CN115803316A - 吡啶酮类化合物及其制备方法和应用 - Google Patents
吡啶酮类化合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN115803316A CN115803316A CN202180049358.1A CN202180049358A CN115803316A CN 115803316 A CN115803316 A CN 115803316A CN 202180049358 A CN202180049358 A CN 202180049358A CN 115803316 A CN115803316 A CN 115803316A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- cancer
- halogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
本发明公开一种吡啶酮类化合物及其制备方法及应用。具体地,本发明涉及式I化合物,其可用于治疗与肠易激综合征(IBS)和其他胃肠道障碍相关的疾病,以及治疗RET和/或TRK功能性障碍或调节RET和/或TRK活性的癌症、炎症性肠病、神经退行性疾病、慢性疼痛、急性疼痛、炎性疾病、克氏锥虫感染、与骨重建调节失衡有关的疾病。
Description
PCT国内申请,说明书已公开。
Claims (18)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010719751 | 2020-07-23 | ||
CN2020107197514 | 2020-07-23 | ||
PCT/CN2021/108286 WO2022017524A1 (zh) | 2020-07-23 | 2021-07-23 | 吡啶酮类化合物及其制备方法和应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115803316A true CN115803316A (zh) | 2023-03-14 |
Family
ID=79728529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202180049358.1A Pending CN115803316A (zh) | 2020-07-23 | 2021-07-23 | 吡啶酮类化合物及其制备方法和应用 |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN115803316A (zh) |
TW (1) | TWI786742B (zh) |
WO (1) | WO2022017524A1 (zh) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20060664A1 (es) * | 2004-09-15 | 2006-08-04 | Novartis Ag | Amidas biciclicas como inhibidores de cinasa |
CA2587207A1 (en) * | 2004-11-23 | 2006-06-01 | Merck & Co., Inc. | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
JP2011511018A (ja) * | 2008-02-05 | 2011-04-07 | サノフィ−アベンティス | Par1阻害剤としてのsf5誘導体、その製造、及び薬剤としての使用 |
US9382238B2 (en) * | 2013-03-15 | 2016-07-05 | Glaxosmithkline Intellectual Property Development Limited | Pyridine derivatives as rearranged during transfection (RET) kinase inhibitors |
EP3191450B1 (en) * | 2014-09-10 | 2019-04-10 | GlaxoSmithKline Intellectual Property Development Limited | Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors |
ES2691227T3 (es) * | 2014-10-16 | 2018-11-26 | Bayer Pharma Aktiengesellschaft | Derivados fluorados de benzofuranil-pirimidina que contienen un grupo sulfoximina |
-
2021
- 2021-07-23 WO PCT/CN2021/108286 patent/WO2022017524A1/zh active Application Filing
- 2021-07-23 CN CN202180049358.1A patent/CN115803316A/zh active Pending
- 2021-07-23 TW TW110127160A patent/TWI786742B/zh active
Also Published As
Publication number | Publication date |
---|---|
TWI786742B (zh) | 2022-12-11 |
WO2022017524A1 (zh) | 2022-01-27 |
TW202210460A (zh) | 2022-03-16 |
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