CN114712060A - Chinese fir fiber bionic traditional Chinese medicine bonesetting splint and manufacturing method thereof - Google Patents
Chinese fir fiber bionic traditional Chinese medicine bonesetting splint and manufacturing method thereof Download PDFInfo
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- CN114712060A CN114712060A CN202210288442.5A CN202210288442A CN114712060A CN 114712060 A CN114712060 A CN 114712060A CN 202210288442 A CN202210288442 A CN 202210288442A CN 114712060 A CN114712060 A CN 114712060A
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- 239000000835 fiber Substances 0.000 title claims abstract description 87
- 239000003814 drug Substances 0.000 title claims abstract description 39
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- 244000050510 Cunninghamia lanceolata Species 0.000 title description 14
- 238000003825 pressing Methods 0.000 claims abstract description 60
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- 239000003513 alkali Substances 0.000 claims abstract description 23
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
- A61F5/01—Orthopaedic devices, e.g. splints, casts or braces
- A61F5/04—Devices for stretching or reducing fractured limbs; Devices for distractions; Splints
- A61F5/05—Devices for stretching or reducing fractured limbs; Devices for distractions; Splints for immobilising
- A61F5/058—Splints
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L97/00—Compositions of lignin-containing materials
- C08L97/02—Lignocellulosic material, e.g. wood, straw or bagasse
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C08K2003/265—Calcium, strontium or barium carbonate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Nursing (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The application discloses a fir fiber bionic traditional Chinese medicine bonesetting splint and a manufacturing method thereof, wherein the manufacturing method comprises the following steps: after the fir trees are crushed into fir fiber, the pre-treated fir fiber is obtained by alkali boiling, cleaning, sterilizing and disinfecting, secondary cleaning, drying and secondary crushing. And (3) blending the pretreated fir fiber and the thermoplastic high polymer material, extruding and granulating, and extruding into a silk-like structure to obtain a silk section. And after filling the wire sections into a cold-pressing die along the same direction, spraying the nanoparticle dispersion liquid into the cold-pressing die, oscillating the cold-pressing die, and cold-pressing the wire sections in the cold-pressing die to obtain the plate. And (3) placing the plate on a traditional Chinese medicine bone setting splint die with a needle-shaped structure, and then carrying out hot pressing to obtain the fir fiber bionic traditional Chinese medicine bone setting splint. The application uses the fir fiber as a substrate, is crosslinked with a high-molecular low-temperature thermoplastic biomaterial, combines a nano inorganic material, and prepares the novel bionic bonesetting splint with light weight, ventilation, vertical high strength and transverse plasticity by a filament extrusion cold pressing technology.
Description
Technical Field
The application relates to the field of medical external fixation bone fracture treatment instruments, in particular to a fir fiber bionic traditional Chinese medicine bone setting splint and a manufacturing method thereof.
Background
The medical splint is the most common external fixation device for treating fracture, and has a long history. The ancient Egyptian uses the bark wrapped by linen to make splint, the ancient Indian uses bamboo splint to treat fracture, and the ancient Chimonad uses wax and resin to make strengthening bandage. At present, the medical splint is mainly made of common gypsum splint and high polymer material, and is assisted by a wooden splint, and the medical splint can be made into fixed medical splints of various specifications according to the difference of injured parts and purposes.
Traditional Chinese medicine bonesetting has a long history of using splints for external fixation. The splint fixation is an essential important link in the whole fracture dislocation treatment process and is a technology with the characteristics of the traditional Chinese medicine. At present, the splints can be divided into China fir bark splints, willow splints, bamboo splints, hard paper splints and the like according to different material sources. The Chinese fir bark splint has the advantages of light material, ventilation, high strength in the longitudinal direction, transverse plasticity, easy replacement and the like, and is a traditional bonesetting external fixation material in south China, especially in Guangdong. The China fir bark splints applied in China have a long history, patients have higher acceptance degree of using the fir bark as splints, and the traditional Chinese medicine clinical application efficacy is good.
The Chinese fir bark splint has excellent performance, has a long history as the traditional Chinese medicine bone setting fixing technology, but the trees with the age of more than 15 years are more and more rare, and the Chinese medicine bone setting splint urgently needs an environment-friendly substitute material in the ecological environment of mountain sealing and forest culture. The Chinese medicine fir bark splint has the defects of low water absorption strength, unstable density, easy mildewing, difficult storage and the like, is not favorable for wide popularization and application of the fir bark splint, has no application to the fir bark splint abroad, and can not only relieve the petroleum crisis and solve the problem of environmental pollution, but also lead the Chinese medicine bone-setting bionic splint to move to the world if the novel bionic fir fiber material can be popularized.
Disclosure of Invention
The application provides a fir fiber bionic traditional Chinese medicine boning splint and a manufacturing method thereof, and the novel bionic boning splint with light weight, ventilation, high longitudinal strength and transverse plasticity can be prepared.
The following technical scheme is adopted in the application:
the application provides a manufacturing method of a fir fiber bionic traditional Chinese medicine bonesetting splint, which comprises the following steps:
after the fir trees are crushed into fir fiber, the pre-treated fir fiber is obtained by alkali boiling, cleaning, sterilizing and disinfecting, secondary cleaning, drying and secondary crushing.
And (3) blending the pretreated fir fiber and a thermoplastic polymer material, extruding the mixture for granulation, and extruding the mixture into a filamentous structure to obtain a silk section.
And filling the wire sections into a cold pressing die along the same direction, spraying the nanoparticle dispersion liquid into the cold pressing die, oscillating the cold pressing die, and cold pressing the wire sections in the cold pressing die to obtain the plate.
And (3) placing the plate on a traditional Chinese medicine bone setting splint die with a needle-shaped structure, and then carrying out hot pressing to obtain the fir fiber bionic traditional Chinese medicine bone setting splint.
Further, in the alkali boiling process, the mass ratio of alkali in the alkali liquor is 16-26%, and the material-liquid ratio of the fir fiber to the alkali liquor is 1: 3-4, the alkali cooking temperature is 165-.
The alkali is one or more of sodium hydroxide, sodium carbonate and sodium sulfide.
Furthermore, in the process of sterilization, the concentration of the sterilization solution is 0.05-0.2ug/ml, the dosage of the cleaned fir fiber in the sterilization solution is 0.05-0.1g/l, and the sterilization time is 20-60 min.
The sterilizing disinfectant in the sterilizing and disinfecting solution is one or a combination of more of catalase, calcium chloride, calcium hypochlorite, sodium borohydride, chlorine dioxide, hydrogen peroxide, sulfamic acid and thiourea dioxide.
Further, the pretreated fir fiber is 2000-3000 mesh.
Further, in the blending process, the mass ratio of the pretreated fir fiber to the thermoplastic polymer material is 1-1.5: 1, the front section temperature of the three-section heating double-screw extruder is 45-60 ℃, the middle section temperature is 60-85 ℃, and the rear section temperature is 45-60 ℃.
The thermoplastic polymer material is one or a combination of more of polycaprolactone, polydimethylsiloxane, polyethylene glycol terephthalate, polyvinylpyrrolidone, polyether-ether-ketone, polymethyl methacrylate, polyvinyl acetate, ethylene acrylic acid copolymer, polyvinyl alcohol, polylactic acid, polyhydroxyalkanoate and glucomannan.
Furthermore, in the process of extruding into filament sections, the extrusion temperature is 60-90 ℃, and the diameter of the extruded filament is 0.08-0.5 mm.
Furthermore, the groove specification of the cold-pressing die is 80cm multiplied by 10mm, the cold-pressing die is filled with a wire section with the length of 80cm, the dosage of the nano-particle dispersion liquid is 10-50ml, and the oscillation time is 10-30 min.
The nano particles in the nano particle dispersion liquid are one or a combination of more of graphene, nano calcium carbonate, nano starch, nano titanium dioxide, nano silicon dioxide, nano silver and nano gold.
The dispersing agent in the nano-particle dispersion liquid is one or a combination of more of polyvinyl alcohol, sodium dodecyl benzene sulfonate, sodium silicate, sodium hydroxide, soda, sodium polyphosphate, polyacrylamide, polyoxyethylene, tannin, lignin, chitosan and a surfactant.
Further, in the cold pressing process, the cold pressing temperature is 30-50 ℃, the cold pressing pressure is 0.1-1MPa, and the cold pressing time is 10-35 min.
Further, in the hot pressing process, the hot pressing temperature is 60-80 ℃, the hot pressing pressure is 5-20MPa, and the hot pressing time is 5-15 min.
The application also provides a fir fiber bionic traditional Chinese medicine bonesetting splint prepared by the preparation method.
Compared with the prior art, the method has the following beneficial effects:
(1) the Chinese fir fiber bionic traditional Chinese medicine bonesetting splint is formed by stacking Chinese fir fiber composite wires, and has good longitudinal mechanical strength, elastic modulus of 400-500 MPa, tensile strength of 10-20 MPa and better plasticity in the transverse direction under the action of thermoplastic polymer materials, and the bionic Chinese fir bark longitudinal filamentous structure simulates the longitudinal filamentous structure of Chinese fir bark; secondly, nanoparticles are used as a filling framework and are uniformly distributed in the wire material gap through dispersion liquid spraying and groove mold vibration, so that transverse fusion of the wire material can be properly kept, and ventilation can be kept.
(2) The application uses the fir fiber as the substrate to extrude silk to simulate the fir bark with larger age, can play the ecological effects of sealing a mountain and cultivating forest and protecting the old tree, and the fiber prepared by using the fir sawdust also has the plant active pharmaceutical ingredients of the fir bark, thereby meeting the clinical requirements of traditional Chinese medicine bone setting.
(2) The thermoplastic polymer used in the application can greatly improve the mechanical property of the fir fiber in strength, has low-temperature thermoplastic property, can soften secondary plasticity under the condition of 60-80 ℃, and more meets the clinical use requirement of the orthopedic external fixation material.
(3) The nano-particles and the dispersion liquid thereof used in the application can also play an antibacterial role while constructing the filamentous bionic gap structure.
Drawings
FIG. 1 is a general schematic view of a cold press mold of the present application;
FIG. 2 is a general schematic view of a sheet material according to the present application;
FIG. 3 is a schematic cross-sectional view of a sheet material of the present application;
FIG. 4 is a schematic view of the whole body of a fir fiber bionic traditional Chinese medicine bone-setting splint on the dorsal aspect of the forearm of the present application;
FIG. 5 is a schematic view of the whole of a fir fiber bionic traditional Chinese medical bone-setting splint on the radial side of the forearm ulnar in the present application;
fig. 6 is an overall schematic view of the fir fiber bionic traditional Chinese medicine bone-setting splint on the inner and outer sides of the calf in the application.
Detailed Description
The technical method in the embodiments of the present application will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The embodiment of the application provides a method for manufacturing a fir fiber bionic traditional Chinese medicine bonesetting splint, which comprises the following steps:
step one, pretreatment of fir fiber:
after the fir trees are crushed into fir fiber, the pre-treated fir fiber is obtained by alkali boiling, cleaning, sterilizing and disinfecting, secondary cleaning, drying and secondary crushing.
Wherein the fir fiber is 30-80 mesh, such as 30 mesh, 50 mesh, and 80 mesh.
In the washing and secondary washing processes, deionized water is repeatedly used for 3-5 times until pH is 7, such as 3 times, 4 times, and 5 times.
In the alkali boiling process, the alkali content in the alkali liquor is 16-26%, such as 16%, 20%, and 26%. The material-liquid ratio of the fir fiber to the alkali liquor is 1: 3-4, such as 1: 3. 1: 3.5, 1: 4. the alkaline cooking temperature is 165-175 deg.C, such as 165 deg.C, 170 deg.C, 175 deg.C. The alkaline cooking time is 4-6h, such as 4h, 5h, 6 h.
The alkali is one or more of sodium hydroxide, sodium carbonate and sodium sulfide, such as sodium hydroxide, mixture of sodium carbonate and sodium sulfide, and mixture of sodium hydroxide, sodium carbonate and sodium sulfide.
In the process of sterilization, the concentration of the sterilization solution is 0.05-0.2ug/ml, such as 0.05ug/ml, 0.1ug/ml, and 0.2 ug/ml. The dosage of the cleaned fir fiber in the sterilizing solution is 0.05-0.1g/l, such as 0.05ug/ml, 0.08ug/ml, and 0.1 ug/ml. The sterilizing time is 20-60min, such as 20min, 40min, and 60 min.
The disinfectant in the disinfectant solution is one or more of catalase, calcium chloride, calcium hypochlorite, sodium borohydride, chlorine dioxide, hydrogen peroxide, sulfamic acid and thiourea dioxide, such as catalase, mixture of calcium chloride and calcium hypochlorite, and mixture of hydrogen peroxide and sulfamic acid and thiourea dioxide.
In addition, sterilization and disinfection are carried out at normal temperature. The sterilization and disinfection process also realizes bleaching.
In the drying process, the drying time is 3-5h, such as 3h, 4h, and 5 h.
The pretreated fir fiber is 2000-3000 mesh, such as 2000 mesh, 2500 mesh, 3000 mesh.
Step two, blending and extruding:
and (3) blending the pretreated fir fiber and a thermoplastic polymer material, extruding the mixture for granulation, and extruding the mixture into a filamentous structure to obtain a silk section.
Wherein in the blending process, the mass ratio of the pretreated fir fiber to the thermoplastic high polymer material is 1-1.5: 1, as shown in 1: 1. 1.2: 1. 1.5: 1. the temperature of the front section of the three-section heating double-screw extruder is 45-60 ℃, such as 45 ℃, 55 ℃ and 60 ℃. The temperature of the middle section is 60-85 deg.C, such as 60 deg.C, 70 deg.C, and 85 deg.C. The temperature of the latter stage is 45-60 deg.C, such as 45 deg.C, 55 deg.C, 60 deg.C.
The thermoplastic polymer material is one or a combination of more of polycaprolactone, polydimethylsiloxane, polyethylene glycol terephthalate, polyvinylpyrrolidone, polyether-ether-ketone, polymethyl methacrylate, polyvinyl acetate, ethylene acrylic acid copolymer, polyvinyl alcohol, polylactic acid, polyhydroxyalkanoate and glucomannan. Such as polycaprolactone, a mixture of polydimethylsiloxane and polyethylene terephthalate, a mixture of polyvinyl alcohol and polylactic acid, and polyhydroxyalkanoates.
The extrusion temperature is 60-90 deg.C, such as 60 deg.C, 80 deg.C, and 90 deg.C, during the extrusion process to form filament section. The extruded filament diameter is 0.08-0.5mm, such as 0.08mm, 0.2mm, and 0.5 mm.
After being extruded into a filamentous structure, the strand was cut into straight and fine strands of 80cm in length.
Step three, blending and cold pressing:
and filling the wire sections into a cold pressing die along the same direction, spraying the nanoparticle dispersion liquid into the cold pressing die, oscillating the cold pressing die, and cold pressing the wire sections in the cold pressing die to obtain the plate.
Wherein the groove specification of the cold pressing die is 80cm multiplied by 10mm, see figure 1. The cold-pressing mold is filled with a filament segment with a length of 80cm, and the amount of the nanoparticle dispersion is 10-50ml, such as 10ml, 30ml, and 50 ml. The oscillation time is 10-30min, such as 10min, 20min, and 30 min.
The nanoparticles in the nanoparticle dispersion liquid are one or more of graphene, nano calcium carbonate, nano starch, nano titanium dioxide, nano silicon dioxide, nano silver and nano gold, such as a mixture of graphene, nano calcium carbonate and nano starch, and a mixture of nano silicon dioxide, nano silver and nano gold.
The dispersing agent in the nanoparticle dispersion liquid is one or more of polyvinyl alcohol, sodium dodecyl benzene sulfonate, sodium silicate, sodium hydroxide, soda, sodium polyphosphate, polyacrylamide, polyethylene oxide, tannin, lignin, chitosan and surfactant, such as a mixture of polyvinyl alcohol, sodium dodecyl benzene sulfonate and sodium silicate, and a mixture of polyethylene oxide, lignin and chitosan.
In the cold pressing process, the cold pressing temperature is 30-50 deg.C, such as 30 deg.C, 40 deg.C, and 50 deg.C. The cold pressing pressure is 0.1-1MPa, such as 0.1MPa, 0.5MPa, 1 MPa. The cold pressing time is 10-35min, such as 10min, 20min, and 35 min.
The thickness of the plate is 6-8mm, such as 6mm, 7mm, and 8mm, as shown in figures 2-3.
Step four, molding a mold:
and (3) placing the plate on a traditional Chinese medicine bone setting splint die with a needle-shaped structure, and then carrying out hot pressing to obtain the fir fiber bionic traditional Chinese medicine bone setting splint.
Wherein, different moulds are manufactured according to the traditional Chinese medicine bonesetting splint, and the moulds are provided with uniform needle-shaped structures of 0.05-0.8mm, such as 0.05mm, 0.2mm and 0.8 mm.
In the hot pressing process, the hot pressing temperature is 60-80 deg.C, such as 60 deg.C, 70 deg.C, and 80 deg.C. The hot pressing pressure is 5-20MPa, such as 5MPa, 10MPa, 20 MPa. The hot pressing time is 5-15min, such as 5min, 10min, and 15 min. And keeping constant temperature in the hot pressing process.
The Chinese fir fiber bionic Chinese medicinal bone-setting splint has a thickness of 2-5mm, such as 2mm, 3mm, and 5 mm. The overall schematic diagram of the fir fiber bionic Chinese medicinal bone-setting splint on the dorsal aspect of the forearm, the radial aspect of the forearm and the medial and lateral aspects of the calf is shown in the attached figures 4-6.
The embodiment of the application also provides the fir fiber bionic traditional Chinese medicine bone setting splint prepared by the preparation method.
The application uses the fir fiber as a substrate, is crosslinked with a high-molecular low-temperature thermoplastic biomaterial, combines a nano inorganic material, and prepares the novel bionic bone-setting splint with light weight, ventilation, high longitudinal strength and transverse plasticity by a filament-extruding cold-pressing technology. The manufacturing method comprises the four steps of fir fiber pretreatment, blending and filament extrusion, blending and cold pressing, mold forming and the like. The fir fiber bionic traditional Chinese medicine bonesetting splint and the manufacturing method thereof are suitable for patients with external fixation of Chinese and western medicine bone injuries. The fir fiber bionic traditional Chinese medicine bone-setting splint can replace the traditional Chinese medicine fir bark splint, and is an external fixation splint prepared by new materials and new technology.
The following is a detailed description with reference to specific examples:
example 1
(1) Pretreatment of fir fiber:
A. pulverizing lignum seu ramulus Cunninghamiae Lanceolatae powder into 60 mesh short fiber, and sieving to obtain lignum seu ramulus Cunninghamiae Lanceolatae fiber.
B. And (2) carrying out sodium hydroxide alkali cooking on the fir fiber, wherein the mass ratio of sodium hydroxide is 24%, and the feed liquid ratio is 1: 3.4, the temperature is 168 ℃, and the time is 5 h. After soda boiling, the mixture was washed repeatedly with deionized water 3 times until the pH was 7.
C. Performing catalase bleaching, sterilizing and disinfecting on the fir fiber, wherein the catalase concentration of the sterilizing and disinfecting solution is 0.1ug/ml, the dosage of the fir fiber is 0.08g/l, and the fir fiber is treated for 30min at normal temperature. After the reaction was completed, the reaction mixture was washed repeatedly with deionized water 5 times until the pH was 7.
D. Drying the fir fiber for 4 h.
E. Pulverizing dried fir fiber to 2500 mesh, and sieving.
(2) Blending and extruding:
the pretreated fir fiber and polycaprolactone are mixed according to the mass ratio of 1.2: 1, mixing and putting the mixture into a three-section heating double-screw extruder for granulation, wherein the temperature of the front section is 50 ℃, the temperature of the middle section is 75 ℃, and the temperature of the rear section is 50 ℃. And extruding the filament-shaped wire rods by a single-screw extruder, wherein the extrusion temperature is 70 ℃, and the diameter of the extruded filament is 0.2 mm. Cutting into straight filament segments according to the length of 80 cm.
(3) Blending and cold pressing:
and completely stacking a plurality of straight filament sections in the same direction and filling the straight filament sections into a cold-pressing die with grooves of 80cm multiplied by 10 cm. And (3) uniformly spraying 20ml of 2% graphene chitosan dispersion liquid to the groove cold pressing die in a spraying mode, and oscillating the groove cold pressing die for 20 min. And (3) putting the groove cold-pressing die filled with the material into a hot press for low-temperature cold pressing, wherein the temperature is 40 ℃, the pressure is 0.5MPa, the treatment time is 15min, and a 6mm plate is pressed.
(4) Molding a mold:
different moulds are manufactured according to the traditional Chinese medicine bonesetting splint, and uniform needle-shaped structures with the diameter of 0.2mm are arranged in the moulds. And (3) placing the plates on a mould, and carrying out constant-temperature hot pressing by using a hot press, wherein the temperature is controlled to be 70 ℃, the pressure intensity is 10MPa, and the treatment time is 8min, so that the bionic Chinese fir fiber bone-setting splint with the thickness of 3mm is pressed.
The elastic modulus is 400-500 MPa, and the tensile strength is 10-20 MPa
Example 2
(1) Pretreatment of fir fiber:
A. pulverizing lignum seu ramulus Cunninghamiae Lanceolatae powder into 30 mesh short fiber, and sieving to obtain lignum seu ramulus Cunninghamiae Lanceolatae fiber.
B. And (2) carrying out sodium carbonate alkali cooking on the fir fiber, wherein the mass ratio of sodium carbonate is 16%, and the feed liquid ratio is 1: 3, the temperature is 165 ℃ and the time is 4 h. After soda boiling, the mixture was washed repeatedly with deionized water 3 times until the pH was 7.
C. Bleaching and sterilizing the cedar fiber with calcium chloride, wherein the sterilizing solution contains 0.05ug/ml of calcium chloride and 0.05g/l of cedar fiber, and treating at room temperature for 20 min. After the reaction was complete, the reaction mixture was washed repeatedly 5 times with deionized water until the pH was 7.
D. Drying the fir fiber for 3 h.
E. Pulverizing the dried fir fiber to 2000 meshes, and sieving.
(2) Blending and extruding:
the pretreated fir fiber and the polydimethylsiloxane are mixed according to the mass ratio of 1: 1, mixing and putting the mixture into a three-section heating double-screw extruder for granulation, wherein the temperature of the front section is 45 ℃, the temperature of the middle section is 60 ℃, and the temperature of the rear section is 45 ℃. And extruding the filament-shaped wire rods by a single-screw extruder, wherein the extrusion temperature is 60 ℃, and the diameter of the extruded filament is 0.08 mm. Cutting into straight filament segments according to the length of 80 cm.
(3) Blending and cold pressing:
and completely stacking a plurality of straight filament sections in the same direction and filling the straight filament sections into a cold-pressing die with grooves of 80cm multiplied by 10 cm. And (3) uniformly spraying 10ml of 2% nano calcium carbonate sodium dodecyl benzene sulfonate dispersion liquid to the groove cold pressing die in a spraying mode, and oscillating the groove cold pressing die for 10 min. And (3) putting the groove cold-pressing die filled with the material into a hot press for low-temperature cold pressing, wherein the temperature is 30 ℃, the pressure is 0.1MPa, the treatment time is 10min, and a 6mm plate is pressed.
(4) Molding a mold:
different moulds are manufactured according to the traditional Chinese medicine bone setting splint, and uniform needle-shaped structures with the diameter of 0.05mm are arranged in the moulds. And (3) placing the plates on a mould, and carrying out constant-temperature hot pressing by using a hot press, wherein the temperature is controlled to be 60 ℃, the pressure intensity is 5MPa, and the treatment time is 5min, so that the bionic Chinese fir fiber bone-setting splint with the thickness of 2mm is pressed.
Example 3
(1) Pretreatment of fir fiber:
A. pulverizing lignum seu ramulus Cunninghamiae Lanceolatae powder into 80 mesh short fiber, and sieving to obtain lignum seu ramulus Cunninghamiae Lanceolatae fiber.
B. Performing sodium sulfide alkaline cooking on the fir fiber, wherein the mass ratio of sodium sulfide is 26%, and the feed liquid ratio is 1: 4, 175 ℃ for 6 h. After soda boiling, the mixture was washed repeatedly with deionized water 3 times until the pH was 7.
C. Bleaching and sterilizing the fir fiber with sodium borohydride, wherein the sterilizing solution contains 0.2ug/ml of sodium borohydride and 0.1g/l of fir fiber, and treating at room temperature for 60 min. After the reaction was completed, the reaction mixture was washed repeatedly with deionized water 5 times until the pH was 7.
D. Drying the fir fiber for 5 h.
E. Pulverizing dried fir fiber to 3000 mesh, and sieving.
(2) Blending and extruding:
the pretreated fir fiber and the polyvinylpyrrolidone are mixed according to the mass ratio of 1.5: 1, mixing and putting the mixture into a three-section heating double-screw extruder for granulation, wherein the temperature of the front section is 60 ℃, the temperature of the middle section is 85 ℃, and the temperature of the rear section is 60 ℃. And extruding the filament wire by a single-screw extruder, wherein the extrusion temperature is 90 ℃, and the diameter of the extruded filament is 0.5 mm. Cutting into straight filament segments according to the length of 80 cm.
(3) Blending and cold pressing:
and completely stacking a plurality of straight filament sections in the same direction and filling the straight filament sections into a cold-pressing die with grooves of 80cm multiplied by 10 cm. And (3) uniformly spraying 50ml of 2% nano titanium dioxide sodium polyphosphate dispersion liquid to the groove cold pressing die in a spraying mode, and oscillating the groove cold pressing die for 30 min. And (3) putting the groove cold-pressing die filled with the material into a hot press for low-temperature cold pressing, wherein the temperature is 50 ℃, the pressure is 1MPa, the treatment time is 35min, and 8mm plates are pressed.
(4) Molding a mold:
different moulds are manufactured according to the traditional Chinese medicine bone setting splint, and uniform needle-shaped structures with the diameter of 0.8mm are arranged in the moulds. And (3) placing the plates on a mould, and carrying out constant-temperature hot pressing by using a hot press, wherein the temperature is controlled to be 80 ℃, the pressure is controlled to be 20MPa, the treatment time is 15min, and the Chinese fir fiber bionic traditional Chinese medicine bone setting splint with the thickness of 5mm is pressed.
The foregoing shows and describes the general principles, essential features, and advantages of the application. It will be understood by those skilled in the art that the present application is not limited to the embodiments described above, which are presented solely for purposes of illustrating the principles of the application, and that various changes and modifications may be made without departing from the spirit and scope of the application, which is defined by the appended claims, the specification, and equivalents thereof.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present application and not for limiting the protection scope of the present application, and although the present application is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present application without departing from the spirit and scope of the technical solutions of the present application.
Claims (10)
1. A manufacturing method of a fir fiber bionic traditional Chinese medicine bonesetting splint is characterized by comprising the following steps:
crushing the fir trees into fir fiber, and then carrying out alkali boiling, cleaning, sterilizing and disinfecting, secondary cleaning, drying and secondary crushing to obtain pretreated fir fiber;
blending the pretreated fir fiber and a thermoplastic high polymer material, extruding and granulating, and extruding into a silk-like structure to obtain a silk section;
after the wire sections are filled into a cold-pressing die along the same direction, spraying a nanoparticle dispersion liquid into the cold-pressing die, oscillating the cold-pressing die, and carrying out cold pressing on the wire sections in the cold-pressing die to obtain a plate;
and (3) placing the plate on a traditional Chinese medicine bone setting splint die with a needle-shaped structure, and then carrying out hot pressing to obtain the fir fiber bionic traditional Chinese medicine bone setting splint.
2. The method of claim 1,
in the alkali boiling process, the mass ratio of alkali in the alkali liquor is 16-26%, and the feed liquor ratio of the fir fiber to the alkali liquor is 1: 3-4, the alkali cooking temperature is 165-;
the alkali is one or a combination of more of sodium hydroxide, sodium carbonate and sodium sulfide.
3. The method of claim 1,
in the process of sterilization, the concentration of the sterilization solution is 0.05-0.2ug/ml, the dosage of the cleaned fir fiber in the sterilization solution is 0.05-0.1g/l, and the sterilization time is 20-60 min;
the sterilization disinfectant in the sterilization disinfectant solution is one or a combination of more of catalase, calcium chloride, calcium hypochlorite, sodium borohydride, chlorine dioxide, hydrogen peroxide, sulfamic acid and thiourea dioxide.
4. The method of claim 1,
the pretreated fir fiber is 2000-3000 meshes.
5. The method of claim 1,
in the blending process, the mass ratio of the pretreated fir fiber to the thermoplastic high polymer material is 1-1.5: 1, the temperature of the front section of a three-section heating double-screw extruder is 45-60 ℃, the temperature of the middle section is 60-85 ℃, and the temperature of the rear section is 45-60 ℃;
the thermoplastic polymer material is one or a combination of more of polycaprolactone, polydimethylsiloxane, polyethylene glycol terephthalate, polyvinylpyrrolidone, polyether-ether-ketone, polymethyl methacrylate, polyvinyl acetate, ethylene acrylic acid copolymer, polyvinyl alcohol, polylactic acid, polyhydroxyalkanoate and glucomannan.
6. The method of claim 1,
in the process of extruding into filament sections, the extrusion temperature is 60-90 ℃, and the diameter of the extruded filament is 0.08-0.5 mm.
7. The method of claim 1,
the groove specification of the cold pressing die is 80cm multiplied by 10mm, the cold pressing die is filled with the filament section with the length of 80cm, the using amount of the nanoparticle dispersion liquid is 10-50ml, and the oscillation time is 10-30 min;
the nano particles in the nano particle dispersion liquid are one or a combination of more of graphene, nano calcium carbonate, nano starch, nano titanium dioxide, nano silicon dioxide, nano silver and nano gold;
the dispersing agent in the nano-particle dispersion liquid is one or a combination of more of polyvinyl alcohol, sodium dodecyl benzene sulfonate, sodium silicate, sodium hydroxide, soda, sodium polyphosphate, polyacrylamide, polyoxyethylene, tannin, lignin, chitosan and a surfactant.
8. The method of claim 1,
in the cold pressing process, the cold pressing temperature is 30-50 ℃, the cold pressing pressure is 0.1-1MPa, and the cold pressing time is 10-35 min.
9. The method of claim 1,
in the hot pressing process, the hot pressing temperature is 60-80 ℃, the hot pressing pressure is 5-20MPa, and the hot pressing time is 5-15 min.
10. A fir fiber bionic traditional Chinese medicine bone-setting splint prepared by the preparation method of any one of claims 1 to 9.
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