CN105343926B - A kind of scar plaster and preparation method thereof containing nano silica - Google Patents
A kind of scar plaster and preparation method thereof containing nano silica Download PDFInfo
- Publication number
- CN105343926B CN105343926B CN201510755628.7A CN201510755628A CN105343926B CN 105343926 B CN105343926 B CN 105343926B CN 201510755628 A CN201510755628 A CN 201510755628A CN 105343926 B CN105343926 B CN 105343926B
- Authority
- CN
- China
- Prior art keywords
- scar
- nano silica
- silica
- containing nano
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 194
- 231100000241 scar Toxicity 0.000 title claims abstract description 96
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 94
- 239000011505 plaster Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000000017 hydrogel Substances 0.000 claims abstract description 42
- 102000008186 Collagen Human genes 0.000 claims abstract description 33
- 108010035532 Collagen Proteins 0.000 claims abstract description 33
- 229920001436 collagen Polymers 0.000 claims abstract description 33
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 23
- 229920000615 alginic acid Polymers 0.000 claims abstract description 23
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940072056 alginate Drugs 0.000 claims abstract description 21
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- -1 alginic acid Salt Chemical class 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- 239000000499 gel Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 241000276701 Oreochromis mossambicus Species 0.000 claims description 9
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 239000010409 thin film Substances 0.000 claims description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- HIHIPCDUFKZOSL-UHFFFAOYSA-N ethenyl(methyl)silicon Chemical compound C[Si]C=C HIHIPCDUFKZOSL-UHFFFAOYSA-N 0.000 claims description 5
- XLXGCFTYXICXJF-UHFFFAOYSA-N ethylsilicon Chemical compound CC[Si] XLXGCFTYXICXJF-UHFFFAOYSA-N 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 230000036961 partial effect Effects 0.000 claims description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 5
- 229920002545 silicone oil Polymers 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 235000014103 egg white Nutrition 0.000 claims 1
- 210000000969 egg white Anatomy 0.000 claims 1
- 230000035699 permeability Effects 0.000 abstract description 11
- 230000035876 healing Effects 0.000 abstract description 10
- 206010020718 hyperplasia Diseases 0.000 abstract description 9
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 15
- 206010052428 Wound Diseases 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000005540 biological transmission Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 206010020649 Hyperkeratosis Diseases 0.000 description 4
- 208000001126 Keratosis Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 210000002808 connective tissue Anatomy 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000002390 hyperplastic effect Effects 0.000 description 2
- 238000005213 imbibition Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000025366 tissue development Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to medical dressing fields, and in particular to a kind of scar plaster and preparation method thereof containing nano silica.A kind of scar plaster containing nano silica is made of following component according to parts by weight: 2 ~ 5 parts of alginate, 80 ~ 100 parts of nanosilica solution, 5 ~ 15 parts of collagen, 50 ~ 80 parts of Silica hydrogel component A, 50 ~ 80 parts of Silica hydrogel B component.Scar plaster provided by the invention containing nano silica can provide wet healing environment, can not only inhibit the hyperplasia of scar, and can repair the blackening of scar, protrusion, accelerate the healing of the surface of a wound, while have good antibiotic property, gas permeability.
Description
Technical field
The invention belongs to medical dressing fields, and in particular to a kind of to contain the scar plaster of nano silica and its preparation side
Method.
Background technique
It in daily life, burns, after incised injury, wounds, the infection such as operation etc. cause skin corium wound, fibroblast increases
It grows, hyperplastic scar easily generated, exhibit tissue color purple is higher than normal skin, and it is extremely difficult in the short time to calm down, it is made to patient
At serious appearance and spiritual influence.In a variety of hyperplastic scar treatment methods, pressure therapy acts on blood vessel by pressure, reduces
Blood flow, so that Inhibiting proliferation tissue development, becomes a kind of universal treatment method.In recent years, the scar prepared using Silica hydrogel
Trace exchange premium row pressure therapy method is rather prevailing and significant in efficacy.
Moisture-vapor transmission is one of the key index for influencing scar plaster therapeutic effect, and importance is penetrated derived from vapor
Significant impact in scar is formed.Human body corium is cell body based on fibroblast and thin based on collagenous fibres
Matrix is constituted, and surface is neatly smooth, after by wound, collagenous fibres missing or structure entanglement, and new capillary and fiber
It grows into, scar is caused to generate；Simultaneously because scar surface cuticula is relatively thin, water evaporation quantity is larger, increases the need to capillary
It asks, promotes the hyperplasia of capillary, accelerate the hyperplasia of scar.On the one hand, the moisture-vapor transmission of Silica hydrogel is relatively low, can be preferable
Make moisture retention on scar surface layer, increase the permeability of water-soluble substances in interstitial, accelerate diffusion, reduce water-soluble in interstitial
The material stream scale of construction, softens scar.On the other hand, Silica hydrogel is covered in scar surface, reduces moisture evaporation, reduces to capillary
Demand, inhibit the increase of capillary, inhibit the hyperplasia of scar.According to pertinent literature, the moisture-vapor transmission of normal skin
For 204 g/(m2.d), the moisture-vapor transmission of compromised skin is 279 ~ 5138 g/(m2.d), when the moisture-vapor transmission of dressing
When lower than skin moisture-vapor transmission, wet healing environment can be provided for the surface of a wound well.
Collagen is a kind of fibrous proteins in three helical structures, is connective tissue and its important albumen knot
Structure, the protein about 75% in skin is collagen, can constantly be formed with itself normal connective tissue, reaches elimination wrinkle
The effect of line and scar.Multinomial result of study and clinical test results show to use collagen film as dressing, can not only add
The metabolism of fast cell promotes the healing of the surface of a wound, and the surface of a wound color after healing is scarlet, flat and smooth, flexible.Collagen
Albumen has no antigen, good biocompatibility, hemostatic, has a wide range of applications in medical treatment.Alginates are natural
Active biomaterial, have good biocompatibility, degradability, can be at colloidality, water imbibition.Nano silica has
Good antibacterial activity is a kind of good medical material.
Mostly there is the disadvantages of poor air permeability, moisture-vapor transmission is excessively high in the Silica hydrogel scar plaster product occurred at present, no
It the disadvantages of wet healing environment can be provided, the hyperplasia that cannot effectively inhibit scar, desalination scar are existed simultaneously, needs to improve
The effect of Silica hydrogel, meets clinical and patient demand product and occurs.
Summary of the invention
The present invention overcomes prior art defect, provides and prepares a kind of good air permeability, is conducive to the doctor for repairing scar blackening, protrusion
Use dressing.The object of the present invention is to provide a kind of scar plaster and preparation method thereof containing nano silica, in the scar plaster
Containing nano silica, microcellular structure can be formed in scar plaster, be conducive to the gas permeability for increasing scar plaster, it can be ensured that
The eupnea of skin acts on, while having certain bacteriostasis；Contain alginate and collagen in scar plaster, not only
It is capable of providing suitable wet environment, inhibits the growth of capillary, while collagen abundant can also be provided, it is dark to repair scar
Spot, protrusion keep skin smooth, flexible.
Technical scheme is as follows: a kind of scar plaster containing nano silica, according to parts by weight by following
Ingredient is constituted:
2 ~ 5 parts of alginate；
80 ~ 100 parts of nanosilica solution；
5 ~ 15 parts of collagen；
50 ~ 80 parts of Silica hydrogel component A；
50 ~ 80 parts of Silica hydrogel B component.
Further, the alginate is sodium alginate.Sodium alginate has very strong water imbibition, can after water suction
To form gel, moisture lock is stayed in three-dimensional netted molecular structure, alginate jelly is added in Silica hydrogel and prepares scar plaster,
When being covered in the surface of a wound, certain hydration environment can be provided, after skin water suction, it is suppressed that the regeneration of capillary, to reduce
The deposition of collagen.Meanwhile keratoderma water content increases, and moisture retention can be made on scar surface layer, increases water-soluble in interstitial
The permeability of substance accelerates diffusion, and scar softening is promoted to subside, and pigment shoals, and mitigates itch pain.
Further, the content of nano silica is 5 wt%, the nanometer in the nanosilica solution
Silica partial size is 20 ~ 35 nm.The nano silica can be uniformly dispersed in scar plaster, be formed in scar plaster
Microcellular structure is conducive to the gas permeability for increasing scar plaster, it can be ensured that the eupnea of skin acts on, while having certain suppression
Bacterium effect.
Further, the collagen is extracted from Java tilapia skin.Tilapia mossambica is that China mainly cultivates
Economic kind, China Tilapia mossambica total output accounts for 48% of Gross World Product or so according to statistics, and source is very rich.Tilapia mossambica is in life
The leftover bits and pieces such as a large amount of fish-skin, fish-bone are generated during producing processing, a large amount of collagen are wherein contained in fish-skin, rationally benefit
The added value for being conducive to improve Tilapia mossambica with these collagens, pushes the development of marine industry and medical industry.Collagen
With no antigen, good biocompatibility, multinomial result of study and clinical test results show to make using collagen film
For dressing, the metabolism of cell can not only be accelerated, promote the healing of the surface of a wound, and the surface of a wound color after healing is scarlet, smooth
It is smooth, flexible.Collagen is the extremely important protein structure of connective tissue in human body, can be with itself normal connective group
Continuous formation is knitted, achievees the effect that smooth away wrinkles and scar.
Preferably, the Silica hydrogel component A includes methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.Described
Silica hydrogel B component is the dimethyl silicone polymer of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
Further, a kind of preparation method of the scar plaster containing nano silica, preparation method include as follows
Step:
S1. collagen is dissolved in nanosilica solution, stirs the h of 0.5 h ~ 1 to being uniformly dissolved, is prepared into
Solution E；Again wherein by alginate dissolution, the h of 1 h ~ 2 is stirred to being completely dissolved, and is prepared into gel F；
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, the h of 0.5 h ~ 1 is to uniform for stirring, is prepared into AB group
Divide compound；
S3. the AB component compound of S2 preparation is added and is stirred under vacuum in tank, then the S1 gel F prepared is slowly added to
It is stirred under vacuum in tank, is that the MPa of -0.8 MPa ~ 0.095 stirs 4 ~ 7 h, and carry out under the conditions of temperature is 20 ~ 35 DEG C in pressure
Vacuum defoamation is prepared into product G；
S4. tile one layer of silica gel thin film in a mold first, and then the S3 product G prepared is laid on pellosil,
Solidify 6 ~ 10 h under the conditions of 50 ~ 70 DEG C, finally shears, dispenses again, sterilizing up to a kind of scar plaster containing nano silica.
Further, in a kind of preparation method of scar plaster containing nano silica, the purpose of S1 is
The solution containing nano silica is set to form gel, in order to avoid nanosilica solution is directly added to AB component compound
In, the viscosity of AB component compound is reduced, influences cross-linking reaction effect, and then influence the solidification effect of S4.
Further, in a kind of preparation method of scar plaster containing nano silica, the purpose of S2, S3
It is to be sufficiently mixed each component uniformly, while excluding bubble, it is ensured that the solidification effect of S4.
Further, in a kind of preparation method of scar plaster containing nano silica, one is tiled in S4
The purpose of layer silica gel thin film can be directly attached on the surface of a wound when in use, nothing to form sticking face scar plaster
Foreign object is needed to fix.
Preferably, the sterilization method in the S4 is irradiation sterilization, and irradiation dose is 15 ~ 25 kGy.
The invention has the benefit that containing microcellular structure in (1) scar plaster, the gas permeability of scar plaster, energy can be increased
Enough ensure the eupnea effect of skin, while there is certain bacteriostasis.(2) alginate can lock a part of water
Point, when being covered in the surface of a wound, certain hydration environment can be provided, after skin water suction, it is suppressed that the regeneration of capillary, to reduce
The deposition of collagen.Meanwhile keratoderma water content increases, and moisture retention can be made on scar surface layer, increased water-soluble in interstitial
Property substance permeability, accelerate diffusion, scar softening promoted to subside, pigment shoals, and mitigates itch pain.(3) collagen without
Antigenicity has good biocompatibility, is the extremely important protein structure of connective tissue, can be with itself normal connective group
Continuous formation is knitted, scar blackening, protrusion are repaired, the surface of a wound color after making healing is scarlet, flat and smooth, flexible.(4) should
Scar plaster has good tensile strength and holds viscosity, and effect affected part is flexible, is also possible to prevent to paste rear or use process China and foreign countries
The case where the case where power is broken can also make scar plaster firmly be fitted in affected part, reduce sliding and fall off.(5)
Preparation process of the invention is simple, does not destroy the active matter function in product, does not influence the stability of product quality, can be obvious
Wound treating effect is improved, meets the needs of clinical and patient.
Specific embodiment
Below with reference to embodiment, the following further describes the technical solution of the present invention.
Embodiment 1
A kind of scar plaster and preparation method thereof containing nano silica, is made of following component according to parts by weight:
2 parts of alginate, 80 parts of nanosilica solution, 5 parts of collagen, 50 parts of Silica hydrogel component A, 50 parts of Silica hydrogel B component.
The alginate is sodium alginate, and the content of nano silica is 5 wt% in the nanosilica solution, described
Nano silica partial size is 20 ~ 35 nm.The collagen is extracted from Java tilapia skin.The Silica hydrogel A group
Divide includes methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.The Silica hydrogel B component is Methyl Hydrogen Polysiloxane Fluid and ethylene
The dimethyl silicone polymer of base opposite end.
A kind of scar plaster and preparation method thereof containing nano silica, preparation method includes the following steps:
S1. collagen is dissolved in nanosilica solution, stirs the h of 0.5 h ~ 1 to being uniformly dissolved, is prepared into
Solution E；Again wherein by alginate dissolution, the h of 1 h ~ 2 is stirred to being completely dissolved, and is prepared into gel F；
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, the h of 0.5 h ~ 1 is to uniform for stirring, is prepared into AB group
Divide compound；
S3. the AB component compound of S2 preparation is added and is stirred under vacuum in tank, then the S1 gel F prepared is slowly added to
It is stirred under vacuum in tank, is that the MPa of -0.8 MPa ~ 0.095 stirs 4 ~ 7 h, and carry out under the conditions of temperature is 20 ~ 35 DEG C in pressure
Vacuum defoamation is prepared into product G；
S4. tile one layer of silica gel thin film in a mold first, and then the S3 product G prepared is laid on pellosil,
Solidify 6 ~ 10 h under the conditions of 50 ~ 70 DEG C, finally shears, dispenses again, sterilizing up to a kind of scar containing nano silica of product
Trace patch.
Sterilization method in the S4 is irradiation sterilization, and irradiation dose is 15 ~ 25 kGy.
Embodiment 2
A kind of scar plaster and preparation method thereof containing nano silica, is made of following component according to parts by weight:
3 parts of alginate, 100 parts of nanosilica solution, 10 parts of collagen, 70 parts of Silica hydrogel component A, Silica hydrogel B component 70
Part.The alginate is sodium alginate, and the content of nano silica is 5 wt% in the nanosilica solution,
The nano silica partial size is 20 ~ 35 nm.The collagen is extracted from Java tilapia skin.The silicon is solidifying
Glue component A includes methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.The Silica hydrogel B component is Methyl Hydrogen Polysiloxane Fluid
With the dimethyl silicone polymer of vinyl opposite end.
A kind of scar plaster and preparation method thereof containing nano silica, preparation method includes the following steps:
S1. collagen is dissolved in nanosilica solution, stirs the h of 0.5 h ~ 1 to being uniformly dissolved, is prepared into
Solution E；Again wherein by alginate dissolution, the h of 1 h ~ 2 is stirred to being completely dissolved, and is prepared into gel F；
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, the h of 0.5 h ~ 1 is to uniform for stirring, is prepared into AB group
Divide compound；
S3. the AB component compound of S2 preparation is added and is stirred under vacuum in tank, then the S1 gel F prepared is slowly added to
It is stirred under vacuum in tank, is that the MPa of -0.8 MPa ~ 0.095 stirs 4 ~ 7 h, and carry out under the conditions of temperature is 20 ~ 35 DEG C in pressure
Vacuum defoamation is prepared into product G；
S4. tile one layer of silica gel thin film in a mold first, and then the S3 product G prepared is laid on pellosil,
Solidify 6 ~ 10 h under the conditions of 50 ~ 70 DEG C, finally shears, dispenses again, sterilizing up to a kind of scar containing nano silica of product
Trace patch.
Sterilization method in the S4 is irradiation sterilization, and irradiation dose is 15 ~ 25 kGy.
Embodiment 3
A kind of scar plaster and preparation method thereof containing nano silica, is made of following component according to parts by weight:
5 parts of alginate, 100 parts of nanosilica solution, 15 parts of collagen, 80 parts of Silica hydrogel component A, Silica hydrogel B component 80
Part.The alginate is sodium alginate, and the content of nano silica is 5 wt% in the nanosilica solution,
The nano silica partial size is 20 ~ 35 nm.The collagen is extracted from Java tilapia skin.The silicon is solidifying
Glue component A includes methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.The Silica hydrogel B component is Methyl Hydrogen Polysiloxane Fluid
With the dimethyl silicone polymer of vinyl opposite end.
A kind of scar plaster and preparation method thereof containing nano silica, preparation method includes the following steps:
S1. collagen is dissolved in nanosilica solution, stirs the h of 0.5 h ~ 1 to being uniformly dissolved, is prepared into
Solution E；Again wherein by alginate dissolution, the h of 1 h ~ 2 is stirred to being completely dissolved, and is prepared into gel F；
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, the h of 0.5 h ~ 1 is to uniform for stirring, is prepared into AB group
Divide compound；
S3. the AB component compound of S2 preparation is added and is stirred under vacuum in tank, then the S1 gel F prepared is slowly added to
It is stirred under vacuum in tank, is that the MPa of -0.8 MPa ~ 0.095 stirs 4 ~ 7 h, and carry out under the conditions of temperature is 20 ~ 35 DEG C in pressure
Vacuum defoamation is prepared into product G；
S4. tile one layer of silica gel thin film in a mold first, and then the S3 product G prepared is laid on pellosil,
Solidify 6 ~ 10 h under the conditions of 50 ~ 70 DEG C, finally shears, dispenses again, sterilizing up to a kind of scar containing nano silica of product
Trace patch.
Sterilization method in the S4 is irradiation sterilization, and irradiation dose is 15 ~ 25 kGy.
To verify whether the scar plaster of the invention containing nano silica reaches expected invention effect, to of the invention
Scar plaster carries out antibacterial tests, animal experiment and testing performance index, as a result as follows:
As can be seen from the above table, this experiment is using Escherichia coli and staphylococcus aureus as subjects, to embodiment 1 ~ 3
Scar plaster carry out anti-microbial property test, find the scar plaster have good antibacterial effect.Simultaneously as can be seen from the above table originally
Invention preparation scar plaster have the advantages that (1) scar plaster have good biocompatibility, no antigen, sensitization,
It can be safe to use；(2) scar plaster has good OTR oxygen transmission rate, it can be ensured that the normal respiration of skin；(3) scar
The moisture-vapor transmission of trace patch is relatively low, it can be ensured that the water content of keratoderma accelerates the logical of water-soluble substances in interstitial
Permeability promotes scar softening to subside, and pigment shoals, and mitigates itch pain.It can inhibit the regeneration of capillary simultaneously, reduce scar
Hyperplasia；(4) scar plaster has good tensile strength, and effect affected part is flexible, can be covered on face, arm, joint, neck
Neck etc. is also possible to prevent to paste the case where external force is broken in rear or use process；(5) scar plaster, which has, glues strong
Property, the case where scar plaster can be made firmly to be fitted in affected part, sliding is reduced and fall off.
Embodiment 4
It is being formulated upper superiority to verify the scar plaster of the invention containing nano silica, present invention progress is following real
It tests.
Experimental group: a kind of scar plaster and preparation method thereof containing nano silica, according to parts by weight by below at
Divide and constitutes: 3 parts of alginate, 100 parts of nanosilica solution, 10 parts of collagen, 70 parts of Silica hydrogel component A, Silica hydrogel B
70 parts of component.
Control group 1: a kind of scar plaster and preparation method thereof containing nano silica, according to parts by weight by below at
Divide and constitute: 100 parts of nanosilica solution, 10 parts of collagen, 70 parts of Silica hydrogel component A, 70 parts of Silica hydrogel B component.
A kind of scar plaster and preparation method thereof containing nano silica of control group 2, according to parts by weight by below at
Divide and constitute: 3 parts of alginate, 10 parts of collagen, 70 parts of Silica hydrogel component A, 70 parts of Silica hydrogel B component.
Control group 3: a kind of scar plaster and preparation method thereof containing nano silica, according to parts by weight by below at
Divide and constitute: 3 parts of alginate, 100 parts of nanosilica solution, 70 parts of Silica hydrogel component A, 70 parts of Silica hydrogel B component.
Antibacterial tests analysis is carried out to experimental group and each control group, as a result as follows:
The experimental group of table and control group, which can be seen that, in comparison has collaboration between each ingredient of scar plaster prepared by the present invention
Effect, it is indispensable.
(1) by comparative experiments group and control group 1 it can be found that alginate plays an important role in scar plaster,
There is the water content that may insure keratoderma in it, accelerate the permeability of water-soluble substances in interstitial, and scar softening is promoted to disappear
It moves back, pigment shoals, and mitigates itch pain.The regeneration that can inhibit capillary simultaneously, reduces the hyperplasia of scar, there is skin smooth
Elasticity.
(2) by comparative experiments group and control group 2 it can be found that nano silica plays important work in scar plaster
With presence can make scar plaster have good OTR oxygen transmission rate, it can be ensured that the normal respiration of skin plays simultaneously
Antibacterial action.
(3) by comparative experiments group and control group 3 it can be found that collagen plays an important role in scar plaster,
In the presence of that can repair scar blackening, protrusion, the wound tissue color after making healing is scarlet, flat and smooth, flexible.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention；For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways, there is no necessity and possibility to exhaust all the enbodiments；It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (7)
1. a kind of scar plaster containing nano silica, which is characterized in that be made of according to parts by weight following component:
The preparation method of the scar plaster includes the following steps:
S1. collagen is dissolved in nanosilica solution, stirs 0.5h~1h to being uniformly dissolved, is prepared into solution E；
Alginate is dissolved in solution E again, 1h~2h is stirred to being completely dissolved, is prepared into gel F；
S2. Silica hydrogel component A is slowly added in Silica hydrogel B component, 0.5h~1h is to uniform for stirring, and it is compound to be prepared into AB component
Object；
S3. the AB component compound of S2 preparation is added and is stirred under vacuum in tank, then the S1 gel F prepared is slowly added to vacuum and is stirred
It mixes in tank, is that -0.8MPa~0.095MPa stirs 4~7h under the conditions of temperature is 20~35 DEG C, and it is de- to carry out vacuum in pressure
Bubble, is prepared into product G；
S4. tile one layer of silica gel thin film in a mold first, and then the S3 product G prepared is laid on pellosil, 50~
Solidify 6~10h under the conditions of 70 DEG C, finally shears, dispenses again, sterilizing up to a kind of scar plaster containing nano silica.
2. a kind of scar plaster containing nano silica according to claim 1, which is characterized in that the alginic acid
Salt is sodium alginate.
3. a kind of scar plaster containing nano silica according to claim 1, which is characterized in that the nanometer two
The content of nano silica is 5wt% in silica solution, and the nano silica partial size is 20~35nm.
4. a kind of scar plaster containing nano silica according to claim 1, which is characterized in that the collagen egg
White extracted from Java tilapia skin.
5. a kind of scar plaster containing nano silica according to claim 1, which is characterized in that the Silica hydrogel
Component A includes methyl vinyl silicon oil, methyl-silicone oil and ethyl silicon oil.
6. a kind of scar plaster containing nano silica according to claim 1, which is characterized in that the Silica hydrogel
B component is the dimethyl silicone polymer of Methyl Hydrogen Polysiloxane Fluid and vinyl opposite end.
7. a kind of preparation method of scar plaster containing nano silica according to claim 1, which is characterized in that institute
The sterilization method in S4 stated is irradiation sterilization, and irradiation dose is 15~25kGy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510755628.7A CN105343926B (en) | 2015-11-09 | 2015-11-09 | A kind of scar plaster and preparation method thereof containing nano silica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510755628.7A CN105343926B (en) | 2015-11-09 | 2015-11-09 | A kind of scar plaster and preparation method thereof containing nano silica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105343926A CN105343926A (en) | 2016-02-24 |
| CN105343926B true CN105343926B (en) | 2018-12-07 |
Family
ID=55320079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510755628.7A Expired - Fee Related CN105343926B (en) | 2015-11-09 | 2015-11-09 | A kind of scar plaster and preparation method thereof containing nano silica |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105343926B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017197542A1 (en) * | 2016-05-20 | 2017-11-23 | 浙江红雨医药用品有限公司 | Antibacterial dressing, and preparation method and use thereof |
| CN109848019A (en) * | 2017-11-30 | 2019-06-07 | 山东朱氏药业集团有限公司 | A kind of Silica hydrogel coating process of scar plaster |
| CN109852333A (en) * | 2017-11-30 | 2019-06-07 | 山东朱氏药业集团有限公司 | A kind of Silica hydrogel preparation process of scar plaster |
| CN107929818A (en) * | 2017-12-21 | 2018-04-20 | 中美之光国际医疗投资管理（北京）有限公司 | New medical silicone pad pasting for meeting partes corporis humani position shape of a kind of dimethyl siloxane and preparation method thereof |
| CN110694118A (en) * | 2019-09-23 | 2020-01-17 | 江苏理工学院 | Antibacterial and anticoagulant ventricles and abdominocentesis shunt tube silica gel tube body and preparation method and application thereof |
| CN112294910A (en) * | 2020-12-24 | 2021-02-02 | 中国人民解放军北部战区总医院 | Medicine for treating strontium 90 scars and preparation method thereof |
| CN113456877B (en) * | 2021-07-09 | 2023-04-11 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
| CN113908066A (en) * | 2021-11-11 | 2022-01-11 | 成都中科娥皇健康咨询有限公司 | Preparation with function of repairing skin tissue fracture and preparation method |
| CN114272227A (en) * | 2022-01-17 | 2022-04-05 | 周建大 | Aspirin-containing scar patch and preparation method thereof |
| CN116617191A (en) * | 2023-05-30 | 2023-08-22 | 南通市优玖医疗用品有限公司 | Application for resisting bacteria and inhibiting scar regeneration and preparation process thereof |
| CN117085174B (en) * | 2023-08-22 | 2024-02-06 | 美蔻生物药业(广州)有限公司 | Liquid dressing for medical and artistic wound care and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481818A (en) * | 2003-05-27 | 2004-03-17 | 上海上大吉申科技开发有限公司 | A scar-removing acne-controlling formulation and preparation method |
| CN101632840A (en) * | 2009-08-28 | 2010-01-27 | 武汉市思泰利医疗器械发展有限公司 | Bio-medical pressure-sensitive adhesive (PSA) and preparation method thereof |
| CN103550254A (en) * | 2013-11-04 | 2014-02-05 | 中国人民解放军第三军医大学第一附属医院 | Breathable itching-relieving antisepsis scar treating paster and preparation method thereof |
| CN103932969A (en) * | 2014-04-16 | 2014-07-23 | 法国奢蔻化妆品有限公司 | Deep-sea fish skin collagen peptide cosmetic capable of delaying ageing, firming skin, brightening and moisturizing and preparation method thereof |
| CN104288828A (en) * | 2014-10-29 | 2015-01-21 | 广西信业生物技术有限公司 | Medical biological scar-inhibiting rhytidectomy dressing and preparation method thereof |
| CN104383580A (en) * | 2014-10-30 | 2015-03-04 | 河北考力森生物科技有限公司 | Preparation method of alginate/collagen-containing membrane |
| CN104436290A (en) * | 2014-11-07 | 2015-03-25 | 广东泰宝医疗科技股份有限公司 | Functional dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN104784104A (en) * | 2015-04-10 | 2015-07-22 | 浙江省诸暨市珠力神医用品有限公司 | Silica gel composition for itching relieving and repairing of scars |
| CN104983721A (en) * | 2015-06-25 | 2015-10-21 | 河南行知专利服务有限公司 | Scar repairing paste |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0129886D0 (en) * | 2001-12-14 | 2002-02-06 | Medtrade Products Ltd | Scar management composition |
-
2015
- 2015-11-09 CN CN201510755628.7A patent/CN105343926B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1481818A (en) * | 2003-05-27 | 2004-03-17 | 上海上大吉申科技开发有限公司 | A scar-removing acne-controlling formulation and preparation method |
| CN101632840A (en) * | 2009-08-28 | 2010-01-27 | 武汉市思泰利医疗器械发展有限公司 | Bio-medical pressure-sensitive adhesive (PSA) and preparation method thereof |
| CN103550254A (en) * | 2013-11-04 | 2014-02-05 | 中国人民解放军第三军医大学第一附属医院 | Breathable itching-relieving antisepsis scar treating paster and preparation method thereof |
| CN103932969A (en) * | 2014-04-16 | 2014-07-23 | 法国奢蔻化妆品有限公司 | Deep-sea fish skin collagen peptide cosmetic capable of delaying ageing, firming skin, brightening and moisturizing and preparation method thereof |
| CN104288828A (en) * | 2014-10-29 | 2015-01-21 | 广西信业生物技术有限公司 | Medical biological scar-inhibiting rhytidectomy dressing and preparation method thereof |
| CN104383580A (en) * | 2014-10-30 | 2015-03-04 | 河北考力森生物科技有限公司 | Preparation method of alginate/collagen-containing membrane |
| CN104436290A (en) * | 2014-11-07 | 2015-03-25 | 广东泰宝医疗科技股份有限公司 | Functional dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN104784104A (en) * | 2015-04-10 | 2015-07-22 | 浙江省诸暨市珠力神医用品有限公司 | Silica gel composition for itching relieving and repairing of scars |
| CN104983721A (en) * | 2015-06-25 | 2015-10-21 | 河南行知专利服务有限公司 | Scar repairing paste |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105343926A (en) | 2016-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105343926B (en) | A kind of scar plaster and preparation method thereof containing nano silica | |
| Zhang et al. | Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing | |
| CN108014366B (en) | Marine biological material composite hydrogel dressing and preparation method thereof | |
| CN103520764B (en) | Functional dressing, and preparation method and application thereof | |
| CN102258801B (en) | Sponge calcium alginate medical dressing, and preparation method | |
| CN106729927B (en) | Modified bioactive glass/polyacrylamide/oxidized sodium alginate hydrogel dressing and preparation method thereof | |
| CN105031740B (en) | A kind of biomimetic prosthetic skin with waterproof and breathable function and preparation method thereof | |
| CN107029272A (en) | A kind of alginate medical dressing and preparation method thereof | |
| CN107118359B (en) | Photo-curing hydrogel and preparation method thereof | |
| CN102580166A (en) | Medical bionic transparent film implanting material, and preparation method and application of material | |
| CN110507842B (en) | Bacterial cellulose/hyaluronic acid/epsilon-polylysine functional dressing and preparation method thereof | |
| CN106377791A (en) | Bamboo alginate functional dressing and preparation method thereof | |
| KR20070118730A (en) | Wound dressing materials with excellent ability to moisturized skin and method of manufacturing the same | |
| CN107551312B (en) | Flocculent collagen hemostatic fiber and preparation method thereof | |
| CN103768650A (en) | Wound regenerating and repairing bandage and manufacture method thereof | |
| CN107903411A (en) | The preparation method of carboxymethyl cotton fiber hydrogel | |
| CN105056285B (en) | It is a kind of can adhesion organization crack growth factor combine dressing and preparation method thereof | |
| WO2016141892A1 (en) | Sheet-like cross-linked hyaluronate hydrogel and preparation method thereof | |
| CN113769156A (en) | Hybrid fiber sponge with functions of hemostasis and wound repair and preparation method thereof | |
| CN104586753A (en) | Carboxymethyl chitosan antibacterial film spray and preparation method thereof | |
| Cheng et al. | Highly absorbent silk fibroin protein xerogel | |
| KR102473363B1 (en) | Spray type hydrogel wound coating preparation method and Spray type hydrogel wound coating thereof | |
| CN114404648A (en) | Preparation method of degradable antibacterial hemostatic hydrogel for promoting diabetic wound repair | |
| CN1775302A (en) | Chitose-gelatine sponge wound dressing preparing method | |
| CN102618954B (en) | Human serum albumin nano biomaterial and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181207 |