CN114829357A - 五元杂环氧代羧酸类化合物及其医药用途 - Google Patents

五元杂环氧代羧酸类化合物及其医药用途 Download PDF

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CN114829357A
CN114829357A CN202080075621.XA CN202080075621A CN114829357A CN 114829357 A CN114829357 A CN 114829357A CN 202080075621 A CN202080075621 A CN 202080075621A CN 114829357 A CN114829357 A CN 114829357A
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compound
cycloalkyl
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段文虎
耿美玉
詹正生
谢作权
赵凯燕
郭玉婷
王玺渊
张燕
周晓倩
丁健
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Shanghai Institute of Materia Medica of CAS
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Abstract

本发明涉及五元杂环氧代羧酸类化合物及其医药用途。具体地，本发明涉及如式(I)所示的化合物、药用盐、前药、水合物、溶剂合物或晶型，也涉及所述化合物的制备方法、包含所述化合物的药物组合物以及其作为I型干扰素的分泌调节剂，尤其是作为STING激动剂，以及在制备预防和/或治疗与I型干扰素相关疾病的药物中的医药用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080075621.XA 2019-10-28 2020-10-23 五元杂环氧代羧酸类化合物及其医药用途 Pending CN114829357A (zh)

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CN110036001A (zh) * 2016-10-04 2019-07-19 默沙东公司 作为STING激动剂的苯并[b]噻吩化合物
WO2019195124A1 (en) * 2018-04-03 2019-10-10 Merck Sharp & Dohme Corp. Benzothiophenes and related compounds as sting agonists

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