CN110882203A - Compound high-permeability moisturizing essence and preparation process thereof - Google Patents
Compound high-permeability moisturizing essence and preparation process thereof Download PDFInfo
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Abstract
The invention discloses a compound high-permeability moisturizing essence and a preparation process thereof. The invention adopts substances such as tetrahydropiperine, water-soluble azone, water-soluble borneol, acetyl glucosamine, PEG-40 hydrogenated castor oil and the like, avoids irritation to human skin, relieves the water shortage of facial skin, keeps the facial skin moist, bright and fair, and simultaneously satisfies the moisturizing effect of moisturizing the skin.
Description
Technical Field
The invention relates to an essence, and in particular relates to a moisturizing essence with compound components and a preparation method thereof.
Background
The global warming of climate makes the phenomenon of water shortage of human skin more and more serious, the moisture retention function of common products is difficult to make up for the demand of skin for water, simultaneously, the aging of human is easy to show on face, mainly focuses on the water shortage of skin, and the most prominent symptom is that wrinkles are gradually increased. As the human body ages, the skin there becomes thinner, loses elasticity, develops age spots, and is more susceptible to irritation. Generally, facial skin aging is always accompanied by the appearance of dryness, water shortage and senile skin laxity, and how to rapidly transport water to the deep parts of the skin becomes an urgent subject of research.
In order to solve the problems, a great deal of meaningful exploration work is carried out in the industry, a large number of essences are emerged on the market and mainly used for preventing aging and delaying dryness, but the essences usually adopt more chemical compositions and easily cause irritation to facial skin, so that the phenomena of skin allergy and red swelling are caused, the skin becomes more fragile and sensitive, and the problem of skin water shortage is not fundamentally solved.
In conclusion, the problem to be solved by the technical personnel in the field is how to provide the essence which has no irritation to the skin, removes wrinkles, resists aging and fully moisturizes the deep layer.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the essence which avoids irritation on human skin, relieves the water shortage of facial skin, keeps the facial skin moist, bright and fair, and simultaneously meets the water replenishing requirement of the skin for moisture preservation, and the preparation method thereof.
In order to solve the technical problems, the invention adopts the following technical scheme: a compound high-permeability moisturizing essence comprises the following components (by weight portion),
the invention also provides a preparation process of the compound high-permeability moisturizing essence, which comprises the following steps:
step 1) heating deionized water with a preset weight to 80-100 ℃, preserving heat for 30 minutes, cooling the deionized water to 40-60 ℃, and respectively putting raw materials of tetrahydropiperine, water-soluble azone, water-soluble borneol, acetyl glucosamine and PEG-40 hydrogenated castor oil into a tank according to a proportion;
step 2) rapidly stirring the heated raw materials respectively, centrifuging, and filtering to obtain a pre-prepared solution;
step 3) sequentially putting the water-phase deionized water, propylene glycol, biological carbohydrate gum-1, 3-butanediol, the green alga extract, tocopherol, sodium hyaluronate and the dendrobe extract into a stirring pot A and stirring to uniformly dissolve the tocopherol and the sodium hyaluronate and distribute the tocopherol and the sodium hyaluronate in the deionized water, heating to 80-100 ℃, and preserving heat for 30 minutes;
step 4) cooling the mixed solution to 50-70 ℃ under the stirring state;
and 5) sequentially putting the pre-prepared solution in the step 2), the alfalfa extract, the lemon balm leaf extract and the hydroxydecyl ubiquinone into a stirring pot A, stirring, cooling to 40-50 ℃, adding p-hydroxyacetophenone and 1, 2-hexanediol to enable the pH value of the mixture to be 6.2-6.8, and obtaining a finished product when the viscosity of the mixture is 1500-3500 mpa.s.
Preferably, in the step 2), the traditional Chinese medicine extract is obtained after being processed by a high-speed centrifuge and then filtered by a filter screen of 800 meshes.
Preferably, in step 2), 20 to 30 parts of deionized water is added.
Preferably, in step 3), the ratio of deionized water to acetyl glucosamine is 99: 1.
preferably, in step 1), the stirring speed is 60 revolutions per minute; step 4) cooling to 60 ℃ under the stirring state, wherein the stirring speed is 35 r/min; and step 5), cooling to 45 ℃ with the stirring speed of 20-30 r/min.
The invention adopts the tetrahydropiperine, the water-soluble azone, the water-soluble borneol, the acetyl glucosamine and the PEG-40 hydrogenated castor oil as raw materials, adopts the components with good permeability to prepare the compound high-permeability moisturizing essence, obviously improves the permeability function of the product, better permeates all nutrient moisturizing components into the skin, promotes the synthesis of collagen fibers and proteoglycan, relieves the water shortage of the facial skin, keeps the facial skin moist, bright and fair, simultaneously meets the water replenishing requirement of the skin, promotes the youthful body skin and reduces the aging.
Drawings
Fig. 1 is a flow chart of a preparation process of the compound high-permeability moisturizing essence.
Fig. 2 is a preparation process diagram of the compound high-permeability moisturizing essence.
Detailed Description
The invention provides a compound high-permeability moisturizing essence which comprises the following components in parts by weight:
the moisturizing essence adopts tetrahydropiperine, water-soluble azone, water-soluble borneol, acetyl glucosamine and PEG-40 hydrogenated castor oil as raw materials, and is used as a main effect component of the moisturizing essence, so that the permeation function of the product is remarkably improved, and the main effects of the components are introduced respectively.
Mono-and tetrahydro piperine
Tetrahydropiperine is the only safe, efficient and natural penetration-promoting component extracted from plants at present. The permeation promoting mechanism of the tetrahydropiperine is as follows: increasing the affinity of the drug molecules/nutrients to the cell membrane.
Experiments prove that the tetrahydropiperine can promote percutaneous absorption of drug molecules and can promote absorption of vitamins, polyphenols, alkaloids, flavonoids and the like in a cosmetic external formula. The tetrahydropiperine is not only suitable for facial products, but also can be used as a penetration enhancer in body products, especially weight-losing and breast-enlarging products, and also can be used as a penetration enhancer in hair-care functional products.
Di, water soluble azone
The oil-soluble azone is modified into a high-efficiency water-soluble product, has obvious transdermal permeation-aiding effect on oleophylic and hydrophilic medicines and active ingredients, enables the skin cuticle to interact with lipid, reduces the phase transfer temperature of the lipid in the gaps of the cuticle from effective substances, increases the fluidity, reduces the diffusion resistance of the medicines or active additives in the cuticle, and plays a strong role in permeation promotion. The product is turbid liquid at room temperature, and is heated and shaken before use. The product is skin penetration enhancer with excellent penetration effect in pharmaceutical and cosmetic industry; the synergist is a high-permeability synergist with remarkable synergistic effect in the pesticide industry; and can also be applied to printing, printing and dyeing and petroleum exploration industries. Safety: the product is proved to be non-toxic, free of side effect and non-irritant by tests of sub-acute toxicity, irritation, sensitization and teratogenesis of skin and damaged skin.
Tetra, water soluble borneol
Borneol is a traditional Chinese medicine commonly used in clinic, the traditional Chinese medicine mostly takes the effects of refreshing brain, inducing resuscitation, clearing heat, relieving pain, preventing corrosion and promoting tissue regeneration, and modern pharmacological research shows that the borneol has various medicinal effects, is easy to permeate a blood brain barrier, and the borneol is easy to permeate the blood brain barrier.
The water-soluble borneol has the effects of resisting bacteria, inflammation and pain, can obviously inhibit the increase of the permeability of the capillary vessels in the abdominal cavity of a mouse caused by acetic acid, and has the anti-inflammatory effect; can obviously prolong the pain response time and the pain response of the mouse caused by thermal stimulation, and has the function of analgesia; the in vitro direct antiviral test shows that the compound has the function of inhibiting influenza virus. And (3) promoting wound healing: borneol can increase granulation tissue structure and epidermal cell regeneration, repair skin accessory organs and has stronger wound healing effect.
Pentasaccharide acetyl glucosamine
Glucosamine is an important component of proteoglycan with extremely strong hydrophilicity, and can synthesize collagen in human body and repair damaged cartilage; can strongly stimulate synovial cells to regenerate, promote the growth and supplement joint synovial fluid, continuously lubricate the layer of the articular cartilage, reduce the friction effect and ensure that the joint part is flexible and free; glucosamine controls not only the health of the human bone joints, but also the metabolic balance of the articular cartilage and the synovial membrane.
① has three basic functions after glucosamine enters human body, wherein glucosamine strongly stimulates articular chondrocytes to synthesize collagen fibers and proteoglycan in human body, and continuously repairs abraded or eroded articular cartilage and surrounding soft tissues, and glucosamine can generate new articular cartilage and synovial membrane, thereby recovering normal functions of joints and surrounding soft tissues.
Sixthly, Aidi benzene
The idebenone is used for treating Alzheimer's disease, is a popular antioxidant drug, can effectively phagocytose free radicals causing skin organism aging, prevents damage of external factors to skin, delays skin collagen loss, provides energy required by skin metabolism, and enables skin to be compact and smooth. The composition is more stable than levorotatory C and milder than vitamin A, and all the advantages enable the idebene to become a popular composition for anti-aging and maintenance immediately after coming out.
Idebenone is the main effective component of PREVAGE' anti-aging formula, belonging to the class of neuroprotective benzoquinone-analogue, which is synthesized and transformed from coenzyme Q10 derivative capable of inhibiting free radicals in human body. Idebene is synthesized and converted from a coenzyme Q10 derivative, but has 66% less molecules than Q10, contains oil-based antioxidant components, is in an orange powder, is originally used for treating brain diseases, is similar to coenzyme Q10(CoQ10) in partial cosmetic applications due to similar antioxidant properties, but has an important difference with Q10 in that Q10 is converted from antioxidant to autooxidation under anoxic conditions to produce free radicals, but the idebene does not have the risk; and the penetration force to the skin is better, and experiments prove that the antioxidant effect is also better.
The antioxidant energy of idebene is stronger than that of coenzyme Q10, and a clinical experiment of externally applying 0.5% -1.0% Idebenone by McDaniel doctors published in 2005 in the literature proves that the formula helps to improve the aging phenomenon of the face. The small scale use test of the anti-aging center in the 2006 Taiwan university hospital also finds that the product containing the component can possibly improve the wrinkle symptoms of the face of women of the aged and older. It is noted in this clinical experience that the user may initially experience mild to moderate irritation and itching, and may even develop desquamation and red rash. It is therefore recommended that the user should preferably try for one to two weeks before purchasing the relevant product, and not use other exfoliating and acidic ingredients together and it has been found in the literature that use of Idebenone causes allergic contact dermatitis.
Example 1: the compound high-permeability moisturizing essence comprises the following components in parts by weight:
example 2: the compound high-permeability moisturizing essence comprises the following components in parts by weight:
example 3: the compound high-permeability moisturizing essence comprises the following components in parts by weight:
the invention also provides a preparation process for preparing the compound high-permeability moisturizing essence, which comprises the following steps:
step 1) heating deionized water with a preset weight to 80-100 ℃ and preserving heat for 30 minutes, preferably heating to 90 ℃, cooling the deionized water to 40-60 ℃, preferably cooling the deionized water to 50 ℃, and respectively putting raw materials of tetrahydropiperine, water-soluble azone, water-soluble borneol, acetyl glucosamine and PEG-40 hydrogenated castor oil into a tank according to a proportion;
step 2) putting the weighed raw materials and a preset amount of deionized water into a stainless steel pot (316#), stirring for 20-30 minutes by adopting rapid stirring (60 revolutions per minute), and filtering to obtain a pre-prepared solution for later use;
step 3) sequentially putting the water-phase deionized water, propylene glycol, biological carbohydrate gum-1, 3-butanediol, green algae extract, tocopherol, sodium hyaluronate and dendrobe extract into a stirring pot A and stirring to uniformly dissolve the tocopherol and the sodium hyaluronate in the deionized water and heating to 80-100 ℃, preferably 90 ℃, and keeping the temperature for 30 minutes;
step 4) cooling the mixed solution to 50-70 ℃ under the stirring state, preferably to 60 ℃;
and 5) sequentially putting the prepared solution in the step 2), the alfalfa extract, the lemon balm leaf extract and the hydroxydecyl ubiquinone into a stirring pot A and stirring at the stirring speed of 20-30 revolutions per minute, then cooling to 40-50 ℃, preferably to 45 ℃, adding p-hydroxyacetophenone and 1, 2-hexanediol to ensure that the pH value of the mixture is 6.2-6.8 and the viscosity of the mixture is 1500-3500 mpa.s, thus obtaining the finished product.
Preferably, in the step 2), the traditional Chinese medicine extract is obtained after being processed by a high-speed centrifuge and then filtered by a filter screen of 800 meshes.
Preferably, in step 2), 20 to 30 parts of deionized water is added.
Preferably, in step 3), the ratio of deionized water to acetyl glucosamine is 99: 1.
preferably, in step 1), the stirring speed is 60 revolutions per minute; step 4) cooling to 60 ℃ under the stirring state, wherein the stirring speed is 35 r/min; and step 5), cooling to 45 ℃ with the stirring speed of 20-30 r/min.
Example one
The preparation process of the compound high-permeability moisturizing essence comprises the following steps:
step 1) heating ionized water to 90 ℃, keeping the temperature for 30 minutes, cooling the deionized water to 50 ℃, and putting 0.5 part of tetrahydropiperine, 0.5 part of water-soluble azone, 0.5 part of water-soluble borneol, 1 part of acetyl glucosamine and 0.5 part of PEG-40 hydrogenated castor oil into a stirring tank according to the proportion;
step 2) putting the raw materials and deionized water into a stainless steel pot (316#), stirring for 20 minutes by rapid stirring (60 revolutions per minute), treating by a high-speed centrifuge, and filtering by a 800-mesh filter screen to obtain a traditional Chinese medicine extracting solution, namely a pre-prepared solution for later use;
step 3) sequentially putting the water-phase deionized water, 2 parts of propylene glycol, 4 parts of bioglycan-1, 3-butanediol, 3 parts of chlorella extract, 0.5 part of tocopherol, 0.2 part of sodium hyaluronate and 3 parts of dendrobe extract into a stirring pot A, stirring to uniformly dissolve the tocopherol and the sodium hyaluronate, and then heating to 90 ℃, and preserving heat for 30 minutes, wherein the ratio of the deionized water to the acetamido sugar is 99: 1;
step 4), cooling the mixed solution to 60 ℃ under the stirring state;
and 5) sequentially putting the prepared liquid obtained in the step 2), 1 part of alfalfa extract, 0.5 part of lemon balm leaf extract and 0.5 part of hydroxydecyl ubiquinone into a stirring pot A, stirring at the stirring speed of 20 r/min, cooling to 45 ℃, adding 0.3 part of p-hydroxyacetophenone and 0.3 part of 1, 2-hexanediol to enable the pH value of the mixture to be 6.3 and the viscosity of the mixture to be 2800mpa.s, and thus obtaining the finished product.
Example two
Step 1) heating deionized water to 95 ℃, keeping the temperature for 30 minutes, and when cooling the deionized water to 50 ℃, respectively putting 1 part of tetrahydropiperine, 1 part of water-soluble azone, 1.5 parts of water-soluble borneol, 1 part of acetyl glucosamine and 1 part of PEG-40 hydrogenated castor oil into a stirring tank according to the proportion;
step 2) putting the raw materials and deionized water into a stainless steel pot (316#), stirring for 25 minutes by adopting rapid stirring (60 revolutions per minute), and filtering to obtain a pre-prepared solution for later use;
step 3) sequentially putting water-phase deionized water, 4 parts of propylene glycol, 6 parts of bioglycan-1, 3-butanediol, 5 parts of green alga extract, 1 part of tocopherol, 0.4 part of sodium hyaluronate and 5 parts of dendrobe extract into a stirring pot A and stirring to uniformly dissolve the tocopherol and the sodium hyaluronate in the deionized water, heating to 90 ℃, and preserving heat for 30 minutes;
step 4), cooling the mixed solution to 60 ℃ under the stirring state;
and 5) sequentially putting the prepared solution obtained in the step 2), 2 parts of alfalfa extract, 1 part of lemon balm leaf extract and 1 part of hydroxydecyl ubiquinone into a stirring pot A, stirring at the stirring speed of 20 r/min, cooling to 45 ℃, adding 0.3 part of p-hydroxyacetophenone and 0.3 part of 1, 2-hexanediol to ensure that the pH value of the mixture is 6.5 and the viscosity of the mixture is 3500mpa.s, and thus obtaining a finished product.
In order to carry out comparison experiments and detect the influence of different essences on the moisture retention type and the irritation of human skin, a group of comparison essences are provided according to the following proportion (in percentage by weight):
first, analysis of chart skin irritation (acute skin irritation test)
| Product name | Extent of skin irritation response |
| Comparative example | 1 |
| Case 1 | 0 |
| Case 2 | 0 |
| Case 3 | 0 |
Therefore, the compound high-permeability moisturizing essence added with the plant extract components has much reduced skin irritation.
Second, photoacoustic methods (photoacoustics):
the periodic light irradiation causes pressure changes of the tissue to generate acoustic signals, and the photoacoustic method is based on a method of measuring such acoustic signals.
Environmental factors have great influence on the moisture content of skin, and the moisture measurement must take the environmental factors into consideration, so that standard measurement conditions are required, such as in a constant-temperature and constant-humidity air-conditioning room. Seasonal and corresponding weather changes will affect the measurement result, and the measurement of the water content of the skin is preferably carried out in winter, because in winter due to the large difference between the basic value and the final measured value, the hydration of the stratum corneum after use of the product is more easily elucidated.
In addition, the moisture content of the skin is also related to the site to be measured, the balance of body water, age, individual lifestyle, eating habits, smoking and drinking, taking medicines and cosmetics, etc., which must be taken into account when measuring.
In addition, the moisture absorption and retention of the product can be measured by in vitro gravimetric method to evaluate the moisture retention effect of the sample.
Influence on people with skin water content change
Therefore, the compound high-permeability moisturizing essence added with the plant extract component has the advantage that the content of skin moisture is obviously improved.
The present invention has been described in detail, and it should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
Claims (9)
1. The compound high-permeability moisturizing essence is characterized in that: comprises the following components (by weight portion):
2. the compound high-permeability moisturizing essence according to claim 1, characterized in that: comprises the following components (by weight portion):
3. the compound high-permeability moisturizing essence according to claim 1, characterized in that: comprises the following components (by weight portion):
4. the compound high-permeability moisturizing essence according to claim 1, characterized in that: comprises the following components (by weight portion):
5. the preparation process of the compound high-permeability moisturizing essence based on claim 1 is characterized by comprising the following steps of:
step 1) heating deionized water with a preset weight to 80-100 ℃, preserving heat for 30 minutes, cooling the deionized water to 40-60 ℃, and respectively putting raw materials of tetrahydropiperine, water-soluble azone, water-soluble borneol, acetyl glucosamine and PEG-40 hydrogenated castor oil into a tank according to a proportion;
step 2) rapidly stirring the heated raw materials respectively, centrifuging, and filtering to obtain a pre-prepared solution;
step 3) sequentially putting the water-phase deionized water, propylene glycol, biological carbohydrate gum-1, 3-butanediol, the green alga extract, tocopherol, sodium hyaluronate and the dendrobe extract into a stirring pot A and stirring to uniformly dissolve the tocopherol and the sodium hyaluronate and distribute the tocopherol and the sodium hyaluronate in the deionized water, heating to 80-100 ℃, and preserving heat for 30 minutes;
step 4) cooling the mixed solution to 50-70 ℃ under the stirring state;
and 5) sequentially putting the pre-prepared solution in the step 2), the alfalfa extract, the lemon balm leaf extract and the hydroxydecyl ubiquinone into a stirring pot A, stirring, cooling to 40-50 ℃, adding p-hydroxyacetophenone and 1, 2-hexanediol to enable the pH value of the mixture to be 6.2-6.8, and obtaining a finished product when the viscosity of the mixture is 1500-3500 mpa.s.
6. The preparation process of the compound high-permeability moisturizing essence according to claim 5, characterized by comprising the following steps: in the step 2), the traditional Chinese medicine extract is obtained after being treated by a high-speed centrifuge and then filtered by a filter screen of 800 meshes.
7. The preparation process of the compound high-permeability moisturizing essence according to claim 5, characterized by comprising the following steps: in the step 2), 20-30 parts of deionized water is added.
8. The preparation process of the plant ingredient high-permeability moisturizing essence according to claim 5, wherein the preparation process comprises the following steps: in the step 3), the ratio of the deionized water to the acetyl glucosamine is 99: 1.
9. the preparation process of the compound high-permeability moisturizing essence according to claim 5, characterized by comprising the following steps: in the step 1), the stirring speed is 60 revolutions per minute; step 4) cooling to 60 ℃ under the stirring state, wherein the stirring speed is 35 r/min; and step 5), cooling to 45 ℃ with the stirring speed of 20-30 r/min.
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| CN201810131855.6A CN108078886A (en) | 2018-02-09 | 2018-02-09 | A kind of compound Thief zone moisturizing elite and its preparation process |
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| CN201810131855.6A Pending CN108078886A (en) | 2018-02-09 | 2018-02-09 | A kind of compound Thief zone moisturizing elite and its preparation process |
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| CN (2) | CN110882203A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113230182A (en) * | 2021-05-06 | 2021-08-10 | 广州市涵美化妆品有限公司 | Firming and repairing face cream and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109497634A (en) * | 2018-11-21 | 2019-03-22 | 长沙浩然医疗科技有限公司 | A kind of athletic undergarment that environmental protection care chest gas permeability stiff stability is high |
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| CN106265372A (en) * | 2016-09-30 | 2017-01-04 | 广东丸美生物技术股份有限公司 | A kind of skin matrix with senile-resistant efficacy and preparation method and application |
| CN107550780A (en) * | 2017-09-22 | 2018-01-09 | 北京汉方淑华美容化妆品有限公司 | A kind of plant essence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105560077B (en) * | 2015-12-31 | 2018-12-18 | 上海宇昂水性新材料科技股份有限公司 | Transdermal enhancer used for cosmetic |
| CN106727164B (en) * | 2017-02-16 | 2018-02-23 | 中山卡丝生物科技有限公司 | A kind of moisture-keeping composition and its preparation method and application |
-
2018
- 2018-02-09 CN CN201911305149.XA patent/CN110882203A/en not_active Withdrawn
- 2018-02-09 CN CN201810131855.6A patent/CN108078886A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106265372A (en) * | 2016-09-30 | 2017-01-04 | 广东丸美生物技术股份有限公司 | A kind of skin matrix with senile-resistant efficacy and preparation method and application |
| CN107550780A (en) * | 2017-09-22 | 2018-01-09 | 北京汉方淑华美容化妆品有限公司 | A kind of plant essence and preparation method thereof |
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| 国家食品药品监督管理总局: "《化妆品安全技术规范（2015年版）》", 1 December 2016 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113230182A (en) * | 2021-05-06 | 2021-08-10 | 广州市涵美化妆品有限公司 | Firming and repairing face cream and preparation method thereof |
| CN113230182B (en) * | 2021-05-06 | 2022-07-19 | 广州市涵美化妆品有限公司 | Firming and repairing face cream and preparation method thereof |
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| CN108078886A (en) | 2018-05-29 |
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