CN114949136B - Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and application thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic pharyngitis, which is prepared from the following raw materials in parts by weight: the invention has good effects of tonifying lung and spleen, warming kidney and strengthening yang, inducing fire and restoring vigor, nourishing yin and clearing lung and relieving sore throat, harmonizing stomach, and treating lung-spleen qi deficiency and kidney-yang deficiency type chronic pharyngitis.

Description

Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic pharyngitis and a preparation method and application thereof.

Background

Western medicine considers that acute simple pharyngitis is acute inflammation of pharyngeal mucosa and submucosal tissues, and lymphoid tissues of the pharynx are also frequently invaded. Cold and damp are the most common causative factors, endocrine dyscrasia, chronic systemic diseases, and chronic diseases of the nose and pharynx are also the cause of this disease. The pathogenic agents are mainly hemolytic streptococcus. Non-hemolytic streptococci, pneumococci, staphylococci and viruses may also be pathogenic. The chronic pharyngitis is a diffuse pharyngeal lesion caused by chronic infection, and the disease causes in various aspects, such as repeated attacks of acute pharyngitis, changes into chronic, and other diseases such as chronic nasal diseases, external bad stimulus, allergic physique and the like can also cause the disease.

As early as in the book "Nei Jing" (book of book) on chronic pharyngitis (pharyngitis), illustrating the etiology and pathogenesis of the pharyngitis and the acupuncture therapy thereof, the close relationship between the pharyngitis-symptoms and the lung, the kidney and the stomach is proposed for the first time. The symptoms of the shaoyin pharyngalgia are discussed in more detail in Zhang Zhongjing Shang Han Dynasty. In jin Kui Yao LWDU, there is a discussion of "adverse flow of fire with upward flow of qi, throat discomfort, adverse flow of qi with downward flow of qi, mai Dong Tang". The theory of typhoid fever, item 334, creates the idea of releasing the sore throat with pharyngeal pain: the patient who has fever after syncope and has spontaneous sweating and pain in the throat, with the throat being arthralgia. Fever without sweat, but with the symptoms of spontaneous stopping, purulent blood, and no arthralgia in the throat. And creates a related prescription for treating the pharyngitis, such as pig skin soup, platycodon root soup, pinellia tuber powder soup, bitter wine soup, tongmai Siqi decoction, dachengqi decoction and the like. The etiology and pathogenesis of the infantile pharyngitis are discussed in Sheng Ji general records. The 'Shengji general records, pediatric throat impediment' say: the disease of the throat obstruction, swelling and pain of the throat, the difficulty of drinking water, the impairment of respiration, and the arrival of cold and heat, the wind-heat affecting the spleen and lung, fumigating the throat, and the pure yang of children are especially the disease. "

Modern medicine is widely studied for chronic pharyngitis. In clinical research, with the progress of etiology research, it has been recognized that chronic pharyngitis is mostly caused by susceptible viral or (and) bacterial infections of acute upper respiratory tract infections, and common pathogenic bacteria are staphylococcus aureus, pneumococcus, streptococcus and the like. The study combining the clinical differentiation and syndrome differentiation has been reported, and various therapies are used for comprehensively treating chronic pharyngitis, but chemical medicaments are easy to generate drug resistance.

Chinese patent application: CN202110621753.4 discloses a honey paste for treating chronic pharyngitis and a preparation method thereof, sesame oil, walnut kernel and red date are adopted as main materials, and ginger, lotus root and other food materials are adopted as auxiliary materials, so that the health of a human body can be effectively regulated, the phenomenon of spleen dysfunction of the human body can be well improved, yin nourishing, lung clearing, body fluid production promoting and dryness moistening are realized, blood circulation activating and stasis removing are realized, and the effects of clearing heat, resolving phlegm, dispelling wind, dredging collaterals, promoting blood circulation, relieving fatigue and relieving sore throat and resolving masses are realized through the conditioning of an endosome, so that the phenomenon of repeated attacks of chronic pharyngitis in the traditional scheme is improved on the basis of effectively treating the chronic pharyngitis.

Chinese patent application: CN202110625229.4 discloses a traditional Chinese medicine composition for treating lung yin deficiency type chronic pharyngitis, an extract and application thereof, which are scientifically combined with clinical practice based on the traditional Chinese medicine dialectical treatment. Wherein, the adenophora root in the composition nourishes yin and moistens lung as principal drug, the schisandra fruit nourishes kidney and moistens lung, the dark plum astringes lung and engenders liquid, and helps principal drug moisten lung and stop cough, the composition is ministerial drug dried orange peel, the snakegourd peel and the raw hawthorn fruit reduce phlegm and promote qi circulation, the oldenlandia diffusa clear heat and detoxify, the fructus chebulae and the mint clear throat, and the six drugs are combined to assist principal drug, the assistant drug, the sore throat and the cough are adjuvant drug. Raw licorice root, radix Glycyrrhizae Praeparata has the effects of expelling phlegm and arresting coughing and harmonizing various drugs, and is used as a guiding drug. The composition has particularly obvious treatment effect on lung yin deficiency type chronic pharyngitis, and is safe and has no toxic or side effect.

However, similar to the invention, the reports of the traditional Chinese medicine composition for tonifying lung and spleen, warming kidney and strengthening yang and treating chronic pharyngitis, and the preparation method and application thereof are not seen at present.

Disclosure of Invention

The first aim of the invention is to provide a traditional Chinese medicine composition for treating chronic pharyngitis aiming at the defects of the prior art.

A second object of the present invention is to provide the use of a Chinese medicinal composition as described above, in view of the deficiencies of the prior art.

The third object of the invention is to provide a medicament for treating chronic pharyngitis aiming at the defects of the prior art.

A fourth object of the present invention is to provide a process for the preparation of a medicament as described above, which aims at the deficiencies of the prior art.

In order to achieve the first object, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating chronic pharyngitis is prepared from the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 15-25 parts of bighead atractylodes rhizome, 10-20 parts of radix sileris, 10-20 parts of ginseng, 15-25 parts of lotus seed pulp, 10-20 parts of semen coicis, 8-12 parts of fructus amomi, 20-30 parts of poria cocos, 8-12 parts of cinnamon, 10-20 parts of prepared rehmannia root, 20-30 parts of Chinese yam, 15-25 parts of pulp of dogwood fruit, 10-20 parts of cortex moutan, 8-16 parts of radix paeoniae alba, 8-12 parts of bulbus fritillariae cirrhosae, 10-16 parts of mint, 10-16 parts of scorched hawthorn fruit, 20-30 parts of roasted malt and 8-12 parts of roasted liquorice.

Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of astragalus membranaceus, 20-25 parts of bighead atractylodes rhizome, 15-20 parts of divaricate saposhnikovia root, 15-20 parts of ginseng, 20-25 parts of lotus seed pulp, 15-20 parts of coix seed, 10-12 parts of fructus amomi, 25-30 parts of poria cocos, 10-12 parts of cinnamon, 15-20 parts of prepared rehmannia root, 25-30 parts of Chinese yam, 20-25 parts of pulp of dogwood fruit, 15-20 parts of cortex moutan, 12-16 parts of white paeony root, 10-12 parts of unibract fritillary bulb, 12-16 parts of mint, 12-16 parts of scorched hawthorn fruit, 25-30 parts of roasted malt and 10-12 parts of roasted liquorice.

Preferably, the preparation method is used for preparing clinically acceptable pharmaceutical preparations according to the conventional preparation method of traditional Chinese medicines.

Preferably, the pharmaceutical preparation is granule, powder, capsule, tablet, decoction or oral liquid.

In order to achieve the second purpose, the invention adopts the following technical scheme:

the application of the traditional Chinese medicine composition in preparing medicines for treating chronic pharyngitis.

Preferably, the chronic pharyngitis is lung-spleen qi deficiency type chronic pharyngitis.

Preferably, the chronic pharyngitis is chronic pharyngitis with deficiency of lung-spleen qi and deficiency of kidney-yang.

In order to achieve the third object, the present invention adopts the following technical scheme:

a medicine for treating chronic pharyngitis is prepared from any one of the traditional Chinese medicine compositions.

Preferably, the medicament further comprises pharmaceutically acceptable adjuvants.

In order to achieve the fourth object, the present invention adopts the following technical scheme:

the preparation method of the medicine comprises the following steps:

(1) Taking the raw materials: astragalus root, bighead atractylodes rhizome, divaricate saposhnikovia root, ginseng, lotus seed flesh, coix seed, fructus amomi, poria cocos, cinnamon, prepared rhizome of rehmannia, chinese yam, dogwood fruit, cortex moutan, white paeony root, bulbus fritillariae cirrhosae, peppermint, charred hawthorn, roasted malt and roasted liquorice are soaked in water for 1 hour;

(2) Adding water for 2 times, adding water 10 times of the weight of the medicinal materials each time, boiling for 50min for the first time, boiling for 40min for the second time, and mixing the decoctions;

(3) Adding pharmaceutically acceptable pharmaceutical adjuvant according to conventional process, and making into clinically acceptable granule, powder, capsule, tablet, decoction or oral liquid.

The radix astragali is root of Astragalus mongholicus bge of Leguminosae. Collected in spring and autumn, removed with soil, fibrous root and root head, sun dried to six seven times, bundled and dried. The main functions are as follows: tonify qi, strengthen superficies, expel pus, promote urination and promote tissue regeneration. Can be used for treating qi deficiency, debilitation, chronic diarrhea, rectocele, spontaneous perspiration, edema, uterine prolapse, chronic nephritis, albuminuria, diabetes, and chronic open sore.

The bighead atractylodes rhizome has the effects of strengthening spleen, tonifying qi, drying dampness, promoting diuresis, stopping sweat and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and fetal movement. Medical Start Source records: "remove dampness and dryness, regulate middle warmer and replenish qi, warm middle warmer and remove dampness in spleen and stomach, remove stomach heat, strengthen spleen and stomach, promote diet, quench thirst and prevent abortion". ".

Radix Saposhnikoviae is the dried root of Umbelliferae plant radix Saposhnikoviae Saposhnikovia divaricata (Turcz.) Schischk. The roots of the plants without the flower stems are picked up in spring and autumn, the fibrous roots and the sediment are removed, and the plants are dried in the sun. Pungent and sweet in flavor and slightly warm in nature. Has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm.

The Ginseng radix is root of Ginseng radix of Araliaceae. The root contains various ginsenosides. Warm nature, sweet, slightly bitter and slightly warm. Enter spleen and lung meridian. Warm nature, sweet, slightly bitter and slightly warm. Enter spleen and lung meridian. To strengthen primordial qi, recover pulse, arrest excessive loss, invigorate spleen, benefit lung, promote fluid production and tranquilize the mind. Can be used for treating asthenia, listlessness, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, asthma, cough, and thirst due to body fluid deficiency.

The lotus seed meat is mature seed of Nelumbo nucifera Gaertn of Nymphaeaceae. Is mainly used for treating chronic diarrhea due to spleen deficiency, seminal emission due to kidney deficiency, diarrhea, difficult urination, metrorrhagia, leukorrhagia, restlessness, palpitation and insomnia.

The Coicis semen is dry mature seed of Coix lacryma-jobi L.var. Harvesting plants in autumn when the fruits are ripe, sun-drying, peeling the fruits, sun-drying, removing the hulls, the yellow brown seed coats and impurities, and collecting kernels. Sweet and bland in flavor and cool in nature. Enter spleen, stomach and lung meridians. Has effects of promoting water permeation, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substances, and resolving hard mass.

Fructus Amomi is dried mature fruit of Amomum villosa Lour.e. Amomum villosa Lour.var.xanthoides T.L.wu et Senjen or Hainan sand Amomum longiligulare T.L.wu of Zingiberaceae plant. Harvesting in summer and autumn, sun drying or low temperature drying. Pungent and warm in nature. It enters spleen, stomach and kidney meridians. Has effects of eliminating dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage. Can be used for treating damp obstruction, gastric fullness, hunger, spleen and stomach deficiency cold, emesis, diarrhea, vomiting of pregnancy, and fetal movement.

Poria is the dry sclerotium of Wolf, a fungus of the Polyporaceae family, poria cocos (Schw.) co. Digging for more than 7-9 months, removing sediment after digging out, piling up for "sweating", spreading out and airing until the surface is dry, then "sweating", repeating for several times until most of internal moisture is lost, and drying in the shade, namely "Fuling Zhi"; or cutting fresh Poria into pieces according to different parts, and drying in the shade, which are called "Poria block" and "Poria tablet", respectively. Sweet and light in nature and neutral in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and excrete dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm retention, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

The cortex Cinnamomi is dried bark of Cinnamomum cassia Cinnamomum cassia Presl belonging to Lauraceae. Peeling in autumn, and drying in the shade. Pungent and sweet in flavor, and big in heat. It enters kidney, spleen, heart and liver meridians. Has effects of invigorating fire, supporting yang, inducing fire, restoring primordial qi, dispelling cold, relieving pain, and warming and dredging channels. Can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, deficient yang floating up, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

The function of the prepared rehmannia root is mainly to nourish yin and enrich blood. For treating deficiency of yin and blood, debility of waist and knee, fatigue, bone steaming, spermatorrhea, metrorrhagia, menoxenia, diabetes, scanty urine, deafness, and dizziness.

The rhizoma Dioscoreae is dried rhizome of Dioscorea opposita Thunb of Dioscoreaceae. Digging for 11-12 months, cutting off root, cleaning soil, scraping off the outer skin with a bamboo knife, and sun-drying or oven-drying to obtain rhizoma Dioscoreae. Coarse Mao Shanyao is selected, soaked in clear water, heated slightly, covered with cotton quilt, moistened and thoroughly mixed, then put on a wood board to be kneaded into a cylinder, cut the two ends well, dried in the sun and polished to obtain the rhizoma dioscoreae. The main functions are as follows: invigorating spleen, tonifying lung, strengthening kidney, and replenishing essence. For diarrhea due to spleen deficiency, chronic dysentery, cough due to consumptive disease, diabetes, spermatorrhea, leukorrhagia, frequent urination. Spleen and stomach tonifying, body fluid generating, lung nourishing, kidney tonifying and seminal emission astringing. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, asthma and cough due to lung deficiency, spermatorrhea due to kidney deficiency, leukorrhagia, frequent urination, and diabetes due to deficiency heat. Bran-fried yam can invigorate spleen and stomach. It can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and leukorrhagia. (1) Book of changes: in the main injury, deficiency is reinforced, cold and heat evil is removed, middle energizer is reinforced, strength is improved, muscles are grown, and the hearing and eyesight are improved after long-term taking. (2) The miscellaneous records: the head and face wind, the head wind (first head wind') is dizzy, downbearing qi, stopping lumbago, treating consumptive disease, emaciation, filling five viscera, relieving dysphoria and heat, and strengthening key. (3) Drug Property theory (L): it is used for treating deficiency of the body, and has effects in invigorating five fatigue and seven injuries, removing cold wind, relieving lumbago, relieving heart-mind, invigorating heart-qi, and relieving deficiency of the body. (4) Diet therapy materia Medica: for headache, it helps to strengthen yin. (5) Japanese Sunji (Japanese Subtu) grass: has effects in strengthening tendons and bones, tranquilizing mind, and relieving amnesia. (6) Zhu Jong: raw and smashed and attached to hard toxin can dispel. (7) Typhoid implications (Shang-Cold implication): deficiency of the nourishment, clearing deficiency heat. (8) Compendium, compendium: tonifying kidney-qi, strengthening spleen and stomach, stopping diarrhea, resolving phlegm and saliva, and moistening skin and hair.

Fructus Corni is dried mature pulp of Corni fructus Cornus officinalis Sieb.et Zucc. Distributed in Shanxi, jiangsu, zhejiang, anhui, jiangxi, shandong, henan, hunan, sichuan, shanxi, gansu and other places. Has effects of invigorating liver and kidney, astringing, and relieving depletion. It is commonly used for dizziness, tinnitus, soreness of waist and knees, impotence, spermatorrhea, enuresis, frequent urination, metrorrhagia, leukorrhagia, excessive sweating, deficiency, internal heat and diabetes.

Cortex moutan is dry root bark of Paeonia suffruticosa of Paeoniaceae. Produced in Anhui, shandong, etc. Digging root in autumn, removing fine root, peeling root bark, and sun drying. Unprocessed or stir-baked. Modern researches have the anti-inflammatory effect of the contained paeonol and other glycoside components; the methanol extract of cortex moutan has platelet inhibiting effect; the paeonol has effects of tranquilizing, cooling, relieving fever, relieving pain, relieving spasm, inhibiting central nervous system, resisting atherosclerosis, promoting urination, and resisting ulcer.

Radix Paeoniae alba is dry root of Paeonia lactiflora Pallas Paeonia lactiflora Pall of Ranunculaceae. Digging in summer and autumn, cleaning, removing head, tail and root, decocting in boiling water, removing skin or peeling, decocting, and sun drying. Has effects of nourishing blood, regulating menstruation, astringing yin, suppressing sweating, softening liver, relieving pain, and suppressing liver yang. It is commonly used for sallow complexion due to blood deficiency, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb contracture pain, headache and dizziness.

The Bulbus Fritillariae Cirrhosae is dry bulb of Bulbus Fritillariae Cirrhosae FritiLlaria cirrhosa D.don, bulbus Fritillariae Ussuriensis FritiLlaria unibracteata Hsiao et K.C.Hsia, fritillaria Gansuensis Fritillaria przewalskii maxim, bolbostemma Pentaphyllum Fritillaria delavayi Franch, bulbus Fritillaria taibaiensis Fritillaria taipaiensis P.Y.Li or fritillaria palladae Fritillaria unibracteata Hsiao et K.C.Hsiavar.wabuensis (S.Tang et S.C.Yue) Z.D.Liu, S.Wanget S.C.Chen. Different characters are known as "Ping Bei", "Qing Bei", "Ku Bei" and "cultivation product". Has effects of clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving hard mass and resolving carbuncle. Can be used for treating cough due to lung heat, dry cough with little phlegm, cough due to yin deficiency, blood in phlegm, scrofula, acute mastitis, and pulmonary abscess.

The peppermint is a Labiatae plant, namely other dry whole grass belonging to the same genus, is mainly used by the mountain wetland beside the river, and the rhizome is transversely grown underground, so that the peppermint is an aromatic crop with special economic value. It is a medicine for inducing sweat and relieving fever, and can be used for treating influenza, headache, conjunctival congestion, fever, laryngopharynx, and gum swelling and pain.

The charred haw has the effects of treating diarrhea, removing food retention, stimulating appetite, promoting blood circulation, removing blood stasis, preventing heatstroke, reducing blood pressure, etc. It is applied to sunny hillside or mountain shrub, and is distributed in Jiangsu, zhejiang, yunnan, sichuan, guangxi and other places.

The roasted malt is mainly indicated for indigestion, abdominal distention and pain, spleen deficiency, anorexia, milk sweat stasis, breast pain and women's weaning. But is not suitable for women in lactation.

The honey-fried licorice root is a slice similar to a round or oval slice, has reddish brown or gray brown surface, is slightly glossy, has yellow to dark yellow section, forms a layer ring obviously and has radial shape. The radix Glycyrrhizae Preparata soup has effects of invigorating qi, nourishing yin, activating yang, and recovering pulse.

The invention has the advantages that:

1. the invention aims at the symptoms of lung and spleen qi deficiency, usually dry throat, no desire to drink, cough, easy phlegm, aversion to cold, excessive sweat, easy cold, tiredness and hypodynamia, low voice, loose stool, light pharyngeal congestion, long disease course and frequent acute attack. The throat is slightly dry, itchy and painful, and has the characteristics of obstruction of foreign bodies or sticky phlegm, and is easy to feel sweats and tired and weak. Sometimes it is combined with soreness and weakness of waist and knees, clear and long urine, listlessness and cold limbs, etc.

The invention is a traditional Chinese medicine composition mainly used for tonifying lung and spleen, warming kidney and strengthening yang, and inducing fire and returning to the origin to treat chronic pharyngitis, and simultaneously, the traditional Chinese medicine composition is used for tonifying middle-jiao and strengthening the spleen, and the traditional Chinese medicine pathological mechanism of chronic pharyngitis patients with chronic diseases of deficiency of kidney qi can be more effectively solved by adding the kidney and strengthening yang and inducing fire and returning to the origin while applying the lung and spleen tonifying medicines.

2. The invention optimizes the raw materials and the weight proportion thereof so as to achieve the optimal clinical curative effect. The research results show that the proportion can improve the clinical symptoms of the lung-spleen qi deficiency type chronic pharyngitis patients.

3. The raw material medicines of the invention conform to the compatibility principle of monarch, minister, assistant and guide: the astragalus root, the bighead atractylodes rhizome, the divaricate saposhnikovia root, the ginseng, the lotus seed meat, the coix seed, the fructus amomi and the poria cocos are used for tonifying lung and spleen; cortex Cinnamomi, radix rehmanniae Preparata, rhizoma Dioscoreae, corni fructus, kidney warming, yang supporting, pathogenic fire inducing and primordial qi strengthening are all monarch drugs, cortex moutan, radix Paeoniae alba, bulbus Fritillariae Cirrhosae, herba Menthae, lung heat clearing and sore throat relieving are ministerial drugs, fructus crataegi, radix Glycyrrhizae Preparata and stomach regulating are adjuvant drugs. The invention has strict formula and mild medicine property, and can improve the compliance of adaptation groups.

Detailed Description

The invention is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present invention and are not intended to limit the scope of the present invention. Further, it is understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the description of the present invention, and that such equivalents are intended to fall within the scope of the claims appended hereto.

Example 1 Chinese medicinal composition (I)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 25 parts of bighead atractylodes rhizome, 10 parts of divaricate saposhnikovia root, 20 parts of ginseng, 15 parts of lotus seed flesh, 20 parts of coix seed, 8 parts of fructus amomi, 30 parts of poria cocos, 8 parts of cinnamon, 20 parts of prepared rehmannia root, 20 parts of Chinese yam, 25 parts of fructus corni, 10 parts of cortex moutan, 16 parts of radix paeoniae alba, 8 parts of fritillaria cirrhosa, 16 parts of mint, 10 parts of scorched hawthorn fruit, 30 parts of roasted malt and 8 parts of roasted liquorice.

Example 2 Chinese medicinal composition (II)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 20 parts of divaricate saposhnikovia root, 10 parts of ginseng, 25 parts of lotus seed pulp, 10 parts of coix seed, 12 parts of fructus amomi, 20 parts of poria cocos, 12 parts of cinnamon, 10 parts of radix rehmanniae preparata, 30 parts of Chinese yam, 15 parts of fructus corni, 20 parts of cortex moutan, 8 parts of radix paeoniae alba, 12 parts of fritillaria cirrhosa, 10 parts of peppermint, 16 parts of scorched hawthorn fruit, 20 parts of roasted malt and 12 parts of roasted liquorice.

Example 3 Chinese medicinal composition (III)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 25 parts of astragalus membranaceus, 20 parts of bighead atractylodes rhizome, 15 parts of divaricate saposhnikovia root, 15 parts of ginseng, 20 parts of lotus seed flesh, 15 parts of coix seed, 10 parts of fructus amomi, 25 parts of poria cocos, 10 parts of cinnamon, 15 parts of prepared rehmannia root, 25 parts of Chinese yam, 20 parts of fructus corni, 15 parts of cortex moutan, 12 parts of white paeony root, 10 parts of fritillaria cirrhosa, 13 parts of mint, 13 parts of scorched hawthorn fruit, 25 parts of roasted malt and 10 parts of roasted liquorice.

Example 4 Chinese medicinal composition (IV)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 10 parts of divaricate saposhnikovia root, 10 parts of ginseng, 15 parts of lotus seed flesh, 10 parts of coix seed, 8 parts of fructus amomi, 20 parts of poria cocos, 8 parts of cinnamon, 10 parts of radix rehmanniae preparata, 20 parts of Chinese yam, 15 parts of fructus corni, 10 parts of cortex moutan, 8 parts of radix paeoniae alba, 8 parts of fritillaria cirrhosa, 10 parts of peppermint, 10 parts of scorched hawthorn fruit, 20 parts of roasted malt and 8 parts of roasted liquorice.

Example 5 Chinese medicinal composition (five)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 25 parts of bighead atractylodes rhizome, 20 parts of divaricate saposhnikovia root, 20 parts of ginseng, 25 parts of lotus seed pulp, 20 parts of coix seed, 12 parts of fructus amomi, 30 parts of poria cocos, 12 parts of cinnamon, 20 parts of prepared rehmannia root, 30 parts of Chinese yam, 25 parts of fructus corni, 20 parts of cortex moutan, 16 parts of radix paeoniae alba, 12 parts of fritillaria cirrhosa, 16 parts of mint, 16 parts of scorched hawthorn fruit, 30 parts of roasted malt and 12 parts of honey-fried licorice root.

Example 6 Chinese medicinal composition (six)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 15-25 parts of bighead atractylodes rhizome, 10-20 parts of radix sileris, 10-20 parts of ginseng, 15-25 parts of lotus seed pulp, 10-20 parts of semen coicis, 8-12 parts of fructus amomi, 20-30 parts of poria cocos, 8-12 parts of cinnamon, 10-20 parts of prepared rehmannia root, 20-30 parts of Chinese yam, 15-25 parts of pulp of dogwood fruit, 10-20 parts of cortex moutan, 8-16 parts of radix paeoniae alba, 8-12 parts of bulbus fritillariae cirrhosae, 10-16 parts of mint, 10-16 parts of scorched hawthorn fruit, 20-30 parts of roasted malt and 8-12 parts of roasted liquorice.

EXAMPLE 7 Chinese medicinal composition (seven)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 10 parts of divaricate saposhnikovia root, 10 parts of ginseng, 15 parts of lotus seed flesh, 10 parts of coix seed, 8 parts of fructus amomi, 20 parts of poria cocos, 8 parts of cinnamon, 20 parts of prepared rehmannia root, 30 parts of Chinese yam, 25 parts of fructus corni, 20 parts of cortex moutan, 16 parts of radix paeoniae alba, 12 parts of fritillaria cirrhosa, 16 parts of mint, 16 parts of scorched hawthorn fruit, 30 parts of roasted malt and 12 parts of honey-fried licorice root.

Example 8 Chinese medicinal composition (eight)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 30 parts of astragalus membranaceus, 25 parts of bighead atractylodes rhizome, 20 parts of divaricate saposhnikovia root, 20 parts of ginseng, 25 parts of lotus seed pulp, 20 parts of coix seed, 12 parts of fructus amomi, 30 parts of poria cocos, 12 parts of cinnamon, 10 parts of prepared rehmannia root, 20 parts of Chinese yam, 15 parts of fructus corni, 10 parts of cortex moutan, 8 parts of radix paeoniae alba, 8 parts of fritillaria cirrhosa, 10 parts of peppermint, 10 parts of scorched hawthorn fruit, 20 parts of roasted malt and 8 parts of roasted liquorice.

Example 9 Chinese medicinal composition (nine)

The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 22 parts of astragalus membranaceus, 22 parts of bighead atractylodes rhizome, 18 parts of divaricate saposhnikovia root, 12 parts of ginseng, 17 parts of lotus seed flesh, 18 parts of coix seed, 8 parts of fructus amomi, 28 parts of poria cocos, 12 parts of cinnamon, 18 parts of prepared rehmannia root, 28 parts of Chinese yam, 18 parts of fructus corni, 18 parts of cortex moutan, 16 parts of radix paeoniae alba, 8 parts of fritillaria cirrhosa, 10 parts of peppermint, 14 parts of scorched hawthorn fruit, 28 parts of roasted malt and 12 parts of roasted liquorice.

Example 10 decoction

The preparation method comprises the following steps: taking the raw materials according to the weight ratio of any one of the embodiments 1-9, soaking the raw materials in water for 1 hour, then adding water for 2 times, adding 10 times of the weight of the raw materials each time, boiling for 50min for the first time, boiling for 40min for the second time, and merging the decoctions; and (3) obtaining the product.

Example 11 granules

The preparation method comprises the following steps: taking the raw materials according to the weight ratio of any one of the embodiments 1-9, soaking the raw materials in water for 1 hour, then adding water for 2 times, adding 10 times of the weight of the raw materials each time, boiling for 50min for the first time, boiling for 40min for the second time, and merging the decoctions; filtering, concentrating the filtrate, cooling to room temperature, collecting supernatant, and concentrating to obtain fluid extract. Granulating fluid extract, dextrin and other medicinal adjuvants.

Example 12 tablet/Capsule

The preparation method comprises the following steps: taking the raw materials according to the weight ratio of any one of the embodiments 1-9, soaking the raw materials in water for 1 hour, then adding water for 2 times, adding 10 times of the weight of the raw materials each time, boiling for 50min for the first time, boiling for 40min for the second time, and merging the decoctions; filtering, concentrating the filtrate, cooling to room temperature, collecting supernatant, concentrating to obtain soft extract, adding medicinal adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule.

Example 13

The beneficial effects of the invention are described below in conjunction with clinical usage data:

diagnostic criteria: referring to the traditional Chinese medicine industry standard of the people's republic of China, namely the traditional Chinese medicine disease diagnosis curative effect standard-otorhinolaryngology disease diagnosis curative effect standard, the main symptoms are dry throat, itching throat, burning, slight pain and throat foreign body sensation; the main physical sign is chronic congestion of pharyngeal mucosa, or atrophy, hypertrophic pharyngeal lateral cable, hyperplasia of lymphatic follicular hyperplasia of pharyngeal rear wall; the course of the disease: for more than 2 months; medical history: can have repeated attack history of acute pharyngitis, smoking and drinking, spicy food history, or long-term smoke and harmful gas irritation history. And combining with the differentiation of symptoms in traditional Chinese medicine: often dry throat, but without desire to drink, cough, easy expectoration, aversion to cold, excessive sweating, easy cold, tiredness, debilitation, low voice, loose stool, light pharyngeal congestion, longer course of disease and acute attack. The throat is slightly dry, slightly itching and slightly painful, has foreign body obstruction feeling or phlegm adhesion feeling, is easy to feel sweats, is tired and debilitated, and sometimes has the effects of soreness and weakness of waist and knees, clear urine and long, and lassitude and cold limbs. The Chinese medicinal composition has the symptoms, and can be used for diagnosing lung-spleen qi deficiency type chronic pharyngitis and kidney-yang deficiency type chronic pharyngitis by combining with local physical signs. The number of patients was 50, 26 men and 24 women.

The administration method comprises the following steps: the two doses of the invention in the embodiment 1 are taken every day before and after meals, and seven days is a treatment course.

Curative effect judgment standard: the effect is shown: the pharyngeal symptoms disappeared and the examination was normal. The method is effective: the pharyngeal symptoms and signs are obviously relieved. Invalidation: no significant changes in symptoms and signs were observed. According to the related conditions of chronic pharyngitis, the traditional Chinese medicine composition is divided into three types of obvious effect, effective effect and ineffective effect.

In 50 cases, after the traditional Chinese medicine provided by the invention is taken, 12 cases are effective, 32 cases are effective, 6 cases are ineffective, the effective rate is 88%, and no toxic or side effect occurs in the treatment period.

Typical cases: zhang Mou A, 45 years old, teachers, cough, phlegm is easy to get out, aversion to cold, excessive sweat, easy to cold, tiredness and hypodynamia, low voice, loose stool, light and soft throat, clear and long urine, listlessness and cold limbs, chronic pharyngitis with deficiency of lung and spleen qi and chronic pharyngitis with deficiency of kidney yang, and after one month, the dry throat is lost, cough is sometimes lost after four months, and the cough is healed without recurrence after two years of back visit.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (10)

1. The traditional Chinese medicine composition for treating the chronic pharyngitis is characterized by being prepared from the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 15-25 parts of bighead atractylodes rhizome, 10-20 parts of radix sileris, 10-20 parts of ginseng, 15-25 parts of lotus seed pulp, 10-20 parts of semen coicis, 8-12 parts of fructus amomi, 20-30 parts of poria cocos, 8-12 parts of cinnamon, 10-20 parts of prepared rehmannia root, 20-30 parts of Chinese yam, 15-25 parts of pulp of dogwood fruit, 10-20 parts of cortex moutan, 8-16 parts of radix paeoniae alba, 8-12 parts of bulbus fritillariae cirrhosae, 10-16 parts of mint, 10-16 parts of scorched hawthorn fruit, 20-30 parts of roasted malt and 8-12 parts of roasted liquorice.

2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-30 parts of astragalus membranaceus, 20-25 parts of bighead atractylodes rhizome, 15-20 parts of divaricate saposhnikovia root, 15-20 parts of ginseng, 20-25 parts of lotus seed pulp, 15-20 parts of coix seed, 10-12 parts of fructus amomi, 25-30 parts of poria cocos, 10-12 parts of cinnamon, 15-20 parts of prepared rehmannia root, 25-30 parts of Chinese yam, 20-25 parts of pulp of dogwood fruit, 15-20 parts of cortex moutan, 12-16 parts of white paeony root, 10-12 parts of unibract fritillary bulb, 12-16 parts of mint, 12-16 parts of scorched hawthorn fruit, 25-30 parts of roasted malt and 10-12 parts of roasted liquorice.

3. The traditional Chinese medicine composition according to any one of claims 1-2, wherein the clinically acceptable pharmaceutical preparation is prepared according to a traditional Chinese medicine conventional preparation method.

4. The traditional Chinese medicine composition according to claim 3, wherein the pharmaceutical preparation is granules, powder, capsules, tablets, decoction or oral liquid.

5. Use of a Chinese medicinal composition according to any one of claims 1-2 in the preparation of a medicament for the treatment of chronic pharyngitis.

6. The use according to claim 5, wherein the chronic pharyngitis is chronic pharyngitis with deficiency of lung-spleen qi.

7. The use according to claim 6, wherein the chronic pharyngitis is chronic pharyngitis of the type of deficiency of the lung-spleen qi, combined with deficiency of the kidney-yang.

8. A medicament for treating chronic pharyngitis, which is characterized by being prepared from the traditional Chinese medicine composition according to any one of claims 1-2.

9. The medicament according to claim 8, characterized in that it further comprises pharmaceutically acceptable auxiliaries.

10. The method of preparing a medicament according to claim 8, comprising the steps of:

(1) Taking the raw materials: astragalus root, bighead atractylodes rhizome, divaricate saposhnikovia root, ginseng, lotus seed flesh, coix seed, fructus amomi, poria cocos, cinnamon, prepared rhizome of rehmannia, chinese yam, dogwood fruit, cortex moutan, white paeony root, bulbus fritillariae cirrhosae, peppermint, charred hawthorn, roasted malt and roasted liquorice are soaked in water for 1 hour;

(2) Adding water for 2 times, adding water 10 times of the weight of the medicinal materials each time, boiling for 50min for the first time, boiling for 40min for the second time, and mixing the decoctions;

(3) Adding pharmaceutically acceptable pharmaceutical adjuvant according to conventional process, and making into clinically acceptable granule, powder, capsule, tablet, decoction or oral liquid.