CN115778882B - Hair-growing essence and preparation method thereof - Google Patents
Hair-growing essence and preparation method thereof Download PDFInfo
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Abstract
The application relates to the technical field of cosmetics, and particularly discloses a hair-growing essence and a preparation method thereof. The hair growth essence provided by the application comprises a plant extract and a bacteriostatic agent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract; the application also provides a preparation method of the hair-growing essence. The hair growth essence provided by the application can accelerate scalp blood circulation, activate and repair scalp hair follicle tissues, and further promote hair growth.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a hair-growing essence and a preparation method thereof.
Background
Hair is a very important feature of the appearance of the human body, and in recent years, people increasingly pay attention to the problem of personal image, and everyone wants to have a black and dense hair. However, modern young people often cause hair loss and alopecia due to irregular diet and work and rest, huge life pressure and other problems, so that the hair is sparse and even bald when many people are in the age, the appearance of the individuals can be influenced, certain wounds can be caused to the psychology of the individuals, personal self-confidence is hit, and the self-help psychology of the individuals is generated.
It has been found that hair thinning and hair loss are mainly caused by several causes: firstly, the ecological scalp of a human body is deteriorated, so that the scalp environment is disturbed, and hair follicles are loosened or blocked; secondly, the metabolism disorder in the body stimulates the sebaceous gland to secrete exuberance, so that a large amount of grease is pressed against the root of the hair, the blood and nutrition supply required by the hair is blocked, and seborrheic alopecia occurs; thirdly, the hair follicle is malnourished and difficult to grow due to the lack of trace elements.
Therefore, there is an urgent need to provide a hair tonic capable of improving scalp environment, activating hair follicle tissue, and promoting hair follicle repair, to solve the problem of rarity of modern young people's hair.
Disclosure of Invention
To improve the scalp environment and activate hair follicle tissue, thereby promoting hair growth. The application provides a hair-growing essence and a preparation method thereof.
In a first aspect, the present application provides a hair tonic essence, which adopts the following technical scheme:
a hair-growing essence, which comprises a plant extract and a bacteriostatic agent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
The hair growth essence provided by the application contains various plant extracts and bacteriostats, wherein the plant extracts can promote the blood circulation of scalp, activate hair follicle tissues of scalp, accelerate the absorption efficiency of scalp to nutrient substances, and further improve the hair growth rate; the antibacterial agent can prevent bacteria in scalp from breeding, thereby improving scalp environment and providing beneficial space for hair growth. In the related art, geranium wilfordii contains a "champagne" substance which is coloured black brown under the action of ferric salt, and is therefore commonly used for preparing hair dyes; roselle contains abundant proteins, organic acids, vitamin C, various amino acids and natural pigments, is commonly used for preparing traditional Chinese medicines to regulate blood pressure and improve sleep, and is also used for shampoo to play roles in removing oil and relieving itching; however, the inventor of the application researches find that the geranium extract and the roselle extract can stimulate and smooth scalp hair follicle tissues, promote hair follicle conversion from rest phase to growing phase, and further realize hair growth. Experiments prove that the addition amounts of the mulberry extract, the geranium extract, the roselle extract and other extracts are controlled within the range, so that the effects of the plant extracts and the synergistic effect among the extracts can be effectively exerted, the proliferation and differentiation of hair follicle stem cells in hair follicle matrixes can be activated, and a good hair growing effect can be obtained.
The geranium extract can inhibit the breeding of scalp germs, stimulate and smooth scalp hair follicle tissues, promote the transformation of hair follicles from rest period to growing period, and further promote hair growth. The roselle extract is an active substance extracted from dried calyx and bract of roselle, contains abundant proteins, organic acids, vitamins and minerals required by human bodies, also contains anthocyanin, hibiscus acid and the like with remarkable antioxidant function, can play a good role in nourishing scalp and hair follicles, and further accelerates metabolism of the scalp; and the roselle extract also changes the contents of relevant factors such as fibroblast growth factor, beta-catenin and the like in the hair growth process, prevents hair follicles from entering the telogen phase, and increases the activity of the hair follicles, thereby promoting hair growth. The cacumen Platycladi extract can promote scalp blood circulation, smooth scalp, promote nutrient absorption by hair root, stimulate and care hair stem, promote hair growth, and promote hair growth. The herba Selaginellae Doederleinii extract can promote blood flow around hair follicle, increase nutrition and oxygen supply of hair follicle cells, and help reduce alopecia. The mulberry extract contains various amino acids and minerals, which not only can blacken hair, but also can provide nutrient substances for scalp. The pine needle extract is extracted from needle of pine tree, and is rich in flavonoids, vitamins, amino acids and minerals, so that it can activate scalp blood circulation, and has certain stimulation effect on hair follicle tissue, thereby promoting hair growth. The peony root extract and the cactus extract have the effects of efficiently moisturizing, cleaning, resisting bacteria and relieving, can moisten the scalp, provide nutrients for the scalp and promote hair growth.
Preferably, the plant extract comprises the following components in parts by weight: 1.4-2.1 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
In a specific embodiment, the delphinium extract is 0.5 parts, the mulberry extract is 0.85 parts, the pine needle extract is 0.5 parts, the cactus extract is 0.4 parts, and the peony root extract is 0.4 parts.
In some embodiments, the geranium extract may be 1.15-1.4 parts, 1.15-1.8 parts, 1.15-2.1 parts, 1.4-1.8 parts, or 1.8-2.1 parts by weight.
In a specific embodiment, the geranium extract may also be 1.15 parts, 1.4 parts, 1.8 parts or 2.1 parts by weight.
In some embodiments, the roselle extract may be 0.5-0.8 parts by weight or 0.8-1.15 parts by weight.
In a specific embodiment, the roselle extract may also be 0.5 parts, 0.8 parts, or 1.15 parts by weight.
In some embodiments, the weight parts of the cacumen Platycladi extract may be 0.4-0.75 parts or 0.75-1 parts.
In a specific embodiment, the weight part of the cacumen Platycladi extract may also be 0.4 part, 0.75 part, or 1 part.
Preferably, the plant extract comprises the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
The geranium extract can induce growth factors in the dermal papilla layer to promote the transformation of hair follicles to the anagen phase, and inhibit the breeding of scalp bacteria; the Hibiscus sabdariffa extract can change the content of related factors such as fibroblast growth factor, beta-catenin and the like in the hair growth process, prevent hair follicles from entering a resting period, and accelerate scalp metabolism, but when the content of the Hibiscus sabdariffa extract is too high, the hair follicles of the scalp are easily blocked, and the problems such as dandruff, alopecia and the like are caused. Therefore, the addition amount of the geranium extract and the roselle extract is further controlled within the range, and the obtained hair-growing essence can accelerate scalp blood circulation, has proper stimulation to hair follicles and has the best hair-growing effect to hair follicles.
Preferably, the bacteriostat is selected from the group consisting of 1, 2-pentanediol, tea polyphenols, propyl p-hydroxybenzoate, and 1, 2-hexanediol.
Preferably, the bacteriostat is a mixture of 1, 2-hexanediol and tea polyphenols; the weight ratio of the 1, 2-hexanediol to the tea polyphenol is 1: (2.5-4).
The application further selects the mixture of the 1, 2-hexanediol and the tea polyphenol as the bacteriostat of the hair growth essence, and controls the weight parts of the 1, 2-hexanediol and the tea polyphenol within the range, so that the obtained hair growth essence can further inhibit bacteria on the surface layer of the scalp, promote benign growth of hair follicle stem cells, thereby stimulating hair follicle regeneration and improving the hair growth rate.
In some embodiments, the weight ratio of 1, 2-hexanediol to tea polyphenols may be 1: (1-2.5), 1: (1-3.5), 1: (1-4), 1: (2.5-3.5) or 1: (3.5-4).
In a specific embodiment, the weight ratio of 1, 2-hexanediol to tea polyphenols may also be 1: 1. 1:2.5, 1:3.5, 1:4.
preferably, the plant extract accounts for 5-7% of the total weight of the hair growth essence.
Preferably, the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair growth essence.
When the addition amount of the bacteriostatic agent is too small, the hair follicle environment of the scalp is difficult to improve, and the hair growth is difficult; when the amount of the bacteriostatic agent added is too large, the growth rate of hair is affected. Therefore, the addition amount of the bacteriostat is controlled within the range, and the obtained hair growth essence has better effect on the growth rate of hair and hair follicle conversion.
Preferably, the hair growth essence further comprises a humectant, a preservative and a solvent.
Preferably, the humectant accounts for 0.8-2.3% of the total weight of the hair growth essence; the antiseptic accounts for 0.2-0.7% of the total weight of the hair growth essence.
Preferably, the humectant is selected from butylene glycol, propylene glycol, PEG-7 glycerol cocoate, methyl glucitol polyether; the preservative is selected from phenoxyethanol and ethylhexyl glycerol.
In a specific embodiment, the humectant is butanediol, and the preservative is phenoxyethanol and ethylhexyl glycerol in a mass ratio of 1:1.
Preferably, the solvent is selected from water, ethanol.
Preferably, the solvent is a mixture of water and ethanol; the volume ratio of the water to the ethanol is 1: (2.4-3.3).
In a specific embodiment, the volume ratio of the water to the ethanol is 1:3.
in a second aspect, the present application provides a method of preparing a hair tonic concentrate.
A preparation method of hair-growing essence comprises the following steps:
dissolving bacteriostatic agent, humectant and antiseptic in solvent, and heating the system to 75-85deg.C; then adding each plant extract into the system, wherein the time interval between every two plant extracts is 3-10min, and the geranium extract and the roselle extract are added at last; cooling the system to 40-50deg.C after the addition, and stirring at the temperature for 0.5-1 hr; finally cooling to normal temperature to obtain the hair growth essence.
According to the preparation method of the hair-growing essence, the plant extracts are sequentially added, the time interval between the two plant extracts is controlled to be 3-10min, the geranium extract and the roselle extract are added last, the weakening of the efficacy of the geranium extract and the roselle extract caused by long-time stirring can be avoided, the optimal synergistic effect can be exerted between the plant extracts, and further the hair-growing effect of the hair-growing essence is better.
In summary, the present application has the following beneficial effects:
(1) The hair-growing essence is prepared from plant extracts such as geranium extract and roselle extract, can stimulate hair follicle tissues, promote hair follicle conversion from rest period to growing period, improve scalp environment, accelerate scalp blood circulation and metabolism, and promote hair growth.
(2) The application further controls the weight parts of the components of the plant extract in the hair growth essence within the following range: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract, the obtained hair-growing essence can further promote the transformation of hair follicles from a resting period to a growing period, effectively activate hair follicle tissues and promote hair growth.
(3) The application adopts a mixture of 1, 2-hexanediol and tea polyphenol as a bacteriostatic agent, and the weight parts of the 1, 2-hexanediol and the tea polyphenol are controlled to be 1: (2.5-4), can further improve the hair follicle environment of scalp, promote the hair follicle to transform to anagen phase, and further accelerate the hair growth.
Detailed Description
The application provides a hair-growing essence which comprises a plant extract, a bacteriostatic agent, a humectant, a preservative and a solvent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract. Further, the plant extract may further comprise the following components in parts by weight: 1.4-2.1 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract. Still further, the plant extract may further comprise the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
Wherein the bacteriostatic agent is selected from 1, 2-pentanediol, tea polyphenols, propyl p-hydroxybenzoate and 1, 2-hexanediol; further, the weight ratio of the bacteriostat is 1: (2.5-4) a mixture of 1, 2-hexanediol and tea polyphenols. The humectant is selected from butanediol, propylene glycol, PEG-7 glycerol cocoate, methyl glucitol polyether; the preservative is selected from phenoxyethanol and ethylhexyl glycerol.
In the hair-growing essence provided by the application, the plant extract accounts for 5-7% of the total weight of the hair-growing essence, and the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair-growing essence. The humectant accounts for 0.8-2.3% of the total weight of the hair growth essence; the antiseptic accounts for 0.2-0.7% of the total weight of the hair growth essence.
The preparation method of the hair growth essence comprises the following steps:
dissolving a bacteriostatic agent, a humectant and a preservative in a volume ratio of 1: (2.4-3.3) in water and ethanol, and heating the system to 75-85 ℃; sequentially adding folium Platycladi extract, herba Selaginellae Doederleinii extract, mori fructus extract, folium Pini extract, radix et caulis Opuntiae Dillenii extract, radix moutan extract, herba Erodii seu Geranii extract and flos Hibisci Sabdariffae extract into the system, wherein the time interval between the two plant extracts is 3-10min; cooling the system to 40-50deg.C after the addition, and stirring at the temperature for 0.5-1 hr; finally cooling to normal temperature to obtain the hair growth essence.
In this application, pine needle extract, cactus extract were purchased from western safety australian biotechnology limited; geranium extract was purchased from Cinnamomum camphora Biotechnology Co., ltd; the mulberry extract and the biota orientalis extract are purchased from the company of Siam Tianguangyuan biotechnology Co., ltd; peony root extract was purchased from Ningxia vanilla biotechnology Co., ltd; roselle extract, delphinium extract, pine needle extract, cactus extract (opuntia ficus-indica extract) were purchased from sienna swirley bioengineering limited; the CAS number of the tea polyphenol is 84650-60-2, and the purity is 98%; the CAS number of the 1, 2-pentanediol is 5343-92-0; the CAS number of the 1, 2-hexanediol is 6920-22-5; the remaining materials, solvents, etc. are commercially available.
The present application is described in further detail below in connection with examples, comparative examples and performance test.
Examples
Examples 1 to 8
Examples 1-8 provide a hair tonic respectively.
The above-described embodiments differ in that: the addition amounts of the components in the plant extracts are shown in Table 1.
The preparation method of the hair growth essence provided in the embodiment 2 specifically comprises the following steps:
(1) The plant extracts were weighed according to the addition amounts in table 1: 1.4g of geranium extract, 0.8g of roselle extract, 0.75g of biota orientalis extract, 0.5g of delphinium extract, 0.85g of mulberry extract, 0.5g of pine needle extract, 0.4g of cactus extract and 0.4g of peony root extract.
(2) 1.1g of bacteriostat (1, 2-pentanediol), 1.7g of humectant (butanediol) and 0.5g of preservative (phenoxyethanol and ethylhexyl glycerol with the mass ratio of 1:1) are dissolved in 100mL of solution with the volume ratio of 1:3 in water and ethanol, and heating the system to 80 ℃; sequentially adding folium Platycladi extract, herba Selaginellae Doederleinii extract, mori fructus extract, folium Pini extract, radix et caulis Opuntiae Dillenii extract, radix moutan extract, herba Erodii seu Geranii extract and flos Hibisci Sabdariffae extract into the system, wherein the time interval between the two plant extracts is 5min; cooling the system to 45 ℃ after the addition is finished, and stirring for 0.5h at the temperature; finally cooling to normal temperature to obtain the hair growth essence.
TABLE 1 addition of plant extract fraction components to the hair tonic concentrates provided in examples 1-8
Example 9
Example 9 was performed as in example 2, except that: the bacteriostat used in example 9 was 1, 2-hexanediol.
Example 10
Example 10 was performed as in example 2, except that: the bacteriostat used in example 10 was tea polyphenols.
Examples 11 to 14
Examples 11-14 provide a hair tonic respectively.
Examples 11-14 were conducted in accordance with the method of example 2 except that: the bacteriostat in the hair growth essence is a mixture of 1, 2-hexanediol and tea polyphenol, and the weight ratio of the 1, 2-hexanediol to the tea polyphenol is shown in table 2.
TABLE 2 weight ratio of the components of the bacteriostat in examples 11-14
Example 15
Example 15 was carried out as in example 2, except that: the bacteriostat used in example 15 was 1 by weight: 3.5 of 1, 2-pentanediol and tea polyphenols.
Example 16
Example 16 was carried out in the same manner as in example 12 except that: the amount of the bacteriostatic agent added in example 16 was 0.5g.
Example 17
Example 17 was conducted in accordance with the method of example 12 except that: the amount of the bacteriostatic agent added in example 17 was 1.8g.
Example 18
Example 18 was carried out as in example 12, except that: the amount of the bacteriostatic agent added in example 18 was 2.5g.
Comparative example
Comparative example 1
Comparative example 1 was conducted in accordance with the method of example 2 except that: the hair tonic essence provided in comparative example 1 was not added with a bacteriostatic agent.
Comparative example 2
Comparative example 2 was conducted in accordance with the method of example 2 except that: the geranium extract was not added to the plant extract of comparative example 2.
Comparative example 3
Comparative example 3 was conducted in accordance with the method of example 2 except that: the plant extract of comparative example 3 was not added with roselle extract.
Comparative example 4
Comparative example 4 was conducted in accordance with the method of example 2 except that: the geranium extract of example 2 was replaced with polygonum multiflorum extract and roselle extract with ginseng root extract.
Comparative example 5
Comparative example 5 was conducted as in example 2 except that: the geranium extract of example 2 was replaced with a desmodium extract (available from western safety australia biotechnology limited) and the roselle extract was replaced with a impatiens extract (available from western safety australia biotechnology limited).
Comparative example 6
Comparative example 6 was conducted in accordance with the method of example 2 except that: the addition amounts of the respective plant extracts in comparative example 6 were: 0.6g of geranium extract, 0.8g of roselle extract, 0.3g of biota orientalis extract, 0.5g of delphinium extract, 1.5g of mulberry extract, 0.8g of pine needle extract, 0.6g of cactus extract and 0.2g of peony root extract.
Comparative example 7
Comparative example 7 was conducted in accordance with the method of example 2 except that: the addition amounts of the respective plant extracts in comparative example 7 were: 2.4g of geranium extract, 0.2g of roselle extract, 0.75g of biota orientalis extract, 0.5g of delphinium extract, 0.25g of mulberry extract, 1.3g of pine needle extract, 1.1g of cactus extract and 0.4g of peony root extract.
Comparative example 8
The preparation method of the hair growth essence comprises the following steps:
(1) The plant extracts were weighed according to the addition amount of example 2 in table 1: 1.4g of geranium extract, 0.8g of roselle extract, 0.75g of biota orientalis extract, 0.5g of delphinium extract, 0.85g of mulberry extract, 0.5g of pine needle extract, 0.4g of cactus extract and 0.4g of peony root extract.
(2) 1.1g of bacteriostat (1, 2-pentanediol), 1.7g of (butanediol), and 0.5g of preservative (phenoxyethanol and ethylhexyl glycerol with the mass ratio of 1:1) are dissolved in 100mL of solution with the volume ratio of 1:3 in water and ethanol, and heating the system to 80 ℃; then adding the mixture of the plant extracts into the system at one time; cooling the system to 45 ℃ after the addition, and stirring for 0.5-1h at the temperature; finally cooling to normal temperature to obtain the hair growth essence.
Performance test
Mouse experiment
The hair growth effect of the hair growth essence provided in examples 1-18 and comparative examples 1-8 of the present application was examined by using a mouse test, and the experimental procedure is as follows:
(1) Test object: 81C 57BL/6 mice were randomly assigned to 27 groups of 3 mice.
(2) The test method comprises the following steps: the parallel vertebrae of the mice are taken as the long axis direction, the back hair of all the mice is firstly cut short, then the depilatory is coated, and then the depilatory is rubbed off, so that the skin of the back of the mice after the hair removal is pink, the surface is smooth, no crumbling and no melanin pigmentation are caused; the next day, a region of 2-2cm is selected as a tested region on the back of the mouse, the hair growth essence is smeared on the back of the mouse by using a cotton swab, and the mouse is smeared for 10min and then cleaned by using normal saline. Wherein, each of 26 groups is coated with hair growth essence provided by an example and a comparative example, and the test groups 1-26 and 1 are respectively coated with physiological saline as a control group; the coating is carried out for 28 days continuously by being coated once daily at regular time according to the coating mode.
(3) Detecting the index:
(1) the skin color change of the mice is observed and recorded every day, and the mice are photographed under the same light source, the skin basic physiological characteristics and the color change of the tested areas on the backs of the mice in each group are recorded, and the time T when the skin color of the tested areas changes from pink (resting period) to black (growing period) is recorded 1 And (b)The time T required for changing from black (growth phase) to grey (retrogradation phase) 2 。
(2) On day 28, 10 new hairs were randomly picked from the area of the back of the mice, and the length l was measured using a digital-percent vernier caliper and recorded.
(3) On day 28, the skin of the back test area of the mice was taken to have an area size of about 2cm×2cm, subjected to conventional tissue dehydration, paraffin embedding, slicing, HE staining (hematoxylin-eosin staining), and observed under a×100 microscope and counted for the total number of hair follicles in the cross section of the hair follicles of the mice.
(3) Test results: the results of the hair growth measurements for the 27 groups of mice are shown in Table 3 below: (the following data are taken as averages of the results of detection in each group of mice).
TABLE 3 Hair growth in group 27 mice
According to the detection results of the test groups 1-18 and the control group, the control group smears the back of the mouse by using normal saline, the number of hair follicles at the back of the mouse is only about 39 on the 28 th day, and the hair length is only about 4.26 cm; the hair growth liquid is used for smearing the back of the mouse, the back of the mouse can grow hair quickly, the hair length of the back of the mouse reaches more than 55cm on the 28 th day, and the hair follicle number reaches more than 60. Therefore, the hair growth essence provided by the application can activate hair follicle tissues, promote hair follicle conversion from telogen to anagen phase, promote hair growth and achieve the hair growth effect.
According to the detection results of the test groups 1-8 and 19-25, the hair growth essence capable of stimulating hair follicle tissues and promoting rapid hair growth is prepared by mixing a plant extract mixture such as geranium extract, roselle extract and the like with a bacteriostatic agent in the embodiment 1-8; in contrast, comparative examples 2 to 5, when one or both of geranium extract and roselle extract were not added, the obtained hair tonic did not improve the hair follicle tissue of the scalp. Further experimental study shows that the hair growth promoting effect and the hair follicle improving effect of the hair growth promoting essence obtained in examples 1-8 are obviously better than those of the hair growth promoting essence obtained in comparative examples 6-7, and the addition amount of each plant extract is controlled in the following range: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract, the obtained hair-growing essence can accelerate the growth rate of hair, promote the transformation of hair follicles from telogen to anagen phase, effectively activate hair follicle tissues and promote the growth of hair.
According to the detection results of the test group 2 and the test group 9-15, the hair growing rate, the hair length and the hair follicle number of the test group 11-15 mice are obviously superior to those of the test group 2 and the test group 9-10 mice, which shows that the hair growing effect of the hair growing essence prepared by using any two matched bacteriostats of 1, 2-hexanediol, 1, 2-pentanediol and tea polyphenol is superior to that of the hair growing essence prepared by using only one of the bacteriostats. Further comparing and finding that the skin of the test group 11-14 mice turns black from pink within 5-6 days and turns grey within 12-13 days, the number of hair follicles reaches more than 67, which indicates that the hair growth essence adopts the mixture of 1, 2-hexanediol and tea polyphenol as a bacteriostatic agent, can further improve the hair follicle environment of scalp, promote the hair follicle to be transformed into a growing period, and further accelerate the growth of hair.
As is clear from the test results of test groups 12 and 16 to 18, the hair length of the hair of the mice of example 2 and example 17 on day 28 is more than 8cm, and the number of hair follicles is more than or equal to 68; whereas the hair length of the test group 16 mice at day 28 was about 7.36cm, the number of hair follicles was 63-64; whereas the hair length of the test group 18 mice was about 6.92cm at day 28, the number of hair follicles was 66-67. Therefore, when the addition amount of the bacteriostat is controlled within the range of 1.1-1.8%, the obtained hair growth essence has better hair growth effect and hair follicle conversion effect.
From the test results of test group 2 and test group 26, it is evident that the test group 26 mice have a longer skin color change time after using the hair tonic essence provided in comparative example 8, and the hair length on day 28 is only about 5.16cm, and the number of hair follicles on day 28 is only about 52, which indicates that the hair tonic essence obtained by the preparation method of the hair tonic essence provided in comparative example 8 has a poor use effect. Therefore, the components of the plant extracts are sequentially added, the adding interval time of two adjacent components of the plant extracts is controlled to be 3-10min, so that the weakening of the efficacy of part of the extracts caused by long-time stirring can be avoided, the optimal synergistic effect of the plant extracts can be exerted, and the hair-growing effect of the hair-growing essence is better.
Hair growth effect test
The hair growth effect and the use comfort of the hair growth essence provided in example 17 of the present application were tested, and the results are shown in table 4.
(1) Searching 30 volunteers, wherein 10 volunteers are coated with the hair-growing essence provided in the application example 17, and the hair-growing essence is set as a group A, and 10 volunteers are coated with commercially available hair-growing liquid (the main components comprise polygonum multiflorum, glossy privet fruit, angelica sinensis, ginseng, ligusticum wallichii, ginger and cacumen biotae), and the hair-growing liquid is set as a group B; 10 volunteers were not suitable for any hair tonic, control group.
(2) The application method of the hair growth essence of the embodiment 17 comprises the following steps: the hair-growing essence is smeared on hair roots, and then the scalp is gently massaged by fingertips for 10min; is used once every 2 days, and the dosage is 2mL each time; the application method of the commercial hair growth promoting liquid is according to the instruction.
(3) The test period is 4 months, and the comfort level of each volunteer to the hair growth essence (whether the scalp is uncomfortable, such as greasy and itching) is recorded during the use process of the test; and the hair growth of volunteers was photographed by a micro camera before use, for 1 month, for 2 months and for 3 months, and evaluated for hair density.
TABLE 4 volunteer hair growth effect and use comfort test results
According to the test results of the hair growth effect and the comfort level, the hair growth essence provided in the embodiment 17 of the application has an excellent hair growth effect, can increase the hair by 24.8% in 4 months, and can be compared with experimental data of the group A and the group B, and the hair growth effect of the hair growth essence is slightly better than that of the commercially available hair growth essence.
In conclusion, the hair growth essence provided by the application can stimulate hair follicle tissues, promote hair follicle conversion from telogen to anagen, improve scalp environment, accelerate scalp blood circulation and further promote hair growth.
While the invention has been described in detail with respect to the general description and specific embodiments thereof, it will be apparent to those skilled in the art that various modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (4)
1. The hair-growing essence is characterized by comprising a plant extract, a bacteriostatic agent, a humectant, a preservative and a solvent; the plant extract comprises the following components in parts by weight: 1.15-2.1 parts of geranium extract, 0.5-1.15 parts of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract;
the bacteriostat is a mixture of 1,2 hexanediol and tea polyphenol, and the weight ratio of the 1,2 hexanediol to the tea polyphenol is 1: (2.5-4); the humectant is selected from butanediol, propylene glycol, PEG-7 glycerol cocoate and methyl glucitol polyether; the preservative is selected from phenoxyethanol and ethylhexyl glycerol;
the preparation method of the hair growth essence comprises the following steps: dissolving bacteriostatic agent, humectant and antiseptic in solvent, and heating the system to 75-85deg.C; then adding each plant extract into the system, wherein the time interval between every two plant extracts is 3-10min, and the geranium extract and the roselle extract are added at last; cooling the system to 40-50deg.C after the addition, and stirring at the temperature for 0.5-1 hr; finally cooling to normal temperature to obtain the hair growth essence.
2. The hair growth essence according to claim 1, wherein the plant extract comprises the following components in parts by weight: 1.4-1.8 parts of geranium extract, 0.5-0.8 part of roselle extract, 0.4-1 part of cacumen biotae extract, 0.25-0.5 part of delphinium extract, 0.75-1 part of mulberry extract, 0.3-0.6 part of pine needle extract, 0.25-0.5 part of cactus extract and 0.3-0.6 part of peony root extract.
3. The hair growth essence according to claim 1, wherein the bacteriostatic agent accounts for 1.1-1.8% of the total weight of the hair growth essence.
4. The hair growth essence according to claim 1, wherein the humectant accounts for 0.8-2.3% of the total weight of the hair growth essence; the antiseptic accounts for 0.2-0.7% of the total weight of the hair growth essence.
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