CN115569080A

CN115569080A - Acne-removing composition, application thereof, curcumin acne-removing essence gel and preparation method

Info

Publication number: CN115569080A
Application number: CN202211126334.4A
Authority: CN
Inventors: 许汉珍; 许建华
Original assignee: Fuzhou Shouchuang Biomedical Technology Co ltd
Current assignee: Fuzhou Shouchuang Biomedical Technology Co ltd
Priority date: 2022-09-16
Filing date: 2022-09-16
Publication date: 2023-01-06
Anticipated expiration: 2042-09-16
Also published as: CN115569080B

Abstract

The invention discloses an acne-removing composition and application thereof, a curcumin acne-removing essence gel and a preparation method; in particular to an acne-removing composition containing tetrahydrocurcumin, application thereof, curcumin acne-removing essence gel of the acne-removing composition containing the tetrahydrocurcumin and a preparation method thereof. Compared with the prior art, the acne-removing cream has the effects of multi-component cooperation, multi-target point acne removal and repair, and can effectively inhibit sebaceous gland secretion, inhibit propionibacterium acnes, resist inflammation, repair skin lesions, remove acne marks, whiten, moisten and relieve skin.

Description

Acne-removing composition, application thereof, curcumin acne-removing essence gel and preparation method

Technical Field

The invention belongs to the technical field of acne-removing cosmetics, and relates to an acne-removing composition and application thereof, curcumin acne-removing essence gel and a preparation method thereof; in particular to an acne-removing composition containing tetrahydrocurcumin, application thereof, curcumin acne-removing essence gel of the acne-removing composition containing the tetrahydrocurcumin and a preparation method thereof.

Background

Acne is clinically called as acne, is a chronic inflammatory skin disease of hair follicles and sebaceous glands, and is one of the most common diseases of the beauty dermatology department.

CN114392203A discloses an essence and a preparation method thereof, wherein the essence comprises the following components in percentage by mass: 1-20% of a fermented curcumin gel madecassoside compound product, 0-7% of an emulsifier, 0-10% of an emollient, 0-3% of a thickener, 3-10% of a humectant, 0-3% of a skin conditioner and 50-90% of water, wherein the fermented curcumin gel madecassoside compound product is obtained by mixing water, fermented turmeric gel and madecassoside according to a ratio of 5; when the aqua essence is prepared, water, humectant and thickener are mixed and heated in proportion, and the mixture is homogenized and stirred uniformly; and after cooling, adding the skin conditioner and the compound product, and uniformly stirring to obtain the aqua essence. The invention has the synergistic effect of the combination of the fermented turmeric gel and the madecassoside to realize the effects of continuously removing acnes and inhibiting acnes and quickly repairing skin.

CN112516040a discloses a whitening cream containing complex whitening agent lipid carrier, which comprises niacinamide and complex whitening and liposome carrier containing tetrahydrocurcumin. The whitening cream can improve oxidation resistance and whitening effect.

CN108338947A discloses a skin care composition with acne removing effect, which mainly comprises xanthan gum, butanediol, glycerol, allantoin, EDTA disodium, a plant soothing agent, a centella asiatica extract, methoxy potassium salicylate, polyquaternium-73, a sebum secretion inhibitor, plant anti-acne essence, theaflavin, theanine, 1,2-pentanediol, benzophenone-4, triethanolamine, essence and water.

CN112891294A discloses a skin care composition for removing acne, eliminating scar, repairing skin, comprising butanediol, water, royal jelly extract, lactobacillus fermentation product, o-cymene-5-ol, and maple sugar. The composition can be used for acne removing cream and emulsion, and has the effects of killing bacteria in hair follicles, preventing the hair follicles from being inflamed again and preventing acnes from recurring.

At present, a plurality of cosmetic products for treating acne exist in the market, but the components are single, and the comprehensive conditioning of multiple components, multiple targets and multiple mechanisms is not carried out aiming at the causes of acne, so the effect is slow when the cosmetic is locally applied, and the effect of relieving acne marks and acne scars is poor.

Disclosure of Invention

In order to solve the technical problems, the invention provides an acne-removing composition containing tetrahydrocurcumin, application of the composition, curcumin acne-removing essence gel and a preparation method of the gel.

In order to achieve the purpose, the invention adopts the following technical scheme:

a composition containing tetrahydrocurcumin for removing acne comprises tetrahydrocurcumin and potassium azeloyl diglycinate.

Preferably, the mass ratio of the tetrahydrocurcumin to the potassium azeloyldiglycinate is 1-10; most preferably 3:10.

preferably, the acne-removing composition also comprises matrine and epigallocatechin gallate.

Further preferably, the mass ratio of the tetrahydrocurcumin to the matrine to the epigallocatechin gallate is 1-10:3-7:0.1-0.3; most preferably 3:5:0.2.

preferably, the acne-removing composition also comprises asiaticoside, nicotinamide, quaternary ammonium salt-73, dipotassium glycyrrhizinate and allantoin.

Further preferably, the mass ratio of the tetrahydrocurcumin to the asiaticoside, the nicotinamide, the quaternary ammonium salt-73, the dipotassium glycyrrhizinate and the allantoin is 1-10: 16-22:0.08-0.12: 6-12; most preferably 3:2:20:0.1:10:5.

Preferably, the acne-removing composition comprises the following components in parts by weight: 1-10 parts of tetrahydrocurcumin, 6-12 parts of potassium nonanedioyl diglycoate, 0.8-1.2 parts of magnolol, 0.08-0.12 part of quaternary ammonium salt, 3-7 parts of matrine, 0.1-0.3 part of epigallocatechin gallate, 6-12 parts of dipotassium glycyrrhizinate, 3-6 parts of allantoin, 1.5-2.5 parts of asiaticoside, 2-4 parts of sodium ascorbyl phosphate, 1-3 parts of sodium hyaluronate and 16-22 parts of nicotinamide.

The invention also provides a preparation method of the acne-removing composition, which comprises the following steps:

(1) Adding matrine, potassium azeloyl diglycine, sodium ascorbyl phosphate, nicotinamide, asiaticoside, dipotassium glycyrrhizinate and epigallocatechin gallate into water, and dissolving in water bath to obtain solution A;

(2) Adding sodium hyaluronate with the formula amount into the solution A obtained in the step (1), soaking overnight, and fully swelling to obtain a solution B;

(3) Dissolving the quaternary ammonium salt-73, the tetrahydrocurcumin, the magnolol and the allantoin according to the formula ratio in a solvent, heating and stirring, and adding the solution B obtained in the step (2) to obtain the acne-removing composition.

The invention also provides application of the acne-removing composition in preparation of acne-removing cosmetics.

Preferably, the acne-removing cosmetic comprises cream, milk, water, gel, powder, spray, aerosol, patch, membrane, lyophilized powder, mud or wax base.

The invention also provides curcumin acne-removing essence gel containing the acne-removing composition.

The invention has the beneficial effects that:

(1) According to the acne-removing composition containing tetrahydrocurcumin, tetrahydrocurcumin and potassium azeloyl diglycinate can synergistically inhibit sebaceous gland cell proliferation induced by dihydrotestosterone, and can effectively inhibit sebaceous gland secretion.

(2) The tetrahydrocurcumin can enhance the anti-inflammatory action of the matrine and the epigallocatechin gallate, and generates a synergistic action.

(3) The acne-removing composition disclosed by the invention is prepared by selecting tetrahydrocurcumin, potassium nonanedioyl diglycine, magnolol, quaternary ammonium salt-73, matrine, epigallocatechin gallate, asiaticoside, sodium ascorbyl phosphate, dipotassium glycyrrhizinate, allantoin, sodium hyaluronate and nicotinamide, and compounding, wherein the tetrahydrocurcumin can enhance the effect of the potassium nonanedioyl diglycine on inhibiting sebaceous glands, soften and dredge sebaceous gland ducts, reduce acne and remove white heads and black heads; tetrahydrocurcumin can enhance anti-inflammatory effect of matrine and epigallocatechin gallate, and can effectively reduce pimple, pustule, nodule, and cyst; the tetrahydrocurcumin can enhance the bacteriostatic action of components such as quaternary ammonium salt-73 and the like for inhibiting propionibacterium acnes, and control the development of comedo; the tetrahydrocurcumin can enhance the healing effect of asiaticoside, repair skin damage, moisten and relieve skin.

Compared with the prior art, the acne-removing composition disclosed by the invention is prepared by selecting tetrahydrocurcumin, potassium nonanedioyl diglycine, magnolol, quaternary ammonium salt-73, matrine, epigallocatechin gallate, asiaticoside, ascorbic acid, sodium hyaluronate and nicotinamide for compounding, and can generate the effects of removing acnes and repairing at multiple targets through multi-component cooperation, so that the acne-removing composition can effectively inhibit sebaceous gland secretion, inhibit propionibacterium acnes, resist inflammation, repair skin lesions, remove acne marks, whiten and moisten and smooth skin.

Detailed Description

The following description of the embodiments is only intended to aid in the understanding of the method of the invention and its core ideas. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention. The following description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

1. Tetrahydrocurcumin and potassium azeloyl diglycine synergically inhibit sebaceous gland cell proliferation

1. Materials and methods

Human sebaceous gland cells SZ95 (Shanghai cell Bank of Chinese academy of sciences) were cultured in Sebomed medium (Merck, USA) containing 10% fetal bovine serum, 500U/ml penicillin, 500. Mu.g/ml streptomycin, and 5ng/ml epidermal growth factor (Gibico, USA) at 37 ℃ in a humidified environment of 5%CO2.

The experimental groups were as follows: (1) Solvent control group, complete medium added with 0.1% dmso; (2) Potassium nonanedioyl diglycoate (PAZ, guangzhou reputation gold) control group, 150 μ M PAZ was added; (3) Tetrahydrocurcumin (THC, shanxi Kang He Biotech) control group, 50 μ M THC; (4) A dihydrotestosterone (DHT, solibao) control group, 10 μ M DHT was added; (5) adding 10 μ M DHT and 150 μ M PAZ into DHT + PAZ group; (6) DHT + THC group, adding 10 μ M DHT and 50 μ M THC; (7) DHT + THC + PAZ group, adding 10 μ M DHT, 50 μ M THC and 150 μ M PAZ; (8) DHT + group of example 1, 10. Mu.M DHT, 5mg/ml sample of example 1 (containing 50. Mu.g/ml PAZ, 15. Mu.g/ml THC); (9) DHT + example 1 THC deficient group, 10. Mu.M DHT, 5mg/ml sample of example 1 lacking THC (containing 50. Mu.g/ml PAZ); (10) DHT + example 1 PAZ-deficient group, 10. Mu.M DHT, 5mg/ml sample of example 1 lacking PAZ (containing 15. Mu.g/ml THC) was added.

Taking SZ95 cells in logarithmic growth phase, and performing cell selection according to the ratio of 5 multiplied by 10 ³ Each cell/well was seeded in 96-well culture plates at 190 μ l per well; adding liquid medicine 1 with different concentrations into the treatment group0 mu L to reach the preset final concentration of the medicine, the final volume of each experimental hole is 200 mu L, and each group is provided with three multiple holes; after culturing at 37 ℃ for 48 hours, 20. Mu.L of MTT was added to each well, and the culture was continued for 4 hours. Centrifuging and removing supernatant; add 150. Mu.L DMSO to each well, shake for 10min with a micro-shaker, and immediately measure its absorbance at 490nm with a microplate reader. Cell viability% = addition drug OD value/solvent control OD.

2. Results

The androgen-induced massive secretion of sebaceous gland lipid is a precondition for the occurrence of acne vulgaris, testosterone is converted into dihydrotestosterone by alpha reductase locally in the acne, the dihydrotestosterone promotes the proliferation of sebaceous gland cells, sebum secretion is increased, the content of proinflammatory and comedogenic monounsaturated fatty acid is higher, and favorable conditions are improved for the formation of the acne.

TABLE 1 synergistic inhibition of DHT-induced proliferation of sebaceous gland cells SZ95 by THC and PAZ

It can be seen from table 1 that DHT has a strong promoting effect on the proliferation of the sebocyte SZ95 cells, the proliferation rate is increased by 38.5% compared with the solvent group, PAZ and THC have an inhibiting effect on DHT-induced human sebocyte SZ95 cell proliferation at concentrations that do not significantly affect SZ95 cell proliferation, so that the increase of DHT on SZ95 cell proliferation rate is reduced from 38.5% to 21.3% and 17.3% respectively, and the increase of DHT on SZ95 cell proliferation rate is further reduced to 9.6% by combining PAZ and THC. The results show that tetrahydrocurcumin and potassium azeloyl diglycine synergistically inhibit dihydrotestosterone-induced sebaceous gland cell proliferation.

The acne removal essence gel prepared in example 1 is used for preparing the PAZ and the THC into the acne removal essence gel, and the result shows that the acne removal essence gel group containing the PAZ and the THC can reduce the increase of the DHT on the proliferation rate of SZ95 cells to 5.5%, while the acne removal essence gel group lacking the THC or the PAZ can only reduce the increase of the DHT on the proliferation rate of the SZ95 cells to 12.6% or 18.3%, which indicates that the tetrahydrocurcumin and the potassium azeloyl diglycinate can also play a synergistic role in inhibiting the dihydrotestosterone induced sebaceous gland cell proliferation in the acne removal gel product.

2. Synergistic anti-inflammatory agent of tetrahydrocurcumin, matrine and epigallocatechin gallate

1. Materials and methods

Mouse monocyte macrophage cell line RAW 264.7 (Wuhan Punuo Sai Life technologies, ltd.) was cultured in DMEM medium containing 10% fetal bovine serum at 37 ℃ in a 5% CO2 incubator, and cells in the logarithmic growth phase were used for the experiment. RAW 264.7 cells in log phase at 3X 10 ⁵ The density of each/ml was seeded in 24-well plates.

And (3) cell grouping medicine adding treatment: (1) adding an equal volume of culture solution into a normal cell group; (2) The inflammation model group was supplemented with 1. Mu.g/ml bacterial Lipopolysaccharide (LPS); (3) model +120 μ M Matrine (MAT) group; (4) model +3 μ M epigallocatechin gallate (EGCG) group; (5) model +50 μ M Tetrahydrocurcumin (THC) group; (6) model +50 μ M THC +120 μ M MAT group; (7) model +50 μ M THC +3 μ M EGCG group; (8) model +50 μ M THC +120 μ M MAT +3 μ M EGCG group; (9) Model +5mg/ml group of samples of example 1 (containing 25. Mu.g/ml MAT, 1. Mu.g/ml EGCG, 15. Mu.g/ml THC); (10) Model +5mg/ml the MAT lacking sample of example 1 (containing 1. Mu.g/ml EGCG, 15. Mu.g/ml THC); (11) Model +5mg/ml the EGCG samples from example 1 (25. Mu.g/ml MAT, 15. Mu.g/ml THC) group; (12) Model +5mg/ml the THC sample from example 1 (containing 25. Mu.g/ml MAT, 1. Mu.g/ml EGCG) group. After the drug acts for 24 hours, cell culture fluid is collected, interleukin 6 (IL-6) ELISA detection kit (Wuhan Ebotaic biotechnology limited) is used, and 3 multiple holes are established according to the strict operation of the kit specification, and the content of IL-6 in each group of culture fluid is detected. IL-6 secretion% = content of IL-6 in each group/content of IL-6 in model group × 100%. The inhibition rate% = model group IL-6 secretion% -drug-added group IL-6 secretion%.

2. Results

TABLE 2 Tetrahydrocurcumin enhances the in vitro anti-inflammatory action of matrine, epigallocatechin gallate

^** P<0.05, ^*** P<0.01, comparing with the model, ^▼▼▼ P<0.01, compared to normal.

It can be seen from table 2 that LPS with pro-inflammatory action can induce mouse mononuclear macrophage RAW 264.7 to produce inflammatory cytokine IL-6, and matrine, epigallocatechin gallate and tetrahydrocurcumin have inhibitory action on IL-6 secretion induced by LPS, so that the compound has significant anti-inflammatory action in vitro, and the inflammation inhibition rates are 23.7%, 14.6% and 26.5%, respectively, and after the combination of tetrahydrocurcumin and matrine, the combination of tetrahydrocurcumin and epigallocatechin gallate and the combination of tetrahydrocurcumin, matrine and epigallocatechin gallate respectively increase to 53.8%, 44.1% and 64.6%, which indicates that the combined group of tetrahydrocurcumin, matrine and epigallocatechin gallate or the combined application of the three compounds has synergistic anti-inflammatory action, and the anti-inflammatory action of the combined group is stronger than that of each individual compound, wherein the combined anti-inflammatory action of the three compounds is strongest.

MAT, EGCG and THC are prepared into the acne-removing essence gel, and by taking the acne-removing essence gel prepared in the embodiment 1 as an example, the MAT, EGCG and THC have a remarkable inhibition effect on IL-6 secretion induced by LPS, the inhibition rate is up to 70.4%, and the in-vitro anti-inflammatory effect is remarkable. When the acne removing essence gel group respectively lacking MAT, EGCG and THC is added, the anti-inflammatory effect is remarkably reduced, and the inhibition rates are respectively reduced to 46.3%, 39.7% and 44.6%. Shows that the combination of tetrahydrocurcumin, matrine and epigallocatechin gallate in the acne-removing gel product can also produce synergistic anti-inflammatory effect.

3. Acne removing, scar eliminating and repairing effects

Example 1

The acne-removing scar-removing repair composition containing tetrahydrocurcumin comprises the following components in parts by weight: 3 parts of tetrahydrocurcumin, 10 parts of potassium nonanedioyl diglycoate, 1 part of magnolol, 0.1 part of quaternary ammonium salt-73.1 parts of matrine, 0.2 part of epigallocatechin gallate, 2 parts of asiaticoside, 3 parts of sodium ascorbyl phosphate, 10 parts of dipotassium glycyrrhizinate, 5 parts of allantoin, 2 parts of sodium hyaluronate and 20 parts of nicotinamide.

Example 2

The acne-removing scar-eliminating repairing composition containing tetrahydrocurcumin comprises the following components in parts by weight: 1 part of tetrahydrocurcumin, 6 parts of potassium nonanedioyl diglycoate, 0.8 part of magnolol, 0.08 part of quaternary ammonium salt-73.08 parts of matrine, 0.1 part of epigallocatechin gallate, 1.5 parts of asiaticoside, 2 parts of sodium ascorbyl phosphate, 6 parts of dipotassium glycyrrhizinate, 3 parts of allantoin, 1 part of sodium hyaluronate and 16 parts of nicotinamide.

Example 3

The acne-removing scar-removing repair composition containing tetrahydrocurcumin comprises the following components in parts by weight: 10 parts of tetrahydrocurcumin, 12 parts of potassium nonanedioyl diglycolate, 1.2 parts of magnolol, 0.12 part of quaternary ammonium salt, 7 parts of matrine, 0.3 part of epigallocatechin gallate, 2.5 parts of asiaticoside, 4 parts of sodium ascorbyl phosphate, 12 parts of dipotassium glycyrrhizinate, 6 parts of allantoin, 3 parts of sodium hyaluronate and 22 parts of nicotinamide.

The compositions of examples 1-3 were prepared into anti-acne essence gels in which anti-acne composition 5.56wt%, disodium EDTA 0.05wt%, carbomer U20 0.75wt%, 1,2-hexanediol 0.69wt%, 1,3-butanediol 8wt%, PEG400 wt%, C12-13 alkanol-9 wt%, p-hydroxyacetophenone 0.3wt%, menthol 0.1wt%, triethanolamine 1wt%, oat kernel extract (available from mascot biotechnology limited, fozhou) 0.05wt%, and deionized water 75.5wt%.

The preparation method of the acne-removing essence gel comprises the following steps:

(1) Dissolving disodium EDTA in deionized water, and dissolving matrine, potassium azelaidate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate and dipotassium glycyrrhizinate in 80 deg.C water bath to obtain A;

(2) Adding sodium hyaluronate and carbomer U20 into A, mixing, soaking overnight, and repeatedly swelling to obtain B;

(3) Mixing 1,2-hexanediol, 1,3-butanediol, PEG400 and C12-13 alkanol polyether-9, sequentially dissolving quaternary ammonium salt-73, tetrahydrocurcumin, magnolol, allantoin, p-hydroxyacetophenone, menthol and oat kernel extract to obtain C;

(4) Heating B to 80 deg.C, stirring at low speed, gradually adding C, adding triethanolamine to adjust pH to 5.5-6.5, and homogenizing at 3000-5000 rpm for 10 min.

1. Materials and methods

Referring to clinical evaluation standards of T/CNMIA 0012-2020 acne-removing efficacy skin care products, 30 qualified subjects are recruited to perform open tests of samples in examples 1,2 and 3, 10 samples in each group are tested, and the acne-removing essence gel of the invention is continuously used by the subjects for 2 weeks to compare skin damage scores before and after use so as to verify the acne-removing efficacy of the product.

The acne removing effect of the product is evaluated by calculating the reduction of the skin lesion integral. The method comprises the following steps of performing numerical evaluation on various skin lesions (closed mouth, acne, pimple, pustule and nodule) of cheeks of subjects, recording the numerical evaluation, and simultaneously evaluating the skin lesion score of each subject, wherein the specific scoring standard is as follows:

TABLE 3 skin damage score criteria

The total integral is the sum of the integral of each type of skin damage.

2. Results

The skin lesions of the subject population (30 persons) are divided into 3 groups, and after 14 days of using the acne removing essence gel containing tetrahydrocurcumin in the examples 1,2 and 3, the skin lesions before use (D0) and 14 days of use (D14) are detected, and the results are shown in the table 4, wherein the total skin lesion points of the use examples 1,2 and 3 on the 14 th day (D14) are remarkably reduced (P is less than 0.001), and the improvement rates are 77.0%, 69.1% and 76.3% respectively; wherein, the example 1 and the example 3 have statistical significance on the regression of white heads, black heads, inflammatory papules, pustule skin lesions, nodules and acne marks, and the example 2 has statistical significance on the regression of white heads, black heads, inflammatory papules, pustule skin lesions and acne marks, but has no statistical significance on the regression of nodules. In conclusion, the acne removing essence gel containing tetrahydrocurcumin has the efficacy of removing acnes and scars and repairing 14 days.

TABLE 4 analytical table of skin damage results

^* P＞0.05, ^** P<0.05, ^*** P<0.01, compared to D0.

The present invention has been further described with reference to specific embodiments, which are only exemplary and do not limit the scope of the present invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and substitutions are intended to be within the scope of the invention.

Claims

1. The acne-removing composition containing tetrahydrocurcumin is characterized by consisting of tetrahydrocurcumin and potassium azeloyl diglycinate.

2. The use of the acne-removing composition according to claim 1 for preparing cosmetics with the effects of removing acne and improving skin oil-water balance through synergistic inhibition of sebaceous gland epithelial cell proliferation.

3. The anti-acne composition according to claim 1, further comprising matrine and epigallocatechin gallate.

4. Use of the acne-removing composition according to claim 3 for preparing cosmetics with acne-removing and anti-inflammatory effects through synergistic anti-inflammatory effects.

5. The acne removing composition according to claim 1 or 3, which comprises the following components in parts by weight: 1-10 parts of tetrahydrocurcumin, 6-12 parts of potassium nonanedioyl diglycoate, 0.8-1.2 parts of magnolol, 0.08-0.12 part of quaternary ammonium salt, 3-7 parts of matrine, 0.1-0.3 part of epigallocatechin gallate, 1.5-2.5 parts of asiaticoside, 2-4 parts of sodium ascorbyl phosphate, 6-12 parts of dipotassium glycyrrhizinate, 3-6 parts of allantoin, 1-3 parts of sodium hyaluronate and 16-22 parts of nicotinamide.

6. A method for preparing the acne-removing composition according to any one of claims 1,3 and 5, which comprises the following steps:

(1) Adding matrine, potassium azeloyl diglycine, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate and dipotassium glycyrrhizinate into water according to formula ratio, and dissolving in water bath to obtain solution A;

7. Use of the acne-removing composition according to claim 5 or the acne-removing composition prepared by the preparation method according to claim 6 in preparation of an acne-removing cosmetic.

8. The use of claim 7, wherein the anti-acne cosmetic is in the form of a cream, milk, water, gel, powder, spray, aerosol, patch, film, lyophilized powder, paste, or wax-based.

9. A curcumin acne-removing essence gel characterized by comprising the acne-removing composition as defined in any one of claims 1,3 and 5 or the acne-removing composition prepared by the preparation method as defined in claim 6.

10. The acne-removing essence gel according to claim 9, which comprises the following components: deionized water, disodium EDTA, matrine, potassium azedioyl diglycinate, sodium ascorbyl phosphate, nicotinamide, asiaticoside, epigallocatechin gallate, sodium hyaluronate, carbomer, 1,2-hexanediol, 1,3-butanediol, PEG400, alkanol polyether, quaternary ammonium salt-73, tetrahydrocurcumin, magnolol, dipotassium glycyrrhizinate, allantoin, p-hydroxyacetophenone, menthol, triethanolamine and oat kernel extract.