CN112313207A - 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 - Google Patents
一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 Download PDFInfo
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- CN112313207A CN112313207A CN201980038142.8A CN201980038142A CN112313207A CN 112313207 A CN112313207 A CN 112313207A CN 201980038142 A CN201980038142 A CN 201980038142A CN 112313207 A CN112313207 A CN 112313207A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
提供一种式(I)所示化合物、其异构体、水合物、溶剂化物、其药学上可接受的盐及其前药,其制备方法及其在制备作为激酶抑制剂的药物中的应用。该化合物对FGFR4及突变型FGFR4V550L等激酶均具有良好的抑制活性。
Description
PCT国内申请,说明书已公开。
Claims (13)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810651996 | 2018-06-22 | ||
CN2018106519960 | 2018-06-22 | ||
PCT/CN2019/092089 WO2019242689A1 (zh) | 2018-06-22 | 2019-06-20 | 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112313207A true CN112313207A (zh) | 2021-02-02 |
CN112313207B CN112313207B (zh) | 2023-02-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201980038142.8A Active CN112313207B (zh) | 2018-06-22 | 2019-06-20 | 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 |
Country Status (2)
Country | Link |
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CN (1) | CN112313207B (zh) |
WO (1) | WO2019242689A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220114643A (ko) * | 2019-12-23 | 2022-08-17 | 베이징 사이텍-엠큐 파마슈티컬즈 리미티드 | 시아노-치환된 피리딘 및 시아노-치환된 피리미딘 화합물 및 이의 제조방법 및 이의 적용 |
CN113754591B (zh) * | 2020-06-05 | 2024-01-05 | 山东大学 | 一种hdac、jak和bet三靶点抑制剂及其制备方法和应用 |
CN114560815A (zh) * | 2022-03-04 | 2022-05-31 | 北京工业大学 | (2-((5-氯-取代苯基氨基嘧啶-2-基)氨基)苯基)氨基甲酸叔丁酯类衍生物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015057963A1 (en) * | 2013-10-18 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Fgfr4 inhibitors |
WO2016164703A1 (en) * | 2015-04-09 | 2016-10-13 | Eisai R & D Management Co., Ltd. | Fgfr4 inhibitors |
WO2017202390A1 (zh) * | 2016-05-27 | 2017-11-30 | 杭州英创医药科技有限公司 | 作为fgfr4抑制剂的杂环化合物 |
WO2018072707A1 (zh) * | 2016-10-18 | 2018-04-26 | 保诺科技(北京)有限公司 | 芳香族醚类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2872491T3 (da) * | 2012-07-11 | 2021-08-09 | Blueprint Medicines Corp | Inhibitorer af fibroblastvækstfaktorreceptoren |
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2019
- 2019-06-20 WO PCT/CN2019/092089 patent/WO2019242689A1/zh active Application Filing
- 2019-06-20 CN CN201980038142.8A patent/CN112313207B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015057963A1 (en) * | 2013-10-18 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Fgfr4 inhibitors |
WO2016164703A1 (en) * | 2015-04-09 | 2016-10-13 | Eisai R & D Management Co., Ltd. | Fgfr4 inhibitors |
WO2017202390A1 (zh) * | 2016-05-27 | 2017-11-30 | 杭州英创医药科技有限公司 | 作为fgfr4抑制剂的杂环化合物 |
WO2018072707A1 (zh) * | 2016-10-18 | 2018-04-26 | 保诺科技(北京)有限公司 | 芳香族醚类衍生物、其制备方法及其在医药上的应用 |
Also Published As
Publication number | Publication date |
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WO2019242689A1 (zh) | 2019-12-26 |
CN112313207B (zh) | 2023-02-14 |
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