CN115487347A - 一种用于皮肤补水消炎祛痘的水凝胶敷料 - Google Patents
一种用于皮肤补水消炎祛痘的水凝胶敷料 Download PDFInfo
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Abstract
本发明公开了一种用于皮肤补水消炎祛痘的水凝胶敷料,水凝胶的主要材料为非离子聚丙烯酰胺,非离子聚丙烯酰胺的分子量为10,000,000‑30,000,000,用于皮肤补水的材料为透明质酸,用于伤口消炎的材料为青链霉素混合液,该水凝胶敷料的pH值为5‑6,可作为敷料涂抹在皮肤上,用于阻隔毛孔和外界环境的接触,给皮肤补水的同时可以保持皮肤透气,给皮肤消炎祛痘。
Description
技术领域
本发明涉及美容医学技术领域,具体涉及一种用于皮肤补水消炎祛痘的水凝胶敷料。
背景技术
皮肤由几层覆盖和保护构成其结构骨架的角蛋白和胶原纤维蛋白的细胞组成,这些层的最外层,称之为角质层,已知是由80A厚的层包围的250A蛋白束所组成。阴离子表面活性剂和有机溶剂典型地穿透角质层膜,并且通过脱脂化作用(即是从角质层去除脂类)破坏其完整。皮肤表面构形的破坏导致粗糙的感觉并可能最终让表面活性剂或溶剂接触角蛋白,产生刺激感。当角质层被破坏后,暴露出的肌肤如果不进行抗菌处理,很容易导致创口反复发炎,无法有效愈合。同时,保持穿过角质层的适当的水分梯度对其功能是重要的。这类水的很大部分来自体内,水有时被看作是角质层的增塑剂。如果湿度太低,象在寒冷的气候下,没有足够的水保留在角质层的外层以适当地增塑组织;并且皮肤开始起皮并且变得瘙痒。当没有充足的水分穿过角质层时,皮肤的透过性也在某种程度上降低。加一方面,皮肤的外层上的水太多会引起角质层最终吸收其自重三至五倍的结合水,这样便使皮肤膨胀和起皱,导至皮肤对水和其它极性分子的透过性增加约二至三倍。痤疮的发生主要与皮脂分泌过多、毛囊皮脂腺导管堵塞、细菌感染和炎症反应等因素密切相关。进入***后人体内雄激素特别是睾酮的水平迅速升高,促进皮脂腺发育并产生大量皮脂。同时毛囊皮脂腺导管的角化异常造成导管堵塞,皮脂排出障碍,形成角质栓即微粉刺。毛囊中多种微生物尤其是痤疮丙酸杆菌大量繁殖,痤疮丙酸杆菌产生的脂酶分解皮脂生成游离脂肪酸,同时趋化炎症细胞和介质,最终诱导并加重炎症反应。所以,本发明将水凝胶敷料、透明质酸、青链霉素混合液和1%皮肤祛痘精华液相结合,制备出一种用于皮肤补水、消炎祛痘的水凝胶敷料。
发明内容
为了解决以上技术问题,本发明目的在于提供了一种用于皮肤补水消炎祛痘的水凝胶敷料。
本发明目的通过以下方案是实现:一种用于皮肤补水消炎祛痘的水凝胶敷料,是以10,000,000-30,000,000的非离子聚丙烯酰胺为基底制备的水凝胶,至少包括皮肤补水材料。
所述的皮肤补水材料为透明质酸,聚丙烯酰胺与透明质酸的质量比为3:1。
进一步的,可以添加用于伤口消炎的材料,该材料为青链霉素混合液,添加量为0.5-1%。
用于皮肤补水消炎祛痘的水凝胶敷料的pH值不大于6。
进一步的,也可以添加1%皮肤祛痘精华液,添加量为1-2%。
本发明以高分子量的水凝胶为基底材料,可以很好地包覆在创口表面,不易脱落,有效阻隔创口和环境的接触。同时,敷料里含有的补水材料,如透明质酸以其独特的分子结构和理化性质在机体内显示出多种重要的生理功能,如调节血管壁的通透性,调节蛋白质,水电解质扩散及运转,促进创伤愈合等。添加青链霉素混合液可以有效地消灭皮肤表面原有的未处理干净的细菌。最后,皮肤祛痘精华液可以有效保证皮肤的水分梯度,抑制炎症的发生,使创口的恢复加快。
有益效果:
本发明公开的一种用于皮肤补水、消炎祛痘的水凝胶敷料,是通过合理搭配制剂制备的一款适用于各个部位皮肤的用于皮肤补水、消炎祛痘的水凝胶敷料。配方中的水凝胶基底可以很好地包覆在创口表面,有效阻隔创口和环境的接触。透明质酸可以调节血管壁的通透性,调节蛋白质,水电解质扩散及运转,促进创伤愈合。青链霉素混合液可以有效地消灭皮肤表面原有的未处理干净的细菌。皮肤祛痘精华液可以有效抑制痤疮的再生。本发明通过多成分的联合配方使用,完善单一产品的效果缺陷,把敷料的复合配方直接作用于主要成分的相应层次,减少单一产品的功能障碍,更大完善皮肤补水、消炎祛痘的需求。
具体实施方式
为了更加清楚、详细地说明本发明的目的技术方案,下面通过相关实施例对本发明进行进一步描述。以下实施例仅为具体说明本发明的实施方法,并不限定本发明的保护范围。
实施例1
一种用于皮肤补水消炎祛痘的水凝胶敷料,由包括15g分子量10,000,000的非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液的聚丙烯酰胺水相,与1 mL水杨酸与5mL乙醇制成的水杨酸乙醇溶液混合制成,形成凝胶,所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将非离子聚丙烯酰胺、加入5g矿物油、1 mL透明质酸、青链霉素混合液加到水中充分混合,得到聚丙烯酰胺水相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入5mL乙醇中并在100 rpm/min混合直至水杨酸溶解,得到水杨酸乙醇溶液;
(3)将步骤(2)的水杨酸乙醇溶液缓慢地加入聚丙烯酰胺水相形成凝胶。所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
实施例2:
一种用于皮肤补水消炎祛痘的水凝胶敷料,由包括15g分子量20,000,000的非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液的聚丙烯酰胺水相,与1 mL水杨酸与5mL乙醇制成的水杨酸乙醇溶液混合制成,按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将15g分子量20,000,000非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液加到水中得到聚丙烯酰胺水上相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入5mL乙醇乙醇中并在100 rpm/min混合直至水杨酸溶解,得到乙醇混合溶液;
(3)将步骤(2)的乙醇混合溶液缓慢地加入聚丙烯酰胺水相形成凝胶,所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
实施例3:
一种用于皮肤补水消炎祛痘的水凝胶敷料,由包括15g分子量30,000,000的非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液的聚丙烯酰胺水相,与1 mL水杨酸与5mL乙醇制成的水杨酸乙醇溶液混合制成,按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将15g分子量30,000,000非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液加到水中,得到聚丙烯酰胺水相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入乙醇中并在100 rpm/min混合直至水杨酸溶解,得乙醇混合溶液;
(3)将步骤(2)的乙醇混合溶液缓慢地加入聚丙烯酰胺水相形成凝胶,所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
应用例:
分别将实施例1/2/3中所制备的三种水凝胶敷料涂抹于三只相同皮肤痤疮模型的小鼠皮肤上,同时准备一只对照组小鼠皮肤痤疮不进行处理,分笼饲养15天。饲养过程中发现在第五天时涂抹水凝胶敷料的小鼠皮损、痤疮已经逐步愈合,同时愈合过程中并未出现发炎现象。而对照组的小鼠痤疮处已发展成溃疡,细菌感染无可避免。
由此可见,本发明公开的水凝胶敷料对皮肤补水、消除痤疮有非常好的帮助作用。
以上所述实施例仅表达了本发明的具体实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。
Claims (7)
1.一种用于皮肤补水消炎祛痘的水凝胶敷料,其特征在于,所述的水凝胶敷料以10,000,000-30,000,000的非离子聚丙烯酰胺为基底制备的水凝胶,至少包括皮肤补水材料。
2.根据权利要求1所述用于皮肤补水消炎祛痘的水凝胶敷料,其特征在于用于皮肤补水的材料为透明质酸,聚丙烯酰胺与透明质酸质量比为3:1。
3.根据权利要求1所述用于皮肤补水消炎祛痘的水凝胶敷料,其特征在于其用于伤口消炎的材料为青链霉素混合液微量,
使用分子量为10,000,000-30,000,000的非离子聚丙烯酰胺制备水凝胶,同时添加1%透明质酸,0.5-1%的青链霉素混合液和1-2%的皮肤祛痘精华液。
4.根据权利要求1所述用于皮肤补水消炎祛痘的水凝胶敷料,其特征在于,含有1%皮肤祛痘精华液。
5.根据权利要求1至4任一项所述用于皮肤补水消炎祛痘的水凝胶敷料的的制备方法:按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将非离子聚丙烯酰胺、加入5g矿物油、1 mL透明质酸、青链霉素混合液加到水中充分混合,得到聚丙烯酰胺水相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入5mL乙醇中并在100 rpm/min混合直至水杨酸溶解,得到水杨酸乙醇溶液;
(3)将步骤(2)的水杨酸乙醇溶液缓慢地加入聚丙烯酰胺水相形成凝胶。所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
6.根据权利要求1至4任一项所述用于皮肤补水消炎祛痘的水凝胶敷料的的制备方法:按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将15g分子量20,000,000非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液加到水中,得到聚丙烯酰胺水上相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入5mL乙醇乙醇中并在100 rpm/min混合直至水杨酸溶解,得到乙醇混合溶液;
(3)将步骤(2)的乙醇混合溶液缓慢地加入聚丙烯酰胺水相形成凝胶,所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
7.根据权利要求1至4任一项所述用于皮肤补水消炎祛痘的水凝胶敷料的的制备方法:按下述步骤:
(1)将73 mL水加到大小适合的容器中,以300 rpm/min搅拌,同时将15g分子量30,000,000非离子聚丙烯酰胺、5g矿物油、1 mL透明质酸、青链霉素混合液加到水中,得到聚丙烯酰胺水相;
(2)将5 mL乙醇置入另一容器并加上盖,采用带有三个螺旋浆的混合器,将1 mL水杨酸加入乙醇中并在100 rpm/min混合直至水杨酸溶解,得乙醇混合溶液;
(3)将步骤(2)的水杨酸乙醇溶液缓慢地加入聚丙烯酰胺水相形成凝胶。所产生的凝胶以中等速度混合直至均匀,得到的皮肤补水消炎祛痘的水凝胶敷料产品的pH值低于6。
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