CN115776898A - 双特异性抗体及其应用 - Google Patents
双特异性抗体及其应用 Download PDFInfo
- Publication number
- CN115776898A CN115776898A CN202180047898.6A CN202180047898A CN115776898A CN 115776898 A CN115776898 A CN 115776898A CN 202180047898 A CN202180047898 A CN 202180047898A CN 115776898 A CN115776898 A CN 115776898A
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- China
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- seq
- sequence
- amino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
Abstract
提供了双特异性抗体及其应用，双特异性抗体或抗原结合片段可以结合两个抗原，或同一抗原的两个个表位。抗体或抗原结合片段可以用于治疗各种疾病，比如炎性疾病、自体免疫性疾病、癌症或脊髓损伤，也可以用于相关疾病的诊断和预后。
Description
PCT国内申请，说明书已公开。
Claims (22)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010643073 | 2020-07-07 | ||
| CN2020106430738 | 2020-07-07 | ||
| PCT/CN2021/104810 WO2022007807A1 (zh) | 2020-07-07 | 2021-07-06 | 双特异性抗体及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115776898A true CN115776898A (zh) | 2023-03-10 |
Family
ID=79552784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180047898.6A Pending CN115776898A (zh) | 2020-07-07 | 2021-07-06 | 双特异性抗体及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115776898A (zh) |
| WO (1) | WO2022007807A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023198015A1 (zh) * | 2022-04-11 | 2023-10-19 | 江苏恒瑞医药股份有限公司 | 特异性结合psma和cd28的抗原结合分子及其医药用途 |
| WO2024046389A1 (zh) * | 2022-08-31 | 2024-03-07 | 百奥泰生物制药股份有限公司 | 抗tigit抗体和抗ctla-4抗体联合用于***中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013026839A1 (en) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| US20130060011A1 (en) * | 2011-08-23 | 2013-03-07 | Peter Bruenker | Fc-free antibodies comprising two fab fragments and methods of use |
| FI3177643T5 (fi) * | 2014-08-04 | 2023-11-28 | Hoffmann La Roche | T-soluja aktivoivia bispesifisiä antigeeniä sitovia molekyylejä |
| SI3789402T1 (sl) * | 2014-11-20 | 2022-10-28 | F. Hoffmann-La Roche Ag | Kombinirano zdravljenje z bispecifičnimi molekulami, ki vežejo antigen in aktivirajo celice T, ter antagonisti za vezavo osi PD-1 |
| JP2018533930A (ja) * | 2015-10-02 | 2018-11-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性ｔ細胞活性化抗原結合分子 |
| EP3356407B1 (en) * | 2015-10-02 | 2021-11-03 | F. Hoffmann-La Roche AG | Bispecific anti-cd19xcd3 t cell activating antigen binding molecules |
| JP7022123B2 (ja) * | 2016-09-30 | 2022-02-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｃｄ３に対する二重特異性抗体 |
| CN110352200B (zh) * | 2018-02-06 | 2020-12-11 | 天境生物科技(上海)有限公司 | 抗具有Ig和ITIM结构域的T细胞免疫受体(TIGIT)的抗体及其应用 |
| AR118619A1 (es) * | 2019-04-10 | 2021-10-20 | Bio Thera Solutions Ltd | Anticuerpos de unión a pd-1 |
| CN114206929B (zh) * | 2019-09-03 | 2023-12-22 | 百奥泰生物制药股份有限公司 | 一种抗tigit免疫抑制剂及应用 |
-
2021
- 2021-07-06 CN CN202180047898.6A patent/CN115776898A/zh active Pending
- 2021-07-06 WO PCT/CN2021/104810 patent/WO2022007807A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022007807A1 (zh) | 2022-01-13 |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination |