Shaanxi Dada biotechnology Co.
The agave stem extract was purchased from the western union chemical company, inc.
The gentiana macrophylla extract is purchased from six-disc rhyme biotechnology company of Bao-ji.
The centella asiatica extract was purchased from Shaanxi da biotechnology Co.
The swertia extract is purchased from Shaanxi Mufei biotechnology limited company.
Example 3:
the embodiment provides a skin oil control composition, which comprises the following components in parts by weight: 1 part of spearmint extract, 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 0.2 part of centella asiatica extract, 0.5 part of swertia japonica extract and 0.1 part of gentiana macrophylla extract.
Wherein the spearmint extract is purchased from Shaanxi Muyun biotechnology Co.
The preparation method of the gentian extract comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
The white willow bark extract was purchased from Shaanxi Dada biotechnology Co.
The agave stem extract was purchased from the western union chemical company, inc.
The gentiana macrophylla extract is purchased from six-disc rhyme biotechnology company of Bao-ji.
The centella asiatica extract was purchased from Shaanxi da biotechnology Co.
The swertia extract is purchased from Shaanxi Mufei biotechnology limited company.
Example 4:
the embodiment provides a skin oil control composition, which comprises the following components in parts by weight: 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 0.2 part of centella asiatica extract, 0.5 part of swertia japonica extract and 0.1 part of gentiana macrophylla extract.
The preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature and acetone entrainer 2 Extracting. Wherein, the dosage of the acetone is 75mL.
The preparation method of the gentian extract comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
The white willow bark extract was purchased from Shaanxi Dada biotechnology Co.
The agave stem extract was purchased from the western union chemical company, inc.
The gentiana macrophylla extract is purchased from six-disc rhyme biotechnology company of Bao-ji.
The centella asiatica extract was purchased from Shaanxi da biotechnology Co.
The swertia extract is purchased from Shaanxi Mufei biotechnology limited company.
Example 5:
the embodiment provides a skin oil control composition, which comprises the following components in parts by weight: 1 part of spearmint extract, 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 0.2 part of centella asiatica extract, 0.5 part of swertia japonica extract and 0.1 part of gentiana macrophylla extract.
The preparation method of the spearmint extract comprises the following steps: the spearmint extract is prepared by supercritical CO under the conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 deg.C extraction temperature, 1 hr extraction, 25 deg.C separation temperature 2 Extracting.
The preparation method of the gentian extract comprises the following steps:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
The white willow bark extract was purchased from Shaanxi Dada biotechnology Co.
The agave stem extract was purchased from the western union chemical company, inc.
The gentiana macrophylla extract is purchased from six-disc rhyme biotechnology company of Bao-ji.
The centella asiatica extract was purchased from Shaanxi da biotechnology Co.
The swertia extract is purchased from Shaanxi Mufei biotechnology limited company.
Example 6:
this example differs from example 1 in that this example provides a skin oil control composition comprising, in parts by weight: 1 part of spearmint extract, 8 parts of white willow bark extract, 2 parts of agave stem extract, 1 part of gentiana macrophylla extract, 10 parts of centella asiatica extract, 0.5 part of swertia japonica extract and 5 parts of gentian extract.
Performance test:
test pieces 1-6 were prepared by mixing 10% of the composition of examples 1-6, 1% xanthan gum, and the balance water.
Wherein, skin oil moisture tests were performed on facial skin (test article 1-5) and head skin (test article 6) according to the skin oil moisture tester standard procedure.
Test purpose: by recruiting a certain number of qualified subjects, the change of sebum secretion content of the face and scalp parts of the subjects before and after the product is used and the self evaluation of the subjects are observed by adopting an instrument test mode, and the oil control efficacy of the product is evaluated.
The skin sebum measuring instrument, a sebometer, is based on the photometer principle of a special adhesive tape and is used for detecting the sebum level on the skin surface, and the instrument collects all grease on the surface of the stratum corneum and is widely used for evaluating the efficacy of various moisturizing, nourishing and oil control products. The greater this value, the higher the amount of stratum corneum oil.
Subject self-evaluation: the subjects scored or described the following respectively
Table 1 self-evaluation table
Score value | Greasy feel |
0 | Without any means for |
1 | Not obvious |
2 | Mild greasiness |
3 | Moderate greasiness |
4 | Very greasy |
The using method comprises the following steps: according to (2.0.+ -. 0.1) mg/cm 2 The sample was uniformly coated with the latex fingerstall.
TABLE 2 subject detailed information
Environmental conditions
The temperature is 21+/-1 ℃ and the relative humidity is 50+/-10 percent.
Statistical analysis is carried out by applying SPSS21.0, significance Test of normal distribution of data improvement values is carried out by using Shapiro-Wilk Test, and Sig (bilateral) >0.01 is in normal distribution; t-test was performed with a significant difference level α of 0.01. If sig (double sided) <0.01, a non-normal distribution is performed, rank sum test is performed, and the significance difference level α is 0.05.
Table 3 descriptive statistics of face/head grease content units: mu g/cm 2
Subject self-scoring pre-post comparison
Table 4 subjects compare (mean) units from before and after scoring: dividing into
From the above performance test, test article 1 and test article 6 have better oil control ability for facial skin and head skin, respectively; meanwhile, the long-term use (the experimental period is 1 month, the product is used once every three days, and other products are not used temporarily) of the test product 2-5 also shows that the phenomenon of alopecia caused in the initial stage after the addition amount of the Agave extract is increased can be improved due to the spearmint extract when the test product is used for head washing and caring. Meanwhile, in the human body efficacy experiment of seborrheic alopecia, the test article 6 has the effect of relieving the seborrheic alopecia.
Meanwhile, the composition provided in the example 1 is subjected to a zebra fish 5α -reductase gene expression test method to further prove the oil control effect, the composition is added at a concentration of 10%, and the test result is as follows
Table 5 5 alpha-reductase gene expression test method
Example 1 can significantly inhibit the expression of zebra fish srd5a1, srd5a2a and/srd 5a2b genes, and has the effect of inhibiting fat secretion.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (10)
1. A skin oil control composition, said composition comprising: spearmint extract, white willow bark extract, agave stem extract and gentiana macrophylla extract.
2. The skin oil control composition of claim 1, wherein the composition further comprises: centella asiatica extract and swertia japonica extract.
3. The skin oil control composition of claim 1, wherein the composition further comprises: gentian extract.
4. The skin oil control composition of claim 1, wherein the spearmint extract is supercritical CO under conditions of 40MPa extraction pressure, 30kg/h fluid flow, 40 ℃ extraction temperature, 1h extraction, 25 ℃ separation temperature, and acetone as entrainer 2 Extracting.
5. The skin oil control composition according to claim 3, wherein the gentian extract is prepared by the following method:
s01, microwave drying: selecting gentian extract, chopping, performing microwave drying, and turning over every 5 minutes, wherein the microwave power is 500W and the microwave time is 20 minutes;
s02, crushing the gentian extract subjected to microwave treatment, extracting with 70% ethanol according to a feed-liquid ratio of 1:15 for 2 hours, and filtering and collecting an extracting solution;
s03, adding chloroform into the extracting solution of the S02, filtering, and collecting precipitate to obtain the gentian extract.
6. The skin oil control composition of any one of claim 1, wherein the weight ratio of spearmint extract to agave stem extract is 1:2.
7. The skin oil control composition according to any one of claims 1-5 for use in protecting or enhancing skin barrier function.
8. The skin oil control composition according to any one of claims 1-5 for use in the hair oil control field.
9. The skin oil control composition according to any one of claims 1 to 5 for use in the field of hair loss due to seborrheic dermatitis.
10. An oil control hair cleansing composition comprising the skin oil control composition of any one of claims 1 to 5, a humectant, a surfactant, and a conditioning agent.
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CN114668695A (en) * | 2022-03-26 | 2022-06-28 | 广州市金翔化妆品有限公司 | Anti-dandruff composition, shampoo containing anti-dandruff composition and preparation method of shampoo |
CN117017883A (en) * | 2023-08-25 | 2023-11-10 | 广州帝臣生物科技股份有限公司 | Deoiling shampoo and preparation method thereof |
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