CN117797106A - Pill with effects of dispelling effects of alcohol and protecting liver and preparation method thereof - Google Patents

Pill with effects of dispelling effects of alcohol and protecting liver and preparation method thereof Download PDF

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Publication number
CN117797106A
CN117797106A CN202311827121.9A CN202311827121A CN117797106A CN 117797106 A CN117797106 A CN 117797106A CN 202311827121 A CN202311827121 A CN 202311827121A CN 117797106 A CN117797106 A CN 117797106A
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parts
liquorice
pill
medicinal
chrysanthemum
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刘周江
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Chongqing Academy of Chinese Materia Medica
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Chongqing Academy of Chinese Materia Medica
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract

The invention discloses a pill with the effects of dispelling the effects of alcohol and protecting liver and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation, wherein the pill comprises, by weight, 5-8 parts of hawthorns, 8-12 parts of dried orange peel, 10-15 parts of Chinese yam, 8-12 parts of cornus officinalis, 10-15 parts of bighead atractylodes rhizome, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of codonopsis pilosula, 10-15 parts of ligusticum wallichii, 4-7 parts of angelica sinensis, 6-10 parts of chrysanthemum, 5-8 parts of momordica grosvenori and 8-13 parts of white paeony root. The raw materials adopted by the invention are mutually compatible, and the hawthorn, the dried orange peel, the Chinese yam, the dogwood fruit, the bighead atractylodes rhizome, the ginseng, the dangshen and the hemlock parsley are mutually matched through two modes of roasting and decocting, so that the biggest play a role, not only can the toxicity of the medicine be relieved, but also the original activity of the medicine can be stimulated, the curative effect of the medicine is enhanced, and the performance of the medicine is changed; 3. the invention pulverizes the decocted medicinal materials, then adds the zymolytic stock solution into the medicinal powder, and the macromolecules in the stock solution are decomposed into small molecules, so that the effective components are separated out, and the medicinal powder can be matched with the medicinal powder to be more beneficial to human body absorption and increase the curative effect.

Description

Pill with effects of dispelling effects of alcohol and protecting liver and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a pill with the effects of dispelling the effects of alcohol and protecting liver and a preparation method thereof.
Background
Liver and stomach are vital to our body and are important components of our viscera. In daily interpersonal interaction, drinking and compensation are avoided, but after drinking, many people feel burned spleen and stomach, serious people can suffer from the phenomenon of vomiting, and the phenomenon is mainly caused by excessive drinking, and the damage to liver, spleen and stomach causes qi and blood stasis in the body and primordial qi injury, so that body dysfunction is caused, and a series of adverse reactions are caused.
At present, a plurality of health care products for protecting liver and nourishing stomach are available on the market, but the preparation raw materials of the health care products are not complete traditional Chinese medicine materials, and other chemical substances are added, so that the health care products have the effects of protecting liver and nourishing stomach, and can also cause burden to the body, and the health care products are suitable for the adverse effect. Other existing anti-inebriation drug products are generally taken after drinking in the form of drink, but the effect is poor, and the user is not willing to take the drink products too much again because the user is drunk, so that the anti-inebriation effect is not achieved.
Disclosure of Invention
In view of the above, the invention aims to provide a pill with the functions of dispelling the effects of alcohol and protecting liver and a preparation method thereof.
In order to achieve the above purpose, the present invention provides the following technical solutions: a pill with the effects of dispelling alcohol and protecting liver comprises, by weight, 5-8 parts of hawthorns, 8-12 parts of dried orange peel, 10-15 parts of Chinese yam, 8-12 parts of cornus officinalis, 10-15 parts of bighead atractylodes rhizome, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of codonopsis pilosula, 10-15 parts of ligusticum wallichii, 4-7 parts of angelica sinensis, 6-10 parts of chrysanthemum, 5-8 parts of fructus momordicae and 8-13 parts of white paeony root
Further, the pill is prepared from 6 parts of hawthorn, 10 parts of dried orange peel, 13 parts of Chinese yam, 10 parts of dogwood fruit, 12 parts of bighead atractylodes rhizome, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis pilosula, 13 parts of ligusticum wallichii, 8 parts of chrysanthemum, 6 parts of momordica grosvenori, 6 parts of angelica and 10 parts of white paeony root by weight.
Further, the preparation method of the pill with the functions of dispelling the effects of alcohol and protecting liver comprises the following steps,
s1, removing impurities on the surfaces of the raw material medicaments in the formula amount, respectively soaking the raw material medicaments except liquorice and chrysanthemum in clear water, airing, uniformly dividing the soaked raw material medicaments into a medicinal material part 1 and a medicinal material part 2, and mixing soaking water of the soaked medicinal materials;
s2, adding a part of roasted liquorice into soaking water for decoction to obtain a first liquorice liquid;
s3, adding the medicine material part 1 into the first liquorice liquid, continuously decocting, taking out the decocted medicine material part 1, stir-frying, and grinding to obtain medicinal powder;
s4, grinding the other part of liquorice, soaking the crushed part of liquorice with chrysanthemum to obtain second liquorice liquid, and taking out the chrysanthemum; adding the medicinal material part 2 into the second liquorice liquid for decoction, taking out the decocted medicinal material part 2, stir-frying, and grinding to obtain medicinal powder;
s5, cooling the decocted first licorice liquid and second licorice liquid to 40-50 ℃ respectively, adding complex enzyme for enzymolysis, and then carrying out reflux extraction and purification;
s6, mixing the stir-fried medicinal materials in the steps S3 and S4, adding the second liquorice liquid after enzymolysis into the medicinal powder, mixing the medicinal powder into a dry paste, and continuously adding the first liquorice liquid after enzymolysis into the dry lake-shaped medicinal powder to prepare the pill
Further, in the step S1, the raw material medicines are soaked in clear water 1.2-1.5 times of that of the raw material medicines respectively, and the soaking time is 2 hours.
Further, in the step S2, the roasting temperature of the liquorice is 110-120 ℃ and the distance from the flame is 2-3cm, and the roasting time is 8-12 minutes; the temperature of the decoction after the baking of the liquorice is 60-80 ℃ and the time of the decoction is 10-20 minutes.
Further, in the step S3, the decoction temperature after adding the medicinal material part 1 is 100-120 ℃, and the decoction time is 50-65 minutes.
Further, in the step S4, the soaking time of the licorice and the chrysanthemum is 20-30 minutes, the decocting temperature is 100-120 ℃ after the second licorice solution is added into the medicinal material part 2, and the decocting time is 50-65 minutes.
Further, in the step S5, the complex enzyme is one or more of a cellulose enzyme, a protease and an amylase, and the complex enzyme is 0.13-0.17% of the total weight of the raw materials.
The invention adopts hawthorn, and organic acids such as crataegolic acid, malic acid and the like in the hawthorn, and has the effects of promoting digestion, improving digestion and resolving food stagnation. Promoting secretion of digestive juice, regulating gastrointestinal peristalsis, stimulating appetite, treating stomach pain, helping to decompose food, relieving stomach burden, and simultaneously pectin component in fructus crataegi can form protective film with gastric acid to protect gastric mucosa, relieve stomach pain, and prevent ulcer.
The dried orange peel has the effects of regulating qi and strengthening spleen, harmonizing middle-jiao, eliminating dampness and resolving phlegm, can promote digestion, treat abdominal distention and fullness, improve the conditions of anorexia, vomiting and diarrhea and food retention, and can also treat symptoms such as excessive phlegm, cough and the like.
The Chinese yam and the dogwood fruit can be matched for nourishing, replenishing qi to invigorate the spleen, moistening lung to arrest cough, and is beneficial to regulating digestion function, increasing appetite, enhancing physical strength and improving fatigue and hypodynamia, and the two can be matched for use to complement each other, so that excessive internal heat and fever can be prevented.
Bai Zhu can tonify qi, invigorate spleen, remove dampness and promote diuresis, treat lung qi deficiency and spleen deficiency edema, dispel the evil of water dampness retained in the body, and treat vomiting, aversion to food, body weakness.
Ginseng is a Chinese medicinal material for invigorating qi and blood, has effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating spleen, benefiting lung, promoting salivation, nourishing blood, tranquilizing mind, improving intelligence, and is suitable for improving symptoms such as sweats, emesis and diarrhea, and relieving fatigue and debilitation.
Licorice is sweet and smooth in tonifying, cool in nature, has the effects of tonifying qi and middle energizer, relieving spasm and pain and the like, and is recorded in the book of Chaenomeles herbal medicine to dispel hundred toxins and relieve toxicity and intensity of medicines. The honey-fried licorice root has the effects of tonifying qi, restoring pulse, tonifying spleen, harmonizing stomach and the like, and can be suitable for symptoms such as weakness of spleen and stomach, fatigue, weakness, palpitation and the like.
The radix codonopsis pilosulae is sweet and smooth, supplements middle-jiao and supplements qi, harmonizes stomach and regulates middle-jiao, is not dry and greasy, and is used for treating spleen and lung qi deficiency, and improving the conditions of anorexia, listlessness, cough, asthma, sallow complexion and limb weakness.
Chuan Xiong and Bai Shao are combined to treat liver Yu Xie pain, sooth liver, promote qi circulation, activate blood and relieve pain, improve retching, insomnia and dreamful sleep, and irritability.
Dang Gui can tonify and moisten, pungent and warm in nature, dispel the heat, invigorate spleen and nourish heart, and has the actions of tranquillizing and protecting liver.
The chrysanthemum has the effects of clearing heat and detoxicating, clearing liver and improving vision, the liquorice has the effects of clearing heat and detoxicating, relieving sore throat, the chrysanthemum and liquorice have the effects of clearing heat, promoting liver to remove toxicity, clearing liver fire, treating conjunctival congestion and swelling and pain, blurred vision and the like, and the fructus momordicae has the effects of clearing heat and moistening lung, treating sore throat and aphonia, and constipation due to dryness of the intestines.
The invention has the beneficial effects that:
1. the raw materials adopted by the invention are mutually compatible, and the hawthorn, the dried orange peel, the Chinese yam, the dogwood fruit, the bighead atractylodes rhizome, the ginseng and the like can regulate qi and strengthen spleen, promote digestion, regulate digestion function and regulate stomach discomfort; the reasonable collocation of the codonopsis pilosula, the ligusticum wallichii, the angelica and the white paeony root can protect the liver, and the chrysanthemum and the momordica grosvenori have the effects of clearing away heat and toxic materials and clearing lung-heat and relieving cough;
2. when the preparation method is used, liquorice is roasted and decocted, and the decoction is matched with each other after the decoction, so that the maximum play effect is achieved, the toxicity of the medicine can be relieved, the original activity of the medicine can be stimulated, the curative effect of the medicine is enhanced, and the medicine performance is changed;
3. the invention pulverizes the decocted medicinal materials, then adds the zymolytic stock solution into the medicinal powder, and the macromolecules in the stock solution are decomposed into small molecules, so that the effective components are separated out, and the medicinal powder can be more beneficial to human body absorption and increase the curative effect when being matched with the medicinal powder;
4. the pill is prepared by adopting the principle of homology of medicine and food, furthest reduces the toxicity of the medicine, furthest plays the curative effect of the medicine, has faint scent and no bitter taste, is convenient to carry and use.
Other advantages, objects and features of the present invention will be set forth in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following, or may be learned from practice of the invention. The objects and other advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out in the specification.
Detailed Description
The applicant provides the following examples to further illustrate the invention, but the invention is not limited to these examples.
Example 1
A pill with effects of relieving hangover and protecting liver:
s1, weighing 6 parts of hawthorn, 10 parts of dried orange peel, 13 parts of Chinese yam, 10 parts of dogwood fruit, 12 parts of bighead atractylodes rhizome, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis pilosula, 13 parts of ligusticum wallichii, 8 parts of chrysanthemum, 6 parts of momordica grosvenori, 4 parts of angelica and 10 parts of white paeony root according to parts by weight, removing impurities on the surfaces of the raw medicinal materials, soaking the rest raw medicinal materials with 1.2-1.5 times of clear water for 2 hours respectively except the liquorice and the chrysanthemum, airing, uniformly dividing the soaked raw medicinal materials into 1 part of medicinal material and 2 part of medicinal material, and mixing the soaked water of the soaked medicinal materials;
s2, roasting 7 parts of liquorice at 110-120 ℃ for 10 minutes, adding the roasted liquorice into soaking water, and decocting the soaked water at 70 ℃ for 15 minutes to obtain a first liquorice solution;
s3, adding the medicinal material part 1 into the first liquorice liquid, heating to 110 ℃, continuously decocting for 60 minutes, taking out the decocted medicinal material part 1, stir-frying, and grinding to obtain medicinal powder;
s4, grinding the other 7 parts of liquorice, soaking the crushed other 7 parts of liquorice in chrysanthemum for 25 minutes to obtain second liquorice liquid, and taking out the chrysanthemum; adding the medicinal material part 2 into the second licorice liquid, decocting for 60 minutes at 110 ℃, taking out the decocted medicinal material part 2, stir-frying, and grinding to obtain medicinal powder;
s5, cooling the decocted first licorice liquid and second licorice liquid to 40-50 ℃ respectively, and then adding the first licorice liquid and the second licorice liquid with the mass ratio of 1.5:1:2, carrying out enzymolysis on the cellulose, the protease and the amylase, and then carrying out reflux extraction and purification;
s6, mixing the stir-fried medicinal materials in the steps S3 and S4, adding a small amount of second licorice liquid subjected to enzymolysis into the medicinal powder for multiple times, mixing the medicinal powder into a dry paste, and then continuously adding the first licorice liquid subjected to enzymolysis into the dry lake-shaped medicinal powder to prepare the pill.
In the invention, the fructus momordicae can clear heat and reduce internal heat, is rich in vitamin C, can help iron absorption, promote alcohol metabolism, is favorable for improving the content of acetaldehyde dehydrogenase and alcohol dehydrogenase, promotes alcohol dissolution, achieves the effects of dispelling the effects of alcohol and protecting liver, and the compatibility of the fructus momordicae, chrysanthemum, liquorice and the like can not only dispel the effects of dispelling the effects of alcohol and protecting liver, but also achieve the effects of clearing heat and detoxicating, and relieves the conditions of sore throat, aphonia, conjunctival congestion and swelling and pain and blurred vision after drinking. The compatibility of hawthorn, dried orange peel, chinese yam, dogwood fruit and the like has the effects of protecting stomach and regulating stomach discomfort, has the effects of promoting digestion and replenishing qi to invigorate spleen, and can reduce stomach pantothenic acid and treat nausea and vomiting, inappetence and diarrhea in abdomen. The ginseng, the codonopsis pilosula, the ligusticum wallichii, the white paeony root and the like are combined to have the effects of nourishing kidney and tonifying liver and moistening lung, can also relieve consumptive cough, lung dryness and diabetes, can be matched with each other, can play a role in nourishing liver and kidney, and can play a role in relieving symptoms such as abdominal pain, poor mood, insomnia and dreaminess, and oligopoliosis caused by liver qi discomfort. The liquorice has flat property and sweet taste, has the effects of invigorating spleen and replenishing qi, relieving spasm and pain and the like, and can relieve toxicity and intensity of the medicine, so that the roasted liquorice can be used for treating weakness of spleen and stomach, lassitude and the like during preparation, and the liquorice is used for soaking, heating and stir-frying the medicinal materials, so that the medicine property can be relieved, and the original bitter taste in the medicinal materials can be removed.
The raw materials of the pill prepared by the invention can protect the liver by matching ginseng, codonopsis pilosula, ligusticum wallichii and white paeony root, can alleviate liver discomfort, can protect the stomach and nourish the stomach by matching hawthorn, dried orange peel, chinese yam and dogwood fruit, and can clear away heat and toxic materials and relieve sore throat by matching grosvenor momordica, chrysanthemum and liquorice.
Example 2
The pill with the effects of dispelling effects of alcohol and protecting liver in embodiment 1 is characterized by comprising, by weight, 8 parts of hawthorn, 8 parts of dried orange peel, 15 parts of Chinese yam, 8 parts of pulp of dogwood fruit, 10 parts of bighead atractylodes rhizome, 8 parts of ginseng, 16 parts of liquorice, 10 parts of radix codonopsis pilosulae, 15 parts of ligusticum wallichii, 6 parts of chrysanthemum, 8 parts of fructus momordicae, 7 parts of angelica and 13 parts of white paeony root, and the preparation method of the pill in embodiment 1 is the same as that of embodiment 1 and is not repeated herein.
Example 3
The pill with the effects of dispelling effects of alcohol and protecting liver in embodiment 1 is characterized by comprising, by weight, 5 parts of hawthorns, 11 parts of dried orange peel, 10 parts of Chinese yam, 11 parts of cornus officinalis, 14.5 parts of bighead atractylodes rhizome, 5 parts of ginseng, 12 parts of liquorice, 15 parts of codonopsis pilosula, 10 parts of ligusticum wallichii, 10 parts of chrysanthemum, 5 parts of momordica grosvenori, 5 parts of angelica and 8 parts of white paeony root, wherein the preparation mode of the pill in embodiment is the same as that of embodiment 1, and the preparation is not repeated.
In order to demonstrate the superiority of the raw material medicines and the proportions of the invention, comparative examples 1 to 4 are provided herein.
Comparative example 1
S1, weighing 5 parts of hawthorn, 6 parts of dried orange peel, 17 parts of Chinese yam, 7 parts of cornus officinalis, 8 parts of bighead atractylodes rhizome, 10 parts of ginseng, 10 parts of liquorice, 9 parts of codonopsis pilosula, 9 parts of ligusticum wallichii, 5 parts of chrysanthemum, 5 parts of fructus momordicae, 9 parts of angelica and 7 parts of white paeony root, removing impurities on the surfaces of the raw medicinal materials, soaking the rest raw medicinal materials except the liquorice and the chrysanthemum in 1.2-1.5 times of clear water for 2 hours respectively, airing, uniformly dividing the soaked raw medicinal materials into 1 part of medicinal material and 2 part of medicinal material, and mixing the soaked water of the soaked medicinal materials;
s2, roasting 5 parts of liquorice at 110-120 ℃ for 10 minutes, adding the roasted liquorice into soaking water, and decocting the soaked water at 70 ℃ for 15 minutes to obtain a first liquorice solution;
s3, adding the medicinal material part 1 into the first liquorice liquid, heating to 110 ℃, continuously decocting for 60 minutes, taking out the decocted medicinal material part 1, stir-frying, and grinding to obtain medicinal powder;
s4, grinding the other 5 parts of liquorice, soaking the crushed other 5 parts of liquorice in chrysanthemum for 25 minutes to obtain second liquorice liquid, and taking out the chrysanthemum; adding the medicinal material part 2 into the second licorice liquid, decocting for 60 minutes at 110 ℃, taking out the decocted medicinal material part 2, stir-frying, and grinding to obtain medicinal powder;
s5, cooling the decocted first licorice liquid and second licorice liquid to 40-50 ℃ respectively, and then adding the first licorice liquid and the second licorice liquid with the mass ratio of 1.5:1:2, carrying out enzymolysis on the cellulose, the protease and the amylase, and then carrying out reflux extraction and purification;
s6, mixing the stir-fried medicinal materials in the steps S3 and S4, adding a small amount of second licorice liquid subjected to enzymolysis into the medicinal powder for multiple times, mixing the medicinal powder into a dry paste, and then continuously adding the first licorice liquid subjected to enzymolysis into the dry lake-shaped medicinal powder to prepare the pill.
Comparative example 2
S1, weighing 10 parts of hawthorn, 13 parts of dried orange peel, 8 parts of Chinese yam, 13 parts of dogwood fruit, 16 parts of bighead atractylodes rhizome, 9 parts of ginseng, 18 parts of liquorice, 16 parts of codonopsis pilosula, 16 parts of ligusticum wallichii, 11 parts of chrysanthemum, 11 parts of momordica grosvenori, 2 parts of angelica and 14 parts of white paeony root, removing impurities on the surfaces of the raw medicinal materials, soaking the rest raw medicinal materials except the liquorice and the chrysanthemum in 1.2-1.5 times of clear water for 2 hours respectively, airing, uniformly dividing the soaked raw medicinal materials into 1 part of medicinal material and 2 part of medicinal material, and mixing the soaked water of the soaked medicinal materials;
s2, 9 parts of liquorice are roasted for 10 minutes at the temperature of 110-120 ℃, added into soaking water, and decocted for 15 minutes at the temperature of 70 ℃ to obtain a first liquorice liquid;
s3, adding the medicinal material part 1 into the first liquorice liquid, heating to 110 ℃, continuously decocting for 60 minutes, taking out the decocted medicinal material part 1, stir-frying, and grinding to obtain medicinal powder;
s4, grinding the other 9 parts of liquorice, soaking the crushed liquorice with chrysanthemum for 25 minutes to obtain a second liquorice solution, and taking out the chrysanthemum; adding the medicinal material part 2 into the second licorice liquid, decocting for 60 minutes at 110 ℃, taking out the decocted medicinal material part 2, stir-frying, and grinding to obtain medicinal powder;
s5, cooling the decocted first licorice liquid and second licorice liquid to 40-50 ℃ respectively, and then adding the first licorice liquid and the second licorice liquid with the mass ratio of 1.5:1:2, carrying out enzymolysis on the cellulose, the protease and the amylase, and then carrying out reflux extraction and purification;
s6, mixing the stir-fried medicinal materials in the steps S3 and S4, adding a small amount of second licorice liquid subjected to enzymolysis into the medicinal powder for multiple times, mixing the medicinal powder into a dry paste, and then continuously adding the first licorice liquid subjected to enzymolysis into the dry lake-shaped medicinal powder to prepare the pill.
Comparative example 3
A pill with effects of relieving hangover and protecting liver:
s1, weighing 6 parts of hawthorn, 10 parts of dried orange peel, 13 parts of Chinese yam, 10 parts of dogwood fruit, 12 parts of bighead atractylodes rhizome, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis pilosula, 13 parts of szechuan lovage rhizome, 8 parts of chrysanthemum, 6 parts of momordica grosvenori, 6 parts of angelica and 10 parts of white paeony root according to parts by weight, and removing impurities on the surfaces of the raw medicinal materials;
s2, grinding all the raw materials into medicinal powder, and preparing pills by using water flooding agent.
Comparative example 4
S1, weighing 6 parts of hawthorns, 10 parts of dried orange peel, 13 parts of Chinese yam, 10 parts of dogwood fruit, 12 parts of bighead atractylodes rhizome, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis pilosula, 13 parts of ligusticum wallichii, 8 parts of chrysanthemum, 6 parts of momordica grosvenori, 6 parts of angelica and 10 parts of white paeony root according to parts by weight, removing impurities on the surfaces of the raw medicinal materials, adding clear water to soak for 2 hours respectively, and uniformly dividing the soaked raw medicinal materials into medicinal material parts 1 and medicinal material parts 2 after airing;
s2, adding the liquorice into clear water, decocting for 30 minutes at 40 ℃,
s3, adding the raw materials into the liquorice liquid, and decocting for 60 minutes at the temperature of 110 ℃;
s4, taking out the medicinal materials, stir-frying the medicinal materials, and grinding the medicinal materials into medicinal powder;
s5, pouring the medicinal juice into the medicinal powder to prepare the pill.
Comparative examples 1 and 2 were different in the proportions of the present invention, and comparative examples 3 and 4 were different in the preparation modes of the present invention.
Results were tested on the pills of examples 1-3, comparative examples 1-4, and 21 adult males with liver and stomach discomfort were selected, each group of 3 persons was divided into 7 groups, and the pills of examples 1-3, comparative examples 1-4 were taken in 1-7 groups, and the results were shown in the following table for 15 consecutive days:
as can be seen from comparative examples 1-3 and comparative examples 1-4, after the subject takes the pill prepared by the raw material formulation of examples 1-3, the anti-hangover effect is obvious, and the pill has good relieving effects on burning after drinking, dizziness and other conditions, and has good effects on relieving liver and stomach discomfort, thereby achieving the effects of soothing liver, relieving depression and nourishing stomach. The pill of the invention is taken without soaking water, does not limit the taking time, is convenient and quick, and has strong practicability.
After taking the pills of the comparative examples 1 and 2, the raw material formulas of the pills are different from the formula of the invention, so that the symptoms of liver and spleen discomfort and stomach flatulence are slightly improved, but the effect is not obvious, and after drinking, the pills have no obvious anti-alcoholic effect, and still have the symptoms of drunk and dizziness after drinking. After the patients take the pills of the comparative examples 3 and 4, no obvious soothing liver-qi relieving Yu Xiaoguo is caused, discomfort after drinking is strong, no obvious improving effect is caused, and the taste of the pills is poor.
In summary, the pill prepared by the raw material formula and the preparation steps of the invention can nourish the stomach and treat liver and stomach discomfort after being taken by a patient, can improve the condition of poor feeling, low rising and easy fatigue of the patient, and can also sober up and reduce hangover, dizziness and flatulence after drinking.
Finally, it is noted that the above-mentioned preferred embodiments are only intended to illustrate rather than limit the invention, and that, although the invention has been described in detail by means of the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention as defined by the appended claims.

Claims (8)

1. A pill with the functions of dispelling the effects of alcohol and protecting liver, which is characterized in that: the pill is prepared from, by weight, 5-8 parts of hawthorns, 8-12 parts of dried orange peel, 10-15 parts of Chinese yam, 8-12 parts of cornus officinalis, 10-15 parts of bighead atractylodes rhizome, 4-8 parts of ginseng, 12-16 parts of liquorice, 10-15 parts of dangshen, 10-15 parts of ligusticum wallichii, 4-7 parts of angelica, 6-10 parts of chrysanthemum, 5-8 parts of fructus momordicae and 8-13 parts of white paeony root.
2. A pill with anti-hangover and hepatoprotective effects according to claim 1, characterized in that: the pill is prepared from 6 parts of hawthorn, 10 parts of dried orange peel, 13 parts of Chinese yam, 10 parts of dogwood fruit, 12 parts of bighead atractylodes rhizome, 6 parts of ginseng, 14 parts of liquorice, 13 parts of codonopsis pilosula, 13 parts of szechuan lovage rhizome, 8 parts of chrysanthemum, 6 parts of momordica grosvenori, 6 parts of Chinese angelica and 10 parts of white paeony root.
3. A pill with anti-hangover and hepatoprotective effects according to any of claims 1-2, further comprising a method for preparing a pill with anti-hangover and hepatoprotective effects, characterized in that: comprises the steps of,
s1, removing impurities on the surfaces of the raw material medicaments in the formula amount, respectively soaking the raw material medicaments except liquorice and chrysanthemum in clear water, airing, uniformly dividing the soaked raw material medicaments into a medicinal material part 1 and a medicinal material part 2, and mixing soaking water of the soaked medicinal materials;
s2, adding a part of roasted liquorice into soaking water for decoction to obtain a first liquorice liquid;
s3, adding the medicine material part 1 into the first liquorice liquid, continuously decocting, taking out the decocted medicine material part 1, stir-frying, and grinding to obtain medicinal powder;
s4, grinding the other part of liquorice, soaking the crushed part of liquorice with chrysanthemum to obtain second liquorice liquid, and taking out the chrysanthemum; adding the medicinal material part 2 into the second liquorice liquid for decoction, taking out the decocted medicinal material part 2, stir-frying, and grinding to obtain medicinal powder;
s5, cooling the decocted first licorice liquid and second licorice liquid to 40-50 ℃ respectively, adding complex enzyme for enzymolysis, and then carrying out reflux extraction and purification;
s6, mixing the stir-fried medicinal materials in the steps S3 and S4, adding the second liquorice liquid after enzymolysis into the medicinal powder, mixing the medicinal powder into a dry paste, and continuously adding the first liquorice liquid after enzymolysis into the dry lake-shaped medicinal powder to prepare the pill.
4. A method for preparing a pill having anti-hangover and hepatoprotective effects according to claim 3, wherein: in the step S1, the raw medicinal materials are soaked in clear water 1.2-1.5 times of that of the raw medicinal materials respectively, and the soaking time is 2 hours.
5. A method for preparing a pill with anti-hangover and hepatoprotective effects according to claim 3, characterized in that: in the step S2, the roasting temperature of the liquorice is 110-120 ℃ and the distance from the flame is 2-3cm, and the roasting time is 8-12 minutes; the temperature of the decoction after the baking of the liquorice is 60-80 ℃ and the time of the decoction is 10-20 minutes.
6. A method for preparing a pill with anti-hangover and hepatoprotective effects according to claim 3, characterized in that: in the step S3, the decoction temperature after adding the medicinal material part 1 is 100-120 ℃ and the decoction time is 50-65 minutes.
7. A method for preparing a pill with anti-hangover and hepatoprotective effects according to claim 3, characterized in that: in the step S4, the soaking time of the liquorice and the chrysanthemum is 20-30 minutes, the decocting temperature is 100-120 ℃ after the second liquorice liquid is added into the medicinal material part 2, and the decocting time is 50-65 minutes.
8. A method for preparing a pill with anti-hangover and hepatoprotective effects according to claim 3, characterized in that: in the step S5, the complex enzyme is one or more of cellulose, protease and amylase, and the complex enzyme accounts for 0.13-0.17% of the total weight of the raw materials.
CN202311827121.9A 2023-12-28 2023-12-28 Pill with effects of dispelling effects of alcohol and protecting liver and preparation method thereof Pending CN117797106A (en)

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