CN109662936A

CN109662936A - Antipruritic toner of antiallergic anti-pruritic compositions, antiallergic and its preparation method and application

Info

Publication number: CN109662936A
Application number: CN201910108289.1A
Authority: CN
Inventors: 林立宇; 段红丽
Original assignee: Guangzhou General Management Consulting Co Ltd
Current assignee: Guangzhou General Management Consulting Co Ltd
Priority date: 2019-01-18
Filing date: 2019-01-18
Publication date: 2019-04-23

Abstract

The present invention relates to a kind of antiallergic anti-pruritic compositions, the antipruritic toner of antiallergic and its preparation method and application.Wherein, antiallergic anti-pruritic compositions include following active component: Radix Ophiopogonis turns round thorn cactus, kuh-seng, HERBA DENDROBII, aloe barbadensis Miller, fructus lycii and purple coneflower.Above-mentioned antiallergic anti-pruritic compositions pass through the mutual compatibility of each component, it makes it possible to and is substantially reduced skin sensitivity and itch phenomenon, there is significant repair to because of damage caused by itch, and above-mentioned antiallergic anti-pruritic compositions can also increase the tolerance of skin, improve sensitive skin, gives skin comprehensive security guarantee.In addition, above-mentioned antiallergic anti-pruritic compositions promote the production of body fluid with fluid infusion, smooth it is dry caused by microgroove, persistently support profit skin, skin sense made to be full of the sliding effect of Rinsing.

Description

Antipruritic toner of antiallergic anti-pruritic compositions, antiallergic and its preparation method and application

Technical field

The present invention relates to technical field of daily necessities, the in particular to antipruritic toner of antiallergic anti-pruritic compositions, antiallergic and its system Preparation Method and application.

Background technique

With the quickening of Working Life rhythm, people's pressure is increasing, and diet work and rest rule is abnormal, environmental pollution etc., Cause skin health situation to be gradually reduced, becomes more sensitive.Further, since to beauty pursuit, it is more using it is all kinds of containing swash The skin care item or cosmetics of plain class cause skin tolerance to be deteriorated, are also easy to cause skin to the transformation of sensibility skin.Most often The symptom seen is red and swollen for appearance, itches, peel, red heat is hot etc., not only influences beauty and has an effect on normal life.

There is the more product for alleviating sensitive skin currently on the market, but most of such product only has alleviation condition susceptible Effect has no the effect for improving sensitive skin, and such product is also readily formed accordance with tolerance dermatitis, causes user can not be again It is detached from the use of such product, if things go on like this, skin becomes very fragile, and the red capillary etc. that allergy leaves can not decorporate, sternly Ghost image rings beautiful.

Summary of the invention

Based on this, it is necessary to provide a kind of antiallergic anti-pruritic compositions, antipruritic toner of antiallergic that can improve sensitive skin And its preparation method and application.

A kind of antiallergic anti-pruritic compositions, including following active component: Radix Ophiopogonis turns round thorn cactus, kuh-seng, HERBA DENDROBII, library Drag-line aloe, kuh-seng, fructus lycii and purple coneflower.

Radix Ophiopogonis, Liliaceae Ophiopogon perennial evergreen herbaceous plant, containing there are many chemical component, especially it is abundant Ophiopogonpolysaccharide, ophiopogonpolysaccharide have good retentiveness, and strong to the adhesion of skin, extensibility is higher, are a kind of natural Moisturizing ingredient.And some researches show that the moisturizer of the root extract containing Radix Ophiopogonis has the effect of adjuvant treatment to adult atopic dermatitis Fruit, therefore the component can be cooperateed with other moisture-keeping efficacy components, Reduce allergy dermatitis symptom, and promote moisture-keeping efficacy component Absorption, improve sensitive skin.

Turn round thorn cactus, Cactaceae, with good antioxidation, also with efficient moisturizing, radiation protection it is aobvious Writing effect can make skin from ultraviolet while guaranteeing the high nutrition, high-purity and high activity of natural organofunctional ingredient Radiation.

Kuh-seng is leguminous plant, has whitening, anti-inflammatory, anti-acne, a variety of effectiveness such as antibacterial especially have pruitus Good relaxation effect, vegetable Chinese herbal medicine can Bergamot Mint Extract, dredge and restrain pore, remove skin endotoxin contamination, Book on Chinese herbal medicine nutrition abundant, promotes the growth and reparation of damaged blood vessels nerve cell, restores subcutaneous capillary cell viability, skin It reappears compact fine and smooth, plays the role of beauty and skin care.

HERBA DENDROBII, one of orchid can improve skin state, and skin is repaired in help, and furthermore it can also be significant Superoxides discrimination China enzyme (SOD) level is improved, is reduced lipid peroxide (LPO), brain monoaminergic transmitters level is adjusted, inhibits Similar monoamine oxidase (MAO), plays the role of anti-aging.

Aloe barbadensis Miller is the perennial evergreen succulent plant of A Fuhua section Aloe, contained by barbaloin can become The sun-screening agent of skin, and other contained compositions such as various saccharides, amino acid, organized enzyme, aloe-emodin etc., there is human skin Good moisten effect, can accelerate skin metabolism, enhance skin elasticity, be allowed to seem soft, smooth, plentiful, can be with Eliminate acne, freckle, chap.There are also in aloe Fresh sap, containing multivitamin, amino acid and small molecule nutrients, it Can play the role of moistening just, fresh aloe barbadensis Miller juice has the function of skin care, but also can play protection skin Effect.

Fructus lycii, perennial shrub, fructus lycii polysaccharides rich in, beta carotene, vitamin E, selenium and flavonoids Equal antioxidant, there is preferable antioxidation.Fructus lycii can mitigate free radical peroxide injury to free radical resisting peroxidating, To help to delay senescence, extend the service life.

Purple coneflower, the plant of composite family are known as " immunopotentiator ", polysaccharide body rich in and anti-oxidant Polyphenols Compound, wherein antioxygen polyphenol can inhibit free radical with high-efficiency antioxidant, and outside contamination is isolated；Polysaccharide body is effectively releived skin, It avoids sodium hyaluronate hydrolyzed, restores compact skin, keep skin more flexible.

Above-mentioned antiallergic anti-pruritic compositions by Radix Ophiopogonis, turn round thorn cactus, kuh-seng, HERBA DENDROBII, aloe barbadensis Miller, fructus lycii and Purple coneflower compounds, and each mutual compatibility of component makes it possible to and is substantially reduced skin sensitivity and itch phenomenon, to because of scabies Damage caused by itching has significant repair, and above-mentioned antiallergic anti-pruritic compositions can also increase the tolerance of skin, change Kind sensitivity skin, gives skin comprehensive security guarantee.

In addition, above-mentioned antiallergic anti-pruritic compositions promotes the production of body fluid with fluid infusion, dry caused microgroove is smoothed, profit skin is persistently supported, Skin sense is set to be full of the sliding effect of Rinsing.

In one embodiment, above-mentioned antiallergic anti-pruritic compositions further include tartaric acid compound, the compound owner of tartaric acid It to be made of sodium lactate, hydroxyacetic acid, sucrose, urea, sodium citrate, malic acid, tartaric acid, Sodium Hyaluronate.

Currently, some researches show that tartaric acid can be made by activation steoid sulfatase and serine protease degradation desmosome The peeling of iuntercellular desmosome moment is formed at cutin, weakens the adhesive of keratinocyte, accelerates falling off for aging cutin layer, Therefore tartaric acid, which can loosen, is deposited in the keratinocyte of sebaceous glands opening, corrects follicular epithelium dyskeratosis, makes sebaceous glands Secretion excretion is unobstructed, and acne is inhibited to be formed.Meanwhile tartaric acid can also activate keratinocyte metabolic, update or rebuild Epidermis, and promote the exclusion of melanin granule, mitigate pigmentation.

By adding mainly in above-mentioned antiallergic anti-pruritic compositions by sodium lactate, hydroxyacetic acid, sucrose, urea, citric acid Sodium, malic acid, tartaric acid, Sodium Hyaluronate composition tartaric acid compound, can reduce epidermal cell adhesion effect, be allowed to compared with It is easy fall in flakes, epidermal cell is accelerated to update, while can be skin replenishing water and preserving moisture, improves skin state.

In addition, the research of the invention finds that, by adding above-mentioned tartaric acid compound, above-mentioned antiallergic can also be further enhanced and stopped Itch the antiallergic itching-relieving efficacies of composition, this may be related to above-mentioned rush cell detachment mechanism, and by cell turnover, it is anti-to strengthen body Quick effect achievees the purpose that profound improvement skin.

In one embodiment, the Radix Ophiopogonis, torsion thorn cactus, kuh-seng, HERBA DENDROBII, aloe barbadensis Miller, kuh-seng, Chinese holly Qi and purple coneflower are the extract of corresponding raw material,

In the antiallergic anti-pruritic compositions, in parts by weight, Radix Ophiopogonis root extract is 1-5 parts, turns round thorn Cactus Pedicel and mentions Taking object is 1-3 parts, and kuh-seng root extract is 1-6 parts, and HERBA DENDROBII stem extraction is 1-5 parts, and aloe barbadensis Miller leaf extract is 1-3 parts, fructus lycii berry extract is 1-3 parts, Echinacea angustifolia extract is 1-3 parts.

In one embodiment, the Radix Ophiopogonis root extract, torsion thorn Cactus Pedicel extract and the radix sophorae The mass ratio of the quality sum of extract and the tartaric acid compound is 1:(1-2)；And/or

The HERBA DENDROBII stem extraction, aloe barbadensis Miller leaf extract, kuh-seng root extract, fructus lycii berry extract, purple The mass ratio of the quality sum of echinacea extract and the tartaric acid compound is 1:(1-2).

Above-mentioned antiallergic anti-pruritic compositions are preparing the application in skin care item.

Since above-mentioned antiallergic anti-pruritic compositions can be substantially reduced skin sensitivity and itch phenomenon, increase the tolerance of skin Property, skin comprehensive security guarantee is given, while skin moisture-keeping water lock ability can also be adjusted, fluid infusion is promoted the production of body fluid, and smooths drying immediately Caused microgroove and bits, persistently support profit skin, therefore are suitable for preparing skin care item.

A kind of preparation method of antiallergic anti-pruritic compositions, comprising the following steps: mix each raw material.

It is to be appreciated that above-mentioned raw materials can be fresh plant, processed Chinese medicinal herbs, or corresponding plant Extract.When selecting fresh plant or processed Chinese medicinal herbs, in the preparation method of above-mentioned antiallergic anti-pruritic compositions, also Include the steps that extracting, extracting method is not particularly limited, and can be solvent extraction method, cryogenic high pressure extraction method, means of supercritical extraction Method, ultrasonic extraction, enzyme extraction method etc..

A kind of antipruritic toner of antiallergic, including being subjected to auxiliary material in above-mentioned antiallergic anti-pruritic compositions and skin care item.

The above-mentioned antipruritic toner of antiallergic can be substantially reduced skin sensitivity and itch phenomenon, increase the tolerance of skin, give Skin comprehensive security guarantee is given, while skin moisture-keeping water lock ability can also be adjusted, fluid infusion is promoted the production of body fluid, caused by smoothing drying immediately Microgroove and bits, persistently support profit skin.

In one embodiment, in the antipruritic toner of the antiallergic, the quality percentage of the antiallergic anti-pruritic compositions Content is 0.5%-28%.

In one embodiment, in the antipruritic toner of the antiallergic, the quality percentage of the antiallergic anti-pruritic compositions Content is 1%-20%.

In one embodiment, in the antipruritic toner of the antiallergic, the quality percentage of the antiallergic anti-pruritic compositions Content is 5%-15%.

In one embodiment, the auxiliary material includes moisturizer, chelating agent, thickener, preservative, solubilizer, assigns perfume Agent and neutralizer.

In one embodiment, the moisturizer is the group of Sodium Hyaluronate, butanediol, glycerol and 1,3-PD It closes；The chelating agent is EDETATE SODIUM；The thickener is xanthan gum；The preservative is Chlorphenesin；The solubilizer is Cremophor RH40；The odorant is essence；The neutralizer is sodium hydroxide；

In the antipruritic toner of the antiallergic, in terms of mass percentage, the Sodium Hyaluronate is 0.02%-0.2%, The butanediol is 0.1%-1%, and the glycerol is 0.1-2%, and the 1,3-PD is 0.1%-1%, the trehalose For 0.1%-1%, the EDETATE SODIUM is 0.01%-0.1%, and the xanthan gum is 0.02%-0.3%, the Chlorphenesin For 0.1%-0.4%, the Cremophor RH40 is 0.1%-0.6%, and the essence is 0.02%-0.15%, described Sodium hydroxide is 0.05%-0.4%.

The preparation method of the antipruritic toner of above-mentioned antiallergic, which comprises the following steps:

Under conditions of 70 DEG C -90 DEG C, the auxiliary material is dissolved in daily necessities in acceptable solvent；

45 DEG C are cooled to hereinafter, the antiallergic anti-pruritic compositions are added, stirs evenly, the antipruritic skin toner of the antiallergic is made Water.

First auxiliary material dissolution is reduced into temperature again, above-mentioned antiallergic anti-pruritic compositions are added, active component can be effectively prevented Decomposition while, guarantee that obtained product has preferable physical behavior.

In one embodiment, the preparation method of the antipruritic toner of above-mentioned antiallergic, comprising the following steps:

EDETATE SODIUM, Sodium Hyaluronate and water are mixed, the xanthan gum, described is added under conditions of 65 DEG C -75 DEG C Butanediol, the 1,3-PD, the glycerol and the trehalose are heated to 82 DEG C -85 DEG C, homogeneous to dispersion while stirring Uniformly, 20-30 minutes are kept the temperature；

It is cooled to 70 DEG C -80 DEG C and the butanediol and Chlorphenesin is added, stir evenly；

Be cooled to 45 DEG C hereinafter, be added the Radix Ophiopogonis root extract, turn round thorn Cactus Pedicel extract, kuh-seng root extract, HERBA DENDROBII stem extraction, aloe barbadensis Miller leaf extract, fructus lycii berry extract, Echinacea angustifolia extract and the tartaric acid are compound Object, and sodium hydrate aqueous solution is added, the pH value of the antipruritic toner of the antiallergic is controlled in 4-6, is stirred evenly, is made described The antipruritic toner of antiallergic.

Detailed description of the invention

Fig. 1 is that 3. st volunteer uses moisture content of skin curve graph before and after the product of embodiment 3；

Fig. 2 is that 7. st volunteer uses moisture content of skin curve graph before and after the product of embodiment 7.

Specific embodiment

To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.

Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases Any and all combinations of the listed item of pass.

Specific embodiment is set forth below, and the present invention will be described.

Embodiment 1

The mass percentage of each raw material of the antipruritic toner of antiallergic: antiallergic anti-pruritic compositions (component such as table 1) 10%, transparent Matter acid sodium 0.05%, butanediol 0.5%, glycerol 2%, 1,3 propylene glycol 0.2%, trehalose 0.1%, EDETATE SODIUM 0.05%, Huang Virgin rubber 0.1%, Chlorphenesin 0.2%, Cremophor RH40 0.3%, essence 0.06%, sodium hydroxide 0.26%, more than water Amount.

Preparation method:

EDETATE SODIUM, Sodium Hyaluronate and water are added in emulsion pot, stirring is opened, is heated to 70 DEG C, institute's xanthan is added Glue, butanediol, 1,3-PD, glycerol and trehalose, are heated to 82 DEG C -85 DEG C while stirring, and homogeneous 3-5 minutes, until complete It is uniformly dispersed, keeps the temperature 20-30 minutes；

It is cooled to 75 DEG C of addition butanediols and Chlorphenesin, is stirred evenly；

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 1 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 4.98；

Heat-resisting (4542 DEG C): 3 months, restore room temperature, no water-oil separating, coarse phenomenon；

Cold-resistant (- 1742 DEG C): 3 months, restore room temperature, no water-oil separating, coarse phenomenon；

Loop test (45 DEG C, room temperature, -17 DEG C): 5 circulations are qualified.

Table 1: the component (parts by weight) of the antiallergic anti-pruritic compositions of embodiment 1- embodiment 7

Embodiment 2

The mass percentage of each raw material of the antipruritic toner of antiallergic: antiallergic anti-pruritic compositions (component such as table 1) 8%, transparent Matter acid sodium 0.05%, butanediol 0.5%, glycerol 2%, 1,3 propylene glycol 0.2%, trehalose 0.1%, EDETATE SODIUM 0.05%, Huang Virgin rubber 0.1%, Chlorphenesin 0.2%, Cremophor RH40 0.3%, essence 0.06%, sodium hydroxide 0.26%, more than water Amount.

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 2 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 4.87；

Embodiment 3

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 3 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.03；

Embodiment 4

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 4 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.12；

Embodiment 5

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 5 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.12；

Embodiment 6

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 6 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 4.92；

Embodiment 7

Preparation method:

45 DEG C are cooled to hereinafter, each component of antiallergic anti-pruritic compositions is added, and sodium hydrate aqueous solution is added, pH is controlled System is stirred evenly in 4-6, and the antipruritic toner of antiallergic of embodiment 7 is made, and appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.11；

Comparative example 1

The mass percentage of each raw material of the antipruritic toner of antiallergic: antiallergic anti-pruritic compositions (component such as table 2) 8%, transparent Matter acid sodium 0.05%, butanediol 0.5%, glycerol 2%, 1,3 propylene glycol 0.2%, trehalose 0.1%, EDETATE SODIUM 0.05%, Huang Virgin rubber 0.1%, Chlorphenesin 0.2%, Cremophor RH40 0.3%, essence 0.06%, sodium hydroxide 0.26%, more than water Amount.

Preparation method: with embodiment 1, appearance and physical and chemical index are as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.20；

Table 2: the component (parts by weight) of the antiallergic anti-pruritic compositions of comparative example 1- comparative example 3

	Comparative example 1	Comparative example 2	Comparative example 3	Comparative example 4
					Radix Ophiopogonis root extract	0	4	0	0
Turn round thorn Cactus Pedicel extract	0	2	0	0
					Kuh-seng root extract	0	4	0	0
HERBA DENDROBII stem extraction	4	0	0	0
					Aloe barbadensis Miller leaf extract	2	0	0	0
Fructus lycii berry extract	1	0	0	0
					Echinacea angustifolia extract	1	0	0	0
Tartaric acid compound	0	0	4	0

Comparative example 2

Appearance: transparency liquid；

PH value (straight to survey): 4.98；

Comparative example 3

Appearance: transparency liquid；

PH value (straight to survey): 5.07；

Comparative example 4 (bare substrate)

The mass percentage of each raw material of the antipruritic toner of antiallergic: Sodium Hyaluronate 0.05%, butanediol 0.5%, glycerol 2%, 1,3 propylene glycol 0.2%, trehalose 0.1%, EDETATE SODIUM 0.05%, xanthan gum 0.1%, Chlorphenesin 0.2%, PEG- 40 rilanit specials 0.3%, essence 0.06%, sodium hydroxide 0.26%, water surplus.

Preparation method: EDETATE SODIUM, Sodium Hyaluronate and water are added in emulsion pot, are opened stirring, are heated to 70 DEG C, add Enter institute's xanthan gum, butanediol, 1,3-PD, glycerol and trehalose, is heated to 82 DEG C -85 DEG C, homogeneous 3-5 points while stirring Clock keeps the temperature 20-30 minutes until being completely dispersed uniformly；It is cooled to 75 DEG C of addition butanediols and Chlorphenesin, is stirred evenly；It is added PH is controlled in 4-6, is stirred evenly by sodium hydrate aqueous solution, and the bare substrate of comparative example 4, appearance and physical and chemical index is made It is as follows:

Appearance: transparency liquid；

PH value (straight to survey): 5.07；

Compliance test result experiment

(1) antiallergic antipruritic effect is verified -- and histamine phosphate causes method of itching

Experimental subjects: the antipruritic toner of the antiallergic of embodiment 3 and embodiment 7.

Experimental material:, female 23, male 22,320g430g, being randomly divided into 3 groups by cavy 45, and every group 15, and every group It is divided into high dose group (1.5g/kg), middle dose group (0.8g/kg) and low dose group (0.1g/kg), each metering group 5.

Wherein, the antiallergic anti-pruritic compositions of first group of testing example 3, antipruritic group of the antiallergic of second group of testing example 7 Object is closed, third group is blank control (distilled water).

Test method:

Weigh histamine phosphate, and be configured to volumn concentration be 0.01%, 0.02%, 0.03%, 0.04%0.3% the concentration gradually increased solution of gradient, it is spare.

Hair (the area about 1cm of cavy back was removed before on-test²), and using the corresponding product of each group, twice daily, After three days, three days, start to test.

Before on-test, place's skin to be tested is gently wiped with distilled water, then uses the corresponding toner of each group, After 15min, start to drip histamine phosphate at test, each 0.05mL, primary every 3min drop, concentration is gradually incremented by, and observation exists In in the 3min at interval, whether cavy has the movement later licked and licked, and continues growing histamine phosphate if without later the movement licked is licked Concentration record the total amount for the histamine phosphate being added dropwise at this time until occurring licking and licking movement, be calculated as itch-threshold value, and will The threshold value of three cavys of every group of each metering group takes mean value, test result such as table 3.

Note: the concentration of histamine phosphate at most increases to 0.3%, if still reactionless to the concentration, is no longer added dropwise, and directly records The total amount of the histamine phosphate being added dropwise at this time, is calculated as itch-threshold value.

Table 3

From table 3 can, the antipruritic toner of the antiallergic of embodiment 3 and embodiment 7 all has preferably compared to control group Antipruritic effect can be improved the itch-threshold of cavy.

(2) replenishing water and preserving moisture is tested

Volunteer: 10, be women, and the age 25-28 years old；

Test product: the toner of embodiment 1- embodiment 7, comparative example 1- comparative example 3.Volunteer is numbered, point Not Wei 1. number~10. number, 1. number using the product of embodiment 1,2. number using the product of embodiment 2, and so on.

Test equipment: Corneometer CM825

Test method: taking the identical region of tester or so inner forearm, respectively in the (test of the corresponding product of left arm film Region), the bare substrate (control zone) of right arm film comparative example 4, test use before (0h), using rear 1h, 2h, 4h, 6h when The moisture content of skin of left and right arms test zone.Test result such as table 4.

Table 4

From table 4, it can be seen that the antipruritic toner of antiallergic of embodiment 1- embodiment 7 has preferable Water-saving effect.

Fig. 1 is that 3. st volunteer uses the moisture content of skin curve graph before and after the product of embodiment 3；Fig. 2 is that 7. livery is willing to Person uses moisture content of skin curve graph before and after the product of embodiment 7.Embodiment 3 is compared with embodiment 7, and embodiment 7 lacks tartaric acid Compound, comparison diagram 1 and Fig. 2, which can be seen that the 3. skin moisture content of st volunteer and Water-saving effect and be superior to 7. livery, to be willing to Person.It may be speculated that the moisturizing that the addition of tartaric acid compound may enhance product is retained effect.

It is mentioned in addition, comparative example 1 lacks Radix Ophiopogonis root extract, torsion thorn Cactus Pedicel extract, radix sophorae compared to embodiment 3 Take object and tartaric acid compound, comparative example 2 compared to embodiment 3 lack HERBA DENDROBII stem extraction, aloe barbadensis Miller leaf extract, Fructus lycii berry extract, Echinacea angustifolia extract and tartaric acid compound.From test result as can be seen that its moisturizing effect and moisturizing effect Fruit all has different degrees of decline, and especially with the 9. st volunteer of comparative example 2, moisture-keeping function decline is more obvious, says The components such as bright HERBA DENDROBII stem extraction, aloe barbadensis Miller leaf extract, fructus lycii berry extract and Echinacea angustifolia extract for The replenishing water and preserving moisture effect for enhancing product has biggish effect.

Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.

The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims

1. a kind of antiallergic anti-pruritic compositions, which is characterized in that including following active component: Radix Ophiopogonis turns round thorn cactus, kuh-seng, gold Hairpin dendrobium nobile, aloe barbadensis Miller, fructus lycii and purple coneflower.

2. antiallergic anti-pruritic compositions according to claim 1, which is characterized in that the Radix Ophiopogonis, turn round thorn cactus, kuh-seng, HERBA DENDROBII, aloe barbadensis Miller, kuh-seng, fructus lycii and purple coneflower are the extract of corresponding raw material；

In the antiallergic anti-pruritic compositions, in parts by weight, Radix Ophiopogonis root extract is 1-5 parts, turns round thorn Cactus Pedicel extract It is 1-3 parts, kuh-seng root extract is 1-6 parts, and HERBA DENDROBII stem extraction is 1-5 parts, and aloe barbadensis Miller leaf extract is 1-3 Part, fructus lycii berry extract is 1-3 parts, and Echinacea angustifolia extract is 1-3 parts.

3. antiallergic anti-pruritic compositions according to claim 1 or 2, which is characterized in that the active component further includes tartaric acid Compound, the tartaric acid compound mainly by sodium lactate, hydroxyacetic acid, sucrose, urea, sodium citrate, malic acid, tartaric acid and Sodium Hyaluronate composition.

4. antiallergic anti-pruritic compositions according to claim 3, which is characterized in that the Radix Ophiopogonis root extract, torsion thorn The mass ratio of the quality sum of Cactus Pedicel extract and the kuh-seng root extract and the tartaric acid compound is (1-2): 1； And/or

The HERBA DENDROBII stem extraction, aloe barbadensis Miller leaf extract, kuh-seng root extract, fructus lycii berry extract, purple pine nut The mass ratio of the quality sum of chrysanthemum extract and the tartaric acid compound is (1-2): 1.

5. the described in any item antiallergic anti-pruritic compositions of claim 1-4 are preparing the application in skin care item.

6. a kind of antipruritic toner of antiallergic, which is characterized in that including the described in any item antiallergic anti-pruritic compositions of claim 1-4 With auxiliary material acceptable in skin care item.

7. the antipruritic toner of antiallergic according to claim 6, which is characterized in that in the antipruritic toner of the antiallergic, institute The mass percentage for stating antiallergic anti-pruritic compositions is 0.5%-28%.

8. the antipruritic toner of antiallergic according to claim 7, which is characterized in that the auxiliary material include moisturizer, chelating agent, Thickener, preservative, solubilizer, odorant and neutralizer.

9. the antipruritic toner of antiallergic according to claim 8, which is characterized in that the moisturizer is Sodium Hyaluronate, fourth The combination of glycol, glycerol, 1,3- propylene glycol and trehalose；The chelating agent is EDETATE SODIUM；The thickener is xanthan gum；Institute Stating preservative is Chlorphenesin；The solubilizer is Cremophor RH40；The odorant is essence；The neutralizer is Sodium hydroxide；

In the antipruritic toner of the antiallergic, in terms of mass percentage, the Sodium Hyaluronate is 0.02%-0.2%, described Butanediol is 0.1%-1%, and the glycerol is 0.1-2%, and the 1,3-PD is 0.1%-1%, and the trehalose is 0.1%-1%, the EDETATE SODIUM are 0.01%-0.1%, and the xanthan gum is 0.02%-0.3%, and the Chlorphenesin is 0.1%-0.4%, the Cremophor RH40 are 0.1%-0.6%, and the essence is 0.02%-0.15%, the hydrogen Sodium oxide molybdena is 0.05%-0.4%.

10. the preparation method of the antipruritic toner of the described in any item antiallergics of claim 6-9, which is characterized in that including following step It is rapid:

45 DEG C are cooled to hereinafter, the antiallergic anti-pruritic compositions are added, stirs evenly, the antipruritic toner of the antiallergic is made.