CN115252651B - 嗜粘蛋白阿克曼菌在制备防治高血压的组合物中的应用和含有其的组合物 - Google Patents
嗜粘蛋白阿克曼菌在制备防治高血压的组合物中的应用和含有其的组合物 Download PDFInfo
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- CN115252651B CN115252651B CN202210642442.0A CN202210642442A CN115252651B CN 115252651 B CN115252651 B CN 115252651B CN 202210642442 A CN202210642442 A CN 202210642442A CN 115252651 B CN115252651 B CN 115252651B
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
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- 235000021023 sodium intake Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000004897 thiazines Chemical class 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940025790 vitamin k 1 injection Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
组别 | 收缩压(mmHg) |
正常对照 | 114.46±18.22* |
模型 | 185.69±15.78 |
替米沙坦 | 133.17±10.02 |
AM06活菌低剂量 | 138.53±9.95 |
AM06活菌高剂量 | 136.82±8.21 |
AM02活菌高剂量 | 139.49±11.85 |
AM06活菌+AM02活菌 | 120.46±8.79* |
BAA-835活菌 | 140.47±10.96 |
AM06灭活菌 | 137.11±12.18 |
AM02灭活菌 | 138.75±10.43 |
AM06灭活菌+AM02灭活菌 | 133.37±10.35 |
BAA-835灭活菌 | 141.50±9.98 |
组别 | ET-1(pg/mL) | NO(mmol/g) |
正常对照 | 65.82±4.42* | 26.45±4.58* |
模型 | 124.19±11.73 | 9.19±1.03 |
替米沙坦 | 73.40±6.76 | 21.47±3.26* |
AM06活菌低剂量 | 80.89±6.40 | 18.12±2.98* |
AM06活菌高剂量 | 81.05±4.74 | 18.36±3.38* |
AM02活菌高剂量 | 85.70±6.84 | 17.74±2.95 |
AM06活菌+AM02活菌 | 76.28±5.58* | 21.42±3.45* |
BAA-835活菌 | 88.85±6.48 | 15.38±2.87 |
AM06灭活菌 | 79.09±5.43 | 18.20±3.86* |
AM02灭活菌 | 86.32±4.85 | 17.35±3.22 |
AM06灭活菌+AM02灭活菌 | 79.39±5.27 | 20.34±3.66* |
BAA-835灭活菌 | 89.99±6.21 | 15.86±3.17 |
组别 | AngII(pg/mL) | NO(μmol/L) |
正常对照 | 36.57±8.03** | 85.43±12.36 |
模型 | 285.54±22.15 | 68.77±8.84 |
卡托普利 | 232.68±19.64 | 72.71±9.63 |
AM06活菌低剂量 | 244.57±14.34 | 125.24±8.92* |
AM06活菌高剂量 | 229.71±12.24 | 122.38±10.83* |
AM02活菌高剂量 | 248.99±11.37 | 120.32±9.48* |
BAA-835活菌 | 250.65±13.68 | 110.88±9.47 |
AM06灭活菌 | 236.78±19.63 | 119.56±10.11 |
AM02灭活菌 | 251.12±13.43 | 118.49±8.26 |
AM06灭活菌+卡托普利 | 71.47±11.42** | 90.37±23.42* |
AM02灭活菌+卡托普利 | 80.32±12.74** | 98.84±20.53* |
BAA-835灭活菌 | 267.38±16.58 | 103.73±11.45 |
组别 | ET-1(ng/L) | NO(μmol/L) |
正常对照 | 60.28±6.94* | 40.11±6.04** |
模型 | 74.46±7.59 | 7.55±1.26 |
缬沙坦 | 66.64±7.48 | 28.92±5.40* |
AM06活菌低剂量 | 68.37±5.01 | 26.51±5.98* |
AM06活菌高剂量 | 67.86±9.61 | 25.88±6.06* |
AM02活菌 | 68.82±7.36 | 25.86±7.52* |
AM06活菌+缬沙坦 | 62.46±7.23* | 34.69±8.26** |
AM02活菌+缬沙坦 | 63.18±8.29 | 32.53±7.47** |
BAA-835活菌 | 70.27±8.76 | 24.37±6.82* |
AM06灭活菌 | 68.74±6.21 | 26.92±5.89* |
AM02灭活菌 | 69.78±8.25 | 25.26±7.99* |
BAA-835灭活菌 | 71.35±7.89 | 23.28±6.78* |
组别 | 收缩压(kPa) |
正常对照 | 11.41±0.98* |
模型 | 19.46±1.83 |
氨氯地平 | 13.24±1.21 |
AM06活菌 | 14.58±1.16 |
AM06活菌+氨氯地平 | 10.76±0.88* |
BAA-835活菌 | 15.67±1.25 |
AM06灭活菌 | 14.97±1.67 |
AM06灭活菌+氨氯地平 | 11.22±1.04* |
BAA-835灭活菌 | 16.85±1.34 |
Claims (11)
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CN104918626A (zh) * | 2012-11-19 | 2015-09-16 | 卢万天主教大学 | 阿克曼氏菌属用于治疗代谢病症的用途 |
EP2919796A1 (en) * | 2012-11-19 | 2015-09-23 | Université catholique de Louvain | Use of akkermansia for treating metabolic disorders |
CN110964650A (zh) * | 2018-09-27 | 2020-04-07 | 上海上药信谊药厂有限公司 | 一种用于预防和治疗代谢疾病的菌株及其应用 |
WO2021133904A1 (en) * | 2019-12-27 | 2021-07-01 | Evelo Biosciences, Inc. | Solid dosage forms containing bacteria and microbial extracellular vesicles |
CN113330109A (zh) * | 2018-10-11 | 2021-08-31 | Ko生物技术有限公司 | 嗜黏蛋白阿克曼氏菌菌株及其用途 |
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CN104918626A (zh) * | 2012-11-19 | 2015-09-16 | 卢万天主教大学 | 阿克曼氏菌属用于治疗代谢病症的用途 |
EP2919796A1 (en) * | 2012-11-19 | 2015-09-23 | Université catholique de Louvain | Use of akkermansia for treating metabolic disorders |
CN110964650A (zh) * | 2018-09-27 | 2020-04-07 | 上海上药信谊药厂有限公司 | 一种用于预防和治疗代谢疾病的菌株及其应用 |
CN113330109A (zh) * | 2018-10-11 | 2021-08-31 | Ko生物技术有限公司 | 嗜黏蛋白阿克曼氏菌菌株及其用途 |
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