CN116172928A - Composition suitable for sensitive muscles and having moisturizing, anti-wrinkle and tightening effects and application thereof - Google Patents

Abstract

The invention discloses a composition suitable for sensitive muscles and having the effects of moisturizing, anti-wrinkle and tightening, which comprises the following components: glycerol, trehalose, 1, 3-propanediol, sodium hyaluronate, octyldodecanol, polydimethylsiloxane, tetrahydropyrimidine carboxylic acid, dipotassium glycyrrhizinate, cyclodextrin/centella asiatica extract, lysates of the fermentation products of the two yeasts/phenoxyethanol/sodium benzoate, butylene glycol/water/centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/licorice glabra extract/chamomile extract/rosemary leaf extract, water/butylene glycol/tremella polysaccharide, isopentylene glycol/p-hydroxyacetophenone/1, 2-hexanediol; also comprises glycerin/water/soapberry leaf/root extract/potassium sorbate/sodium benzoate and butylene glycol/water/perilla leaf extract. The essence prepared by the composition has effects of increasing skin moisture content, reducing head line and fish tail line length, and reducing skin compactness R0 value.

Description

Composition suitable for sensitive muscles and having moisturizing, anti-wrinkle and tightening effects and application thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a composition suitable for sensitive muscles and having the effects of moisturizing, anti-wrinkle and tightening and application thereof.

Background

Sensitive skin is a skin state which is easy to sensitize and highly intolerant, and the skin is easy to redness, swelling or stinging and easy to rash or acne under the conditions of external stimulus and environmental change. But also has the problems of poor water retention capability, relatively tight and dry skin, easy acne mark leaving after inflammation is removed, and the like. In the sensitive muscle skin, the skin sensitivity degree of the ultra-seven sensitive muscle women is weak or mild, and the near-three sensitive muscle women have sensitive symptoms such as red swelling, inflammation and the like.

Therefore, aiming at sensitive muscle groups, the skin care product with the effects of moisturizing, resisting wrinkles and tightening is developed, and the skin care product has a very good application prospect.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a composition which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and an application thereof.

The invention aims at realizing the following technical scheme:

in a first aspect, the invention provides a composition suitable for sensitive muscles and having moisturizing, anti-wrinkle and tightening effects, which comprises the following components in parts by weight: 1 to 6 parts of glycerin, 0.1 to 2 parts of trehalose, 2 to 5 parts of 1, 3-propanediol, 0.005 to 0.015 part of sodium hyaluronate, 0.1 to 1 part of octyl dodecanol, 0.5 to 2 parts of polydimethylsiloxane, 0.1 to 0.2 part of tetrahydropyrimidine carboxylic acid, 0.1 to 0.2 part of dipotassium glycyrrhizinate, 0.1 to 0.3 part of cyclodextrin/centella asiatica extract, 5 to 10 parts of a lysis yeast fermentation product lysate/phenoxyethanol/sodium benzoate, 0.5 to 2 parts of butanediol/water/centella asiatica extract/polygonum cuspidatum root extract/radix scutellariae extract/licorice root extract/chamomile extract/rosemary leaf extract, 2 to 5 parts of water/butanediol/polysaccharide, and 1 to 3 parts of isovalerate/p-hydroxyacetophenone/1, 2-hexanediol.

As a preferred scheme, the composition comprises the following components in parts by weight: 3 parts of glycerin, 0.5 part of trehalose, 3 parts of 1, 3-propanediol, 0.01 part of sodium hyaluronate, 0.4 part of octyl dodecanol, 1 part of polydimethylsiloxane, 0.1 part of tetrahydropyrimidine carboxylic acid, 0.1 part of dipotassium glycyrrhizinate, 0.1 part of cyclodextrin/centella asiatica extract, 8 parts of a lysate of a fermentation product of two-split yeast, phenoxyethanol/sodium benzoate, 1 part of butanediol/water/centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/licorice glabra extract/chamomile flower extract/rosemary leaf extract, 3 parts of water/butanediol/tremella polysaccharide, and 2.5 parts of isopentyl glycol/p-hydroxyacetophenone/1, 2-hexanediol.

Preferably, the mass ratio of the cyclodextrin to the centella asiatica extract is 15.5%.

As a preferred scheme, the mass ratio of the butanediol to the water to the centella asiatica extract to the polygonum cuspidatum root extract to the baical skullcap root extract to the tea extract to the glabra licorice extract to the mother chrysanthemum extract to the rosemary leaf extract is 5:2:2:1:1:0.5:0.5.

Preferably, the mass ratio of the lysate of the fermentation product of the saccharomyces cerevisiae to the phenoxyethanol to the sodium benzoate is 98.75 percent.

In the preferred scheme, in the water/butanediol/tremella polysaccharide, the mass ratio of tremella polysaccharide is 0.2%.

Preferably, the composition further comprises 1-3 parts of glycerin/water/soapberry leaf/root extract/potassium sorbate/sodium benzoate and 3-6 parts of butylene glycol/water/perilla leaf extract. The addition of the added soapberry leaf/root extract and the perilla leaf extract further improves the anti-wrinkle and tightening effects of the composition.

Preferably, the composition further comprises 2 parts of glycerin/water/soapberry leaf/root extract/potassium sorbate/sodium benzoate and 5 parts of butylene glycol/water/perilla leaf extract.

In a second aspect, the invention provides the use of a composition having moisturizing, anti-wrinkle and tightening effects for sensitive muscles in the preparation of a cosmetic.

Preferably, the cosmetic is in the form of cream, emulsion, water aqua, essence, facial mask, gel, base makeup, spray or face cleaning product.

In a third aspect, the invention provides a moisture-preserving, anti-wrinkle and tightening essence for sensitive muscles, comprising the composition with moisture-preserving, anti-wrinkle and tightening effects.

As a preferred scheme, the essence also comprises the following components: at least one of solvent, chelating agent, thickener, emulsifier, pH regulator, solubilizer, and perfume.

Preferably, the solvent is water;

the chelating agent is disodium EDTA;

the thickener is at least one selected from acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum and acrylamide dimethyl taurate/VP copolymer;

the emulsifier is PEG-20 methyl glucose sesquistearate;

the pH regulator is tromethamine;

the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water;

the aromatic is castor oil/North African cedar bark oil.

As a preferred scheme, the essence also comprises the following components in parts by weight:

50-90 parts of water, 0.01-0.05 part of EDTA disodium, 0.05-0.2 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.03-0.1 part of xanthan gum, 0.3-0.7 part of acrylamide dimethyl taurate/VP copolymer, 0.3-0.5 part of PEG-20 methyl glucose sesquistearate, 0.1-0.2 part of tromethamine, 0.1-0.2 part of PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water and 0.04-0.06 part of castor oil/North African cedar bark oil.

In a fourth aspect, the invention provides a preparation method of essence with moisturizing, anti-wrinkle and tightening effects, which is suitable for sensitive muscles, and comprises the following steps:

s1, mixing a solvent, a chelating agent, a thickener, glycerol, trehalose, 1, 3-propylene glycol and sodium hyaluronate, and uniformly stirring to obtain a phase A;

s2, mixing an emulsifier, octyl dodecanol, polydimethylsiloxane and a solubilizer, and uniformly stirring to obtain a phase B;

s3, dissolving the pH regulator with water to form a C phase;

s4, dissolving dipotassium glycyrrhizinate, cyclodextrin/centella asiatica extract and tetrahydropyrimidine carboxylic acid by using a solvent to form a phase D;

s5, mixing a lysate of a fermentation product of the saccharomyces cerevisiae, phenoxyethanol, sodium benzoate, butanediol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra extract, chamomile flower extract, rosemary leaf extract, water, butanediol, tremella polysaccharide, glycerol, water, soapy leaves, root extract, potassium sorbate, sodium benzoate, butanediol, water, perilla leaf extract, isopentyl glycol, p-hydroxyacetophenone, 1, 2-hexanediol and an aromatic agent, and uniformly stirring to obtain an E phase;

and S6, sequentially adding the phase B, the phase C, the phase D and the phase E into the phase A, stirring, cooling, and defoaming to obtain the moisturizing and anti-wrinkle essence.

Compared with the prior art, the invention has the following beneficial effects:

the invention prepares the composition which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening by adopting the combination of a two-split yeast fermentation product lysate, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra extract, chamomile extract, rosemary leaf extract and tremella polysaccharide and other functional components. And further, by adding the soapberry leaf extract and the perilla extract, the synergistic effect is generated between the soapberry leaf extract and the lysate of the fermentation product of the two-split yeast, the centella asiatica extract, the polygonum cuspidatum root extract, the scutellaria baicalensis root extract, the tea extract, the glycyrrhiza glabra extract, the chamomile extract, the rosemary leaf extract and the tremella polysaccharide, the anti-wrinkle and tightening effects are further improved, the improvement rate of the head lifting line length is up to 9.07 percent (after 2 weeks of use) and 7.56 percent (after 4 weeks of use), the improvement rate of the fish tail line length is up to 12.19 percent (after 2 weeks of use) and 13.99 percent (after 4 weeks of use), and the improvement rate of the skin tightening R0 value is up to 13.57 percent (after 2 weeks of use) and 18.96 percent (after 4 weeks of use), and the improvement rate of the skin tightening R0 value is statistically significant compared with the basic value (P value is less than 0.01).

Drawings

Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which:

FIG. 1 is a graph showing the results of skin moisture content measured using the moisturizing anti-wrinkle essence prepared in example 4; the figures show that there is a statistical difference from the basal value, P values < 0.001 are marked "/x", 0.001 +.p values < 0.01 are marked "/x", 0.01 +.p values < 0.05 are marked "/x";

FIG. 2 is a graph showing the result of the length of the head line measured using the moisturizing anti-wrinkle essence prepared in example 4; the figures show that there is a statistical difference from the basal value, P values < 0.001 are marked "/x", 0.001 +.p values < 0.01 are marked "/x", 0.01 +.p values < 0.05 are marked "/x";

FIG. 3 is a graph showing the length of fish tail measured using the moisturizing anti-wrinkle concentrate prepared in example 4; the figures show that there is a statistical difference from the basal value, P values < 0.001 are marked "/x", 0.001 +.p values < 0.01 are marked "/x", 0.01 +.p values < 0.05 are marked "/x";

FIG. 4 is a graph showing the result of the skin firmness R0 measured by the moisturizing and anti-wrinkle essence prepared in example 4; the figures show that there is a statistical difference from the basal value, P values < 0.001 are marked "/x", 0.001 +.p values < 0.01 are marked "/x", 0.01 +.p values < 0.05 are marked "/x";

FIG. 5 is a graph showing the result of measuring the R2 value of skin elasticity using the moisturizing and anti-wrinkle essence prepared in example 4; the graph shows that there is a statistical difference between P values < 0.001 and 0.001 are marked "," 0.001 less than or equal to P values < 0.01 and 0.01 are marked "," 0.01 less than or equal to P values < 0.05 and "respectively".

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.

The words "preferred," "more preferred," and the like in the present disclosure refer to embodiments of the present disclosure that may provide certain benefits in some instances. However, other embodiments may be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

It should be understood that all numbers expressing, for example, amounts of ingredients used in the specification and claims, except in any operating example or otherwise indicated, are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

In the following examples, the butylene glycol/water/centella asiatica (CENTELLA ASIATICA) extract/giant knotweed

(POLYGONUM CUSPIDATUM) root extract/scutellaria baicalensis (SCUTELLARIA BAICALENSIS) root extract/tea (CAMELLIA SINENSIS) leaf extract/glycyrrhiza glabra (GLYCYRRHIZA GLABRA) extract/chamomile (CHAMOMILLA RECUTITA) flower extract/rosemary (ROSMARINUS OFFICINALIS) leaf extract, the mass ratio of the respective constituent raw materials is: 50:38:5:2:2:1:1:0.5:0.5.

The mass ratio of the raw materials of the lysate of the fermentation product of the saccharomyces cerevisiae to the phenoxyethanol to the sodium benzoate is as follows: 98.75:1:0.25.

The mass ratio of the cyclodextrin to the centella asiatica (CENTELLA ASIATICA) extract is as follows: 84.5:15.5.

The PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water comprises the following raw materials in percentage by mass: 54:36:10.

The mass ratio of the castor (RICINUS COMMUNIS) oil to the northern african cedar (CEDRUS ATLANTICA) bark oil is as follows: 63:37.

The mass ratio of the glycerin to the water to the soapberry (SAPONARIA OFFICINALIS) leaf/root extract to the potassium sorbate to the sodium benzoate is 48.8:48.8:2:0.2:0.2.

The mass ratio of the raw materials of the butanediol/water/perilla (PERILLA OCYMOIDES) leaf extract is as follows: 49.6:49.6:0.8.

The water/butanediol/tremella (TREMELLA FUCIFORMIS) polysaccharide comprises the following raw materials in percentage by mass: 59.8:40:0.2.

The PEG-20 methyl glucose sesquistearate/tocopherol (vitamin E) comprises the following raw materials in percentage by mass: 99.975:0.025.

The mass ratio of the components of the isoprene glycol/p-hydroxyacetophenone/1, 2-hexanediol is as follows: 50:25:25.

Example 1

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation method of the moisturizing anti-wrinkle essence comprises the following steps:

1. before manufacturing, the emulsifying pot is cleaned and disinfected.

2. Adding EDTA disodium, acrylic acid (esters) C10-30 alkanol acrylate crosslinked polymer and part of water into an emulsifying pot at normal temperature, stirring at 30rpm for 30 minutes until the mixture is uniformly stirred, then sequentially adding glycerol and trehalose, and uniformly stirring;

3. adding 1, 3-propylene glycol, xanthan gum and sodium hyaluronate into a pre-dispersing container, dispersing for 30 minutes to completely disperse, and adding the obtained dispersion into an emulsifying pot, and uniformly stirring;

4. adding the ammonium acryloyldimethyl taurate/VP copolymer into an emulsifying pot, heating to 75-80 ℃, homogenizing for 3 minutes at 4500rpm, stirring for 10 minutes at 30rpm until the ammonium acryloyldimethyl taurate/VP copolymer is uniformly dissolved, and preserving heat for 30 minutes at 80 ℃ to obtain a phase A mixture;

5. adding PEG-20 methyl glucose sesquistearate/tocopherol, octyl dodecanol, polydimethylsiloxane, PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water into an oil phase pot, heating to 70-75 ℃, and stirring at 30rpm for 10 minutes until stirring is uniform to obtain a phase B;

6. adding the uniformly stirred phase B into the emulsifying pot treated in the step 4 from the oil phase pot, homogenizing for 3-5 minutes at 4200rpm, stirring for 15 minutes at 40rpm, and emulsifying uniformly under vacuum-0.03 MPa;

7. pre-dissolving tromethamine with water to obtain a phase C; pre-dissolving tetrahydromethylpyrimidine carboxylic acid, dipotassium glycyrrhizinate, cyclodextrin/herba Centellae extract with water to obtain phase D; mixing the two-split yeast fermentation product lysate/phenoxyethanol/sodium benzoate, butylene glycol/water/centella asiatica extract/polygonum cuspidatum root extract/baical skullcap root extract/tea extract/glabra root extract/chamomile flower extract/rosemary leaf extract, castor oil/North African cedar bark oil, water/butylene glycol/tremella polysaccharide, isopentyl glycol/p-hydroxyacetophenone/1, 2-hexanediol as an E phase;

8. step 6, after the emulsification is uniform, cooling the emulsifying pot to 60-65 ℃, adding the pre-dissolved C phase into the emulsifying pot, and stirring at 40rpm for 15 minutes until the mixture is uniformly stirred;

9. cooling to 38-40 ℃, sequentially adding the E phase and the pre-dissolved D phase, homogenizing for 1 minute at 2500rpm, stirring for 15 minutes at 30rpm, and uniformly stirring under vacuum-0.03 MPa;

10. cooling to 30deg.C under vacuum-0.07 MPa while maintaining stirring at 30rpm, defoaming;

11. and (3) after defoaming is finished, loading the sterilized essence into a sterilized specified barrel after quality control confirmation, storing for more than 2 days, and checking, wherein the essence is obtained after the checking is qualified.

Example 2

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation procedure of the said essence is basically the same as in example 1, except that: in step 7, glycerin/water/soapy leaf/root extract/potassium sorbate/sodium benzoate, butylene glycol/water/perilla leaf extract is also added to the prepared E phase.

Example 3

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation procedure of the serum was the same as in example 2.

Example 4

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation procedure of the serum was the same as in example 2.

Example 5

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation procedure of the said essence is basically the same as in example 1, except that: in step 7, glycerin/water/soapy leaf/root extract/potassium sorbate/sodium benzoate is also added to the prepared E phase.

Example 6

The embodiment provides essence which is suitable for sensitive muscles and has the effects of moisturizing, anti-wrinkle and tightening, and the compositions of the raw materials are shown in table 1. The preparation procedure of the said essence is basically the same as in example 1, except that: in step 7, butanediol/water/folium Perillae extract is also added into the prepared E phase.

TABLE 1

Comparative example 1

This comparative example provides a serum with the raw material compositions shown in table 2, without the addition of the two-part yeast fermentation product lysate/phenoxyethanol/sodium benzoate, as compared to example 4. The preparation steps of the moisturizing and anti-wrinkle essence are the same as those of the example 4.

Comparative example 2

The comparative example provides a serum, the composition of the raw materials of which is shown in table 2, and compared with example 4, only butylene glycol/water/centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/glycyrrhiza glabra extract/chamomile extract/rosemary leaf extract are not added. The preparation steps of the moisturizing and anti-wrinkle essence are the same as those of the example 4.

Comparative example 3

This comparative example provides a serum with the raw material composition shown in table 2, and compared with example 4, no water/butylene glycol/tremella polysaccharide was added. The preparation steps of the moisturizing and anti-wrinkle essence are the same as those of the example 4.

TABLE 2

Efficacy verification:

the essences prepared in examples 1 to 6 and comparative examples 1 to 3 were subjected to moisturizing, anti-wrinkle and tightening efficacy tests, and each test data was an average value of a plurality of test subjects (n.gtoreq.5), and specifically as follows:

1) Skin moisture content test

Taking 18-65 years old healthy subjects as test subjects, cleaning the faces of the subjects by using standard facial cleanser, drying by using paper towels, balancing for 30 minutes in a temperature control room, then smearing test products on the faces, and waiting for absorption. Using non-invasive skin test instruments before (0 hours) and 1 and 8 hours after application of the test product

CM825 (Coura-Khazaka) measures the moisture content of the stratum corneum of facial skin. All measurements were carried out in a constant temperature and humidity room at a temperature of 20-22℃and a relative humidity of 40-60%.

The results of the tests using the moisturizing and anti-wrinkle essence prepared in examples 1 to 3 as a test sample are shown in Table 3.

TABLE 3 Table 3

Improvement rate = (measured value after application of test product-base value)/base value x 100%, wherein base value is measured value before application of test product (0 hours).

As can be seen from the results in Table 3, the moisturizing and anti-wrinkle essence prepared in examples 1 to 6 can effectively increase the moisture content of skin, and especially the moisturizing and anti-wrinkle essence prepared in example 4 has improved improvement rates of 31.08% and 22.27% after 1 hour and 8 hours respectively, and has a significant difference from the basic value (as shown in FIG. 1, P value < 0.01).

2) Wrinkle removal, skin elasticity and firmness test

The method is characterized in that a healthy subject 35-55 years old, which is judged to be sensitive to a lactic acid stinging test (the stinging score is more than or equal to 3 minutes), is taken as a test object, after the skin of the subject is cleaned, a proper amount of test product is taken to be applied to the palm, the skin is gently and evenly coated on the face, the skin is massaged until the skin is absorbed, the skin is used for 2 times a day, each time in the morning and evening, the test period does not change other life, eating habits and skin care habits, and the provided test product is completely used for replacing the essence product during the test period.

Subjects were tested before use (D0 day), after 2 weeks of use (D14 day), after 4 weeks of use (D28 day), respectively. At the test site, subjects cleaned their faces with standard facial washes, with tissues, with the tissues dry, and after 30 minutes of sitting in the temperature controlled room, the wrinkles were photographed using the texture image analysis system PRIMOS CR (Canfield), obtaining the head line length and the tail line length results. By using

Dual MPA 580 (Coura+Khazaka) measures the skin elasticity R0 value and the firmness R2 value, and the measurement parameters are set as follows: on-Time:1.0s, off-Time:1.0s, pressure:450mbar, repetition:10, wherein the R0 value reflects passive feedback of the skin to external forces, the smaller the R0 value, the tighter the skin; the R2 value is the total elasticity, the closer the R2 value is to 1 (100%), the more elastic is represented.

The results of the head-up and tail-line length measurements obtained using the moisturizing anti-wrinkle essence prepared in example 1 as a test sample are shown in fig. 2 and 3 as typical examples, and the results of the improvement rates of the head-up and tail-line lengths obtained using the moisturizing anti-wrinkle essence prepared in examples 1 to 3 and comparative examples 1 to 4 as a test sample are shown in table 4.

TABLE 4 Table 4

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Improvement rate = (wrinkle length value after use of test product-base value)/base value x 100%, wherein base value is wrinkle length value before use of test product (D0 day).

As can be seen from the results in table 4, fig. 2 and fig. 3, the moisturizing and anti-wrinkle essence prepared in examples 2-4 has very obvious anti-wrinkle effect, and especially the moisturizing and anti-wrinkle essence prepared in example 4 has a head line length improvement rate respectively reduced by 9.07% and 7.56% after 2 weeks and after 4 weeks, and has a significant difference compared with the basic value (P value < 0.01 as shown in fig. 2); the improvement rates of the length of the fish tail of the moisturizing anti-wrinkle essence prepared in the example 4 after 2 weeks and after 4 weeks are respectively reduced by 12.19 percent and 13.99 percent, and the moisturizing anti-wrinkle essence has a significant difference compared with a basic value (as shown in figure 3, the P value is less than 0.01). And the improvement rate results of the example 4 are obviously improved compared with those of the comparative examples 1-3 and examples 1, 5 and 6, which shows that in the moisturizing and anti-wrinkle essence of the invention, the adopted two-split yeast fermentation product lysate has obvious synergistic effect with centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/glycyrrhiza glabra extract/mother chrysanthemum extract/rosemary leaf extract, tremella polysaccharide, glycerin/water/soapy leaves/root extract/potassium sorbate/sodium benzoate and butylene glycol/water/perilla leaf extract, so that a very good anti-wrinkle effect is obtained.

The results of the measurements of the skin firmness R0 value and the skin elasticity R2 value obtained using the moisturizing anti-wrinkle essence prepared in example 4 as a test sample are shown in fig. 4 and 5 as typical examples, and the results of the improvement rates of the skin firmness R0 value and the skin elasticity R2 value obtained using the moisturizing anti-wrinkle essence prepared in examples 1 to 6 and comparative examples 1 to 3 as a test sample are shown in table 5.

TABLE 5

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As can be seen from the results of table 5 and fig. 4, the moisturizing and anti-wrinkle essence prepared in examples 2 to 4 has a very remarkable effect of improving skin firmness, and particularly the improvement rate of R0 value of the moisturizing and anti-wrinkle essence prepared in example 4 is respectively reduced by 13.57% and 18.96% after 2 weeks and after 4 weeks, which is significantly different from the basic value (P value < 0.01 as shown in fig. 4). And the improvement rate of the R0 value of the example 4 is obviously improved compared with the results of comparative examples 1-4 and examples 1, 5 and 6, which shows that in the moisturizing and anti-wrinkle essence of the invention, the adopted two-split yeast fermentation product lysate has obvious synergistic effect with centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/licorice root extract/mother chrysanthemum extract/rosemary leaf extract, tremella polysaccharide, glycerin/water/soapy leaves/root extract/potassium sorbate/sodium benzoate and butanediol/water/perilla leaf extract, so that a very good effect of improving skin firmness is obtained.

As can be seen from the results of table 5 and fig. 5, the essences prepared in examples 1 to 6 and comparative examples 1 to 3 all had a certain effect of improving skin elasticity, but the difference in effect between each example and comparative example was not obvious, and as can be seen from the results of examples 1, 4 to 6 and comparative examples 1 to 3, the use of the lysate of the fermentation product of the two-split yeast and centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/licorice extract/chamomile flower extract/rosemary leaf extract, tremella polysaccharide, glycerin/water/soapy leaves/root extract/potassium sorbate/sodium benzoate and butylene glycol/water/perilla leaf extract did not have the effect of synergistically improving skin elasticity. The improvement rates of R2 values of the moisturizing and anti-wrinkle essence prepared in the example 4 after 2 weeks and after 4 weeks are respectively improved by 2.68% and 5.47%, and the moisturizing and anti-wrinkle essence has a certain difference compared with a basic value (as shown in figure 5, the P value is less than or equal to 0.01 and less than 0.05 after 4 weeks).

In addition, each test sample is considered to have no itching, stinging, fever, redness, edema and the like in the use process after each test sample is used by each test sample, so that the essence prepared by the invention is applicable to sensitive muscles.

There are many ways in which the invention may be practiced, and what has been described above is merely a preferred embodiment of the invention. It should be noted that the above examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. It will be apparent to those skilled in the art that modifications may be made without departing from the principles of the invention, and such modifications are intended to be within the scope of the invention.

Claims (10)

1. The composition suitable for sensitive muscles and having the effects of moisturizing, anti-wrinkle and tightening is characterized by comprising the following components in parts by weight: 1 to 6 parts of glycerin, 0.1 to 2 parts of trehalose, 2 to 5 parts of 1, 3-propanediol, 0.005 to 0.015 part of sodium hyaluronate, 0.1 to 1 part of octyl dodecanol, 0.5 to 2 parts of polydimethylsiloxane, 0.1 to 0.2 part of tetrahydropyrimidine carboxylic acid, 0.1 to 0.2 part of dipotassium glycyrrhizinate, 0.1 to 0.3 part of cyclodextrin/centella asiatica extract, 5 to 10 parts of a lysis yeast fermentation product lysate/phenoxyethanol/sodium benzoate, 0.5 to 2 parts of butanediol/water/centella asiatica extract/polygonum cuspidatum root extract/radix scutellariae extract/licorice root extract/chamomile extract/rosemary leaf extract, 2 to 5 parts of water/butanediol/polysaccharide, and 1 to 3 parts of isovalerate/p-hydroxyacetophenone/1, 2-hexanediol.

2. The composition with moisturizing, anti-wrinkle and tightening effects suitable for sensitive muscles according to claim 1, wherein the composition comprises the following components in parts by weight: 3 parts of glycerin, 0.5 part of trehalose, 3 parts of 1, 3-propanediol, 0.01 part of sodium hyaluronate, 0.4 part of octyl dodecanol, 1 part of polydimethylsiloxane, 0.1 part of tetrahydropyrimidine carboxylic acid, 0.1 part of dipotassium glycyrrhizinate, 0.1 part of cyclodextrin/centella asiatica extract, 8 parts of a lysate of a fermentation product of two-split yeast, phenoxyethanol/sodium benzoate, 1 part of butanediol/water/centella asiatica extract/polygonum cuspidatum root extract/scutellaria baicalensis root extract/tea extract/licorice glabra extract/chamomile flower extract/rosemary leaf extract, 3 parts of water/butanediol/tremella polysaccharide, and 2.5 parts of isopentyl glycol/p-hydroxyacetophenone/1, 2-hexanediol.

3. The composition for sensitive muscle having the effects of moisturizing, anti-wrinkle and tightening according to claim 1 or 2, further comprising 1 to 3 parts of glycerin/water/soapberry leaf/root extract/potassium sorbate/sodium benzoate and 3 to 6 parts of butylene glycol/water/perilla leaf extract.

4. The composition for sensitive muscle having the combined moisturizing, anti-wrinkle and tightening effects according to claim 3, further comprising 2 parts of glycerin/water/soapstock leaf/root extract/potassium sorbate/sodium benzoate and 5 parts of butylene glycol/water/perilla leaf extract.

5. Use of the composition for sensitive muscle according to any one of claims 1 to 4 for the preparation of cosmetics, which has the effects of moisturizing, anti-wrinkle and tightening.

6. The use according to claim 5, wherein the cosmetic is in the form of any one of cream, lotion, aqua, essence, mask, gel, make-up, spray and cleansing product.

7. A moisture-retaining, anti-wrinkle and tightening essence suitable for sensitive muscles, characterized by comprising the composition having moisture-retaining, anti-wrinkle and tightening effects as claimed in any one of claims 1 to 4.

8. The essence with moisturizing, anti-wrinkle and tightening effects suitable for sensitive muscles according to claim 7, wherein the essence further comprises the following components: at least one of solvent, chelating agent, thickener, emulsifier, pH regulator, solubilizer, and perfume.

9. The essence for sensitive muscles with moisturizing, anti-wrinkle and tightening effects according to claim 8, wherein the solvent is water;

the chelating agent is disodium EDTA;

the thickener is at least one selected from acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum and acrylamide dimethyl taurate/VP copolymer;

the emulsifier is PEG-20 methyl glucose sesquistearate;

the pH regulator is tromethamine;

the solubilizer is PPG-26-butanol polyether-26/PEG-40 hydrogenated castor oil/water;

the aromatic is castor oil/North African cedar bark oil.

10. A method for preparing the essence with moisturizing, anti-wrinkle and tightening effects suitable for sensitive muscles according to any one of claims 7 to 9, characterized by comprising the following steps:

s1, mixing a solvent, a chelating agent, a thickener, glycerol, trehalose, 1, 3-propylene glycol and sodium hyaluronate, and uniformly stirring to obtain a phase A;

s2, mixing an emulsifier, octyl dodecanol, polydimethylsiloxane and a solubilizer, and uniformly stirring to obtain a phase B;

s3, dissolving the pH regulator with water to form a C phase;

s4, dissolving dipotassium glycyrrhizinate, cyclodextrin/centella asiatica extract and tetrahydropyrimidine carboxylic acid by using a solvent to form a phase D;

s5, mixing a lysate of a fermentation product of the saccharomyces cerevisiae, phenoxyethanol, sodium benzoate, butanediol, water, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea extract, glycyrrhiza glabra extract, chamomile flower extract, rosemary leaf extract, water, butanediol, tremella polysaccharide, glycerol, water, soapy leaves, root extract, potassium sorbate, sodium benzoate, butanediol, water, perilla leaf extract, isopentyl glycol, p-hydroxyacetophenone, 1, 2-hexanediol and an aromatic agent, and uniformly stirring to obtain an E phase;

and S6, sequentially adding the phase B, the phase C, the phase D and the phase E into the phase A, stirring, cooling, and defoaming to obtain the moisturizing and anti-wrinkle essence.

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