CN117838583A - Anti-photoaging skin care composition and preparation method and application thereof - Google Patents
Anti-photoaging skin care composition and preparation method and application thereof Download PDFInfo
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- CN117838583A CN117838583A CN202311268636.XA CN202311268636A CN117838583A CN 117838583 A CN117838583 A CN 117838583A CN 202311268636 A CN202311268636 A CN 202311268636A CN 117838583 A CN117838583 A CN 117838583A
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- CN
- China
- Prior art keywords
- photoaging
- skin care
- extract
- care composition
- sodium hyaluronate
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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- Botany (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses an anti-photoaging skin care composition, and a preparation method and application thereof. The composition is prepared by compounding sodium hyaluronate-ferulic acid graft and one or two of viola diffusa extract and calendula extract, and experiments prove that the photoaging resistant composition and the product containing the photoaging resistant composition can achieve the photoaging resistance effect by promoting the generation of elastic fibers and Collagen IV, can be used in cosmetics to improve the skin aging problem caused by skin photoaging, and has good application prospect in photoaging resistant cosmetics.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-photoaging skin care composition, a preparation method and application thereof.
Background
Aging, also known as aging, is a process by which organisms lose and deteriorate from constituent substances, tissue structures to physiological functions over time or age, and gradually tend to die, and is a complex and irreversible natural phenomenon. Skin aging is a direct manifestation of body aging, and is mainly characterized by wrinkling, dry skin, atrophy, loss of elasticity and the like. The skin is gradually aged along with time and seriously influences the life quality of people under the influence of external environmental factors such as endogenous aging of the organism, ultraviolet rays, environmental pollution and the like.
Ultraviolet rays are divided into three wave bands, wherein short wave ultraviolet UVC is absorbed by the atmosphere and cannot reach the ground, and part of medium wave ultraviolet UVB and almost all long wave ultraviolet UVA can penetrate the atmosphere to reach the ground. UVB energy is strong, the penetrating power is weak, and the UVB energy mainly damages epidermal cells, damages skin barrier and inhibits immunity, thereby causing erythema and pigmentation. UVA energy is weaker, but penetration is stronger, and can reach dermis to damage collagen, elastic fiber and proteoglycan of dermis. Skin photoaging is the result of UVB co-acting with UVA. Photoaging is mainly manifested by skin sagging, roughness, increased wrinkles, irregular pigmentation, vasodilation, hypoparagonism, and abnormal proliferation of the epidermis in the exposed areas. From the analysis of microstructure and biological indexes, the content of Collagen, collagen fibers and elastic fibers is remarkably reduced after ultraviolet irradiation, wherein the Collagen IV is the main protein of the junction of the dermis (DEJ region), and the skin wrinkles are generated due to the reduction of the related effect of the dermis after the content of the Collagen IV is reduced. The elastic fiber is composed of microfibril and elastin, has elasticity but poor toughness, and the elastic fiber and the collagen fiber are mutually crosslinked, so that the elasticity and toughness of the skin are maintained. Therefore, the synthesis of the Collagen IV and elastic fiber is promoted, and the anti-photoaging effect can be achieved, so that the anti-aging effect is achieved.
In order to resist skin photoaging, not only are more and more effective ingredients sought and developed, but also how to apply the effective ingredients to cosmetics needs to be studied, so that the skin health state of the public is truly improved.
Disclosure of Invention
The invention aims to provide an anti-photoaging skin care composition, and a preparation method and application thereof. The composition is prepared by compounding sodium hyaluronate-ferulic acid graft and one or two of viola diffusa extract and calendula extract, has good photo-aging resistance effect through test verification, can be used for improving the skin aging problem caused by photo-aging of skin in cosmetics, and has good application prospect in photo-aging resistant cosmetics.
In order to achieve the technical purpose, the technical scheme provided by the invention is as follows: an anti-photoaging skin care composition comprises the following components in parts by mass: 0.1-1.5 parts of sodium hyaluronate-ferulic acid graft, and one or two of the following two extracts are contained: 1.0-15.0 parts of viola diffusa extract and 1.0-15.0 parts of calendula extract.
Preferably, the composition comprises the following components in parts by mass: 0.3-1.0 part of sodium hyaluronate-ferulic acid graft, 5.0-10.0 parts of viola diffusa extract, and 5.0-10.0 parts of calendula extract.
The preparation method comprises the following steps: sodium hyaluronate-ferulic acid graft, viola diffusa extract, and calendula extract were mixed together and dissolved in purified water (100 parts total).
The preparation method of the sodium hyaluronate-ferulic acid graft comprises the following steps: adding sodium hyaluronate and ferulic acid into water, adding vitamin C to activate under nitrogen protection, adding hydrogen peroxide to react under nitrogen, centrifuging after the reaction is finished to obtain supernatant, dialyzing the supernatant by a dialysis membrane, and freeze-drying at low temperature to obtain the preferred sodium hyaluronate (average molecular weight is 9 KD), dissolving sodium hyaluronate (10 mg/ml) into water, and mixing with sodium hyaluronate 1: 1. 5:1, respectively adding ferulic acid and vitamin C in proportion by weight, introducing nitrogen, activating for 30min under the protection of nitrogen, adding 5mol/L hydrogen peroxide according to the volume ratio of 2%, introducing nitrogen at room temperature, stirring for reaction for 12h, dialyzing for 48h in 3500D dialysis bag, and lyophilizing to obtain white flocculent powder.
The viola diffusa flower extract can be obtained in a commercial mode, and the preferred method is as follows: the Viola northeast flower is obtained by ultrasonic extraction with glycerol at 25-45deg.C, and the concentration of Viola northeast flower extract is 0.17-0.25g/mL based on crude drug (the amount of Viola northeast flower powder).
The calendula extract can be obtained in a commercially available manner, and the preferred method is as follows: decocting calendula petals in water at 70-90 ℃, concentrating the extracting solution in vacuum, adding glycerin 1.0-1.2 times of the mass of the calendula petal concentrate, uniformly stirring, and filtering to obtain calendula extract, wherein the concentration of the calendula extract is 0.18-0.30g/mL calculated by the crude drug (the dosage of calendula petal powder).
In a second aspect of the invention, there is provided the use of the above composition for the preparation of a cosmetic product for anti-photoaging skin care. The experiment proves that the composition can achieve the effect of effectively resisting photoaging by promoting the synthesis of the Collagen IV and the elastic fiber, and is safe and free of toxic and side effects, so that the composition can be applied to photoaging-resisting skin-care cosmetics.
In a third aspect of the present invention, there is provided a cosmetic product for anti-photoaging skin care comprising an anti-photoaging skin care composition.
Further, the photo-aging resistant skin care composition is added in an amount of 0.5 to 30%, preferably 2 to 30%, based on the total mass of the photo-aging resistant skin care cosmetic.
The anti-photoaging skin care cosmetic may also contain any other ingredients that the cosmetic art allows to add, including but not limited to emulsifiers, emollients, moisturizers, thickeners, and the like.
Wherein the anti-photoaging skin care cosmetic comprises, by the total mass of the anti-photoaging skin care cosmetic, 0.5-30% of the anti-photoaging skin care composition, 1-6% of an emulsifying agent, 6-30% of an emollient, 2-15% of a humectant, 0.02-1.0% of a thickening agent, and the balance of water and other auxiliary materials (preservative, pH regulator and the like).
Preferably, the anti-photoaging skin care cosmetic comprises the following components, by weight, based on the total mass of the anti-photoaging skin care cosmetic, 2-30% of the anti-photoaging skin care composition, 2-5% of an emulsifying agent, 10-25% of an emollient, 5-12% of a humectant and 0.05-0.8% of a thickening agent.
Preferably, the emulsifier comprises any one or a combination of two or more of PEG-100 stearate, glyceryl stearate, polyglyceryl-6 behenate, polyglyceryl-6 distearate, polyglyceryl-3 bee wax, C14-22 alcohol, C12-20 alkyl glucoside, cetostearyl olive oleate, sorbitan olive oleate, hydrogenated lecithin, cetyl alcohol, stearyl alcohol, glyceryl stearate, jojoba esters, sunflower seed wax, sodium stearyl glutamate, polyglyceryl-3, polyglyceryl-10 laurate, and sodium bis (lauramide glutamine) lysine.
Preferably, the emollient comprises any one or a combination of more than two of cetostearyl alcohol, isononyl isononanoate, squalane, caprylic/capric triglyceride, beeswax, mineral oil, berhard walnut seed oil, white pool seed oil, polydimethylsiloxane, cyclopentadimethicone, isododecane, jojoba seed oil, tri (ethylhexanoic) acid ester, behenyl alcohol, shea butter, pentaerythritol tetraisostearate, dioctyl carbonate, tocopheryl acetate.
Preferably, the humectant comprises any one or more than two of glycerin, butanediol, dipropylene glycol, 1, 3-propylene glycol, 1, 2-hexanediol, ethylhexyl glycerin, betaine, sodium hyaluronate, panthenol and trehalose.
Preferably, the thickener comprises any one or more than two of sodium polyacrylate, sodium polyacrylate grafted starch, carbomer, xanthan gum, hydroxyethyl cellulose, polyacrylate crosslinked polymer-6, ammonium acryloyldimethyl taurate/VP copolymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
Preferably, the preservative comprises any one or a combination of more than two of hydroxyacetophenone, octanoyl hydroxamic acid and phenoxyethanol.
Preferably, the pH regulator comprises any one of tromethamine, triethanolamine and arginine.
Meanwhile, different cosmetic formulations such as essence water, essence cream and essence cream can be prepared by reasonably adding the raw material components, and meanwhile, the obtained cosmetic products are further derived and prepared based on the basic cosmetic products, which obviously belong to the protection scope of the application.
In a fourth aspect of the present invention, there is provided a method for preparing the above-mentioned photoaging-resistant skin care cosmetic, characterized in that the photoaging-resistant skin care composition and other raw material components are mixed.
The beneficial technical effects of the invention are as follows:
1. experiments prove that the anti-photoaging composition and the product containing the same can achieve the effects of resisting photoaging and aging by promoting the generation of elastic fibers and Collagen IV, and have remarkable effects when being used in skin care products.
2. The preparation method of the anti-photoaging skin care cosmetic is simple and easy to implement, raw materials are easy to obtain, and the anti-photoaging skin care cosmetic is suitable for mass production, so that the anti-photoaging skin care cosmetic has good practical application value.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the invention thereto. Based on the embodiments of the present invention, any changes to the present invention without making any creative changes to the present invention fall within the protection scope of the present invention. Meanwhile, in the examples of the present invention, all the preparation materials are commercially available products well known to those skilled in the art unless otherwise specified.
Examples 1 to 5:
an anti-photoaging skin care composition comprises sodium hyaluronate-ferulic acid graft, viola northeast extract, and calendula extract.
Examples 1-5 and comparative examples 1-4 preparation methods: sodium hyaluronate-ferulic acid grafts, viola diffusa extract, calendula extract (according to the ingredients and amounts of table 1) were mixed together and dissolved in purified water. The specific scheme is shown in the following table 1, calculated as mass ratio.
Table 1: specific examples and comparative examples ingredient list (mass ratio)
The preparation method of the sodium hyaluronate-ferulic acid graft comprises the following steps: in a conical flask with a stopper, sodium hyaluronate (average molecular weight (measured by black-type viscometer) of 9 KD) was dissolved in water (10 mg/ml) and purified according to the procedure of sodium hyaluronate 1: 1. 5:1, respectively adding ferulic acid and vitamin C in proportion by weight, introducing nitrogen, activating for 30min under the protection of nitrogen, adding 5mol/L hydrogen peroxide according to the volume ratio of 2%, introducing nitrogen at room temperature, stirring for reaction for 12h, dialyzing for 48h in 3500D dialysis bag, and lyophilizing to obtain white flocculent powder.
The preparation method of the viola diffusa flower extract comprises the following steps:
(1) Removing impurities from dried herba Violae, and pulverizing;
(2) Placing pulverized Viola nordsinae flower in an ultrasonic extractor, adding glycerol, soaking for 1-2 hr, ultrasonic treating at 35deg.C for 30min, filtering after extraction, standing filtrate at 4deg.C for 24 hr, and plate centrifuging to obtain Viola nordsinae flower extract with concentration of 0.18g/mL calculated from crude drug (amount of Viola nordsinae flower powder).
The calendula extract is obtained by the following steps:
(1) Removing impurities from dried calendula petals, pulverizing, and sieving with 100 mesh sieve;
(2) Adding deionized water 13 times of the weight of the crushed calendula petals into the calendula petals, refluxing and decocting at normal pressure and 80 ℃ for at least two times, wherein the time of each refluxing and decocting is not less than 60 minutes, filtering and merging the extracting solutions after the extraction is finished, vacuum concentrating the extracting solutions, adding glycerin 1.1 times of the mass of the calendula petal concentrated solution, uniformly stirring, and filtering to obtain calendula extract, wherein the concentration of the calendula extract is 0.25g/mL calculated by the crude drug (the dosage of the calendula petal powder).
Example 6: essence water
The formula of the essence aquatic product containing the anti-photoaging composition is shown in table 2.
Table 2: essence aquatic product formula
The preparation method of the essence water comprises the following steps:
s1: preparing an aqueous phase: respectively adding the raw materials in the phase A, heating to 85 ℃ and stirring for dissolution;
s2: preparing an oil phase: heating the phase B raw material to 80 ℃ for melting;
s3: mixing phase A and phase B, homogenizing (3000 rpm) for 12min;
s4: when the temperature is reduced to 45 ℃, the C phase component and the D phase component are sequentially added, and the mixture is stirred, dissolved and dispersed uniformly to obtain the essential aquatic product.
Comparative example 5 was prepared as in example 6 except that comparative example 5 did not contain the photoaging resistant skin care composition and the photoaging resistant composition of example 6 was supplemented with water.
Example 7: essence emulsion
The formula of the essence emulsion product containing the photo-aging resistant skin care composition is shown in table 3.
Table 3: essence milk product formula
The preparation method of the essence emulsion comprises the following steps:
s1: preparation of an aqueous phase: respectively adding the raw materials in the phase A, heating to 85 ℃ and stirring for dissolution;
s2: preparation of an oil phase: respectively adding the raw materials in the phase B, heating to 80 ℃ and melting;
s3: mixing phase A and phase B, homogenizing (3000 rpm) for 12min;
s4: after homogenization, adding phase C, stirring uniformly, and starting to cool;
s5: adding phase D when the temperature is reduced to 70 ℃, stirring and dissolving, and continuing to reduce the temperature after dissolving;
s6: and when the temperature is reduced to 45 ℃, adding the E phase component, stirring, dissolving and dispersing uniformly to obtain the essence milk product.
Example 8: essence cream
The formula of the essence cream product containing the photo-aging resistant skin care composition is shown in table 4.
Table 4: essence cream product formula
The preparation method of the essence cream comprises the following steps:
s1: preparation of an aqueous phase: respectively adding the raw materials in the phase A, heating to 85 ℃ and stirring for dissolution;
s2: preparation of an oil phase: respectively adding the raw materials in the phase B, heating to 80 ℃ and melting;
s3: mixing phase A and phase B, homogenizing (3000 r/min), homogenizing for 12min;
s4: after homogenization, cooling is started, when the temperature is reduced to 70 ℃, adding the phase C, stirring and dissolving, and cooling is continued after the dissolution is completed;
s5: when the temperature is reduced to 45 ℃, adding the phase D component, stirring, dissolving and dispersing uniformly to obtain the essence cream product.
Test example 1: safety test experiment
The product was subjected to eye irritation test, i.e., safety test, with reference to SN/T2329-2009 "cosmetic eye irritation/chick embryo chorioallantoic membrane test".
The experimental method comprises the following steps: fertilized chick embryos within 7 days of age are adopted to be incubated for 9 days in an incubator with humidity of 50% -70% at 37.6+/-0.5 ℃.
CAM preparation: egg candling is performed by marking the air chamber locations on the eggshell surface, and the labeled eggshell portions are peeled off with tweezers to expose the white eggshell membrane, taking care not to disrupt the integrity of the eggshell membrane. 0.5mL of 0.9% NaCl solution is added dropwise to fully wet the egg membrane, surface liquid is gently sucked by a paper towel, and the inner membrane is carefully removed by forceps, so that the vascular membrane is not damaged.
Reaction end point method: and uniformly dripping or smearing 0.3mL of transparent test object on the surface of the CAM, washing the test object by using 0.9% NaCl solution after 3min of action, and observing the degree of each toxicity effect change of the CAM.
Endpoint scoring method (end point score ES): the end point score (ES) should be calculated for the test performed using the reaction end point method, with the result remaining two decimal places. Score per chick embryo = sum of extent of bleeding, clotting and vascular thawing observed per chick embryo, ES = mathematical sum of 6 chick embryo scores. The eye irritation of the test subjects was classified according to the ES values as shown in table 5.
Table 5: determination standard for reaction end point method result
| Stimulation scoring | ES≤12 | 12＜ES＜16 | ES≥16 |
| Irritation classification | No/light irritation | Moderate irritation | Strong irritation/corrosiveness |
The test results are shown in Table 6, and the chick embryo chorioallantoic membrane test of the anti-photoaging skin care compositions of examples 1-5 shows no irritation, which indicates that the sodium hyaluronate-ferulic acid graft is safe and has no toxic or side effects when combined with one or both of viola diffusa extract and calendula extract.
TABLE 6 statistical tables of results of irritation experiments
Test example 2: experiment for detecting content of elastic fiber and Collagen IV in vitro
The test is based on an in vitro model of UVR stimulated in-vitro skin tissue, and adopts Victoria blue staining and immunohistochemical methods to detect the content change of elastic fibers and Collagen IV so as to evaluate the anti-photoaging capability of a test object. The specific test protocols are shown in Table 7.
Tissue treatment: freshly obtained skin tissue (from Guangdong Boxi Biotechnology Co., ltd.) was immersed in 75% alcohol, washed for 30s, and washed three times with sterile PBS buffer; after completion, the skin tissue was cut into small discs of 0.6cm diameter with the epidermis facing up and the dermis facing down with a disposable sterile skin sampler, placed in a culture mold, and the mold was transferred to a 6-well plate with 3.7mL of culture broth (FSK 4, boxi organism) added to each well at 37℃with 5% CO 2 Culturing in incubator, and changing liquid every day.
Administration: after 2 days of ex-vivo skin tissue culture, UVR irradiation and administration was started with reference to the test groups and corresponding treatment conditions in table 7; UVR exposure dose was UVA (30J/cm) 2 ) And UVB (50 mJ/cm) 2 ) (UVA irradiation followed by UVB irradiation)Irradiation, the irradiation time(s) =irradiation dose (J/cm) was calculated according to the following formula 2 ) Irradiation intensity (W/cm) 2 ) Wherein the irradiation intensity is measured by an intensity dosage instrument. In the test, UVA irradiates for 29min and UVB irradiates for 21 s), the fresh culture solution is replaced after each irradiation is finished for 4 days, and administration treatment is carried out, positive control (VC+VE) is carried out in a submerged administration mode, and a sample to be tested is carried out in a surface administration mode. After 4 days of continuous irradiation, the isolated skin tissue was cultured for 3 days, during which time no UVR stimulation was performed and only sample administration was performed.
And (3) elastic fiber detection: skin tissue after the end of administration was fixed with 4% paraformaldehyde, tissue was embedded, sectioned, subjected to Victoria blue staining, the sectioned results were recovered, photographed using a microscope, and usedPlus image processing software performs the analysis.
Immunohistochemical detection: taking a model for detection, cutting off the model, fixing with 4% paraformaldehyde for 24 hours, performing immunohistochemical detection of the Collagen IV content, photographing and observing under a microscope, and collecting and analyzing pictures.
Table 7 test protocol
The test results are shown in tables 8 and 9.
TABLE 8 summary of elastic fiber content test results
| Sample name | Average value of relative area | SD | P-value | Rate of rise |
| BC | 1.00 | 0.10 | / | / |
| NC | 0.59 | 0.04 | 0.0028 ## | / |
| PC | 1.33 | 0.09 | 0.0002 ** | / |
| Example 1 | 0.73 | 0.05 | 0.0177* | 23.73％ |
| Example 2 | 0.95 | 0.07 | 0.0015** | 61.02％ |
| Example 3 | 0.90 | 0.1 | 0.0081** | 52.54％ |
| Example 4 | 0.78 | 0.06 | 0.0096** | 32.20％ |
| Example 5 | 0.80 | 0.05 | 0.0053** | 35.59％ |
| Comparative example 1 | 0.65 | 0.01 | 0.0453* | 10.17％ |
| Comparative example 2 | 0.61 | 0.02 | 0.4818 | / |
| Comparative example 3 | 0.59 | 0.03 | 1.000 | / |
| Comparative example 4 | 0.60 | 0.02 | 0.7183 | / |
| Example 6 | 0.92 | 0.09 | 0.0044** | 55.93％ |
| Comparative example 5 | 0.63 | 0.02 | 0.1963 | / |
( And (3) injection: # represents p <0.01 compared to the blank; * Represents p <0.01 compared to negative control; * Represents 0.01< p <0.05 compared to the negative control )
As can be seen from table 8, the NC group had significantly lower elastic fiber content than the BC group, indicating that the test stimulation conditions were effective. Compared with the NC group, the elastic fiber content of the PC group is obviously increased, which proves that the positive control of the test is effective. The elastic fiber contents of examples 1 to 6 and comparative example 1 were significantly increased, and the elastic fiber contents of comparative examples 2 to 5 were not significantly changed, as compared with NC groups. Examples 1-5 are compared with comparative examples 1-4, which demonstrate that sodium hyaluronate-ferulic acid grafts significantly promote the formation of elastic fibers, and that sodium hyaluronate-ferulic acid grafts have synergistic effects with one or both of viola diffusa extract and calendula extract, and that one or both of viola diffusa extract and calendula extract alone does not have the effect of promoting the formation of elastic fibers. Example 6 comparative example 5 demonstrates that cosmetics containing the photoaging-resistant composition have a remarkable effect of promoting the generation of elastic fibers. The anti-photoaging composition and the cosmetic containing the same can achieve effective photoaging resistance by promoting the synthesis of elastic fibers.
TABLE 9 Collagen IV average optical Density value summary table
( And (3) injection: # represents p <0.01 compared to the blank; * Represents p <0.01 compared to negative control; * Represents 0.01< p <0.05 compared to the negative control. )
As can be seen from table 9, the Collagen IV in NC group was significantly reduced compared to BC group, indicating that the stimulation conditions of this test were effective. The Collagen IV in the PC group increased significantly compared to the NC group, indicating that the positive control of this test was valid. The Collagen IV of examples 1-6, comparative example 1 were significantly elevated compared to NC groups, and the Collagen IV of comparative examples 2-5 were not significantly altered. Examples 1-5 are compared with comparative examples 1-4, demonstrating that sodium hyaluronate-ferulic acid grafts significantly promote the production of Collagen IV, and that sodium hyaluronate-ferulic acid grafts synergistically act with one or both of viola diffusa extract and calendula extract, and that one or both of viola diffusa extract and calendula extract alone does not promote the production of Collagen IV. Example 6 compares to comparative example 5, demonstrating that cosmetics containing the anti-photoaging composition have a significant effect in promoting the production of Collagen IV. The anti-photoaging composition and the cosmetic containing the same can achieve effective photoaging resistance by promoting the generation of Collagen IV.
The results show that: the anti-photoaging composition and the product containing the same can achieve the anti-photoaging effect by promoting the generation of elastic fibers and Collagen IV so as to achieve the anti-aging effect, and have remarkable effect when being used in skin care products.
It should be noted that the above examples are only for illustrating the technical solution of the present invention and are not limiting thereof. Although the present invention has been described in detail with reference to the examples given, those skilled in the art can make modifications and equivalents to the technical solutions of the present invention as required, without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The anti-photoaging skin care composition is characterized by comprising the following active ingredients in parts by mass: 0.1-1.5 parts of sodium hyaluronate-ferulic acid graft, and one or two of the following two extracts are contained: 1.0-15.0 parts of viola diffusa extract and 1.0-15.0 parts of calendula extract;
the viola diffusa flower extract is as follows: ultrasonic extracting herba Violae at 25-45deg.C with glycerin to obtain herba Violae extract with concentration of 0.17-0.25g/mL;
the calendula extract is as follows: decocting calendula petals in water at 70-90 ℃, concentrating the extracting solution in vacuum, adding glycerin 1.0-1.2 times of the calendula petal concentrate, uniformly stirring, and filtering to obtain the calendula petal extract; the concentration of calendula extract is 0.18-0.30g/mL.
2. The photoaging-resistant skin care composition according to claim 1, wherein the skin care composition comprises the following active ingredients in parts by mass: 0.3-1.0 part of sodium hyaluronate-ferulic acid graft, 5.0-10.0 parts of viola diffusa extract, and 5.0-10.0 parts of calendula extract.
3. The photoaging-resistant skin care composition according to claim 1 or 2, wherein the preparation method of the sodium hyaluronate-ferulic acid graft comprises the following steps: adding sodium hyaluronate and ferulic acid into water, adding vitamin C, activating under nitrogen protection, adding hydrogen peroxide, reacting under nitrogen, centrifuging, collecting supernatant, dialyzing the supernatant with dialysis membrane, and lyophilizing at low temperature.
4. A photoaging-resistant skin care composition according to claim 3, wherein the preparation method of the sodium hyaluronate-ferulic acid graft comprises the following steps: sodium hyaluronate with average molecular weight of 9KD is dissolved in water at concentration of 10mg/ml according to the following formula with sodium hyaluronate 1: 1. 5:1, respectively adding ferulic acid and vitamin C in proportion by weight, introducing nitrogen, activating for 30min under the protection of nitrogen, adding 5mol/L hydrogen peroxide according to the volume ratio of 2%, introducing nitrogen at room temperature, stirring for reaction for 12h, dialyzing for 48h in 3500D dialysis bag, and lyophilizing to obtain the final product.
5. The method for preparing the photoaging-resistant skin care composition according to claim 1 or 2, wherein one or both of viola diffusa extract and calendula extract and sodium hyaluronate-ferulic acid graft are mixed together, dissolved in purified water, and the purified water is added to 100 parts by mass.
6. Use of the photoaging-resistant skin care composition according to claim 1 or 2 for the preparation of photoaging-resistant skin care cosmetics.
7. The use according to claim 6, wherein the anti-photoaging skin care composition is effective against photoaging by promoting the synthesis of Collagen iv and elastic fibers.
8. An anti-photoaging skin care cosmetic comprising the anti-photoaging skin care composition of claim 1 or 2.
9. The photoaging-resistant skin care cosmetic according to claim 8, comprising, based on the total mass of the photoaging-resistant skin care cosmetic, 0.5 to 30% of the photoaging-resistant skin care composition, 1 to 6% of an emulsifier, 6 to 30% of an emollient, 2 to 15% of a humectant, 0.02 to 1.0% of a thickener, and the balance of water and other auxiliary materials; the photoaging resistant skin care composition prepared according to the method of claim 6.
10. A skin care cosmetic product having an anti-photoaging effect as claimed in claim 9, characterized in that,
the emulsifier is any one or more than two of PEG-100 stearate, glyceryl stearate, polyglycerol-6 behenate, polyglycerol-6 distearate, polyglycerol-3 bee wax ester, C14-22 alcohol, C12-20 alkyl glucoside, cetostearyl alcohol oleyl oleate, sorbitan oleyl oleate, hydrogenated lecithin, cetyl alcohol, stearyl alcohol, glyceryl stearate, jojoba esters, sunflower seed wax, sodium stearyl glutamate, polyglycerol-3, polyglycerol-10 laurate and sodium bis (laurel glutamine) lysine;
the emollient is one or more than two of cetostearyl alcohol, isononyl isononanoate, squalane, caprylic/capric triglyceride, beeswax, mineral oil, berkusnezoff seed oil, white pool flower seed oil, polydimethylsiloxane, cyclopentadimethicone, isododecane, jojoba seed oil, tri (ethylhexanoic acid) ester, behenyl alcohol, shea butter, pentaerythritol tetraisostearate, dioctyl carbonate and tocopheryl acetate;
the humectant is one or more of glycerol, butanediol, dipropylene glycol, 1, 3-propylene glycol, 1, 2-hexanediol, ethylhexyl glycerol, betaine, sodium hyaluronate, panthenol and trehalose;
the thickener is any one or more than two of sodium polyacrylate, sodium polyacrylate grafted starch, carbomer, xanthan gum, hydroxyethyl cellulose, polyacrylate crosslinked polymer-6, acrylamide dimethyl taurate/VP copolymer and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.
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