CN105535416A - Medicine for treating thyroid nodules and preparation method - Google Patents

Abstract

The invention discloses a formula of a medicine for treating thyroid nodules and a preparation method, and belongs to the technical field of medicines. The medicine is prepared from, by weight, 30 parts of raw radix astragali, 30 parts of Radix Salviae Miltiorrhizae, 30 parts of root peel of Lycium chinense Mill., Hedyotis diffusa, 20 parts of raw oysters, 20 parts of Fritillaria thunbergii Miq., 20 parts of roots of Catclaw Buttercup, 10 parts of Rhizoma Dioscoreae bulbiferae, 15 parts of algae, 6 parts of radix bupleuri, 4 parts of ginseng, 4 parts of Lilium brownii var. viridulum Baker, 4 parts of common vladimiria roots, 4 parts of wild chrysanthemum flowers and 4 parts of barbed skullcap herb. The preparation method of the medicine includes the following steps of firstly, weighing and mixing the medicinal materials; secondly, smashing the medicinal materials; thirdly, boiling the raw medicinal materials; fourthly, extracting and concentrating liquid medicine; fifthly, mixing and dissolving the concentrated solution; sixthly, regulating PH and conducting drying and processing to form the medicine. The medicine overcomes the defects of existing medicines for treating thyroid nodules and existing preparation methods.

Description

A kind of medicine and manufacture method for the treatment of thyroid nodule

Technical field

The present invention relates to a kind of pharmaceutical formulation and preparation method thereof, especially a kind of medicine and manufacture method for the treatment of thyroid nodule, belongs to medical art.

Background technology

Along with people's operating pressure, dietary habit and living-pattern preservation, the people comprising some Poor Mountainous Areas live in the middle of poor life for a long time, thyroid nodule is as a kind of very common disease, increasing people starts to suffer from thyroid nodule, thyroid nodule is the lump in thyroid, thyroid nodule can single-shot, also can be multiple, multiple nodules is higher than the sickness rate of Solitary nodules, the incidence rate of Solitary nodules thyroid carcinoma is higher, thyroid nodule is concurrent in various thyroid disease, as simple goiter, thyroiditis, thyroid tumor etc., its tuberosity has single-shot or multiple, there is dividing of good evil clinically, nodular goiter thyroid adenoma etc. is mainly comprised in optimum, pernicious thyroid nodule is then based on thyroid carcinoma.

At present, the pathogenic factor that thyroid nodule is main: thyroid nodules diseases removes by patient's emotion influence, eats excessive iodine or family has goiter medical history, edible goitrogenic food and a large amount of drug administration or Other diseases all likely to cause occurring thyroid nodule; The reason of generally acknowledging at present comprises: (1) chronic high Brassica oleracea L.var.capitata L., Radix Raphani, Maninot esculenta crantz. etc. are rich in thiocyanates class vegetable: show according to Related Experimental Study, the generation of iodide may be affected containing thiocyanates in Brassica oleracea L.var.capitata L., if and the generation of iodide is hindered, and the synthesis of thyroxin also may be affected, thyroid is therefore easily impelled to increase; (2) budding iodine uptake is not enough: if adolescence does not absorb enough vitamin, cause iodine deficiency, and health will be caused to occur as this common disease of thyroid nodule; (3) Chinese herbal medicine that edible content is high or long-term edible seaweed group food: the Chinese herbal medicine that some content edible is high, also thyroid nodule can be caused, although iodine deficiency may cause thyroid nodule to produce, the seaweeds food that long-term edible amount of iodine is high is very favorable to the health of health; (4) also having also can because of drinking and eating irregularly or the impact occupying the reasons such as high mountain, water and soil is inappropriate.

The traditional Chinese medical science is thought, why thyroid produces the diseases such as thyroid nodule, thyroid cyst, thyroid tumor, hypothyroidism, thyroiditis, mainly because organism metabolic disorder, negative and positive of qi and blood are lacked of proper care, visceras function is unbalance, cause knot in phlegm-damp, alluvial forms, add that people's diet does not save, incoordination of seven emotions, work be immoderate, thus cause the thyroid diseases such as thyroid nodule day by day occurred frequently.Thyroid nodule is normally not present change functionally, and patient base's metabolic rate is normal, also has small number of patients can secondary hyperthyroidism; But when tuberosity is larger, there will be following symptom: 1, tracheas suppressed: more common.From side compressing, trachea is to opposite side displacement or bending; From both sides compressing, tracheal stenosis, dyspnea, especially more seriously aobvious when retrosternal goiter.The long-term pressurized of tracheal wall, can cause tracheomalacia, cause and suffocate.2, recurrent laryngeal nerve is oppressed: can cause vocal cord paralysis (mostly being side), patient pronounces hoarse.Compressing cervical region sympathetic nerve pitch chain, can cause Horner syndrome, extremely rare.3, esophagus is oppressed: rare.Only retrosternal goiter may oppress esophagus, causes sense of discomfort when swallowing, but can not cause obstruction.4, throat depth portion large vein is oppressed: the blood backflow difficulty that can cause incidence.This situation is more common in superior aperture of thorax, large goiter, especially retrosternal goiter.Patient facial region is violaceous edema.

Thyroid nodule belongs to the category of the traditional Chinese medical science " goiter " disease, traditional Chinese medical herbal treatment goiter with a long history, has the record about wart as far back as the Warring States Period, as " a Springs and Autumns of Master Lü total number section " " light water institute, how bald with wart people ".Illustrate that the morbidity having observed wart is at that time relevant with geographical environment.Shennong's Herbal is that the simplicity of centuries medication experience before Qin Han is summed up, and wherein also has the record of Sargassum " main goiter gas ".First " Handbook of Prescriptions for Emergencies " of Jin Daige flood refer to Sargassum and Thallus Laminariae (Thallus Eckloniae) treatment goiter.In the Thousand Golden Prescriptions of the Tang Dynasty Sun Simiao, discussed the sick acupuncture point selections such as goiter respectively and treated, in book, described many specially good effect sides medicine, as Sargassum, Thallus Laminariae (Thallus Eckloniae), Thyreoid Caprae seu Ovis treatment goiter.Ming Dynasty's Chen Shigong " Waike Zhengzong, Orthodox Manual of External Diseases goiter opinion " is inner proposes that the main pathology of goiter is gas, expectorant, stasis of blood harmony knot forms: " disease of the raw goiter of madam, non-negative and positive are just depressed swollen, be the five internal organs blood stasis, foul smell, expectorant is stagnant forms ".Period of Ming and Qing have formulated many prescriptions controlling wart, as Haizao Yuhu Tang, four seas Shu Yu ball etc. at method for the treatment of prescription.The present invention develops on the basis that have studied a large amount of documents and materials and a large amount of clinical practice, good therapeutic effect is had to thyroid nodule, and powder, unguentum, granule, Tablet and Capsula is developed on the basis of decoction, substantially increase the clinical value for the treatment of by Chinese herbs thyroid nodule.

And present stage, thyroid disease betides various age groups, wherein in the majority with female middle-aged, according to currently available technology, the curative effect of the medicine for the treatment of thyroid nodule is generally undesirable, and curative effect contains larger uncertain factor, therefore, present stage is badly in need of a kind of medicine effectively can treating thyroid nodule.

Summary of the invention

Main purpose of the present invention is the defect in order to solve in existing Therapeutic Method, provide a kind of applied widely, safe and reliable, have no side effect, medicine that medical effect effectively can treat thyroid nodule significantly.

Another object of the present invention is to provide the preparation method of this treatment thyroid nodule medicine.

The object of the invention is by adopting following technical scheme to reach:

Treat a medicine for thyroid nodule, described pharmaceutical formulation is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 26 ~ 33 parts, Radix Salviae Miltiorrhizae 24 ~ 37 parts, Herba Hedyotidis Diffusae 25 ~ 35 parts, Concha Ostreae 15 ~ 22 parts, Bulbus Fritillariae Thunbergii 18 ~ 25 parts, Radix Ranunculi Ternati 17 ~ 26 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 15 parts, Sargassum 12 ~ 18 parts, Radix Bupleuri 5 ~ 10 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

A kind of preferred as the present invention:

The formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 28 ~ 32 parts, Radix Salviae Miltiorrhizae 28 ~ 35 parts, Herba Hedyotidis Diffusae 28 ~ 32 parts, Concha Ostreae 17 ~ 22 parts, Bulbus Fritillariae Thunbergii 18 ~ 22 parts, Radix Ranunculi Ternati 17 ~ 22 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 12 parts, Sargassum 12 ~ 16 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

A kind of preferred as the present invention:

The formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 ~ 32 parts, Radix Salviae Miltiorrhizae 30 ~ 35 parts, Herba Hedyotidis Diffusae 30 ~ 32 parts, Concha Ostreae 20 ~ 22 parts, Bulbus Fritillariae Thunbergii 20 ~ 22 parts, Radix Ranunculi Ternati 20 ~ 22 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 12 parts, Sargassum 12 ~ 15 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

A kind of preferred as the present invention:

The formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 12 ~ 15 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

A kind of preferred as the present invention:

The formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts.

The manufacture method of the medicine for the treatment of thyroid nodule of the present invention, described method comprises:

Step 1: weigh medical material and mix

Above-mentioned various raw medicinal material is taken and fully mixing according to described ratio;

Step 2: by pulverizing medicinal materials

Various raw medicinal material mixed in described step 1 is pulverized, is ground into 60 ~ 75 object medicated powder;

Step 3: raw medicinal material boils

Boil pulverizing rear remaining raw medicinal material in described step 2, and divide 4 extractions to boiling liquid, obtain extracting medicinal liquid;

Step 4: extract concentration of liquid medicine

The extraction medicinal liquid that in described step 3 point obtains for 4 times is concentrated, is concentrated into the concentrated solution of 1.15-1.25 proportion;

Step 5: mixed dissolution concentrated solution

Described step 2 is ground into 60 ~ 75 object medicated powder to join in described step 4 in the described concentrated solution obtained, and fully dissolve, mixing, form new concentrated solution;

Step 6: adjust PH, dry, be processed into medicine

The pH value of the concentrated solution obtained in described step 5 is adjusted to 5.0-7.0, and filters 60 mesh filter screens, and remove moisture, be processed into medicine.

A kind of preferred as the present invention:

The manufacture method of the medicine for the treatment of thyroid nodule of the present invention, described method comprises:

Step 1: weigh medical material and mix

Take above-mentioned various raw medicinal material according to described ratio and fully mixing, make according to the raw medicinal material of following weight proportion number: Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts;

Step 2: by pulverizing medicinal materials

Various raw medicinal material mixed in described step 1 is pulverized, is ground into 60 ~ 75 object medicated powder, and described medicated powder is soaked 8 hours in distilled water;

Step 3: raw medicinal material boils

Boil pulverizing rear remaining raw medicinal material in described step 2, first add quality 4 doubly to the distilled water of described raw medicinal material, first boil 6 hours, first time extracts boiling liquid, then boils 4 hours, second time extracts boiling liquid, boil 4 hours again, third time extracts boiling liquid, then boils 3 hours, extract boiling liquid, the boiling liquid of above-mentioned four times is mixed to get extracting solution for 4th time;

Step 4: extract concentration of liquid medicine

The extraction medicinal liquid that in described step 3 point obtains for 4 times is concentrated, is concentrated into the concentrated solution of 1.15-1.25 proportion;

Step 5: mixed dissolution concentrated solution

Described step 2 is ground into 60 ~ 75 object medicated powder to join in described step 4 in the described concentrated solution obtained, and fully dissolve, mixing, form new concentrated solution;

Step 6: adjust PH, dry, be processed into medicine

The pH value of the concentrated solution obtained in described step 5 is adjusted to 5.0-7.0, and filters 60 mesh filter screens, dry and remove moisture, be processed into medicine.

Each raw material property of medicine in the effective ingredient of above-mentioned treatment thyroid nodule is as follows:

Radix Astragali: Yiqiyangyuan, strengthening vital QI to eliminate pathogenic factors, nourishes heart and promotes blood circulation, invigorating spleen to remove dampness.The hepatitis (Traditional Chinese medicine historical preparation the 17) of the viral myocarditis of, blood-vessel obstructive deficient for the motive, cardiac insufficiency and stagnation of dampness due to deficiency of the spleen.

Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.[function with cure mainly] blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, and removing heat from blood disappears pain.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain ， lumps in the chest and abdomen, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.

Herba Hedyotidis Diffusae: " Quanzhou book on Chinese herbal medicine ": heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest." Guangxi Chinese herbal medicine ": heat-clearing and toxic substances removing, diuresis of blood circulation promoting.Treating tonsillitis, pharyngolaryngitis, appendicitis, hepatitis, dysentery, urinary tract infection, infantile malnutrition.

Concha Ostreae: salty in the mouth wets is flat.Enter liver, kidney channel.Yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass.Cure mainly palpitation with fear insomnia, vertigo and tinnitus, tuberculous lymphadenitis, abdominal mass abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid." detailed outline ": resolving phlegm and softening hard masses, removing damp-heat, only heart temper pain, under dysentery, reddish and whitish turbid urine, the hernia that disappears abdominal mass amasss block, wart disease tuberculosis.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, return lung, heart channel.Effect: removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating.Pharmacological action: 1, spasmolytic: Bulbus Fritillariae Uninbracteatae alkaloid has atropine-like effect, show rabbit, cat isolated lung perfusion, low concentration can make Bronchial Relaxation, and high concentration then has slight shrinkage effect to bronchus.2, to the effect of nervus centralis: peimine and peiminine 2mg/kg subcutaneous injection, spontaneous activity in mice is reduced, the mouse sleep time that 4mg/kg gavage makes mice pentobarbital sodium cause extends, 2mg/kg subcutaneous injection, shows there is analgesic activity to the test of mice acetic acid writhing test.

Radix Ranunculi Ternati: taste sweet, acrid, warm.Enter liver, lung meridian.Eliminating stagnation, detumescence.Control scrofula, pulmonary tuberculosis, malaria.

Rhizoma Dioscoreae Bulbiferae: bitter in the mouth is flat.Enter liver, heart channel.Removing heat from blood, pathogenic fire reducing, disappear wart, removing toxic substances.Control haematemesis, epistaxis, sore throat, goiter, carbuncle sore scrofula.

Sargassum: bitter in the mouth, salty, cold.Enter liver, kidney, stomach warp.Softening the hard mass, expectorant, clearing away heat and promoting diuresis.Goiter scrofula, hernia, painful and swollen testis, phlegm retention edema." herbal classic ": " main goiter gas, core under neck, broken eliminating stagnation gas, the hard gas of Yong Zhong mass in the abdomen." "Nei Jing" cloud, salty energy softening the hard mass.Stagnation of nutrient QI, be outward edema, it is controlled by the medicine with each tying-in, and do not disappear without swollen, also sluice gas." detailed outline ": " Sargassum, salty can relaxing the bowels with lubricant drugs, the cold diversion that can expel the heat-evil, therefore the goiter that can disappear, tuberculosis, cloudy heavily fortified point of bursting gather, and remove edema, beriberi, prolonged fluid-retention, mental disorder damp and hot, pathogen is gone out also from urine." " by eastern wall Li Shi, control the loose swollen hard soup of bursting of scrofula Concha Solen gouldii, Sargassum, Radix Glycyrrhizae dual-purpose it, the disease that Gai Yijian is long-pending, non-gentle medicine can get victory, must make counter taking by force, with Cheng Qigong also." " book on Chinese herbal medicine is high former ": " Sargassum, its bitter in the mouth is salty, and it is cold in nature clean, therefore cures mainly the outer interior heavily fortified point knot of passages through which vital energy circulates.Goiter stagnation of QI, stone pain carbuncle under neck, be through abnormal pulse disease tie in outer also.The hard gas of mass in the abdomen, thundering up and down in abdomen, is that disease is tied in also interior through abnormal pulse.The main qualcomm meridian of Sargassum, therefore control 12 through edema, personal twelve regular channels circulation, then edema spontaneous recovery.

Radix Bupleuri: bitter in the mouth is put down, and enters liver, gallbladder meridian.There is delivering, bring down a fever, the effect of soothing the liver, resolving depression, yang invigorating.Cure mainly alternate attack of chill and fever, malaria, side of body distending pain, menoxenia.

Radix Ginseng: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock (pharmacopeia 2010 editions second);

Bulbus Lilii: sweet, cold, GUIXIN, lung meridian, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded (pharmacopeia 2010 editions second);

The Radix Aucklandiae: pungent, bitter, temperature, returns spleen, stomach, large intestine, three burnt, gallbladder meridians, promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, and for breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia, and the real intestinal antidiarrheal of Radix Aucklandiae (roasted), for stomachache of having loose bowels (pharmacopeia 2010 editions second);

Flos Chrysanthemi Indici: bitter, pungent, is slightly cold, and returns liver, heart channel, heat-clearing and toxic substances removing, for furuncle carbuncle, and conjunctival congestion and swelling pain, have a headache dizzy (pharmacopeia 2010 editions second);

Herba Scutellariae Barbatae: pungent, bitter, cold, return lung, liver, kidney channel, heat-clearing and toxic substances removing, blood stasis dispelling diuresis, for furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice (pharmacopeia 2010 editions second).

Advantageous Effects of the present invention is: activating QI to eliminate phlegm, the wart that disappears eliminating stagnation, nourishing YIN to lower pathogenic fire, mind calming easing the affected liver Be very effective, follows traditional Chinese medical science Gu Fa reasonable compatibility, and theories integration is sufficient, pure Chinese herbal and crude drugs preparations, have no side effect, steady quality, taking convenience, be easy to carry, compliance is good, and preparation technology is simple, and cost is low.

Detailed description of the invention

For making those skilled in the art clearly and technical scheme clearly of the present invention, below in conjunction with specific embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.

As a kind of preferred embodiment of the present invention, the formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts.

As a kind of preferred embodiment of the present invention, the manufacture method of the medicine for the treatment of thyroid nodule of the present invention, described method comprises:

Step 1: weigh medical material and mix

Take above-mentioned various raw medicinal material according to described ratio and fully mixing, make according to the raw medicinal material of following weight proportion number: Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts;

Step 2: by pulverizing medicinal materials

Various raw medicinal material mixed in described step 1 is pulverized, is ground into 60 ~ 75 object medicated powder, and described medicated powder is soaked 8 hours in distilled water;

Step 3: raw medicinal material boils

Boil pulverizing rear remaining raw medicinal material in described step 2, first add quality 4 doubly to the distilled water of described raw medicinal material, first boil 6 hours, first time extracts boiling liquid, then boils 4 hours, second time extracts boiling liquid, boil 4 hours again, third time extracts boiling liquid, then boils 3 hours, extract boiling liquid, the boiling liquid of above-mentioned four times is mixed to get extracting solution for 4th time;

Step 4: extract concentration of liquid medicine

The extraction medicinal liquid that in described step 3 point obtains for 4 times is concentrated, is concentrated into the concentrated solution of 1.15-1.25 proportion;

Step 5: mixed dissolution concentrated solution

Described step 2 is ground into 60 ~ 75 object medicated powder to join in described step 4 in the described concentrated solution obtained, and fully dissolve, mixing, form new concentrated solution;

Step 6: adjust PH, dry, be processed into medicine

The pH value of the concentrated solution obtained in described step 5 is adjusted to 5.0-7.0, and filters 60 mesh filter screens, dry and remove moisture, be processed into medicine.

The above; be only patent preferred embodiment of the present invention; but the protection domain of patent of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the scope disclosed in patent of the present invention; be equal to according to the technical scheme of patent of the present invention and design thereof and replaced or change, all belonged to the protection domain of patent of the present invention.

Claims (7)

1. treat a medicine for thyroid nodule, described pharmaceutical formulation is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 26 ~ 33 parts, Radix Salviae Miltiorrhizae 24 ~ 37 parts, Herba Hedyotidis Diffusae 25 ~ 35 parts, Concha Ostreae 15 ~ 22 parts, Bulbus Fritillariae Thunbergii 18 ~ 25 parts, Radix Ranunculi Ternati 17 ~ 26 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 15 parts, Sargassum 12 ~ 18 parts, Radix Bupleuri 5 ~ 10 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

2. a kind of medicine for the treatment of thyroid nodule according to claim 1, is characterized in that: the formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 28 ~ 32 parts, Radix Salviae Miltiorrhizae 28 ~ 35 parts, Herba Hedyotidis Diffusae 28 ~ 32 parts, Concha Ostreae 17 ~ 22 parts, Bulbus Fritillariae Thunbergii 18 ~ 22 parts, Radix Ranunculi Ternati 17 ~ 22 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 12 parts, Sargassum 12 ~ 16 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

3. a kind of medicine for the treatment of thyroid nodule according to claim 2, is characterized in that: the formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 ~ 32 parts, Radix Salviae Miltiorrhizae 30 ~ 35 parts, Herba Hedyotidis Diffusae 30 ~ 32 parts, Concha Ostreae 20 ~ 22 parts, Bulbus Fritillariae Thunbergii 20 ~ 22 parts, Radix Ranunculi Ternati 20 ~ 22 parts, Rhizoma Dioscoreae Bulbiferae 10 ~ 12 parts, Sargassum 12 ~ 15 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

4. a kind of medicine for the treatment of thyroid nodule according to claim 3, is characterized in that: the formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 12 ~ 15 parts, Radix Bupleuri 5 ~ 8 parts, Radix Ginseng 2 ~ 5 parts, Bulbus Lilii 2 ~ 5 parts, the Radix Aucklandiae 2 ~ 5 parts, Flos Chrysanthemi Indici 2 ~ 5 parts, Herba Scutellariae Barbatae 2 ~ 5 parts.

5. a kind of medicine for the treatment of thyroid nodule according to claim 4, is characterized in that: the formula of the medicine of described treatment thyroid nodule is made up of the raw medicinal material of following weight proportion number:

Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts.

6. a manufacture method for the medicine of the treatment thyroid nodule according to claim 1-5 any one, described method comprises:

Step 1: weigh medical material and mix

Above-mentioned various raw medicinal material is taken and fully mixing according to described ratio;

Step 2: by pulverizing medicinal materials

Various raw medicinal material mixed in described step 1 is pulverized, is ground into 60 ~ 75 object medicated powder;

Step 3: raw medicinal material boils

Boil pulverizing rear remaining raw medicinal material in described step 2, and divide 4 extractions to boiling liquid, obtain extracting medicinal liquid;

Step 4: extract concentration of liquid medicine

The extraction medicinal liquid that in described step 3 point obtains for 4 times is concentrated, is concentrated into the concentrated solution of 1.15-1.25 proportion;

Step 5: mixed dissolution concentrated solution

Described step 2 is ground into 60 ~ 75 object medicated powder to join in described step 4 in the described concentrated solution obtained, and fully dissolve, mixing, form new concentrated solution;

Step 6: adjust PH, dry, be processed into medicine

The pH value of the concentrated solution obtained in described step 5 is adjusted to 5.0-7.0, and filters 60 mesh filter screens, and remove moisture, be processed into medicine.

7. the manufacture method of the medicine for the treatment of thyroid nodule according to claim 6, described method comprises:

Step 1: weigh medical material and mix

Take above-mentioned various raw medicinal material according to described ratio and fully mixing, make according to the raw medicinal material of following weight proportion number: Radix Astragali 30 parts, Radix Salviae Miltiorrhizae 30 parts, Herba Hedyotidis Diffusae 30 parts, Concha Ostreae 20 parts, Bulbus Fritillariae Thunbergii 20 parts, Radix Ranunculi Ternati 20 parts, Rhizoma Dioscoreae Bulbiferae 10 parts, Sargassum 15 parts, Radix Bupleuri 6 parts, Radix Ginseng 4 parts, Bulbus Lilii 4 parts, the Radix Aucklandiae 4 parts, Flos Chrysanthemi Indici 4 parts, Herba Scutellariae Barbatae 4 parts;

Step 2: by pulverizing medicinal materials

Various raw medicinal material mixed in described step 1 is pulverized, is ground into 60 ~ 75 object medicated powder, and described medicated powder is soaked 8 hours in distilled water;

Step 3: raw medicinal material boils

Boil pulverizing rear remaining raw medicinal material in described step 2, first add quality 4 doubly to the distilled water of described raw medicinal material, first boil 6 hours, first time extracts boiling liquid, then boils 4 hours, second time extracts boiling liquid, boil 4 hours again, third time extracts boiling liquid, then boils 3 hours, extract boiling liquid, the boiling liquid of above-mentioned four times is mixed to get extracting solution for 4th time;

Step 4: extract concentration of liquid medicine

The extraction medicinal liquid that in described step 3 point obtains for 4 times is concentrated, is concentrated into the concentrated solution of 1.15-1.25 proportion;

Step 5: mixed dissolution concentrated solution

Described step 2 is ground into 60 ~ 75 object medicated powder to join in described step 4 in the described concentrated solution obtained, and fully dissolve, mixing, form new concentrated solution;

Step 6: adjust PH, dry, be processed into medicine

The pH value of the concentrated solution obtained in described step 5 is adjusted to 5.0-7.0, and filters 60 mesh filter screens, dry and remove moisture, be processed into medicine.