CN115569080B

CN115569080B - Acne-removing composition and application thereof, curcumin acne-removing essence gel and preparation method

Info

Publication number: CN115569080B
Application number: CN202211126334.4A
Authority: CN
Inventors: 许汉珍; 许建华
Original assignee: Fuzhou Shouchuang Biomedical Technology Co ltd
Current assignee: Fuzhou Shouchuang Biomedical Technology Co ltd
Priority date: 2022-09-16
Filing date: 2022-09-16
Publication date: 2023-10-20
Anticipated expiration: 2042-09-16
Also published as: CN115569080A

Abstract

The invention discloses an acne-removing composition and application thereof, curcumin acne-removing essence gel and a preparation method thereof; in particular to an acne-removing composition containing tetrahydrocurcumin and application thereof, curcumin acne-removing essence gel containing the acne-removing composition containing tetrahydrocurcumin and a preparation method, wherein the acne-removing composition consists of tetrahydrocurcumin and potassium azenoyl diglycine. Compared with the prior art, the acne-removing and repairing agent has the effects of multicomponent synergy and multi-target acne-removing and repairing, and can effectively inhibit sebaceous gland secretion, inhibit propionibacterium acnes, resist inflammation, repair skin damage, remove acne marks, whiten, moisten and relieve skin.

Description

Acne-removing composition and application thereof, curcumin acne-removing essence gel and preparation method

Technical Field

The invention belongs to the technical field of acne-removing cosmetics, and relates to an acne-removing composition and application thereof, curcumin acne-removing essence gel and a preparation method thereof; in particular to an anti-acne composition containing tetrahydrocurcumin, application thereof, curcumin anti-acne essence gel containing the anti-acne composition containing tetrahydrocurcumin and a preparation method thereof.

Background

Acne is clinically called acne, is a chronic inflammatory skin disease of hair follicles and sebaceous glands, and is one of the most common diseases of cosmetology dermatology.

CN114392203a discloses an essence and a preparation method thereof, wherein the essence comprises the following components in percentage by mass: 1-20% of a fermentation type curcumin gel hydroxyl snowmobile glycoside compound product, 0-7% of an emulsifying agent, 0-10% of an emollient, 0-3% of a thickening agent, 3-10% of a humectant, 0-3% of a skin conditioning agent and 50-90% of water, wherein the fermentation type curcumin gel hydroxyl snowmobile glycoside compound product is obtained by mixing water, fermentation type turmeric gel and madecassoside according to a ratio of 5:10-30:1, and then performing ultrasonic treatment, and the fermentation type turmeric gel is obtained by fermenting turmeric powder by lactic acid bacteria, extracting the turmeric powder by ethanol, concentrating under reduced pressure, and freeze-drying; when the water aqua essence is prepared, water, a humectant and a thickener are mixed and heated according to a certain proportion, and are uniformly stirred; and cooling, adding the skin conditioner and the compound product, and uniformly stirring to obtain the aqueous essence. The invention has the synergistic effect of fermenting turmeric gel and hydroxy asiaticoside to realize the continuous acne removing and inhibiting effects and quickly repair skin.

CN112516040a discloses a whitening cream containing a complex whitening agent lipid carrier, which comprises nicotinamide and a complex whitening and liposome carrier containing tetrahydrocurcumin. The whitening cream can improve oxidation resistance and whitening effect.

CN108338947a discloses a skin care composition with acne removing effect, which mainly comprises xanthan gum, butanediol, glycerol, allantoin, EDTA disodium, plant allergy relieving agent, centella asiatica extract, potassium methoxysalicylate, polyquaternium-73, sebum secretion inhibitor, plant acne inhibitor, theaflavin, theanine, 1, 2-pentanediol, benzophenone-4, triethanolamine, essence and water.

CN112891294a discloses an acne-removing mark-eliminating repairing skin-care composition, which comprises butylene glycol, water, royal jelly extract, lactobacillus fermentation product, o-cymene-5-ol and maple sugar. The acne-removing mark-removing repairing skin care composition can be used for acne-removing cream and emulsion, and has the effects of killing bacteria in hair follicles, so that the hair follicles are not easy to inflame again, and acnes are not easy to relapse.

At present, the cosmetic products for treating acne are more in the market, but the components are single, and the comprehensive conditioning of multiple components, multiple targets and multiple mechanisms is not performed according to the cause of acne, so that the effect is slow when the cosmetic products are locally applied, and the acne mark and acne scar can be relieved poorly.

Disclosure of Invention

In order to solve the technical problems, the invention provides an acne removing composition containing tetrahydrocurcumin, application thereof, curcumin acne removing essence gel and a preparation method thereof.

In order to achieve the above purpose, the present invention adopts the following technical scheme:

an anti-acne composition containing tetrahydrocurcumin comprises tetrahydrocurcumin and potassium nonyldiglycolate.

Preferably, the mass ratio of tetrahydrocurcumin to potassium nonyldiglycolate is 1-10:6-12; most preferably 3:10.

preferably, the acne-removing composition further comprises matrine and epigallocatechin gallate.

Further preferably, the mass ratio of tetrahydrocurcumin to matrine to epigallocatechin gallate is 1-10:3-7:0.1-0.3; most preferably 3:5:0.2.

preferably, the acne-removing composition further comprises asiaticoside, nicotinamide, quaternary ammonium salt-73, dipotassium glycyrrhizinate and allantoin.

Further preferably, the mass ratio of tetrahydrocurcumin to asiaticoside, nicotinamide, quaternary ammonium salt-73, dipotassium glycyrrhizinate and allantoin is 1-10:1.5-2.5:16-22:0.08-0.12:6-12:3-6; most preferably 3:2:20:0.1:10:5.

Preferably, the acne-removing composition comprises the following components in parts by weight: 1-10 parts of tetrahydrocurcumin, 6-12 parts of potassium nonyldiglycolate, 0.8-1.2 parts of magnolol, 0.08-0.12 part of quaternary ammonium salt-73, 3-7 parts of matrine, 0.1-0.3 part of epigallocatechin gallate, 6-12 parts of dipotassium glycyrrhizinate, 3-6 parts of allantoin, 1.5-2.5 parts of asiaticoside, 2-4 parts of sodium ascorbyl phosphate, 1-3 parts of sodium hyaluronate and 16-22 parts of nicotinamide.

The invention also provides a preparation method of the acne-removing composition, which comprises the following steps:

(1) Adding matrine, potassium nonodiglycinate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, dipotassium glycyrrhizinate and epigallocatechin gallate into water, and dissolving in water bath to obtain solution A;

(2) Adding sodium hyaluronate with the formula amount into the solution A obtained in the step (1) to soak overnight, and fully swelling to obtain a solution B;

(3) And (3) dissolving the quaternary ammonium salt-73, tetrahydrocurcumin, magnolol and allantoin in the formula amount in a solvent, heating and stirring, and adding the solution B obtained in the step (2) to obtain the acne-removing composition.

The invention also provides application of the acne-removing composition in preparing an acne-removing cosmetic.

Preferably, the acne-removing cosmetic comprises cream, milk, water, gel, powder, spray, aerosol, patch, film, lyophilized powder, mud or wax base.

The invention also provides curcumin acne-removing essence gel containing the acne-removing composition.

The beneficial effects of the invention are as follows:

(1) The tetrahydrocurcumin-containing acne-removing composition disclosed by the invention has the advantages that tetrahydrocurcumin and potassium nonyldiglycolate can synergistically inhibit sebaceous gland cell proliferation induced by dihydrotestosterone, and can effectively inhibit sebaceous gland secretion.

(2) The acne-removing composition containing tetrahydrocurcumin can enhance the anti-inflammatory effect of matrine and epigallocatechin gallate, and has a synergistic effect.

(3) The acne-removing composition disclosed by the invention is prepared by carefully selecting tetrahydrocurcumin, potassium nonyldiglycolate, magnolol, quaternary ammonium salt-73, matrine, epigallocatechin gallate, asiaticoside, sodium ascorbyl phosphate, dipotassium glycyrrhizinate, allantoin, sodium hyaluronate and nicotinamide for compounding, wherein the tetrahydrocurcumin can enhance the effect of the potassium nonyldiglycolate in inhibiting sebaceous glands, soften and dredge sebaceous gland ducts, reduce acne and remove white heads and blackheads; tetrahydrocurcumin can enhance antiinflammatory effects of matrine and epigallocatechin gallate, and is effective in reducing pimple, pustule, nodule and cyst; tetrahydrocurcumin can enhance antibacterial effects of quaternary ammonium salt-73 and the like for inhibiting Propionibacterium acnes, and can control development of acnes; tetrahydrocurcumin can enhance the wound healing effect of asiaticoside, repair skin injury, moisten and relieve skin.

Compared with the prior art, the acne-removing composition disclosed by the invention has the advantages that tetrahydrocurcumin, potassium nonodi-glycinate, magnolol, quaternary ammonium salt-73, matrine, epigallocatechin gallate, asiaticoside, ascorbic acid, sodium hyaluronate and nicotinamide are selected for compounding, and the effects of multi-target acne removal and repair are generated through multi-component synergy, so that the acne-removing composition can effectively inhibit secretion of sebaceous glands, inhibit propionibacterium acnes, resist inflammation, repair skin damage, remove acne marks, whiten and moisten and relieve skin.

Detailed Description

The following examples are presented only to aid in understanding the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that various modifications and adaptations of the invention can be made without departing from the principles of the invention and these modifications and adaptations are intended to be within the scope of the invention as defined in the following claims. The following description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

1. Synergistic inhibition of sebaceous cell proliferation by tetrahydrocurcumin and potassium nonodiglycinate

1. Materials and methods

Human sebaceous gland cell SZ95 (Shanghai cell Bank of China) was cultured in Sebomed medium (Merck Co., ltd., USA) containing 10% fetal bovine serum, 500U/ml penicillin, 500. Mu.g/ml streptomycin, 5ng/ml epidermal growth factor (both from Gibico Co., USA) at 37℃under a moist atmosphere of 5% CO 2.

The experimental groupings were as follows: (1) Solvent control, complete medium with 0.1% dmso was added; (2) A control group of potassium azelate (PAZ, guangzhou Yujin) was added with 150. Mu.M PAZ; (3) Tetrahydrocurcumin (THC, shanxi Kang He biotechnology) control group, 50 μm THC was added; (4) A control group of dihydrotestosterone (DHT, soleba) was added with 10 μm DHT; (5) DHT+PAZ group, 10. Mu.M DHT, 150. Mu.M PAZ was added; (6) DHT+THC group, 10. Mu.M DHT, 50. Mu.M THC was added; (7) Dht+thc+paz group, 10 μΜ DHT, 50 μΜ THC and 150 μΜ PAZ were added; (8) DHT+example 1 group, 10. Mu.M DHT, 5mg/ml example 1 sample (containing 50. Mu.g/ml PAZ, 15. Mu.g/ml THC) was added; (9) DHT + example 1 THC deficient group, 10 μm DHT, 5mg/ml THC deficient example 1 sample (50 μg/ml PAZ) was added; (10) DHT+example 1 PAZ-deficient group, 10. Mu.M DHT, 5mg/ml PAZ-deficient example 1 sample (15. Mu.g/ml THC) was added.

Taking SZ95 cells in logarithmic growth phase according to 5×10 ³ Individual cells/well were seeded in 96-well culture plates, 190 μl per well; adding 10 mu L of liquid medicine with different concentrations into the treatment group to reach the preset final concentration of the medicine, wherein the final volume of each experimental hole is 200 mu L, and each group is provided with three compound holes; after 48h incubation at 37℃20. Mu.L MTT was added to each well and incubation was continued for 4h. Centrifuging, and discarding supernatant; 150 μl DMSO was added to each well, and the microplate reader was immediately used to measure the absorbance at 490nm wavelength by shaking for 10 min. Cell viability% = dosing OD value/solvent control OD.

2. Results

Androgen-induced sebaceous gland lipid massive secretion is a precondition for the occurrence of acne vulgaris, and acne is promoted by converting testosterone into dihydrotestosterone locally by alpha reductase, the latter promotes sebaceous gland cell proliferation, sebum secretion is increased, and monounsaturated fatty acid content of pro-inflammatory and acne-inducing substances is higher, so that the formation of acne is improved.

TABLE 1 synergistic inhibition of DHT-induced proliferation of sebaceous cell SZ95 by THC and PAZ

As can be seen from Table 1, the DHT has a strong promoting effect on the proliferation of sebaceous gland cells SZ95, compared with a solvent group, the proliferation rate is improved by 38.5%, the concentration of PAZ and THC has no obvious effect on the proliferation of SZ95 cells, the DHT-induced human sebaceous gland cells SZ95 proliferation is inhibited, the increase of the proliferation rate of the SZ95 cells by the DHT is reduced from 38.5% to 21.3% and from 17.3%, and the increase of the proliferation rate of the SZ95 cells by the DHT is further reduced to 9.6% by combining the PAZ and the THC. The results show that tetrahydrocurcumin and potassium nonoxydiglycinate synergistically inhibit dihydrotestosterone-induced sebaceous gland cell proliferation.

PAZ and THC are prepared into acne-removing essence gel, and the acne-removing essence gel prepared in the example 1 is taken as an example, and the acne-removing essence gel group containing PAZ and THC is found to reduce the increase of DHT to 5.5% on SZ95 cell proliferation rate, while the acne-removing essence gel group containing THC or PAZ is added to reduce the increase of DHT to 12.6% or 18.3% on SZ95 cell proliferation rate, so that tetrahydrocurcumin and potassium azenoyl diglycolate can play the role of synergistically inhibiting sebaceous gland cell proliferation induced by dihydrotestosterone in the acne-removing gel product.

2. Synergistic anti-inflammatory agent of tetrahydrocurcumin, matrine and epigallocatechin gallate

1. Materials and methods

Mouse mononuclear macrophage strain RAW 264.7 (Woheprunocel Life technologies Co., ltd.) was cultured in DMEM medium containing 10% fetal bovine serum at 37℃in a 5% CO2 incubator, and cells in logarithmic growth phase were taken for experiment. RAW 264.7 cells in log phase were cultured at 3X 10 ⁵ The density of each/ml was seeded in 24-well plates.

Cell grouping and dosing treatment: (1) adding an equal volume of culture solution to a normal cell group; (2) Bacterial Lipopolysaccharide (LPS) was added at 1 μg/ml to the inflammation model group; (3) model+120 μΜ Matrine (MAT) group; (4) model +3. Mu.M epigallocatechin gallate (EGCG) group; (5) model+50 μΜ Tetrahydrocurcumin (THC) group; (6) model +50 μM THC +120 μM MAT group; (7) model +50 μM THC +3 μM EGCG group; (8) model +50 μM THC +120 μM MAT +3 μM EGCG group; (9) Model+5 mg/ml sample of example 1 (25. Mu.g/ml MAT, 1. Mu.g/ml EGCG, 15. Mu.g/ml THC); (10) Model +5mg/ml example 1 MAT-deficient samples (containing 1. Mu.g/ml EGCG, 15. Mu.g/ml THC) group; (11) Model +5mg/ml example 1 EGCG deficient samples (25. Mu.g/ml MAT, 15. Mu.g/ml THC) group; (12) Model +5mg/ml example 1 THC deficient samples (25. Mu.g/ml MAT, 1. Mu.g/ml EGCG) group. After the medicine is acted for 24 hours, cell culture liquid is collected, interleukin 6 (IL-6) ELISA detection kit (Wu Han Aibo taek Biotechnology Co., ltd.) is used, 3 compound holes are set up according to the strict operation of the kit instruction, and the content of IL-6 in each group of culture liquid is detected. IL-6 secretion% = IL-6 content of each group/IL-6 content of model group x 100%. Inhibition% = model group IL-6 secretion%dosing group IL-6 secretion%.

2. Results

Table 2 in vitro anti-inflammatory action of tetrahydrocurcumin to enhance matrine, epigallocatechin gallate

^** P<0.05, ^*** P<0.01, compared with the model, ^▼▼▼ P<0.01, compared to normal.

It can be seen from Table 2 that LPS with pro-inflammatory effect can induce mouse mononuclear macrophage RAW 264.7 to produce inflammatory cytokine IL-6, while matrine, epigallocatechin gallate and tetrahydrocurcumin have inhibition effect on IL-6 secretion induced by LPS, thus having remarkable anti-inflammatory effect in vitro, the inhibition rate of inflammation is 23.7%, 14.6% and 26.5% respectively, tetrahydrocurcumin and matrine, tetrahydrocurcumin and epigallocatechin gallate and tetrahydrocurcumin and matrine and epigallocatechin gallate are combined, the inhibition rate of inflammation is improved to 53.8%, 44.1% and 64.6% respectively, which indicates that the combined use of two or three of tetrahydrocurcumin, matrine and epigallocatechin gallate has synergistic anti-inflammatory effect, and the anti-inflammatory effect of the combined group is stronger than that of each single compound, wherein the combined anti-inflammatory effect of the three is strongest.

MAT, EGCG and THC are prepared into acne-removing essence gel, and the acne-removing essence gel prepared in example 1 is taken as an example, so that the MAT, EGCG and THC have remarkable inhibition effect on IL-6 secretion induced by LPS, the inhibition rate is up to 70.4%, and the acne-removing essence gel has remarkable in-vitro anti-inflammatory effect. When the acne-removing essence gel group with the defects of MAT, EGCG, THC is added, the anti-inflammatory effect is obviously reduced, and the inhibition rates are respectively reduced to 46.3%, 39.7% and 44.6%. It is shown that the combination of tetrahydrocurcumin, matrine and epigallocatechin gallate in an anti-acne gel product can also produce a synergistic anti-inflammatory effect.

3. Acne and scar removing and repairing effects

Example 1

The acne and mark removing repairing composition containing tetrahydrocurcumin comprises the following components in parts by weight: 3 parts of tetrahydrocurcumin, 10 parts of potassium nonyldiglycolate, 1 part of magnolol, 0.1 part of quaternary ammonium salt-73, 5 parts of matrine, 0.2 part of epigallocatechin gallate, 2 parts of asiaticoside, 3 parts of sodium ascorbyl phosphate, 10 parts of dipotassium glycyrrhizinate, 5 parts of allantoin, 2 parts of sodium hyaluronate and 20 parts of nicotinamide.

Example 2

The acne and mark removing repairing composition containing tetrahydrocurcumin comprises the following components in parts by weight: 1 part of tetrahydrocurcumin, 6 parts of potassium nonyldiglycolate, 0.8 part of magnolol, 0.08 part of quaternary ammonium salt-73, 3 parts of matrine, 0.1 part of epigallocatechin gallate, 1.5 parts of asiaticoside, 2 parts of sodium ascorbyl phosphate, 6 parts of dipotassium glycyrrhizinate, 3 parts of allantoin, 1 part of sodium hyaluronate and 16 parts of nicotinamide.

Example 3

The acne and mark removing repairing composition containing tetrahydrocurcumin comprises the following components in parts by weight: 10 parts of tetrahydrocurcumin, 12 parts of potassium nonyldiglycolate, 1.2 parts of magnolol, 0.12 part of quaternary ammonium salt-73, 7 parts of matrine, 0.3 part of epigallocatechin gallate, 2.5 parts of asiaticoside, 4 parts of sodium ascorbyl phosphate, 12 parts of dipotassium glycyrrhizinate, 6 parts of allantoin, 3 parts of sodium hyaluronate and 22 parts of nicotinamide.

The compositions of examples 1-3 were prepared as acne-removing essential gels, wherein the acne-removing composition was 5.56wt%, disodium EDTA was 0.05wt%, carbomer U20.75 wt%, 1, 2-hexanediol was 0.69wt%, 1, 3-butanediol 8wt%, PEG400 5wt%, C12-13 alkanol polyether-9 3wt%, p-hydroxyacetophenone 0.3wt%, menthol 0.1wt%, triethanolamine 1wt%, oat kernel extract (available from melissa biotechnology company, foodstone, inc.) 0.05wt%, deionized water 75.5wt%.

The preparation method of the acne-removing essence gel comprises the following steps:

(1) Dissolving EDTA disodium with deionized water, and dissolving matrine, potassium nonyldiglycolate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate and dipotassium glycyrrhizinate in 80deg.C water bath to obtain A;

(2) Adding sodium hyaluronate and carbomer U20 into the A, mixing, soaking overnight, and repeatedly swelling to obtain B;

(3) Mixing 1, 2-hexanediol, 1, 3-butanediol, PEG400 and C12-13 alkanol polyether-9, sequentially dissolving quaternary ammonium salt-73, tetrahydrocurcumin, magnolol, allantoin, p-hydroxyacetophenone, menthol and oat kernel extract to obtain C;

(4) Heating the B to 80 ℃, stirring at a low speed, gradually adding the C, adding triethanolamine to adjust the pH to 5.5-6.5, homogenizing for 10 minutes at 3000-5000 rpm, and obtaining the product.

1. Materials and methods

Referring to the clinical evaluation standard of T/CNMIA 0012-2020 acne-removing efficacy skin care products, 30 qualified subjects are recruited, the open test of the samples of example 1, example 2 and example 3 is carried out, 10 subjects in each group continuously use the acne-removing essence gel of the example of the invention for 2 weeks, and skin damage scores before and after use are compared to verify the acne-removing efficacy of the product.

The acne removal effect of the product is evaluated by calculating the integral reduction of skin loss. The number of various skin lesions (closed mouth, acne, papules, pustules, nodules) on the cheeks of the subjects was evaluated, the number was recorded, and the skin lesions of each subject were evaluated at the same time as the specific scoring criteria:

TABLE 3 skin loss scoring criteria

The total integral is the sum of the integral of the various types of skin lesions.

2. Results

The subject population (30 persons) is divided into 3 groups, after 14 days of using the acne-removing essence gel containing tetrahydrocurcumin in the examples 1,2 and 3, the skin lesions before use (D0) and after 14 days of use (D14) are detected, the results are shown in Table 4, and the total skin lesions of the days (D14) of the examples 1,2 and 3 are obviously reduced (P < 0.001), and the improvement rates are 77.0%, 69.1% and 76.3% respectively; examples 1 and 3 were statistically significant for the regression of white head, black head, inflammatory papules, pustule lesions, nodules, and acne marks, and example 2 was statistically significant for the regression of white head, black head, inflammatory papules, pustule lesions, and acne marks, but not for the regression of nodules. In conclusion, the acne-removing essence gel containing tetrahydrocurcumin has the effects of removing acnes and eliminating scars for 14 days.

TABLE 4 skin loss results analysis Table

^* P＞0.05, ^** P<0.05, ^*** P<0.01, compared to D0.

The invention has been further described above in connection with specific embodiments, which are exemplary only and do not limit the scope of the invention in any way. It will be understood by those skilled in the art that various changes and substitutions of details and forms of the technical solution of the present invention may be made without departing from the spirit and scope of the present invention, but these changes and substitutions fall within the scope of the present invention.

Claims

1. An acne-removing composition containing tetrahydrocurcumin, which is characterized by comprising tetrahydrocurcumin, potassium nonodiglycinate, matrine and epigallocatechin gallate;

the mass ratio of tetrahydrocurcumin to potassium nonyldiglycolate is 1-10:6-12;

the mass ratio of tetrahydrocurcumin to matrine to epigallocatechin gallate is 1-10:3-7:0.1-0.3.

2. The acne-removing composition is characterized by comprising the following components in parts by weight: 1-10 parts of tetrahydrocurcumin, 6-12 parts of potassium nonyldiglycolate, 0.8-1.2 parts of magnolol, 0.08-0.12 part of quaternary ammonium salt-73, 3-7 parts of matrine, 0.1-0.3 part of epigallocatechin gallate, 1.5-2.5 parts of asiaticoside, 2-4 parts of sodium ascorbyl phosphate, 6-12 parts of dipotassium glycyrrhizinate, 3-6 parts of allantoin, 1-3 parts of sodium hyaluronate and 16-22 parts of nicotinamide.

3. A method of preparing the acne-removing composition of claim 2, comprising the steps of:

(1) Adding matrine, potassium nonodiglycinate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate and dipotassium glycyrrhizinate into water, and dissolving in water bath to obtain solution A;

4. Use of the acne-removing composition according to claim 1 for preparing cosmetics having acne-removing and skin oil-water balance improving effects by synergistically inhibiting sebaceous gland epithelial cell proliferation.

5. Use of the acne-removing composition according to claim 1 for the preparation of cosmetics with acne-removing and anti-inflammatory effects by synergistic anti-inflammatory action.

6. Use of the acne-removing composition of claim 2 or the acne-removing composition prepared by the preparation method of claim 3 in the preparation of an acne-removing cosmetic.

7. The use according to claim 6, wherein the formulation of the anti-acne cosmetic comprises a cream, a milk, a water, a gel, a powder, a spray, an aerosol, a patch, a film, a mud or a wax base.

8. A curcumin acne-removing essence gel, which is characterized by comprising the acne-removing composition according to any one of claims 1-2 or the acne-removing composition prepared by the preparation method according to claim 3.

9. The acne-removing essence gel according to claim 8, wherein the acne-removing essence gel comprises the following components: deionized water, disodium EDTA, matrine, potassium nonodiglycinate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate, sodium hyaluronate, carbomer, 1, 2-hexanediol, 1, 3-butanediol, PEG400, alkyl polyether, quaternary ammonium salt-73, tetrahydrocurcumin, magnolol, dipotassium glycyrrhizinate, allantoin, p-hydroxyacetophenone, menthol, triethanolamine, and oat kernel extract.