CN116492437B - 一种改善呼吸道免疫力的植物***片及其制备工艺 - Google Patents
一种改善呼吸道免疫力的植物***片及其制备工艺 Download PDFInfo
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Abstract
本发明公开了一种改善呼吸道免疫力的植物***片,按重量份计,包括以下组分:改善呼吸道免疫力组合物20~30份;香橼提取物15~20份;糖或代糖20~30份;增稠剂30~40份;清凉醇0.2~0.4份;药用辅料0.5~1份;水溶性老香橼食用香精0.5~1.5份;采用药食同源的草本免疫成分,对身体无毒副作用,能够通过人体多归经调理,综合改善呼吸道免疫力及其紊乱所致的咳嗽、咳痰、乏力、嗜睡、精神不济等症状。本发明还公开了一种改善呼吸道免疫力的植物***片的制备工艺,使用直接压片法,成本低且工艺操作省时简单。
Description
技术领域
本发明涉及一种改善呼吸道免疫力的植物***片及其制备工艺。
背景技术
当前呼吸道免疫力紊乱(免疫力过高或过低)的主要诱因为生态环境的恶化。外部环境的恶化导致呼吸道敏感性增强,从而易得各种呼吸道疾病,比如气管炎、支气管炎、肺炎、咽炎、扁桃体炎、上呼吸道感染、过敏反应等,疾病的长期反复发作,最终导致肺部免疫力紊乱。
为了缓解这一系列症状,有的人会选择购买市面上推出的清热茶饮,或吃清肺止咳药物等等,但对症效果参差不齐,且药物摄入后的毒副作用需要依赖肝脏去消除,无疑是再一次增加了身体负担。片剂具有体积小、质量稳定、易于生产,易携带,食用方便等优点,能够在感到不适时及时服用,缓解症状。目前,市场上还未见有改善呼吸道免疫力的可食用的***片产品。
发明内容
本发明的目的是克服现有技术的缺陷,提供一种改善呼吸道免疫力的植物***片,采用药食同源的草本免疫成分,对身体无毒副作用,能够通过人体多归经调理,综合改善呼吸道免疫力及其紊乱所致的咳嗽、咳痰、乏力、嗜睡、精神不济等症状。
本发明的另外一个目的是提供一种改善呼吸道免疫力的植物***片的制备工艺,使用直接压片法,成本低且工艺操作省时简单。
实现上述目的一种技术方案是:一种改善呼吸道免疫力的植物***片,按重量份计,包括以下组分:
所述改善呼吸道免疫力组合物由以下重量份的组分制成:金银花50~150份、陈皮20~80份、余甘子10~50份、甘草10~50份、山药10~30份、薄荷10~30份、显齿蛇葡萄叶10~30份、紫苏籽5~15份、罗汉果5~15份、云南小黄姜1~5份、姜黄12~48份和黑胡椒20~80份。
上述的一种改善呼吸道免疫力的植物***片,其中,所述糖采用蔗糖、葡萄糖和/或果糖;
所述代糖采用木糖醇、甜菊糖苷和/或赤藓糖醇;
所述增稠剂采用麦芽糊精、淀粉或预胶化淀粉;
所述清凉醇采用薄荷醇;
所述药用辅料采用硬脂酸镁、二氧化硅、滑石粉、聚乙二醇4000、聚乙二醇6000和/或十二烷基硫酸镁。
上述的一种改善呼吸道免疫力的植物***片,其中,所述改善呼吸道免疫力组合物中的各组分采用生药饮片水提取物或生药饮片超微粉,或者所述改善呼吸道免疫力组合物中的山药采用山药超微粉,剩余的组分采用生药饮片水提取物。
本发明还提供了一种改善呼吸道免疫力的植物***片的制备工艺,包括以下步骤:
S1,制备改善呼吸道免疫力组合物步骤:所述改善呼吸道免疫力组合物采用水提物提取工艺或超微粉工艺制备而成;或者所述改善呼吸道免疫力组合物中山药采用由超微粉工艺制备得到山药超微粉,其余的组分采用水提物提取工艺制备得到的水提取物冻干粉,然后将山药超微粉和水提取物冻干粉混合后得到所述改善呼吸道免疫力组合物;
S2,将改善呼吸道免疫力组合物、香橼提取物、糖或代糖、增稠剂、清凉醇和药用辅料分别打磨成超微粉形态后,分别过80~200目筛,取通过筛网的粉体备用;
S3,按照如权利要求1所述的植物***片的配方,将步骤S2中过筛后的改善呼吸道免疫力组合物、香橼提取物、糖或代糖、增稠剂和清凉醇混合均匀;然后再加入硬脂酸镁混合均匀,采用压片机直接压片,最后用包衣机包裹含有水溶性老香橼食用香精的薄膜衣即得改善呼吸道免疫力的植物***片。
上述的一种改善呼吸道免疫力的植物***片的制备工艺,步骤S1中,所述改善呼吸道免疫力组合物采用水提物提取工艺制备而成的具体步骤为:按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10~15倍体积的水,90℃~100℃加热回流1.5~3h,得到的提取液使用150目~300目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度50℃~70℃、真空度70~100mbar的条件下真空浓缩至原有滤液体积的1/5至1/10,然后将浓缩液冷冻干燥得到改善呼吸道免疫力组合物。
上述的一种改善呼吸道免疫力的植物***片的制备工艺,步骤S1中,所述改善呼吸道免疫力组合物采用超微粉工艺制备而成的具体步骤为:按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,置于中药打粉机中进行初步粉碎,过4号筛或5号筛,然后采用超微粉碎机进行粉碎得到改善呼吸道免疫力组合物。
上述的一种改善呼吸道免疫力的植物***片的制备工艺,步骤S1中,山药超微粉和水提取物冻干粉混合得到改善呼吸道免疫力组合物的具体步骤为:
A.按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片;
B.取除山药外的其余组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10~15倍体积的水,90℃~100℃加热回流1.5-3h,提取液使用150目~300目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度50℃~70℃、真空度70~100mbar的条件下真空浓缩至原有滤液体积的1/5至1/10,然后将浓缩液冷冻干燥得到水提取物冻干粉备用;
C.再取山药的生药饮片,置于中药打粉机中进行初步粉碎,过4号筛或5号筛,采用超微粉碎机进行粉碎得到山药超微粉备用;
D.将步骤B中的水提取物冻干粉和步骤C中的山药超微粉混合后置于超微粉碎机中粉碎得到改善呼吸道免疫力组合物。
上述的一种改善呼吸道免疫力的植物***片的制备工艺,其特征在于,所述超微粉碎机的转速为300~400rpm,粉碎时间20~40min,球料比(5~20):1,大小球的比例为1:(1~6)。
采用本发明的改善呼吸道免疫力的植物***片及其制备工艺的技术方案,有益效果体现在:
(1)使用的所有成分均为食品级原、辅料,采用药食同源的草本免疫成分,对身体无毒副作用;
(2)综合改善呼吸道免疫力及其紊乱所致的咳嗽、咳痰、乏力、嗜睡、精神不济等症状,且在改善缓解呼吸道感染症状方面起到积极效果的同时不会对身体造成其他损伤;
(3)香橼提取物和清凉醇,使改善呼吸道免疫力的植物***片含有香橼的果味和薄荷的清凉口感;另外,香橼作为云南特色水果,性温,微酸甜,可以起到疏肝理气,止咳化痰的作用;
(4)***片可以直接作用口腔、口腔粘膜及舌下腺,快速吸收,改善呼吸道感染症状方面效果显著;
(5)***片可以直接作用在咽部,由于缓慢的含化,使有效成分能较长时间停留在咽部持续发挥功效,对于缓解咽干、咽痛等不适感觉见效快;
(6)改善呼吸道免疫力组合物中含有山药,山药富含淀粉和黏蛋白,可以发挥粘合剂和崩解剂的效果,既是活性组分又是辅料;
(7)***片具有含糖版和无蔗糖版两种版本。其中无蔗糖版添加的代糖,热量低,进入血液后不需要胰岛素就能透过细胞,代谢速度快,一般不会引起血糖升高,糖尿病患者也可食用;
(8)***片的制备工艺使用直接压片法,成本低且工艺操作省时简单。
附图说明
图1为本发明的一种改善呼吸道免疫力的植物***片的制备工艺的流程图。
具体实施方式
为了使本技术领域的技术人员能更好地理解本发明的技术方案,下面结合附图对其具体实施方式进行详细地说明:
实施例1:
一种改善呼吸道免疫力的植物***片(含糖版),按重量份计,包括以下组分:
改善呼吸道免疫力组合物由以下重量份的组分制成:金银花100份、陈皮50份、余甘子30份、甘草30份、山药20份、薄荷20份、显齿蛇葡萄叶20份、紫苏籽10份、罗汉果10份、云南小黄姜3份、姜黄30份和黑胡椒50份。
请参阅图1,本实施例的改善呼吸道免疫力的植物***片,采用以下制备工艺制成:
S1,采用超微粉工艺制备改善呼吸道免疫力组合物,具体步骤为:按照上述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,置于中药打粉机中进行初步粉碎,过5号筛(180μm±7.6μm,80目),采用超微粉碎机进行粉碎得到改善呼吸道免疫力组合物(超微粉),超微粉碎机的参数为:转速400rpm,时间30min,球料比10:1,大小球(7mm:3mm)=1:4;
S2,将改善呼吸道免疫力组合物(超微粉)、香橼提取物、蔗糖、麦芽糊精、薄荷醇和硬脂酸镁分别打磨成超微粉形态后,分别过100目筛,取通过筛网的粉体备用,得到原料粒径为150μm;
S3,取30份改善呼吸道免疫力组合物(超微粉)、15份香橼提取物、20份蔗糖、30份麦芽糊精和0.2份薄荷醇混合均匀后,再加入0.5份硬脂酸镁混合均匀,用压片机进行压片,再用包衣机对片剂包薄膜衣。其中,包衣预混剂中含0.5份水溶性老香橼食用香精。得到10mm,0.6g/片规格的改善呼吸道免疫力的植物***片15片。
实施例2:
一种改善呼吸道免疫力的植物***片(无糖版),按重量份计,包括以下组分:
改善呼吸道免疫力组合物由以下重量份的组分制成:金银花100份、陈皮50份、余甘子30份、甘草30份、山药20份、薄荷20份、显齿蛇葡萄叶20份、紫苏籽10份、罗汉果10份、云南小黄姜3份、姜黄30份和黑胡椒50份。
请参阅图1,本实施例的改善呼吸道免疫力的植物***片,采用以下制备工艺制成:
S1,采用超微粉工艺制备改善呼吸道免疫力组合物(超微粉),具体步骤为:按照上述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,置于中药打粉机中进行初步粉碎,过5号筛(180μm±7.6μm,80目),采用超微粉碎机进行粉碎得到改善呼吸道免疫力组合物(超微粉),超微粉碎机的参数为:转速400rpm,时间30min,球料比10:1,大小球(7mm:3mm)=1:4;
S2,将改善呼吸道免疫力组合物(超微粉)、香橼提取物、木糖醇、麦芽糊精、薄荷醇和硬脂酸镁分别打磨成超微粉形态后,分别过100目筛,取通过筛网的粉体备用,得到原料粒径为150μm;
S3,取30份改善呼吸道免疫力组合物(超微粉)、15份香橼提取物、20份木糖醇、30份麦芽糊精和0.2份薄荷醇混合均匀后,再加入0.5份硬脂酸镁混合均匀,用压片机进行压片,再用包衣机对片剂包薄膜衣。其中,包衣预混剂中含0.5份水溶性老香橼食用香精。得到10mm,0.6g/片规格的改善呼吸道免疫力的植物***片15片。
实施例3:
一种改善呼吸道免疫力的植物***片(无糖版),按重量份计,包括以下组分:
改善呼吸道免疫力组合物由以下重量份的组分制成:金银花100份、陈皮50份、余甘子30份、甘草30份、山药20份、薄荷20份、显齿蛇葡萄叶20份、紫苏籽10份、罗汉果10份、云南小黄姜3份、姜黄30份和黑胡椒50份。
请参阅图1,本实施例的改善呼吸道免疫力的植物***片,采用以下制备工艺制成:
S1,改善呼吸道免疫力组合物中山药采用由超微粉工艺制备得到山药超微粉,其余的组分采用水提物提取工艺制备得到的水提取物冻干粉,然后将山药超微粉和水提取物冻干粉混合后得到所述改善呼吸道免疫力组合物的具体步骤为:
A.按照上述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片;
B.取除山药外的其余组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10倍体积的水,100℃加热回流3h,提取液使用200目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度60℃、真空度100mbar的条件下真空浓缩至原有滤液体积的1/10,然后将浓缩液冷冻干燥得到水提取物冻干粉备用;
C.再取山药的生药饮片,置于中药打粉机中进行初步粉碎,5号筛(180μm±7.6μm,80目),采用超微粉碎机进行粉碎得到山药超微粉备用,超微粉碎机的参数为转速400rpm,时间30min,球料比10:1,大小球(7mm:3mm)=1:4;
D.将步骤B中的水提取物冻干粉和步骤C中的山药超微粉按照质量比为19:1的比例混合后置于超微粉碎机中粉碎得到改善呼吸道免疫力组合物,粉碎机参数300rpm,时间5min,球料比5:1,大小球(7mm:3mm)=1:4,这种改善呼吸道免疫力组合物采用除山药外的水提取物冻干粉+山药超微粉的形式;
S2,将改善呼吸道免疫力组合物、香橼提取物、木糖醇、麦芽糊精、薄荷醇和硬脂酸镁分别打磨成超微粉形态后,分别过100目筛,取通过筛网的粉体备用,得到原料粒径为150μm;
S3,取30份改善呼吸道免疫力组合物、15份香橼提取物、20份木糖醇、30份麦芽糊精和0.2份薄荷醇混合均匀后,再加入0.5份硬脂酸镁混合均匀,用压片机进行压片,再用包衣机对片剂包薄膜衣。其中,包衣预混剂中含0.5份水溶性老香橼食用香精。得到10mm,0.6g/片规格的改善呼吸道免疫力的植物***片15片。
以上各实施例中,改善呼吸道免疫力组合物也可以采用水提物提取工艺制备而成,具体步骤为:按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10~15倍体积的水,90℃~100℃加热回流1.5~3h,得到的提取液使用150目~300目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度50℃~70℃、真空度70~100mbar的条件下真空浓缩至原有滤液体积的1/5至1/10,然后将浓缩液冷冻干燥得到改善呼吸道免疫力组合物。
改善呼吸道免疫力组合物的功效验证实验:
经过4天10人次的试服试验,在10个症状咳嗽、乏力、精神不济、脑袋反应变慢、气喘或呼吸急促、嗜睡、味觉/嗅觉衰退、咳痰、鼻塞/流鼻涕、情绪低落均有改善趋势,尤其在咳嗽、咳痰、乏力、嗜睡、精神不济等症状方面均具有显著性改善。
人体试服的具体试验过程如下:
干预组的试服人员选取感染后呼吸道不适人员10人进行人体试服本发明的改善呼吸道免疫力组合物,连续试服4天,每个人每天根据症状改善情况进行打分,之后根据打分进行统计分析,评估产品配方的有效性。
同时设置对照组,对照组中选取感染后呼吸道不适人员10人,不服用本发明的改善呼吸道免疫力组合物,根据每个人每天的症状进行打分,之后根据打分进行统计分析。
1.产品形态:袋泡茶(3.8g/袋)形式的改善呼吸道免疫力组合物,由以下重量份的组分制成:金银花100份、陈皮50份、余甘子30份、甘草30份、山药20份、薄荷20份、显齿蛇葡萄叶20份、紫苏籽10份、罗汉果10份、云南小黄姜3份、姜黄30份和黑胡椒50份;
2.服用方法:每人一天2次,每次1袋,用开水冲泡5分钟后服用;
3.干预组的试服人员:10个感染后呼吸道不适的患者;
4.对照组的人员:10个感染后呼吸道不适的患者;
5.打分指标:16个指标—咳嗽、气喘或呼吸急促、咯痰、乏力、嗜睡、鼻塞/流鼻涕、精神不济、失眠、肠胃不适、味觉和嗅觉衰退、咳嗽引起的胸口疼、情绪低落、偶尔眩晕、关节痛、偶尔心慌、脑袋反应变慢,每个指标设置1-5分,分值越小表示症状减轻较多;
6.干预组对呼吸道免疫力紊乱所致症状的改善情况的统计结果见表1:
表1:
表1中,数值表示为均值±标准差(mean±SEM);*表示vs.0Days(与0天的数据相比),P<0.05;**表示vs.0Days(与0天的数据相比),P<0.01;***表示vs.0Days(与0天的数据相比),P<0.001。
7.对照组的呼吸道免疫力紊乱所致症状的情况的统计结果见表2:
表2:
表2中,数值表示为均值±标准差(mean±SEM);#表示vs.1Days(与第1天相比),P<0.05。
通过表1和表2中的数据相比,服用本发明中的改善呼吸道免疫力组合物,对10个症状如咳嗽、乏力、精神不济、脑袋反应变慢、气喘或呼吸急促、嗜睡、味觉/嗅觉衰退、咳痰、鼻塞/流鼻涕和情绪低落,均有改善趋势,尤其在咳嗽、咳痰、乏力、嗜睡、精神不济等症状方面均具有显著性改善效果。
本发明的改善呼吸道免疫力的植物***片,改善呼吸道免疫力组合物,选取药食同源且具有改善呼吸道免疫力的药味或其提取物,组合物中的金银花、陈皮、甘草、余甘子以达到清热解毒、燥湿化痰、补脾养胃、生津止渴的功效,再配以利湿、化痰止咳、祛痰利咽、补肺气等功效的显齿蛇葡萄叶、紫苏籽、薄荷、云南小黄姜、山药、罗汉果。此外,组合物中再加入对呼吸道免疫力紊乱所致症状具有辅助改善作用的姜黄和黑胡椒,从而综合达到改善呼吸道免疫力的作用。香橼提取物和清凉醇,使改善呼吸道免疫力的植物***片含有香橼的果味和薄荷的清凉口感;另外,香橼作为云南特色水果,性温,微酸甜,可以起到疏肝理气,止咳化痰的作用;山药富含淀粉和黏蛋白,可以发挥粘合剂和崩解剂的效果,既是活性组分又是辅料。
本发明的改善呼吸道免疫力的植物***片,采用药食同源的草本免疫成分,对身体无毒副作用,能够通过人体多归经调理,综合改善呼吸道免疫力及其紊乱所致的咳嗽、咳痰、乏力、嗜睡、精神不济等症状,另外,症状主要集中在上呼吸道,尤其是咳嗽、咯痰、咽干、咽痛等,相对于咀嚼片或崩解片,***片可以直接作用在口腔及咽部,通过口腔粘膜及舌下腺快速吸收;同时,含化过程可以使有效成分能较长时间停留在口腔及咽部持续发挥功效,维持久,见效快。***片具有含糖版和无蔗糖版两种版本,其中无蔗糖版添加的代糖,热量低,进入血液后不需要胰岛素就能透过细胞,代谢速度快,一般不会引起血糖升高,糖尿病患者也可食用。***片的制备工艺使用直接压片法,成本低且工艺操作省时简单。
综上所述,本发明的改善呼吸道免疫力的植物***片及其制备工艺,采用药食同源的草本免疫成分,对身体无毒副作用,能够通过人体多归经调理,综合改善呼吸道免疫力及其紊乱所致的咳嗽、咳痰、乏力、嗜睡、精神不济等症状。且使用直接压片法制备,成本低且工艺操作省时简单。
本技术领域中的普通技术人员应当认识到,以上的实施例仅是用来说明本发明,而并非用作为对本发明的限定,只要在本发明的实质精神范围内,对以上所述实施例的变化、变型都将落在本发明的权利要求书范围内。
Claims (8)
1.一种改善呼吸道免疫力的植物***片,其特征在于,按重量份计,包括以下组分:
改善呼吸道免疫力组合物 20~30份;
香橼提取物 15~20份;
糖或代糖 20~30份;
麦芽糊精、淀粉或预胶化淀粉 30~40份;
清凉醇 0.2~0.4份;
硬脂酸镁 0.5~1份;
水溶性老香橼食用香精 0.5~1.5份;
所述改善呼吸道免疫力组合物由以下重量份的组分制成:金银花50~150份、陈皮20~80份、余甘子10~50份、甘草10~50份、山药10~30份、薄荷10~30份、显齿蛇葡萄叶10~30份、紫苏籽5~15份、罗汉果5~15份、云南小黄姜1~5份、姜黄12~48份和黑胡椒20~80份。
2.如权利要求1所述的一种改善呼吸道免疫力的植物***片,其特征在于,所述糖采用蔗糖、葡萄糖和/或果糖;
所述代糖采用木糖醇、甜菊糖苷和/或赤藓糖醇;
所述清凉醇采用薄荷醇;
所述硬脂酸镁采用二氧化硅、滑石粉、聚乙二醇4000、聚乙二醇6000和/或十二烷基硫酸镁替代。
3.如权利要求1所述的一种改善呼吸道免疫力的植物***片,其特征在于,所述改善呼吸道免疫力组合物中的各组分采用生药饮片水提取物或生药饮片超微粉,或者所述改善呼吸道免疫力组合物中的山药采用山药超微粉,剩余的组分采用生药饮片水提取物。
4.一种如权利要求1所述的改善呼吸道免疫力的植物***片的制备工艺,其特征在于,包括以下步骤:
S1,制备改善呼吸道免疫力组合物步骤:所述改善呼吸道免疫力组合物采用水提物提取工艺或超微粉工艺制备而成;或者所述改善呼吸道免疫力组合物中山药采用由超微粉工艺制备得到山药超微粉,其余的组分采用水提物提取工艺制备得到的水提取物冻干粉,然后将山药超微粉和水提取物冻干粉混合后得到所述改善呼吸道免疫力组合物;
S2,将改善呼吸道免疫力组合物、香橼提取物、糖或代糖、麦芽糊精、淀粉或预胶化淀粉、清凉醇和硬脂酸镁分别打磨成超微粉形态后,分别过80~200目筛,取通过筛网的粉体备用;
S3,按照如权利要求1所述的植物***片的配方,将步骤S2中过筛后的改善呼吸道免疫力组合物、香橼提取物、糖或代糖、麦芽糊精、淀粉或预胶化淀粉和清凉醇混合均匀;然后再加入硬脂酸镁混合均匀,采用压片机直接压片,最后用包衣机包裹含有水溶性老香橼食用香精的薄膜衣即得改善呼吸道免疫力的植物***片。
5.如权利要求4所述的一种改善呼吸道免疫力的植物***片的制备工艺,其特征在于,步骤S1中,所述改善呼吸道免疫力组合物采用水提物提取工艺制备而成的具体步骤为:按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10~15倍体积的水,90℃~100℃加热回流1.5~3h,得到的提取液使用150目~300目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度50℃~70℃、真空度70~100mbar的条件下真空浓缩至原有滤液体积的1/5至1/10,然后将浓缩液冷冻干燥得到改善呼吸道免疫力组合物。
6.如权利要求4所述的一种改善呼吸道免疫力的植物***片的制备工艺,其特征在于,步骤S1中,所述改善呼吸道免疫力组合物采用超微粉工艺制备而成的具体步骤为:按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片,置于中药打粉机中进行初步粉碎,过4号筛或5号筛,然后采用超微粉碎机进行粉碎得到改善呼吸道免疫力组合物。
7.如权利要求4所述的一种改善呼吸道免疫力的植物***片的制备工艺,其特征在于,步骤S1中,山药超微粉和水提取物冻干粉混合得到改善呼吸道免疫力组合物的具体步骤为:
A.按照如权利要求1所述的改善呼吸道免疫力组合物的配方称取各组分的生药饮片;
B.取除山药外的其余组分的生药饮片,无需捣碎或捣碎后过3目~5目的标准筛,混匀后,加入10~15倍体积的水,90℃~100℃加热回流1.5-3h,提取液使用150目~300目筛过滤,重复加热提取1~3次并过滤,将所有滤液合并,在温度50℃~70℃、真空度70~100mbar的条件下真空浓缩至原有滤液体积的1/5至1/10,然后将浓缩液冷冻干燥得到水提取物冻干粉备用;
C.再取山药的生药饮片,置于中药打粉机中进行初步粉碎,过4号筛或5号筛,采用超微粉碎机进行粉碎得到山药超微粉备用;
D.将步骤B中的水提取物冻干粉和步骤C中的山药超微粉混合后置于超微粉碎机中粉碎得到改善呼吸道免疫力组合物。
8.如权利要求6或7所述的一种改善呼吸道免疫力的植物***片的制备工艺,其特征在于,所述超微粉碎机的转速为300~400rpm,粉碎时间20~40min,球料比(5~20):1,大小球的比例为1:(1~6)。
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CN104027440A (zh) * | 2014-04-28 | 2014-09-10 | 张聪聪 | 止咳化痰含片及其制备方法 |
CN114681568A (zh) * | 2020-12-30 | 2022-07-01 | 石家庄以岭药业股份有限公司 | 一种止咳化痰组合物、代用茶、糖果及制备方法 |
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CN104027440A (zh) * | 2014-04-28 | 2014-09-10 | 张聪聪 | 止咳化痰含片及其制备方法 |
CN114681568A (zh) * | 2020-12-30 | 2022-07-01 | 石家庄以岭药业股份有限公司 | 一种止咳化痰组合物、代用茶、糖果及制备方法 |
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