CN1175885C - Zibei Cough stopping granules and its preparation method - Google Patents

Abstract

The present invention discloses Zibei cough stopping granules for treating trachitis and bronchitis and a preparation method thereof. The granules are prepared from tatarian aster root, japanese ardisia herb, thunberg fritillary bulb, willowleaf swallowwort rhizome, stemona root, platycodon root, white mulberry root-bark, processed pinellia tuber, bitter apricot seed, dried tangerine peel, fineleaf schizonepeta herb, mint and radix glycyrrhiza as raw materials. According to different characteristics of all the traditional Chinese medicines, the granules are made through the procedures of distillation, clathration, alcohol reflux extraction, decoction, filtration, concentration by centrifuging, vacuum drying, pulverization, granulation, etc. respectively. The present invention has the main effects of diffusing and downbearing lung qi, eliminating phlegm and stopping cough; according to the pathological characteristics of wet spleen, unsmooth air passage and impaired lung depuration caused by the wind evil of protracted cough because of trachitis and bronchitis, the problems of protracted cough and expectoration of phlegm are especially considered. The formulation of the present invention is characterized in that both cold medicines and warm medicines are selected and used together, the formulation is warm but not dry, and moist but not sticky; the formulation has the effects of dissipating cold but not assisting heat, and resolving the exterior but not damaging healthy energy. The prescription has the effects of regulating and smoothening functional activity of vital energy, ascending and descending mutual causality, diffusing and clearing away lung depuration, promoting qi and phlegm, repairing lung depuration, and stopping cough and counterflow. The Zibei cough stopping granules are suitable for patients whose lungs are easily damaged by evil which belongs to trachitis and bronchitis.

Description

A kind of anti-cough granules and preparation method for the treatment of tracheobronchitis

Technical field: the present invention relates to a kind of Chinese medicine preparation, being specifically related to a kind of is raw material with the Chinese herbal medicine, and the treatment tracheobronchitis is with anti-cough granules and prepare the technology of this granule.

Background technology: acute tracheobronchitis be at present clinical in modal disease, wherein have a patient can delay with the passing of time, outbreak then becomes chronic bronchitis repeatedly.According to statistics, the sickness rate of chronic bronchitis is 3%-5%, and prevalence can sharply rise to 10%-15% more than 50 years old.This and acute tracheobronchitis are failed in time treatment or malpractice, so that having coughed for a long time is not more or more and recurrence has some relations.The medicine of the acute tracheobronchitis of Chinese traditional treatment is a lot, but not more or more not and the recidivist does not still have Chinese patent medicine targetedly, be suitable for ailment said due to cold or exposure as the antitussive ball to violate lung the Lung Qi obstraction card for having coughed for a long time, but square Chinese medicine is partial to warm-dryness syndrome, and the medicine with expectorant effect under the sending down the abnormal ascending QI is not strong, and having coughed for a long time is not more or more and the recidivist has heat-transformation trend unavoidably, if be used for this surplus evil lung disease of loving, probably pathogenic first evil heat-transformation, the power of second falling expectorant is not enough, so be unwell to this card; SUNJU GANMAO PIAN, Chinese ephedra and almond containing cough stopping sheet, Succus Bambusae phlegm-resolving pill, qingfei yihuo ball, Chinese white olive for relieving cough ball, cough syrup I, cough syrup II, Fel Serpentis et Bulbus Fritillariae Cirrhosae Liquidus etc., though all be used for cough, but they or only be used for pathogenic wind-warm (heat) and violate lung, or singly be used for phlegm-heat obstructing in the lung, or and be used for lung-dryness syndrome due to deficiency of YIN, for this surplus evil cough of loving lung naturally the medicine card be not inconsistent; Tongxuan lifei pills induce sweat cold expelling, lung qi dispersing cough-relieving, the wind and cold that can be used for cough is violated the lung card, and this surplus evil cough of loving lung is had the fraud of injuring YIN due to production of dryness.The cough-relieving treasured is more excellent to the few person's effect of chronic cough expectorant, so to this surplus evil cough with copious phlegm person who loves lung, the anxiety of loving the unconsciousness due to blockage of phlegm lung is arranged then.Above preparation is all made laws from preventing phlegm from forming and stopping coughing, or warm-dryness syndrome relatively, or it is relatively hot cool, or it is relatively clear and rich, or clear beautiful heat and the exterior cold of hold concurrently loosing, or purte the white and and logical intestinal internal organs, or expectorant heat and the lung moistening of holding concurrently is dry, emphasis has been considered impaired depurative descending of lung QI cough phlegm dyspnea, only is suitable for simple wind and cold, wind heat, dryness of the lung card or lung-heat and the exterior cold of holding concurrently, expectorant is stopped up and see that internal organs is real, the hot and double dryness of the lung person of expectorant.

Summary of the invention: technical problem to be solved by this invention is according to evil symptom feature and etiology and pathogenesis thereof of loving the lung card after the acute tracheobronchitis patient, with dispersing and lowering lung-QI, preventing phlegm from forming and stopping coughing method with rapid reduction of patient expectoration symptom, double the executing of cold temperature, lifting is also used, the lung spleen people having the same aspiration and interest, its legislation, select medicine, prescription, meet Chinese medical theory and adapt to the etiology and pathogenesis of disease.

Technical problem of the present invention is to solve by following technical scheme.It is characterized in that its granule is to make with the raw material of following weight parts: Radix Asteris 300-600 gram; Herba Ardisiae Japonicae 300-600 gram; Bulbus Fritillariae Thunbergii 300-500 gram; Rhizoma Cynanchi Stauntonii 300-600 gram; Radix Stemonae 300-500 gram; Radix Platycodonis 300-500 gram; Cortex Mori 200-500 gram; Rhizoma Pinelliae Preparatum 300-400 gram; Semen Armeniacae Amarum 200-300 gram; Pericarpium Citri Reticulatae 200-500 gram; Herba Schizonepetae 200-500 gram; Herba Menthae 200-500 gram; Radix Glycyrrhizae 200-500 gram, wherein Radix Asteris is the processed with honey Radix Asteris.Its process for producing granula comprises the steps: 1. Pericarpium Citri Reticulatae, Herba Schizonepetae, Herba Menthae three in the above-mentioned prescription to be distinguished the flavor of distillating extracting oils, the volatile oil β-CDBao He, and clathrate is standby, and medicinal residues and extracting solution are put in addition; 2. get Bulbus Fritillariae Thunbergii, the Radix Stemonae, Semen Armeniacae Amarum and add 70% alcohol reflux secondary, merge extractive liquid,, decompression recycling ethanol be not to there being the alcohol flavor, and to be concentrated into relative density be 1.2～1.5 thick paste, and be standby; 3. get Cortex Mori, Radix Asteris, Herba Ardisiae Japonicae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Rhizoma Pinelliae Preparatum, Radix Glycyrrhizae and decoct with water once, then medicinal residues and aforementioned Pericarpium Citri Reticulatae, Herba Schizonepetae, Herba Menthae three flavors are decocted the back medicinal residues and merge again and decoct once; 4. with the aforesaid liquid collecting decoction, filter, it is 0.9～1.2 clear paste that filtrate is concentrated into relative density, make centrifugal treating after, being evaporated to relative density is 1.2～1.5 thick pastes, merges with above-mentioned alcohol extraction thick paste again; 5. above-mentioned paste is carried out vacuum drying, grinding and sieving adds beta-CD inclusion and adjuvant, and mixing is granulated, drying, and granulate forms.

The present invention has dispersing and lowering lung-QI, preventing phlegm from forming and stopping coughing effect, is suitable for the surplus evil lung person that loves of genus of acute tracheobronchitis.With prior art, the present invention has following characteristics: attach most importance to dispersing and lowering lung-QI, preventing phlegm from forming and stopping coughing, wet at the ailment said due to cold or exposure priming spleen of primary disease chronic cough, air flue is unfavorable, and the pathological characteristic of impairment of purifying function of the lung is considered chronic cough emphatically, the problem of coughing up phlegm; Its prescription is selected the medicine using medicines of both cold and hot natures simultaneously, temperature and not dry, profit and oiliness, cold expelling and do not help heat, induce sweat and just do not hinder, be different from the prior art Chinese medicine and be used for the shortcoming that wind and cold, wind heat, dryness of the lung disease etc. often obviously can not be taken, affect the treatment because of nausea and vomiting after the chemotherapy merely; Prescription is noted harmonizing the functional activities of vital QI, and mutual causality of ascending and descending is declared respectful developing simultaneously, and makes the capable then expectorant of gas capable, clear respectful must the answering of lung, and cough with dyspnea is from ending.

The specific embodiment:

In recent years result of study shows: the main pathogenesis of acute tracheobronchitis, be that ailment said due to cold or exposure is violated lung, can press from both sides cold, hot, phlegm-damp, stagnated fire etc., but wind, expectorant are many, its clinical disease mainly contains: wind and cold is violated lung, wind heat is attacked lung, wind-phlegm resistance lung or loved diseases such as lung, stagnant pathogen of Shaoyang, and with regard to clinical findings, the cough caused primary symptom of acute tracheobronchitis is cough, coughs up phlegm, so it is wet that the key of its pathogenesis is exopathogen priming spleen, it is unfavorable to cause air flue, impairment of purifying function of the lung, so primary disease is many with the disease of wind-phlegm resistance lung or love lung often.The present invention is according to above-mentioned result of study, at patient's having coughed for a long time more or more do not recur, cough up phlegm, cardinal symptom such as uncomfortable in chest, select for use and have the lung qi dispersing dissipating depression of QI, fall the phlegm and relieving cough effect, and character is gentle, temperature and not dry, profit and oiliness, cold expelling does not help heat, induce sweat and do not hinder positive medicine symptomatic treatment, its interrelated data of respectively forming medicine is as follows:

Radix Asteris: bitter in the mouth, suffering, warm in nature, return lung meridian.Main cough with dyspnea is treated spitting bloody pus, and Zhichuan is throbbed with fear, soft and moist having a surplus, though the toil of saying and temperature is non-scorching comparable is specially can the using pungent drugs for dispersion and bitter drugs for purgation lung strongly fragrant, cough sending down the abnormal ascending QI surely, and a surname is logical to stop up stagnantly, holds concurrently and dredges the man QI and blood of lung.The Radix Asteris fluid extract is the what is said or talked about antitussive of dispelling; Radix Asteris condensed water decoct 10g/kg gives mouse stomach, and tangible phlegm-dispelling functions is arranged; The Radix Asteris decoct irritates stomach for anesthetized rabbit 1g/kg, and the trachea secretory volume is increased, and phlegm-dispelling functions is remarkable, and is sustainable more than 4 hours.More than narration shows: Radix Asteris have can open can fall, the preventing phlegm from forming and stopping coughing effect, and obvious expectorant pharmacological action is arranged.

Herba Ardisiae Japonicae: bitter in the mouth, property are put down, and return lung, Liver Channel.But pathogenic wind expelling cold expelling, control all as the cough, spit blood, pain due to disorder of QI, with single Herba Ardisiae Japonicae decoct, extractum and alcohol extraction sheet are successively treated chronic tracheitis 567 examples, every day 30-60g, serve on 10 days, effective percentage is 61.6%～75.6%, this medicine has antitussive, eliminate the phlegm, effect such as relieving asthma, the mouse cough that cough that its decoct and Bergeninum cause electricity irritation cat superior laryngeal nerve and ammonia spraying cause all has tangible antitussive action, the cough-relieving intensity of Bergeninum is equivalent to 1/4～1/7 of codeine by calculating correction values, the antitussive action of clinical oral administration 125mg is similar to the effect of 25mg carbetapentane citrate or omit, and this medicine is to coughing centre inhibitory action selectively; This medicine decoct all has tangible phlegm-dispelling functions for the oral or lumbar injection of mice; Rhizoma Seu Herba Bergeniae for oral administration have people's effect of certain prevention and treatment chronic tracheitis, and show as goblet cell and reduce, cell infiltration, pathologic change degree such as the emphysema and the pulmonary collapse alleviate.More than narration shows: Herba Ardisiae Japonicae has the merit of preventing phlegm from forming and stopping coughing, and antitussive is arranged, pharmacological action such as eliminate the phlegm, relieving asthma.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, return lung, heart channel.Mental disorder falls most in great order lung abscess, consumptive lung disease, cough with asthma, haematemesis, epistaxis, kind relieving stagnation; The sharp expectorant that detoxifies is opened lung qi dispersing gas, all lungs man folder wind-fire has expectorant person suitable this; Merit is specially detoxified, and the diffusing expectorant of holding concurrently stagnates; Removing heat from the lung and dissipating phlegm, cough cures cold.Peimine and peiminine 4mg/kg subcutaneous injection or gastric infusion draw oxyammonia and to cough mice, mechanical stimulus and draw and cough Cavia porcellus and electricity irritation superior laryngeal nerve and draw and cough cat and all show antitussive effect.Peimine 3mg/kg lumbar injection draws sulfur dioxide and to cough mice antitussive effect is arranged.More than narration shows: Bulbus Fritillariae Thunbergii can removing heat from the lung and dissipating phlegm, the sending down the abnormal ascending QI cough-relieving, and the pharmacological action of antitussive is arranged.

Rhizoma Cynanchi Stauntonii: acrid in the mouth, sweet, slightly warm in nature is returned lung meridian.Cure mainly cough with dyspnea; But Baoding lung qi is controlled use of coughing more; Protect the lung lung heat clearing, the cough due to disorder of QI chronic cough is used more; But expectorant under the sending down the abnormal ascending QI; Eliminating the pathogens from the lung, it is real to control the lung qi harmony, chest and diaphragm fullness due to adverse ascending of QI, chronic cough hemoptysis.The extract of Flos Genkwa leaf Rhizoma Cynanchi Stauntonii is given mouse stomach, its water extract 5g/kg, 10g/kg, 20g/kg, and alcohol extract 5g/kg and ether extract 10g/kg have tangible antitussive effect; Water extract 20g/kg, 10g/kg and alcohol extract 5g/kg all have significant phlegm-dispelling functions.The antitussive of its water extract, phlegm-dispelling functions have certain dose-effect relationship; Flos Genkwa leaf Rhizoma Cynanchi Stauntonii water extract 5g/kg, 2.5g/kg lumbar injection, the Cavia porcellus asthma that acetylcholine and histamine mixed liquor are brought out all has tangible preventive effect.More than narration shows: Rhizoma Cynanchi Stauntonii has the eliminating the pathogens from the lung sending down the abnormal ascending QI, the effect of following phlegm and relieving cough, and obvious antitussive is arranged, eliminate the phlegm and the pharmacological action of prevention of asthma.

The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature is returned lung meridian.Main cough with dyspnea; Control lung man heat, last gas cough with dyspnea, main profit lung benefiting; Temperature is and cold, and cough of cold type should it; But phlegm eliminating and Qi-regulating is for controlling the panacea of hectic fever due to YIN-deficiency chronic cough; The deficiency-heat cough is spitted blood and be shoulded it.Control pertussis, pulmonary tuberculosis, bronchitis.The Radix Stemonae 20 gram, decocting 2 times be decocting liquid 60ml altogether, divide clothes every day 3 times, treat chronic tracheitis 110 examples, and medication is after 10 days, total effective rate 87.27%.The immersion of Radix Stemonae ethanol has antibacterial action to staphylococcus aureus, Staphylococcus albus, beta hemolytic streptococcus, anthrax bacillus, pneumobacillus, Bacillus tuberculosis etc.; Radix Stemonae alkaloid can reduce the irritability of animal breath maincenter, suppresses coughre flex.100% Radix Stemonae alkaloid has its intensity of relexation and amine tea to be similar to the stripped guinea pig bronchial smooth muscle spasm due to the histamine, but slowly and lastingly.More than narration shows: the Radix Stemonae can nourishing the lung to arrest cough, can be used for treating tracheitis, bronchitis, cough, pertussis, pulmonary tuberculosis cough, and the pharmacological action of antibiotic, antitussive, alleviation bronchitis smooth muscle spasm is arranged.

Radix Platycodonis: bitter in the mouth, suffering, property is flat, attaches to the lung and stomach meridians; But removing food stagnancy is poly-, sputum, and main lung-heat tachypnea is coughed contrary; The tonify deficiency expectorant; Control lung-heat gas run quickly short cough contrary, the lung abscess evacuation of pus; End pharyngalgia, hold concurrently and remove nasal obstruction; Sharp diaphragm gas is still controlled lung abscess; Open chest and diaphragm, remove last gas and stop up, by lung-heat, firmly cough, descend expectorant, control the lung abscess evacuation of pus; Main sharp lung qi, logical throat, alleviating distention in middle-JIAO is regulated the flow of vital energy, and the key medicine of the capable expectorant of dissipating depression of QI is also.Abundant expectoration cough, is coughed the vomiting bloody pus Platycodi Pill at laryngopharynx swelling and pain, lung abscess, the function evacuation of pus, eliminate the phlegm, sore-throat relieving; 1g/kg gavages with the Radix Platycodonis decoct, can significantly increase anesthetized dog respiratory mucus secretory volume, and its intensity can be compared with ammonium chloride; The phlegm-dispelling functions of Radix Platycodonis stimulates gastric mucosa when oral mainly due to its contained Saponin, increase the bronchial mucosa secretion reflectingly, makes the sputum dilution and is discharged from.Kikyosaponin has antitussive effect; The Radix Platycodonis water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves activity of lysozyme.More than narration shows: Radix Platycodonis can be opened lung qi dispersing gas, expelling phlegm for arresting cough.Can be used for the cough due to common cold, chronic bronchitis etc., and eliminate the phlegm, pharmacological action such as antitussive, sterilization.

Cortex Mori: sweet in the mouth, suffering, cold in nature, return lung, spleen channel, and eliminate the phlegm, pharmacological action such as antitussive, sterilization; Can sharp the five internal organs, control all pathogenic wind, aqueous vapor; The therapeutic method to keep the adverse QI flowing downwards in the accent, beneficial the five internal organs, expectorant is quenched the thirst; Eliminating the pathogens from the lung, sharp intestine and small intestine, sending down the abnormal ascending QI, blood looses; End the cough due to lung-heat; Cortex Mori fluid extract 2～3ml, oral, every day 3 times, the function eliminating phlegm and relieving cough is used for the cough due to lung-heat; The Cortex Mori severe edema due to hypofunction of the spleen or n-butanol extract have the body temperature of reduction and slight antitussive effect to more than the mouse peritoneal injection 50mg/kg.More than narration shows: Cortex Mori has eliminating pathogen from the lung for relieving asthma, clearing and antitussive effect, and the pharmacological action that reduces body temperature, slight antitussive is arranged.

Rhizoma Pinelliae Preparatum: Xin Wen goes into lung, spleen, stomach warp.Expectorant saliva, appetite promoting and the spleen strengthening, preventing or arresting vomiting is told, and goes in the heart expectorant full, following lung qi, cough-relieving knot; The full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea; Control cold-phlegm and cold physique drink cold injury lung and coughing; Can walk and can loose, the stomach function regulating spleen invigorating, dehumidifying is reduced phlegm, and delivers dissipating depression of QI, and subinverse gas ends tired vomitting.The decoct of Rhizoma Pinelliae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), the Alumen Rhizoma Pinelliae is irritated stomach to cat, and obvious suppression cough effect is arranged, and the antitussive effect of 0.6g/kg is similar to codeine 1g/kg, and sustainable more than 5 hours.Rhizoma Pinelliae Preparatum has the effect of the spleen of accent stomach function regulating simultaneously to control cold-phlegm, damp-phlegm.More than narration shows: Rhizoma Pinelliae Preparatum has obvious expectorant saliva, cough-relieving retroaction, and can invigorating the spleen and regulating the stomach, the dissipating depression of QI eliminating stagnation, and the pharmacological action of obvious inhibition cough, society's expectorant is arranged.

Semen Armeniacae Amarum: bitter in the mouth, warm in nature, return lung, large intestine channel.Main cough with dyspnea is thunderous, sore throat, the therapeutic method to keep the adverse QI flowing downwards; The cough of treatment lung qi, dyspnea; Can sharp laryngopharynx, go in sore throat, expectorant saliva, cough, the larynx accumulation of heat to give birth to skin ulcer; Remove lung-heat, control part of the body cavity above the diaphragm housing the heart and lungs wind-dryness, sharp chest and diaphragm QI rising in reverse order; Cough-relieving is coughed, the expectorant lung moistening; Expelling pathogenic factors from muscles by diaphoresis, the cold cough of the lung-wind syndrome that looses, the women's head-ornaments ailment said due to cold or exposure, the Semen Armeniacae Amarum decocting in water is a cream, can draw the expectorant intake of food in the morning and vomitting in the evening; Fry Semen Armeniacae Amarum with belt leather Semen Armeniacae Amarum and peeling and grind, respectively add the equivalent crystal sugar and make amygdalose respectively, the treatment senile chronic bronchitis, effective percentage 96.8% is to coughing, expectorant, breathing heavily good action is all arranged; Peeling amygdalose effective percentage 75.1% Antitussive and Expectorant Effect is arranged, but the Zhichuan effect is relatively poor.Amygdalin is decomposed by the enteric microorganism enzyme or is decomposed by the contained emulsin of Semen Armeniacae Amarum itself at lower digestive tract, produces micro-hydrocyanic acid, can suppress respiratory center and reaches the antitussive and antiasthmatic effect.More than narration shows: Semen Armeniacae Amarum has lowering the adverse-rising QI to resolve phlegm, function of relieving cough and calming asthma, and the pharmacodynamics effect that has antitussive to cough to relieving asthma.

Pericarpium Citri Reticulatae: acrid in the mouth, hardship, warm in nature, go into lung, spleen channel.But the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is coughed; Main abdominal mass heat in the heart, contrary gas, diuretic paddy.Clothes are deodorized for a long time, and the therapeutic method to keep the adverse QI flowing downwards is logical refreshing; Control gas between chest and diaphragm, appetizing, main diarrhea due to disorder of qi, expectorant saliva is controlled the gas cough; Go cold-evil in the heart, the broken gas that stagnates, strengthening the spleen stomach; Fast diaphragm logical refreshing and in pleasant; The dampness expectorant; Sharp lung qi; The activating QI that reduces phlegm is controlled cough with dyspnea; The contained volatile oil of Pericarpium Citri Reticulatae has the zest phlegm-dispelling functions, and sputum is easily brought up; Commercially available bright Pericarpium Citri tangerinae decoct has faint dilating effect to the rabbit bronchitis, the Pericarpium Citri Reticulatae alcohol extract has than the effect of prednisone relaxation guinea-pig isolated trachea, it is higher in 11 kinds of QI regulating medicine of Rutaceae that the relievining asthma of Pericarpium Citri tangerinae tired, its ethanol extract 0.02g (crude drug)/ml, the contraction of guinea-pig isolated trachea due to the antagonism histamine fully.More than narration shows: Pericarpium Citri Reticulatae has drying dampness to eliminate phlegm, the merit of regulating qi-flowing for harmonizing stomach, and the pharmacological action that eliminating the phlegm is arranged, relieving asthma.

Herba Schizonepetae: acrid in the mouth, hardship, warm in nature.Go into lung, Liver Channel.The wind heat of can loosing, refresh oneself, throat; Diaphoresis, all wind of peeling hair; Control aversion to wind harmful wind.Main cold and heat person, cold and heat must and be done by the heresy Sheng, and the evil expelling pathogenic factors from muscles that looses is perspired then cold and heat spontaneous recovery; Can go into the Liver Channel edema caused by disorder of QI, disperse ailment said due to cold or exposure.All wind is outside the flesh side film, and sees that skin is scorching hot, and the head is giddy, and discomfort in the throat is carried pain person on the body, controls invariably with this and imitates.Herba Schizonepetae decoct 4.4g (crude drug)/kg lumbar injection to fever in rabbits due to typhoid fever, paratyphoid fever vaccine and the tetanus endotoxin mix preparation, has remarkable refrigeration function.Herba Schizonepetae volatile oil 0.5ml/kg irritates stomach, and normal rat is had the body-temp. reducing effect; Herba Schizonepetae oil 0.5ml/kg irritates stomach, or oily 0.25ml/kg lumbar injection, and the phenol red method test of mice shows that phlegm-dispelling functions is arranged; Herba Schizonepetae oil can direct loose guinea pig tracheal smooth muscle, can the tracheal smooth muscle due to the antihistamine be shunk, and spraying or irritate that stomach can obviously prolong acetylcholine and the histamine mixed liquor was breathed heavily incubation period drawing of Cavia porcellus, and reduce the number of animals of twitching takes place.More than narration shows: Herba Schizonepetae has dispelling wind to relieve the exterior syndrome, the effect of lung qi dispersing sore-throat relieving, and analgesic, pharmacological action such as eliminate the phlegm, relieving asthma is arranged.

Herba Menthae: acrid in the mouth, cool in nature, return lung, Liver Channel.Main harmful wind typhoid fever, diaphoresis; Wind, wind syndrome of the head cure the wound; Go high top and skin wind heat; The all wind of last refresh oneself ends headache, dizzy, heating, and expectorant dispels the wind.The wind that cures the wound cough, the sinusitis with purulent discharge nose flows smelly tears, moves back men and women's deficient fever; A small amount of Herba Menthae for oral administration has the effect of stimulating central nervous system, makes skin capillary vascular expansion by peripheral nerve, promotes sweat gland secretion, increases heat radiation, and the sweating and heat resolving effect is arranged; The irritation effect of menthol causes trachea to produce new secretion, and makes stiff mucus be easy to discharge, so phlegm-dispelling functions is arranged, report is also arranged, and it reaches Cavia porcellus good antitussive action is arranged per capita, and the pharmacological action of sweating and heat resolving, expelling phlegm for arresting cough is arranged.

Radix Glycyrrhizae: sweet in the mouth, property is flat, returns spleen, stomach, lung meridian.The lung being apt to suffer from adverse rising of QI, coughing is pneumonopathy, sweet flavor has the effect of relaxing is so control cough; Nourishing the lung to arrest cough, and the merit of eliminating the phlegm is arranged, genus diseases caused by exogenous pathogenic factor, the internal injury of no matter coughing have expectorant not have expectorant, all use it always; Coordinating the actions of various ingredients in a prescription is assisted mutually, and is out of question for power altogether, and property is slow, is apt to separate all urgency.Cause the Cavia porcellus subcutaneous injection enoxolone choline salt 1ml/kg that coughs to the aerosol that sucks ammonia and can suppress 80% coughing fit, similar with the effectiveness of codeine; Enoxolone, licoflavone, Radix Glycyrrhizae extractum all have tangible antitussive, phlegm-dispelling functions, and its antitussive effect system produces by acting on maincenter; Radix Glycyrrhizae can also promote throat and bronchial secretion, makes the easy expectoration of expectorant; Glycyrol extract and sodium glycyrrhetate all have inhibitory action external to staphylococcus aureus, tubercule bacillus, escherichia coli and infusorian.Radix Glycyrrhizae has significant antiinflammatory action, and anti-inflammatory component is glycyrrhizic acid and enoxolone; Glycyrrhizin can strengthen the activate the phagocytic capacity of macrophage non-specificly, and can remove the cytophagous inhibition activity of inhibition; Angelica Polysaccharide all has obvious inhibitory action external to vesicular stomatitis virus, adenovirus II type, I herpes simplex virus type and vaccinia virus.More than narration shows: Radix Glycyrrhizae has and middle emergency, coordinating the actions of various ingredients in a prescription, the merit of nourishing the lung to arrest cough.And relieving cough and expelling phlegm arranged, and suppressing antibacterial, virus, antiinflammatory strengthens the pharmacological actions such as activate the phagocytic capacity of macrophage, can expelling phlegm for arresting cough, again can coordinating the actions of various ingredients in a prescription.

The present invention is directed to acute tracheobronchitis symptom, above-mentioned Chinese herbal medicine with various pharmacology features is organically combined, make it have dispersing and lowering lung-QI, preventing phlegm from forming and stopping coughing and antitussive, eliminate the phlegm, relieving asthma, sterilize, suppress effects such as virus, antiinflammatory, and it is warm and not dry, the profit and oiliness, cold expelling does not help heat, induces sweat just not hinder, and is suitable for the surplus evil lung person that loves of genus of acute tracheobronchitis.

Embodiment:

Take by weighing raw material by following proportioning: Radix Asteris (processed with honey) 500 grams, Herba Ardisiae Japonicae 500 grams, Bulbus Fritillariae Thunbergii 417 grams, Rhizoma Cynanchi Stauntonii 500 grams, the Radix Stemonae 417 grams, Radix Platycodonis 417 grams, Cortex Mori 333 grams, Rhizoma Pinelliae Preparatum 250 grams, Semen Armeniacae Amarum 250 grams, Pericarpium Citri Reticulatae 333 grams, Herba Schizonepetae 333 grams, Herba Menthae 333 grams, Radix Glycyrrhizae 209 grams.With Pericarpium Citri Reticulatae, Herba Schizonepetae, Herba Menthae three flavor distillating extracting oils in the above-mentioned prescription, the volatile oil β-CDBao He, clathrate is standby, and medicinal residues and extracting solution are put in addition; Other gets Bulbus Fritillariae Thunbergii, the Radix Stemonae, Semen Armeniacae Amarum and adds 70% alcohol reflux secondary, and 2 hours for the first time, 1.5 hours for the second time, merge extractive liquid,, decompression recycling ethanol be not to there being the alcohol flavor, and be concentrated into the thick paste that relative density is 1.30 (60 ℃ of surveys), and be standby; Getting surplus medicines such as Cortex Mori then decocts with water twice, it is 2 hours for the first time, medicinal residues decocted 1.5 hours after adding for the second time Pericarpium Citri Reticulatae, Herba Schizonepetae, Herba Menthae decoction, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.05 (60 ℃ of surveys), make centrifugal treating after, being evaporated to relative density is the thick paste of 1.3 (60 ℃ of surveys), carry out vacuum drying after merging with above-mentioned alcohol extraction thick paste, grinding and sieving adds beta-CD inclusion and adjuvant again, mixing, granulate drying, granulate, make 1000 grams approximately.

Experimentation: the present invention stimulates the mouse breathing road to have tangible antitussive action to ammonia and sulfur dioxide; Be significantly increased (eliminate the phlegm) effect at mice trachea and capillary glass-tube at the excretion measurer of rat trachea to phenol red; Auricle edema of mice and abdominal cavity capillary permeability have tangible anti-swelling respectively and (antiinflammatory) effect is oozed out in minimizing; The fatality rate of mouse peritoneal pathogenic infection has tangible reduction (protection) effect; 8 kinds of common respiratory tract infection pathogenic bacterium all there is the different external antibacterial or bactericidal action of degree.Show that the present invention has tangible cough-relieving, eliminates the phlegm, antiinflammatory, bacteriostasis.

Clinical data:

One, physical data:

1, two groups of case sex ratios: see Table 1.

Table 1 liang group case sex (example)

Total routine number masculinity femininity

Treatment organizes 32 16 16

Matched group 31 14 17

Annotate: compare between group: x ²=0.148, P＞0.05

2, two groups of case age ratios: see Table 2.

Table 2 liang group case age distribution and mean age (year, x ± s)

The minimum maximum x ± SD of total routine number

Treatment organizes 32 18 65 42.62 ± 14.16

Matched group 31 18 65 142.19 ± 15.84

Annotate: compare between group: (T=0.114): P＞0.05

3, two groups of preceding main state of an illness indexs of treatment: see Table 3～4.

Table 3 liang group course of disease comparison (my god, x ± s)

Minimum x ± the SD at most of total routine number

Treatment organizes 32 3 30 7.87 ± 6.56

Matched group 31 3 30 7.45 ± 5.55

Annotate: compare between group: (T=0.276): P＞0.05

The total score value of syndrome before the table 4 liang group treatment (divide, x ± s)

The total score value of syndrome before total routine number treatment

Treatment organizes 32 11.69 ± 3.52

Matched group 31 12.65 ± 2.93

Annotate: compare between group: (T=1.17): equal P＞0.05

Above-mentioned physical data and state of an illness data are learned processing by statistics, and difference that there are no significant between treatment group and matched group group is pointed out between two groups harmonious well, has comparability.

Two, observed result:

All include the observation case in and all finish the course of treatment according to plan, do not have to lose and visit and reject case.

The efficacy result that disease is total:

1, doctor trained in Western medicine curative effect of disease: see Table 5.As known from Table 5, treatment group, matched group are respectively 71.8%, 61.2% to total obvious effective rate of acute tracheobronchitis, total effective rate is respectively 87.5%, 90.3%, through the significance test of two sample rate difference, and treatment group and matched group therapeutic equivalence (all P＞0.05).

Table 5 liang group treatment acute trachea-bronchitis curative effect and comparison thereof (example, %)

The total obvious effective rate total effective rate of total routine number clinical recovery produce effects enabledisable

Treatment organizes 32 18 554 71.8 ^▲87.5 ^▲

Matched group 31 9 10 93 61.2 90.3

Annotate: compare between group: total obvious effective rate (μ=0.890), total effective rate (μ=0.356), all ^▲P＞0.05

2, the surplus evil lung card curative effect of loving: see Table 6.From the table as can be known, treatment group, matched group are respectively 78.1%, 51.6% to surplus evil total obvious effective rate of loving the lung card, total effective rate is respectively 87.5%, 87.1%, show that two groups surplus heresy being loved the lung card all has better curative effect, other significance test of rate variance between group: total obvious effective rate, the treatment group is better than matched group (P＞0.05); Total effective rate, treatment and matched group therapeutic equivalence (P＞0.05).

Surplus evil love lung card therapeutic effect of syndrome of table 6 liang group treatment and comparison thereof (example, %)

The total obvious effective rate total effective rate of total routine number clinical recovery produce effects enabledisable

Treatment organizes 32 18 734 78.1 ^{▲ ▲}87.5 ^▲

Matched group 31 79 11 4 51.6 87.1

Annotate: compare between group: total obvious effective rate (μ=2.206) ^{▲ ▲}P＜0.05; Total effective rate (μ=0.048) ^▲P＞0.05

Three, change before and after the main parameters for observation on effect treatment

1, situation of change before and after the syndrome primary symptom score treatment: see Table 7.As shown in Table 7, two groups of syndrome primary symptom integrated values compare not statistically significant (P＞0.05) between group before the treatment, show to have comparability between group; Before treatment back 1,2,3,4,5 day and the treatment self relatively, two groups all have statistical significance (P＜0.01), point out two groups all can obviously improve the surplus evil lung card syndrome primary symptom scoring value of loving; Two groups of medications relatively, all have statistical significance (P＜0.05, P＜0.01) between organizing after 1,2,3,4,5 days, and prompting is better than matched group to the improvement treatment group of syndrome primary symptom integrated value.

Syndrome primary symptom integration situation of change before and after the table 7 liang group treatment (divide, x ± s)

Medication medication in 1 day medication in 2 days medication in 3 days medication in 4 days is 5 days before the treatment

11.68± 9.91± 7.59± 5.69± 3.66± 2.47±

Treatment component value

3.5 ^▲ 2.9 ^▲▲ 2.8 ^▲▲▲ 3.2 ^▲▲▲ 3.5 ^▲▲▲ 3.3 ^▲▲▲

1.78± 4.09± 6.0± 8.03± 9.22±

(n=32) difference

2.9 ^*** 2.8 ^*** 3.2 ^*** 4.2 ^*** 4.3 ^***

12.64± 11.32± 9.39± 7.81± 5.61± 4.58±

The matched group score value

2.9 2.4 2.4 2.2 2.8 3.3

1.32+ 3.26+ 4.84+ 7.03+ 8.06+

(n=31) difference

2.4 ^*** 2.4 ^*** 2.2 ^*** 3.0 ^*** 3.7 ^***

Annotate: self compares before and after the treatment: ^{* *}P＜0.01; Compare between group: ^▲P＞0.05, ^{▲ ▲}P＜0.05, ^{▲ ▲ ▲}P＜0.01

2, effective case onset time: see Table 8.As shown in Table 8, effectively case onset time treatment group is the shortest 4 hours, the longest 72 hours, average 24.64 ± 19.1 hours; Matched group is the shortest 6 hours, and is the longest 96 hours, and average 26.71 ± 23.5 hours, not statistically significant (P＞0.05) relatively between group showed that two groups of effective case onset times are close.

The effective case of table 8 liang group onset time (hour, x ± s)

Total routine number the longest the shortest x ± SD

Treatment organizes 28 4 72 24.64 ± 19.1

Matched group 28 6 96 26.71 ± 23.5

Annotate: compare between group (T=0.361): equal P＞0.05.

3, cough, expectorant, breathe heavily situation of change before and after the score treatment for two groups: see Table 9.As shown in Table 9, cough, expectorant, breathe heavily integrated value for two groups, not statistically significant (P＞0.05) relatively between group shows to have comparability between group before the treatment.Medication 1 day and medication 5 days self are compared before cough degree, cough frequency, expectoration and the treatment, and two groups all have statistical significance (P＜0.01); Compare between group, except that 1 day cough degree of medication, cough frequency have the statistical significance (P＜0.05) all the other equal not statistically significants (P＞0.05).

Panted tachypnea medication 2 days, with the treatment before compare, the treatment group has statistical significance (P＜0.05), matched group is not statistically significant (P＞0.05) then, and statistical significance (P＜0.05) is relatively arranged between group; Medication 5 days, two groups all have statistical significance (P＜0.01); Compare not statistically significant (P＞0.05) between group.

Cough before and after the treatment of table 9 liang group, expectorant, breathe heavily the integration situation of change and (divide x ± s)

Example medication (1) medication in 1 day 5 days

Score value difference score value difference before the treatment of primary symptom packet count

Treatment of cough group 32 2.00 ± 0.50 ^▲1.62 ± 0.55 ^{▲ ▲}0.37 ± 0.49 ^{* *}0.56 ± 0.71 ^▲1.43 ± 0.80 ^{* *}

Degree matched group 31 2.19 ± 0.54 1.90 ± 0.39 0.29 ± 0.52 ^{* *}0.77 ± 0.61 1.41 ± 0.84 ^{* *}

Treatment of cough group 32 2.03 ± 0.64 ^▲1.59 ± 0.55 ^{▲ ▲}0.43 ± 0.61 ^{* *}0.50 ± 0.62 ^▲1.53 ± 0.87 ^{* *}

Frequency matched group 31 2.16 ± 0.52 1.90 ± 0.53 0.25 ± 0.44 ^{* *}0.77 ± 0.56 1.38 ± 0.76 ^{* *}

Treatment organizes 32 2.06 ± 0.71 ^▲1.59 ± 0.55 ^▲0.46 ± 0.62 ^{* *}0.37 ± 0.55 ^▲1.68 ± 0.82 ^{* *}

Expectoration

Matched group 31 1.87 ± 0.84 1.51 ± 0.62 0.35 ± 0.48 ^{* *}0.48 ± 0.67 1.38 ± 1.08 ^{* *}

The treatment of panting organizes 32 0.40 ± 0.61 ^▲0.25 ± 0.43 ^{▲ ▲}0.15 ± 0.36 ^{* *}0.03 ± 0.17 ^{▲ ▲}0.37 ± 0.60 ^{* *}

Tachypnea matched group 31 0.67 ± 0.74 0.61 ± 0.71 0.06 ± 0.35 ^{* *}0.25 ± 0.51 0.41 ± 0.67 ^{* *}

Annotate: (1) tachypnea of wherein panting is 2 days data of medication.

Self compares before and after the treatment: ^*P＞0.05, ^*P＜0.05, ^{* *}P＜0.01; Compare between group: ^▲P＞0.05, ^{▲ ▲}P＜0.05

4, situation of change before and after two groups of dried moist rale, itching throat, score uncomfortable in chest and greasy fur, floating-rolling pulses are treated: see Table 10～13.By table 10～13 as can be known, two groups of dried moist rales, itching throat, score uncomfortable in chest and greasy fur, floating-rolling pulse, not statistically significant (P＞0.05) relatively between group shows to have comparability between group before the treatment.Self compare before dried moist rale, itching throat, scoring value uncomfortable in chest and the treatment of medication after 2 days and after the 5th day, except that 2 days score value not statistically significant uncomfortable in chest (P＞0.05) of matched group medication, all the other all have statistical significance (P＜0.05, P＜0.01); Score value more uncomfortable in chest has statistical significance (P＜0.05, P＜0.01), all the other equal not statistically significants (P＞0.05) between group.

Sign such as greasy fur, floating-rolling pulse self relatively all has statistical significance (P＜0.01) after two groups of treatments and before the treatment, between group statistical significance (P＜0.05, P＜0.01) is arranged more all after treating.

Dried moist rale integration situation of change before and after the table 10 liang group treatment (divide, x ± s)

Example medication medication in 2 days 5 days

Score value difference score value difference before the packet count treatment

Treatment organizes 32 0.59 ± 0.83 ^▲0.37 ± 0.75 ^{▲ ▲}0.21 ± 0.42 ^{* *}0.15 ± 0.36 ^▲0.43 ± 0.61 ^{* *}

Matched group 31 0.61 ± 0.76 0.48 ± 0.62 0.12 ± 0.34** 0.16 ± 0.37 0.45 ± 0.67***

Annotate: self compares before and after the treatment: ^*P＜0.05, ^{* *}P＜0.01; Compare between group: ^▲P＞0.05

Itching throat integration situation of change before and after the table 11 liang group treatment (example, x ± SD)

Example medication medication in 2 days 5 days

Score value difference score value difference before the packet count treatment

Treatment organizes 32 1.62 ± 0.70 ^▲0.84 ± 0.57 ^{▲ ▲}0.78 ± 0.60 ^{* *}0.25 ± 0.56 ^▲1.37 ± 0.79 ^{* *}

Matched group 31 1.80 ± 0.79 1.09 ± 0.70 0.70 ± 0.52*** 0.29 ± 0.52 1.51 ± 0.85***

Annotate: self compares before and after the treatment: ^{* *}P＜0.01; Compare between group: ^▲P＞0.05

Integration situation of change uncomfortable in chest before and after the table 12 liang group treatment (example, x ± s)

Example medication medication in 2 days 5 days

Score value difference score value difference before the packet count treatment

Treatment organizes 32 1.12 ± 1.03 ^▲0.84 ± 0.76 ^{▲ ▲}0.28 ± 0.45 ^{* *}0.15 ± 0.44 ^{▲ ▲ ▲}0.96 ± 1.06 ^{* *}

Matched group 31 1.41 ± 0.99 1.32 ± 0.97 0.09 ± 0.30* 0.80 ± 1.04 0.61 ± 0.66***

Annotate: self compares before and after the treatment: ^*P＞0.05, ^{* *}P＜0.01; Compare between group: ^▲P＞0.05, ^{▲ ▲}P＜0.05, ^{▲ ▲ ▲}P＜0.01

Greasy fur, floating-rolling pulse situation of change (example) before and after the table 13 liang group treatment

After controlling before controlling

Tongue arteries and veins total routine number that divides into groups has or not

The treatment of treatment group organizes 32 31 1 ^▲7 25 ^{* * ▲ ▲ ▲}

Matched group 31 30 1 19 12 ^{* *}

Treatment of control group group 32 28 4 ^▲7 25 ^{* * ▲ ▲ ▲}

Matched group 31 29 2 13 18 ^{* *}

Annotate: self compares before and after the treatment: ^{* *}P＜0.01; Compare between group: ^▲P＞0.05, ^{▲ ▲}P＜0.05, ^{▲ ▲ ▲}P＜0.01

5, two groups of conducting lung X-ray examination inspection treatment front and back situations: see Table 14.As shown in Table 14, more equal not statistically significant (P＞0.05) between two groups of conducting lung X-ray examination inspection treatment front and back are organized.

Pulmonary condition X ray examination (example) before and after the table 14 liang group treatment

The normal increase in the lung markings of total routine number is not looked into

Treatment group treatment preceding 32 15 3 14

Treatment back 32 14 1 17

Contrast treatment preceding 31 92 20

Contrast back 31 82 21

Four, safety observed result:

1, untoward reaction: see Table 15.32 examples are organized in treatment, and obvious adverse reaction does not all take place.In matched group 31 examples, have 2 examples untoward reaction to occur, incidence rate of adverse reaction is 6.45%, and wherein 1 example thick sputum occurs and is difficult to bring up, and constipation appears in 1 example, and its degree is all lighter.Thick sputum is difficult to the person of bringing up uses the Concha Erosariae seu Cypraeae cough-stopping granule instead and can smooth and easyly bring up after finishing the course of treatment, constipation is then died away after 3 days in drug withdrawal, does not influence treatment.

Situation (example) appears in table 15 a liang group untoward reaction

Total routine number does not have the sticking difficulty of expectorant and goes out constipation with dry stool

Treatment organizes 32 32 00

Matched group 31 29 11

2, safety detects index: main safety observation index such as routine blood test, routine urinalysis, stool routine examination and electrocardiogram, AST, BUN, Cr there is no special variation before and after two groups of treatments.

Five, conclusion: for preliminary clinical efficacy and the untoward reaction of inquiring into the present invention to the surplus evil love lung card patient of acute tracheobronchitis, observe the surplus evil lung of loving of acute tracheobronchitis November June calendar year 2001 to calendar year 2001 and demonstrate,prove 63 examples, wherein adopt the present invention's (treatment group) 32 examples, cough-relieving treasured (matched group) 31 examples.The result: two groups of total obvious effective rates to surplus evil love lung card are respectively 78.1%, 51.6%, and total effective rate is respectively 87.5%, 87.1%.Two groups of total obvious effective rates to acute tracheobronchitis are respectively 71.8%, 61.2%, and total effective rate is respectively 87.5%, 90.3%.This medicine is characteristic aspect the improving of cough degree, the frequency of coughing, the tachypnea of panting, symptom such as uncomfortable in chest.Period in a medicine is not found obvious adverse reaction.

Claims (5)

1, a kind of anti-cough granules for the treatment of tracheobronchitis is characterized in that it is to make with the raw material of following weight parts:

Radix Asteris 300-600 gram; Herba Ardisiae Japonicae 300-600 gram; Bulbus Fritillariae Thunbergii 300-500 gram; Rhizoma Cynanchi Stauntonii 300-600 gram; Radix Stemonae 300-500 gram; Radix Platycodonis 300-500 gram; Cortex Mori 200-500 gram; Rhizoma Pinelliae Preparatum 300-400 gram; Semen Armeniacae Amarum 200-300 gram; Pericarpium Citri Reticulatae 200-500 gram; Herba Schizonepetae 200-500 gram; Herba Menthae 200-500 gram; Radix Glycyrrhizae 200-500 gram.

2, the anti-cough granules of treatment tracheobronchitis according to claim 1 is characterized in that Radix Asteris is the processed with honey Radix Asteris in the above-mentioned raw materials.

3, the anti-cough granules preparation method of treatment tracheobronchitis according to claim 1 is characterized in that it is made up of following step:

1. with Pericarpium Citri Reticulatae in the above-mentioned raw materials, Herba Schizonepetae, Herba Menthae three flavor distillating extracting oils, the volatile oil β-CDBao He, clathrate is standby, and medicinal residues and extracting solution are put in addition;

2. get Bulbus Fritillariae Thunbergii, the Radix Stemonae, Semen Armeniacae Amarum and add 70% alcohol reflux secondary, merge extractive liquid,, decompression recycling ethanol be not to there being the alcohol flavor, and to be concentrated into relative density be 1.2～1.5 thick paste, and be standby;

3. get Cortex Mori, Radix Asteris, Herba Ardisiae Japonicae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Rhizoma Pinelliae Preparatum, Radix Glycyrrhizae and decoct with water once, then medicinal residues and aforementioned Pericarpium Citri Reticulatae, Herba Schizonepetae, Herba Menthae three flavors are decocted the back medicinal residues and merge again and decoct once;

4. with the aforesaid liquid collecting decoction, filter, it is 0.9～1.2 clear paste that filtrate is concentrated into relative density, make centrifugal treating after, being evaporated to relative density is 1.2～1.5 thick pastes, merges with above-mentioned alcohol extraction thick paste again;

5. above-mentioned paste is carried out vacuum drying, grinding and sieving adds beta-CD inclusion and adjuvant, and mixing is granulated, drying, and granulate forms.

4, the anti-cough granules preparation method of treatment tracheobronchitis according to claim 3 is characterized in that Bulbus Fritillariae Thunbergii, the Radix Stemonae, Semen Armeniacae Amarum added for 70% alcohol reflux time and be: being 1.5-2.5 hour for the first time, is 1-2 hour for the second time.

5, the anti-cough granules preparation method of treatment tracheobronchitis according to claim 3, it is characterized in that getting Cortex Mori, Radix Asteris, Herba Ardisiae Japonicae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Rhizoma Pinelliae Preparatum, Radix Glycyrrhizae and decoct with water the time and be 1.5-2.5 hour for the first time, for the second time with medicinal residues after aforementioned medicinal residues and Pericarpium Citri Reticulatae, Herba Schizonepetae, the decoction for the first time of Herba Menthae three flavors again decocting time be 1-2 hour.