CN114903950A - A pharmaceutical composition for improving male hyposexuality - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving male hyposexuality. The pharmaceutical composition of the invention comprises the following components in parts by weight: 15-20 parts of prepared rehmannia root, 30-40 parts of Chinese yam, 10-15 parts of achyranthes root, 20-15 parts of poria cocos, 10-15 parts of eucommia bark, 15-30 parts of polygala root, 20-30 parts of schisandra chinensis, 15-30 parts of rhizoma acori graminei, 20-30 parts of fennel, 30-50 parts of morinda officinalis, 30-50 parts of cistanche, 20-30 parts of monkshood and 10-30 parts of asarum. The invention further utilizes the medicinal composition to prepare the incense spice, which not only can effectively improve the problem of male hyposexuality, but also has thick and elegant taste when being burnt and gives good smell feeling to users. Compared with oral medicines, the incense perfume has the advantages of safety and convenience in use, and has good application prospect.

Description

A pharmaceutical composition for improving male hyposexuality

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving male hyposexuality.

Background

Sexual dysfunction, including decreased libido, erectile dysfunction, and ejaculatory dysfunction. Wherein hypoactive sexual desire is a condition characterized by a decrease in both sexual life responsiveness and initial sexual performance levels. Manifested by sexual desire, sexual hobbies and related sexual thoughts or lack of sexual fantasy. Hyposexuality can occur at any age, regardless of sex.

Not only does sexual dysfunction affect the well-being of people's daily lives, but severe individuals may also be associated with a range of secondary symptoms, including emotional problems, and even somatic symptoms. Therefore, clinical treatment of hyposexuality is also required. The treatment method is mainly carried out according to the etiology, is supplemented with medicines, and can adopt methods such as psychotherapy, sexual sensation centralized training and the like.

The existing drug treatment for male sexual dysfunction mainly aims at improving symptoms such as impotence, premature ejaculation and the like, but the improvement on the problem of hyposexuality of patients is not obvious. The Chinese invention patent 'CN 104736150B method for restoring male sexual desire (more than much) by adopting dietary supplement with effect of restoring male sexual desire (more than much)' provides an oral composition for improving decreased sexual desire, which comprises L-arginine, pollen or bee bread, drone pupa, zinc compound, vitamin B6, herba Epimedii, radix Ginseng, rhaponticum carthamoides or rhizoma et radix Linderae. However, the composition provided in this patent is an oral drug, and from the viewpoint of improving the safety of administration and facilitating the use, it is still desired to develop a drug in a form other than oral administration.

Incense is a unique way of administering drugs. In ancient times, incense is also a very popular activity, is particularly widely applied to the noble level and the life of ink guests of the civilians, and is a necessary daily necessity for home health preservation and good sentiment. The incense is mostly prepared by the ways of bathing, wearing, atomized releasing, heated releasing, normal-temperature releasing and the like, is a non-invasive, simple and safe relieving or intervention means taking volatile substances synthesized by the secondary metabolism of plants as media, and is similar to the inhalation therapy of the modern aromatherapy.

In the preparation of medicinal incense, besides good treatment effect, the problem of feeling of aroma to human needs to be further considered, which makes the development of medicinal incense have great difficulty. Therefore, no incense medicine composition with good effect of improving the male hyposexuality exists at present.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a pharmaceutical composition for improving male hyposexuality, and aims to provide a pharmaceutical composition which can effectively improve male hyposexuality and has good sense for people and a incense spice prepared from the pharmaceutical composition.

A pharmaceutical composition for improving male hyposexuality comprises the following components in parts by weight:

15-20 parts of prepared rehmannia root, 30-40 parts of Chinese yam, 10-15 parts of achyranthes root, 20-15 parts of poria cocos, 10-15 parts of eucommia bark, 15-30 parts of polygala root, 20-30 parts of schisandra chinensis, 15-30 parts of rhizoma acori graminei, 20-30 parts of fennel, 30-50 parts of morinda officinalis, 30-50 parts of cistanche, 20-30 parts of monkshood and 10-30 parts of asarum.

Preferably, the composition consists of the following components in parts by weight:

15 parts of prepared rehmannia root, 45 parts of Chinese yam, 45 parts of achyranthes root, 30 parts of tuckahoe, 30 parts of eucommia bark, 30 parts of polygala root, 30 parts of schisandra fruit, 30 parts of grassleaf sweelflag rhizome, 30 parts of common fennel, 30 parts of morinda officinalis, 30 parts of desertliving cistanche, 30 parts of prepared common monkshood daughter root and 30 parts of asarum.

The invention also provides application of the pharmaceutical composition in preparing a medicament for improving male hyposexuality.

Preferably, the dosage form of the medicament is a gas preparation.

Preferably, the medicament is a stacte fragrance.

The invention also provides a medicine for improving male hyposexuality, which is prepared by taking the medicine composition as an active ingredient and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

Preferably, the dosage form of the medicament is a gas preparation.

Preferably, the medicament is a stacte fragrance.

The invention also provides a preparation method of the incense spice, which comprises the following steps:

step 1, grinding the medicinal composition into powder;

and 2, uniformly stirring the powder obtained in the step 1 with honey, and preparing the obtained powder into incense spice by using an incense press.

Preferably, in step 1, the powder is also sieved through a 200 mesh sieve.

The invention provides a pharmaceutical composition for improving male hyposexuality, and further provides a stacte spice prepared from the pharmaceutical composition. The external traditional Chinese medicine composition takes the morinda officinalis and the cistanche deserticola for warming and invigorating kidney yang, the prepared rehmannia root and the schisandra chinensis for nourishing kidney yin and achieving the wonderful effect of yin and yang harmony, the morinda officinalis and the cistanche deserticola are used as monarch drugs together, the peony and the poria cocos are used as ministerial drugs for tonifying spleen and stimulating appetite, transporting and transforming middle warmer, the eucommia ulmoides for tonifying governor vessels, the polygala tenuifolia and the calamus for opening emotion, the heart spirit is joyful, qi and blood are vigorous, qi and blood of the governor vessel of the yang pulse are enabled to run vigorously, male wind is enabled to be recruited, the fennel, the monkshood and the asarum are used as adjuvant drugs for warming and drying, the running speed of the drugs is accelerated, the feeling of male pleasure is enhanced, meanwhile, the achyranthes are used as the drugs are enabled to reach the position where male tendons and the vulva are located, the male libido is enhanced, the sexual indifference is improved, the yin and yang is established in sequence, the day collocation is taught, and the whole formula is enabled to play the wonderful effect of filling yin and tonifying yang and joyful feeling of joyful.

The incense spice is prepared by a simple process, is used by burning, and has the advantages of simple operation, safety and reliability compared with oral medicines. It can not only effectively improve the problem of male hyposexuality, but also has thick and elegant taste when incinerated, and gives users a good smell feeling. Therefore, the invention has good application prospect.

It will be apparent that various other modifications, substitutions and alterations can be made in the present invention without departing from the basic technical concept of the invention as described above, according to the common technical knowledge and common practice in the field.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Detailed Description

Example 1

This example provides a fragrance composition, which is prepared by the following steps:

the following drugs were: prepared rehmannia root five-piece cash (15 g), Chinese yam one-two half (45 g), achyranthes root one-two half (45 g), poria cocos one-two (30 g), eucommia bark one-two (30 g), polygala root one-two (30 g), schisandra chinensis one-two (30 g), grassleaf sweelflag rhizome one-two (30 g), common fennel fruit one-two (30 g), morinda officinalis one-two (30 g), cistanche one-two (30 g), aconite root one-two (30 g) and asarum herb one-two (30 g) are ground into powder, the powder is sieved by a 200-mesh sieve, the filtered powder is uniformly stirred by old honey, and the obtained product is extruded into linear incense with the thickness of 20cm and the diameter of 0.1cm by a incense press.

Example 2

This example provides a fragrance composition, which is prepared by the following steps:

the following drugs were: 12 g of prepared rehmannia root, 36 g of Chinese yam, 36 g of achyranthes root, 24 g of tuckahoe, 24 g of eucommia bark, 24 g of polygala root, 36 g of schisandra fruit, 36 g of grassleaf sweelflag rhizome, 36 g of fennel, 36 g of morinda officinalis, 36 g of desertliving cistanche, 36 g of prepared common monkshood daughter root and 36 g of asarum, grinding into powder, sieving by a 200-mesh sieve, uniformly stirring the filtered powder with old honey, and extruding the powder into a linear incense with the diameter of 0.1cm and the length of 20cm by a incense pressing device.

Example 3

This example provides a fragrance composition, which is prepared by the following steps:

the following drugs were: 18 g of prepared rehmannia root, 54 g of Chinese yam, 54 g of achyranthes root, 36 g of tuckahoe, 36 g of eucommia bark, 36 g of polygala root, 24 g of schisandra fruit, 24 g of grassleaf sweelflag rhizome, 24 g of fennel, 24 g of morinda officinalis, 24 g of desertliving cistanche, 24 g of monkshood and 24 g of asarum, grinding into powder, sieving by a 200-mesh sieve, uniformly stirring the filtered powder with old honey, and extruding the powder into a linear incense with the diameter of 0.1cm and the length of 20cm by a incense press.

The advantageous effects of the present invention will be further described below by experiments.

Experimental example 1

To demonstrate the efficacy of the incense fragrance of this example, control observations were made clinically on 30 male patients with decreased libido:

the method comprises the following steps: 30 patients with decreased libido who were collected from 2021 to 2021 at 3 months of a hospital and 6 months of the hospital were divided into treatment groups and control groups according to a random number table method, and each group had 15 patients.

Control patients were treated routinely: one daily treatment with sildenafil tablets; the patients in the observation group were fumigated with the fumigant of example 1 after taking sildenafil tablets one by one daily. The therapeutic method using incense and perfume comprises igniting the incense 21 o' clock per day, and keeping silent and smelling for 30 min within 1 m of the incense.

After 3 months of treatment, the two groups of patients were compared for treatment efficacy, sex hormone indicators [ testosterone (T), estradiol (E2), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL) ], the International erectile function index (IIEF-5), the world health organization quality of Life Scale for Life (WHOQOL-BREF) score.

The results are given in the following table:

TABLE 1 therapeutic Effect

TABLE 2 comparison of sex hormone indicators (x + -s) before and after treatment for two groups of patients

Note: aP is less than 0.05 compared with the group before treatment

TABLE 3 comparison of IIEF-5 scores before and after treatment (x. + -. s, points)

TABLE 4 WHOQOL-BREF score comparison (x + -s, points) before and after treatment for two groups of patients

Note: aP is less than 0.05 compared with the group before treatment

As can be seen from the above table, the total effective rate of the treatment in the observation group is 86.67% (13/15), which is obviously higher than 60% (9/15) of the control group, and the difference has statistical significance (P < 0.05); the IIEF-5 score and the WHOQOL-BREF score of the observation group are higher than those of the control group, and the difference has statistical significance (P is less than 0.05); after treatment, the observed group of patients had higher T control group, lower E2, FSH, LH, PRL than the control group, and the difference was statistically significant (P < 0.05). The experimental results show that the albizzia amurensis fragrance can effectively improve the treatment effect of the patient with decreased libido, improve the sex hormone level of the patient, improve the sexual erection function of the patient and improve the life quality.

As can be seen from the above examples and experimental examples, the present invention provides a pharmaceutical composition, and further provides a fragrance perfume prepared using the pharmaceutical composition. The incense spice of the invention not only can effectively improve the problem of hyposexuality of men, but also has thick and elegant taste when being burnt, and gives users good smell feeling. Compared with oral medicines, the incense perfume has the advantages of safety and convenience in use, and has good application prospect.

Claims (10)

1. A pharmaceutical composition for improving hypoactive sexual desire in a male, comprising: the composition comprises the following components in parts by weight:

15-20 parts of prepared rehmannia root, 30-40 parts of Chinese yam, 10-15 parts of achyranthes root, 20-15 parts of poria cocos, 10-15 parts of eucommia bark, 15-30 parts of polygala root, 20-30 parts of schisandra chinensis, 15-30 parts of rhizoma acori graminei, 20-30 parts of fennel, 30-50 parts of morinda officinalis, 30-50 parts of cistanche, 20-30 parts of monkshood and 10-30 parts of asarum.

2. The pharmaceutical composition according to claim 1, wherein: the composition consists of the following components in parts by weight:

15 parts of prepared rehmannia root, 45 parts of Chinese yam, 45 parts of achyranthes root, 30 parts of tuckahoe, 30 parts of eucommia bark, 30 parts of polygala root, 30 parts of schisandra fruit, 30 parts of grassleaf sweelflag rhizome, 30 parts of common fennel, 30 parts of morinda officinalis, 30 parts of desertliving cistanche, 30 parts of prepared common monkshood daughter root and 30 parts of asarum.

3. Use of a pharmaceutical composition according to claim 1 or 2 in the manufacture of a medicament for improving hypoactive sexual desire in men.

4. Use according to claim 3, characterized in that: the dosage form of the medicine is a gas preparation.

5. Use according to claim 4, characterized in that: the medicine is incense perfume.

6. A medicament for improving hypoactive sexual desire in men, comprising: the pharmaceutical composition is prepared by taking the pharmaceutical composition as defined in claim 1 or 2 as an active ingredient and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

7. The medicament of claim 6, wherein: the dosage form of the medicine is a gas preparation.

8. The medicament of claim 7, wherein: the medicine is incense perfume.

9. The method of producing a stacte fragrance of claim 8, wherein: the method comprises the following steps:

step 1, grinding the pharmaceutical composition of claim 1 or 2 into powder;

and 2, uniformly stirring the powder obtained in the step 1 with honey, and preparing the obtained powder into incense spice by using an incense press.

10. The method of claim 9, wherein: in step 1, the powder is also sieved through a 200 mesh sieve.