CN108272700A - A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies - Google Patents

Abstract

The present invention relates to a kind of compositions and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies.The composition is made of the raw material of following weight percent meter：Fructus Viticis extract 0.5~20%, mulberry bark extract 0.5~12%, Cacumen Platycladi extract 0.5~10%, cystine 0.2~2%, diguanosine tetraphosphate 0.2~2%, vitamin B6 1~2%, sesame oil 1~10%, moisturizer 1~5%, thickener 0.1~2%, preservative 0.01~1.0%, surplus are deionized water.Composition property of the present invention is mild, non-stimulated, can efficiently reduce epilation, prevents hair loss phenomenon, promotes the regeneration and growth of hair, has notable anti-dandruff and itching-relieving efficacies, and preparation method is simple, cost is relatively low.

Description

A kind of composition and preparation method thereof with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies

Technical field

The present invention relates to daily cosmetics fields, and in particular to a kind of combination with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies Object and preparation method thereof.

Background technology

The abuse of the hairdressings molded product such as the fast pace of modern life, the pressure of work and nervous, hair dyeing and hair-waving with And the factors such as diet and communication, keep depilation phenomenon more and more common, rejuvenation trend is presented, not only influences beauty, returns Spirit, the psychology of people generates large effect.Therefore, the research and development of anti-hair loss products more and more by world's medicine with The attention of cosmetics circle.

Alopecia is common trichonosis, including alopecia areata, alopecia seborrheica, androgenetic alopecia, psychogenic alopecia, old age Property alopecia and alopecia due to chemotherapy etc. are since certain factors cause hair especially with the incidence highest of alopecia areata and alopecia seborrheica Hair is entered the resting stage of hair growth by growth period too early, hair follicle and ball top atrophy, is become thin hair from terminal hair and is drawn It rises.Studies have shown that alopecia is with heredity except having outside the Pass, also with androgen levels, bacterium and fungal infection, endocrine disturbance, nutrition The factors such as bad, blood vessel microcirculation disorder, stress, stress reaction and drug side-effect are related.

Daily cosmetics about phalacrosis prevention and hair generation on the market are dazzling at present, and it is more to be mostly that product is added to Chemical substance, rapid-action, effect is apparent, but easily causes more side effect, such as allergic reaction.Therefore, natural activity Hair tonic ingredient is the characteristics of research now, and as active ingredient of natural plant extraction and separation technology becomes better and approaching perfection day by day, various functions Property active skull cap components are determined and apply to phalacrosis prevention and hair generation field, such as：Centella, ginseng, Radix Angelicae Sinensis, the tuber of multiflower knotweed, ginkgo, rat-tail The natural plant extracts such as grass and seaweeds.But these natural components have a single function, and to preventing hair loss, promote the effect of hair tonic not Significantly, and have the shortcomings that active ingredient preserves that unstable, extraction efficiency is not high.

Invention content

The purpose of the present invention is to provide a kind of hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies, the combination physical property Matter is mild, non-stimulated, can efficiently reduce epilation, prevents hair loss phenomenon, promotes the regeneration and growth of hair, has notable Anti-dandruff and itching-relieving efficacies, and preparation method is simple, cost is relatively low.

The present invention is by following technical solution to realize above-mentioned purpose：

It is a kind of with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition be made of the raw material of following weight percent meter：It is climing Chaste tree seed extract 0.5~20%, mulberry bark extract 0.5~12%, Cacumen Platycladi extract 0.5~10%, cystine 0.2~ 2%, diguanosine tetraphosphate 0.2~2%, vitamin B6 1~2%, sesame oil 1~10%, moisturizer 1~5%, thickener 0.1~ 2%, preservative 0.01~1.0%, surplus are deionized water.

Further, the sesame oil is prepared by the raw material of following weight percent meter：It is rice chaff oil 5~10%, pungent The smooth oleate 1~8% of acid/Triglyceride DDD 1~5%, phosphatidase 1~8%, sorb, Phenoxyethanol 0.1~1% and water 68~ 80%.

Further, the moisturizer is polyalcohols, polysaccharide, natural silk peptide, NMF-50, saualane and pyrrolidines At least one of ketone acid sodium；

The thickener is at least one in xanthan gum, guar gum, carragheen, gellan gum, cellulose, card wave class Kind；

The preservative is dimethyl isothiazolinone, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen At least one of ethyl alcohol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDM hydantoin.

In addition, the present invention also provides a kind of preparation method of the composition, include the following steps：

(1) it takes thickener and water to mix, is warming up to 85 DEG C, stirs evenly, after material is completely dissolved, keep the temperature 30min；

(2) 50 DEG C are cooled to, Fructus Viticis extract, mulberry bark extract, Cacumen Platycladi extract, sesame oil and guarantor are sequentially added Humectant, 1500~2000r/min homogeneous, 6~12min；

(3) continue to be cooled to 40 DEG C, sequentially add cystine, diguanosine tetraphosphate, vitamin B6 and preservative, fully stir Mix uniformly to get.

Wherein, the preparation method of the Fructus Viticis extract includes the following steps：Fresh fructus viticis is taken to dry, pulverize, Cross 10~15 mesh sieve, the ethyl alcohol that 8~10 times of raw material weight amount volume fractions are 70% be added, add raw material total amount 0.8~ 1.2% cellulase extracts 1~2h, then in 80~90 DEG C of condition 2~3h of refluxing extraction, mistake under the conditions of 38~45 DEG C Filtrate is carried out vacuum-concentrcted drying to get Fructus Viticis extract by filter, and it is 5000U/g that the ratio of cellulase, which is lived,.

Wherein, the preparation method of the mulberry bark extract includes the following steps：The fresh root bark of white mulberry is taken to dry, pulverize, 10~15 mesh sieve is crossed, coarse powder is placed in supercritical carbon dioxide extraction apparatus, 30~45% volume fraction of coarse powder total amount is added For 60~85% ethyl alcohol, regulation and control carbon dioxide flow is 15~20L/h, and extracting pressure is 15~20MPa, extraction temperature 40 ~60 DEG C, extraction time is 1.5~2h, and mulberry bark extract is made in decompression separation.

Wherein, the preparation method of the Cacumen Platycladi extract includes the following steps：Fresh cacumen biotae is taken to dry, pulverize, 10~15 mesh sieve is crossed, the ethyl alcohol that 8~10 times of amount volume fractions of raw material weight are 70% is added, is continuously carried under the conditions of 60~70 DEG C It takes 2~3 times, 3~4h, is filtered, merging filtrate every time；The carboxymethyl starch adsorbent of filtrate weight 5% is added into filtrate, stirs It mixes uniformly, stands 12h under room temperature, be filtered to remove contamination precipitation；Filtered fluid after removing contamination precipitation is carried out vacuum to subtract Pressure is concentrated and dried to get Cacumen Platycladi extract.

Composition of the present invention with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies can be used directly, can also conduct Main component is used to prepare the products such as shampoo class, hair conditioner (breast) class, hair-care essence liquid.

Composition of the present invention with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies is carried with Fructus Viticis extract, the root bark of white mulberry Take object and Cacumen Platycladi extract as main active.Wherein, Fructus Viticis extract comes from plant fructus viticis, and fructus viticis is horse The fruit of Bian Cao sections plant Vitex rotundifolia, cold nature, acrid flavour, hardship, dispelling wind and heat from the body, head clearing, for anemopyretic cold headache, tooth Gum swelling and pain, the more tears of hot eyes, mesh are secretly unknown, have a dizzy spell.Wherein, mulberry bark extract comes from the plant root bark of white mulberry, and the root bark of white mulberry is mulberry The dry bark of section plant mulberry, property is sweet, cold, distributed in lung channel, removing heat from lung and relieving asthma, inducing diuresis for removing edema, is used for dyspnea and cough due to lung-heat, oedema turgor urine It is few, appearance skin edema.Wherein, Cacumen Platycladi extract comes from plant cacumen biotae, and cacumen biotae is the drying branch of cupressaceae plant arbor-vitae The tip and leaf, matter is crisp, frangibility, gas faint scent, bitter and puckery flavor, micro- core, and property is bitter, puckery, cold, return lung, liver, the spleen channel, cooling blood and hemostasis, and resolving sputum stops Cough, growing and blacking hair, for spitting blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood is had blood in stool, metrostaxis, cough with lung heat, blood-head alopecia, poliosis.

In addition, the composition of the present invention with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies is aided with addition cystine, four phosphorus Sour two guanosines, vitamin B6 assign hair root living from nutrition mechanism is restored, and the angle for nourishing hair matricyte and hair is set out, and head is moistened Skin promotes the regeneration and growth of hair.

The diguanosine tetraphosphate (GP4G) is a kind of cellular energy element extracted from halomereid, can be fast Speed supplements energy to cell, activates various physiological activities and the metabolism of Skin Cell, and with work(DNA protections and repaired Energy.

The vitamin B6 participates in body metabolism, acts on hair by blood circulation, can prevent epilation, reduces White hair is grown.

Composition of the present invention with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies is aided with addition sesame oil, the sesame oil Property micro-sweet, cool, there is the effect of solution taking poison and growing muscle due.《Draft detailed outline》In it is also on the books, Li Shizhen (1518-1593 A.D.) is said：It is upper to be used as medicine with black sesame oil, Hemp oil takes second place.

Composition of the present invention with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies is aided with addition cystine, cystine association The formation of skin is helped, and critically important to detoxication, by the ability for lowering body absorption copper, cystine protects cell from copper Poisoning, can also promote cell Redox, keep liver function vigorous, promote leucocyte hyperplasia, and pathogen is prevented to develop.

Compared with prior art, beneficial effects of the present invention are to provide one kind having hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies Composition, the composition property is mild, and non-stimulated, each component is mutually coordinated, mutual gain, improve microcirculation, promote Cytothesis can efficiently reduce epilation, prevent hair loss phenomenon, promote the regeneration and growth of hair, and using effect is notable, Securely and reliably, and there are notable anti-dandruff and itching-relieving efficacies, and preparation method is simple, cost is relatively low.

Specific implementation mode

The present invention is further described below by way of specific implementation mode, but the present invention is not limited only to following embodiment.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of embodiment 1

The embodiment of the present invention 1 have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 12%, mulberry bark extract 8%, Cacumen Platycladi extract 6%, cystine 1.0%, tetraphosphate two Guanosine 1.5%, vitamin B6 2%, sesame oil 6%, moisturizer 3%, thickener 0.5%, preservative 0.2%, surplus are deionization Water.

Preparation method：

(1) preparation of Fructus Viticis extract：It takes fresh fructus viticis complete stool dry, pulverize, crosses 15 mesh sieve, raw material weight is added The ethyl alcohol that 10 times of amount volume fractions of amount are 70%, adds the cellulase of raw material total amount 1.2%, is extracted under the conditions of 45 DEG C 2h, then in 90 DEG C of condition refluxing extraction 3h, filtrate is carried out vacuum-concentrcted and dried to get Fructus Viticis extract by filtering, It is 5000U/g that the ratio of its cellulase, which is lived,.

(2) preparation of mulberry bark extract：It takes the fresh root bark of white mulberry dry, pulverize, crosses 15 mesh sieve, coarse powder is placed in super face In boundary's carbon dioxide extraction apparatus, the ethyl alcohol that 45% volume fraction of coarse powder total amount is 60% is added, regulation and control carbon dioxide flow is 20L/h, extracting pressure 20MPa, extraction temperature are 40 DEG C, and mulberry bark extract is made in extraction time 2h, decompression separation.

(3) preparation of Cacumen Platycladi extract：It takes fresh cacumen biotae dry, pulverize, crosses 15 mesh sieve, raw material weight 10 is added The ethyl alcohol that amount volume fraction is 70% again, is continuously extracted 3 times, each 3h under the conditions of 70 DEG C, is filtered, merging filtrate；Toward filtrate The middle adsorbent that filtrate weight 5% is added, stirs evenly, stands 12h under room temperature, be filtered to remove contamination precipitation；It will remove Filtered fluid after contamination precipitation carries out vacuum-concentrcted and dries to get Cacumen Platycladi extract.

(4) preparation of anti-shed hair growth liquid：

1 takes thickener and water to mix, and is warming up to 85 DEG C, stirs evenly, and after material is completely dissolved, keeps the temperature 30min；

2 are cooled to 50 DEG C, sequentially add Fructus Viticis extract, mulberry bark extract, Cacumen Platycladi extract, sesame oil and moisturizing Agent, 2000r/min homogeneous 6min；

3 continue to be cooled to 40 DEG C, sequentially add cystine, diguanosine tetraphosphate, vitamin B6 and preservative, are sufficiently stirred Uniformly to get.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of embodiment 2

The embodiment of the present invention 2 have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 20%, mulberry bark extract 0.5%, Cacumen Platycladi extract 8%, cystine 2%, tetraphosphate two Guanosine 0.2%, vitamin B6 1%, sesame oil 10%, moisturizer 5%, thickener 2%, preservative 0.01%, surplus are deionization Water.

Preparation method：

(1) preparation of Fructus Viticis extract：It takes fresh fructus viticis complete stool dry, pulverize, crosses 10 mesh sieve, raw material weight is added The ethyl alcohol that 8 times of amount volume fractions of amount are 70%, adds the cellulase of raw material total amount 0.8%, 1h is extracted under the conditions of 38 DEG C, Then in 80 DEG C of condition refluxing extraction 2h, filtrate is carried out vacuum-concentrcted and dried to get Fructus Viticis extract by filtering, It is 5000U/g that the ratio of cellulase, which is lived,.

(2) preparation of mulberry bark extract：It takes the fresh root bark of white mulberry dry, pulverize, crosses 10 mesh sieve, coarse powder is placed in super face In boundary's carbon dioxide extraction apparatus, the ethyl alcohol that 30% volume fraction of coarse powder total amount is 85% is added, regulation and control carbon dioxide flow is 15L/h, extracting pressure 15MPa, extraction temperature are 60 DEG C, extraction time 1.5h, and root bark of white mulberry extraction is made in decompression separation Object.

(3) preparation of Cacumen Platycladi extract：It takes fresh cacumen biotae dry, pulverize, crosses 10 mesh sieve, raw material weight 8 is added The ethyl alcohol that amount volume fraction is 70% again, is continuously extracted 2 times, each 4h under the conditions of 60 DEG C, is filtered, merging filtrate；Toward filtrate The middle adsorbent that filtrate weight 5% is added, stirs evenly, stands 12h under room temperature, be filtered to remove contamination precipitation；It will remove Filtered fluid after contamination precipitation carries out vacuum-concentrcted and dries to get Cacumen Platycladi extract.

(4) preparation of anti-shed hair growth liquid：

1 takes thickener and water to mix, and is warming up to 85 DEG C, stirs evenly, and after material is completely dissolved, keeps the temperature 30min；

2 are cooled to 50 DEG C, sequentially add Fructus Viticis extract, mulberry bark extract, Cacumen Platycladi extract, sesame oil and moisturizing Agent, 1500r/min homogeneous 12min；

3 continue to be cooled to 40 DEG C, sequentially add cystine, diguanosine tetraphosphate, vitamin B6 and preservative, are sufficiently stirred Uniformly to get.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of embodiment 3

The embodiment of the present invention 3 have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 8%, mulberry bark extract 12%, Cacumen Platycladi extract 0.5%, cystine 0.6%, tetraphosphate Two guanosines 2%, vitamin B6 1.5%, sesame oil 4%, moisturizer 2%, thickener 1%, preservative 1%, surplus are deionized water.

Preparation method reference implementation example 1.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of embodiment 4

The embodiment of the present invention 4 have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 0.5%, mulberry bark extract 6%, Cacumen Platycladi extract 2%, cystine 0.2%, tetraphosphate two Guanosine 1%, vitamin B6 1%, sesame oil 1%, moisturizer 1%, thickener 0.1%, preservative 0.5%, surplus are deionized water.

Preparation method reference implementation example 1.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of comparative example 1

Comparative example 1 of the present invention have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 12%, mulberry bark extract 8%, Cacumen Platycladi extract 6%, cystine 1.0%, tetraphosphate two Guanosine 1.5%, vitamin B6 2%, moisturizer 3%, thickener 0.5%, preservative 0.2%, surplus are deionized water.

Preparation method reference implementation example 1, difference lies in do not add sesame oil with embodiment 1 for this comparative example.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of comparative example 2

Comparative example 2 of the present invention have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Mulberry bark extract 12%, Cacumen Platycladi extract 8%, cystine 1.0%, diguanosine tetraphosphate 1.5%, vitamin B62%, sesame oil 6%, moisturizer 3%, thickener 0.5%, preservative 0.2%, surplus are deionized water.

Preparation method reference implementation example 1, this comparative example and embodiment 1 difference lies in not adding Fructus Viticis extract, and The corresponding ratio for increasing mulberry bark extract and Cacumen Platycladi extract.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of comparative example 3

Comparative example 3 of the present invention have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 12%, mulberry bark extract 8%, Cacumen Platycladi extract 6%, cystine 1.0%, vitamin B62%, sesame oil 6%, moisturizer 3%, thickener 0.5%, preservative 0.2%, surplus are deionized water.

Preparation method reference implementation example 1, difference lies in do not add diguanosine tetraphosphate with embodiment 1 for this comparative example.

A kind of preparation with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of comparative example 4

Comparative example 4 of the present invention have hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies composition by following weight percent meter original Material composition：Fructus Viticis extract 12%, mulberry bark extract 8%, Cacumen Platycladi extract 6%, cystine 1.0%, sesame oil 6%, Moisturizer 3%, thickener 0.5%, preservative 0.2%, surplus are deionized water.

Preparation method reference implementation example 1, difference lies in do not add vitamin B6 with embodiment 1 for this comparative example.

Test example one, skin irritation test

100 volunteers are screened, at 20~50 years old age, men and women is fifty-fifty, and all volunteers are without dermatopathy, experiment position Skin it is completely normal.According to Ministry of Health of the People's Republic of China《Cosmetics health specification》The base of middle human skin patch This principle and method, to the group with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies made from 1-4 of the embodiment of the present invention and comparative example 1-4 It closes object and carries out human skin patch, specially：Composition is diluted to 1% aqueous solution, as given the test agent；Use syringe It takes 0.025ml sample drops to be added on filter paper appended by spot examination device, is placed in spot examination device.Spot examination device is affixed on subject back, together When one by one light pressing room and trier is made to be uniformly distributed to drive away air, remove given the test agent afterwards for 24 hours, knot observed after 30min Fruit for 24 hours, 48h repeated observations, and makees blank control.

Wherein skin irritation test standard of perfection is：0 grade：It is non-stimulated, without erythema；1 grade：Slight erythema；2 grades：Erythema； 3 grades：Erythema, papule, blister；4 grades：Serious edema, bulla, the results are shown in Table 1.

A kind of Skin Irritation Test result with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies of 1 present invention of table

The results show that it is provided by the invention it is a kind of have hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies is stingless to skin Swash, erythema will not be caused, it is safe.

Test example two, the experiment of phalacrosis prevention and hair generation effect assessment

The alopecia seborrheica volunteer patients and each 450 of alopecia areata volunteer patients of screening clinical definite, 25~55 years old age, In, male's alopecia seborrheica volunteer patients 360, women alopecia seborrheica volunteer patients 90；Male's alopecia areata volunteer patients 315 Example, women alopecia areata volunteer patients 135.Alopecia seborrheica volunteer patients and alopecia areata volunteer patients are randomly divided into control respectively Group, embodiment 1-4 combination comparative example 1-4 groups, every group 50.Wherein, control group gives commercially available overlord's hair nourishing liquid, takes every time about 5ml is uniformly applied to volunteer patients' alopecia position, and suitably massages to promote to absorb, 1~2 times/day；Embodiment 1-4 combinations pair Ratio 1-4 groups give volunteer patients respectively to be had hair-loss preventing and hair-restoring, is gone using what 3-6 of the embodiment of the present invention and comparative example 1-4 was provided Consider the composition of itching-relieving efficacies to be worth doing, 1~2 times/day, composition, is applied to the position for needing hair tonic, then massaged by about 2ml every time 5min, then washed off with clear water, with 2 months for 1 course for the treatment of, 2 courses for the treatment of are persistently used, observe curative effect.

The standard of curative effect evaluation is：1) it fully recovers：Hair stopping falls off, newly hair is all grown, distribution density, thickness, color and luster Identical as the areas Jian Fa, sebum secretion restores normal.2) effective：Hair stopping falls off, and up to 70% or more, distribution is close for new hair regeneration Close to the areas Jian Fa, sebum secretion significantly reduces for degree, thickness, color and luster.3) effectively：Hair stopping falls off, new hair regeneration up to 30% with On, including fine hair on birds or animals hair and white hair grow.4) invalid：New hair regeneration is less than 30% or continues to take off originator.It the results are shown in Table 2 and table 3.

Phalacrosis prevention and hair generation effect of 2 present composition of table to alopecia seborrheica volunteer patients

Group	It cures	It is effective	Effectively	In vain	Efficient (%)
						Control group	17	23	4	6	88
Embodiment 1	19	21	6	4	92
						Embodiment 2	17	22	6	5	90
Embodiment 3	16	24	4	6	88
						Embodiment 4	14	25	3	8	84
Comparative example 1	8	10	14	18	64
						Comparative example 2	10	14	12	14	72
Comparative example 3	12	19	8	11	78
						Comparative example 4	12	17	9	12	76

Phalacrosis prevention and hair generation effect of 3 present composition of table to alopecia areata volunteer patients

The results show that composition made from 1-4 of the embodiment of the present invention suffers from alopecia seborrheica volunteer patients and alopecia areata aspiration Person all has preferable phalacrosis prevention and hair generation effect, and effective percentage is up to 80% or more, wherein composition is to fat made from Examples 1 and 2 The phalacrosis prevention and hair generation effect of excessive property alopecia volunteer patients and alopecia areata volunteer patients are superior to commercially available overlord's hair nourishing liquid.And comparative example 1-4 The decrease with obvious effects of composition phalacrosis prevention and hair generation obtained, it is especially worst with composition phalacrosis prevention and hair generation effect made from comparative example 1.

Test example three, the experiment of scalp care efficacy assessments

Screen the trial volunteer of 450 problems of itching with dandruff, head, 25~55 years old age, wherein male 180, female Property 270.Trial volunteer is randomly divided into control group, embodiment 3-6 groups and comparative example 1-4 groups, every group 50.Control group is given Commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo is given, about 1ml is taken every time, is uniformly applied to hair, and is suitably massaged to promote Into absorption, then cleaned with clear water, 1 times/day；Embodiment 1-4 groups and comparative example 1-4 groups give 1-4 of the embodiment of the present invention respectively The composition provided with comparative example 1-4, daily external application 1 time, about 1ml, is uniformly applied to hair, and suitably press by composition every time It rubs to promote to absorb, is then cleaned with clear water, is used continuously 15, evaluating dandruff and head and itching improves situation, the results are shown in Table 4.

4 present composition scalp care effect assessment result of table

The results show that composition made from 1-4 of the embodiment of the present invention has preferable hair nursing effect, can substantially reduce Dandruff and head are itched, and effect is superior to commercially available Paris L'Oreal hyaluronic acid anti-dandruff shampoo, and dandruff and head will not be caused to itch increasing Add.And the decrease with obvious effects of composition hair nursing made from comparative example 1-4, especially with composition head made from comparative example 1 It is worst to send out nursing efficacy.

It the above is only the preferred embodiment of the present invention, it is noted that the above embodiment is not construed as to this hair Bright limitation, protection scope of the present invention should be subject to claim limited range.For the common of the art For technical staff, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these improve and Retouching also should be regarded as protection scope of the present invention.

Claims (6)

1. a kind of composition with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies, which is characterized in that the composition is by following weight The raw material of percentages forms：Fructus Viticis extract 0.5~20%, mulberry bark extract 0.5~12%, Cacumen Platycladi extract 0.5~10%, cystine 0.2~2%, diguanosine tetraphosphate 0.2~2%, vitamin B6 1~2%, sesame oil 1~10%, moisturizing Agent 1~5%, thickener 0.1~2%, preservative 0.01~1.0%, surplus are deionized water.

2. a kind of composition with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies according to claim 1, which is characterized in that institute The composition stated is made of the raw material of following weight percent meter：Fructus Viticis extract 12%, mulberry bark extract 8%, arbor-vitae Leaf extract 6%, cystine 1.0%, diguanosine tetraphosphate 1.5%, vitamin B6 2%, sesame oil 6%, moisturizer 3%, thickening Agent 0.5%, preservative 0.2%, surplus are deionized water.

3. a kind of composition with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies according to claim 1 or 2, which is characterized in that

The moisturizer be polyalcohols, polysaccharide, natural silk peptide, NMF-50, saualane and pyrrolidines ketone acid sodium in extremely Few one kind；

The thickener is at least one of xanthan gum, guar gum, carragheen, gellan gum, cellulose, card wave class；

The preservative is dimethyl isothiazolinone, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen second At least one of alcohol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDM hydantoin.

4. a kind of composition with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies according to claim 1, which is characterized in that institute The preparation method for stating composition includes the following steps：

(1) it takes thickener and water to mix, is warming up to 85 DEG C, stirs evenly, after material is completely dissolved, keep the temperature 30min；

(2) 50 DEG C are cooled to, Fructus Viticis extract, mulberry bark extract, Cacumen Platycladi extract, sesame oil and moisturizing are sequentially added Agent, 1500~2000r/min homogeneous, 6~12min；

(3) continue to be cooled to 40 DEG C, sequentially add cystine, diguanosine tetraphosphate, vitamin B6 and preservative, be sufficiently stirred It is even to get.

5. a kind of composition with hair-loss preventing and hair-restoring, anti-dandruff and itching-relieving efficacies according to claim 1-4, which is characterized in that The preparation method of the Fructus Viticis extract includes the following steps：It takes fresh fructus viticis dry, pulverize, crosses 10~15 mesh sieve, The ethyl alcohol that 8~10 times of amount volume fractions of raw material weight are 70% is added, adds the cellulase of raw material total amount 0.8~1.2%, 1~2h is extracted under the conditions of 38~45 DEG C, then in 80~90 DEG C of condition 2~3h of refluxing extraction, filtrate is carried out vacuum by filtering Drying is concentrated under reduced pressure to get Fructus Viticis extract, it is 5000U/g that the ratio of cellulase, which is lived,；

The preparation method of the mulberry bark extract includes the following steps：It takes the fresh root bark of white mulberry dry, pulverize, crosses 10~15 mesh Sieve, coarse powder is placed in supercritical carbon dioxide extraction apparatus, and it is 60~85% that 30~45% volume fraction of coarse powder total amount, which is added, Ethyl alcohol, regulation and control carbon dioxide flow be 15~20L/h, extracting pressure be 15~20MPa, extraction temperature be 40~60 DEG C, extraction It is 1.5~2h to take the time, and mulberry bark extract is made in decompression separation；

The preparation method of the Cacumen Platycladi extract includes the following steps：It takes fresh cacumen biotae dry, pulverize, crosses 10~15 mesh Sieve is added the ethyl alcohol that 8~10 times of amount volume fractions of raw material weight are 70%, is continuously extracted under the conditions of 60~70 DEG C 2~3 times, 3~4h every time, filtering, merging filtrate；The carboxymethyl starch adsorbent of filtrate weight 5% is added into filtrate, stirs evenly, room 12h is stood under the conditions of temperature, is filtered to remove contamination precipitation；Filtered fluid after removing contamination precipitation is carried out vacuum-concentrcted to do It is dry to get Cacumen Platycladi extract.

6. a kind of preparing the method according to any one of claims 1 to 5 with hair-loss preventing and hair-restoring, the composition of anti-dandruff and itching-relieving efficacies, It is characterized by comprising the following steps：

(1) it takes thickener and water to mix, is warming up to 85 DEG C, stirs evenly, after material is completely dissolved, keep the temperature 30min；

(2) 50 DEG C are cooled to, Fructus Viticis extract, mulberry bark extract, Cacumen Platycladi extract, sesame oil and moisturizing are sequentially added Agent, 1500~2000r/min homogeneous, 6~12min；

(3) continue to be cooled to 40 DEG C, sequentially add cystine, diguanosine tetraphosphate, vitamin B6 and preservative, be sufficiently stirred It is even to get.