CN114652654A

CN114652654A - Mild non-irritant moisturizing and whitening composition and preparation method thereof

Info

Publication number: CN114652654A
Application number: CN202110417456.8A
Authority: CN
Inventors: 潘璐; 张若飞; 童俊
Original assignee: Shanghai Kangmei International Biochemical Co ltd
Current assignee: Shanghai Kangmei International Biochemical Co ltd
Priority date: 2021-04-19
Filing date: 2021-04-19
Publication date: 2022-06-24

Abstract

The invention discloses a mild non-irritant moisturizing and whitening composition, which comprises the following raw materials in percentage by mass: 0.05-0.2% of plant extract, 10-15% of organic acid, 1-4% of isoprene glycol, 3-8% of glycerol, 0.2-0.8% of auxiliary agent and the balance of dihydric alcohol. According to the invention, through the synergistic effect of the plant extract and auxiliaries such as the tetrahydro-methyl pyrimidine carboxylic acid, the skin care composition which has good effects of moisturizing, whitening, free radical removal, skin softening and the like, is mild and non-irritant in the use process, does not harm the skin, is suitable for being popularized in the field of skin care products, and has a wide development prospect.

Description

Mild non-irritant moisturizing and whitening composition and preparation method thereof

Technical Field

The invention relates to the field of skin care products, in particular to a mild non-irritating moisturizing and whitening composition and a preparation method thereof.

Background

The skin is the primary defense line for defending external harmful diseases, pests, substances and chemical substances, and is an important barrier for survival. Skin care products are increasingly paid more attention to people as daily necessities for guaranteeing, repairing and maintaining skin. In recent years, with the improvement of chemical synthesis and chemical technology, more and more synthetic chemicals are used in skin care products, and the effects of moisturizing, whitening and the like of the skin care products are improved. However, with the outbreak of some public skin care products and cosmetics, the requirements of people for skin care products and cosmetics tend to be gentle, friendly and harmless, and especially some skin care products and cosmetics with whitening effect.

In the existing whitening skin care products or cosmetics, the skin is whitened mainly by methods of reducing the formation of melanin, preventing a large amount of melanin from transferring to the skin surface, accelerating the shedding of cells on the skin surface and the like. However, key whitening components in some existing cosmetics are mainly arbutin and hydroquinone derivatives, and although the whitening effect is remarkable, other problems of skin irritation, light sensitivity and the like exist.

Therefore, it is a significant task to develop a skin care composition that has good whitening, moisturizing, and mild and non-irritating properties.

Disclosure of Invention

In order to solve the problems, the invention provides a mild non-irritant moisturizing and whitening composition in a first aspect, which comprises the following raw materials in percentage by mass: 0.05-0.2% of plant extract, 10-15% of organic acid, 1-4% of isoprene glycol, 3-8% of glycerol, 0.2-0.8% of auxiliary agent and the balance of dihydric alcohol.

In a preferred embodiment, the diol is at least one of 1, 3-propanediol, propylene glycol, methyl propanediol and dipropylene glycol.

In a preferred embodiment, the organic acid is at least one of ascorbic acid, ferulic acid and tranexamic acid.

As a preferred embodiment, the plant extract is at least one of turmeric root extract, withania extract, centella asiatica extract, and aloe vera extract.

In a preferred embodiment, the auxiliary agent is undecylenoyl phenylalanine, and tetrahydro-methyl pyrimidine carboxylic acid.

In a preferable embodiment, the mass ratio of the undecylenoyl phenylalanine to the tetrahydro-methyl pyrimidine carboxylic acid is 1-2: 1.

in a preferred embodiment, the diol is 1, 3-propanediol or methyl propanediol.

Preferably, the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 7-9: 10 to 12.

As a preferable scheme, the mass ratio of the organic acid to the dihydric alcohol is 2-3: 15-16.

The invention provides a preparation method of the mild non-irritant moisturizing and whitening composition, which comprises the following steps: (1) putting the plant extract and the dihydric alcohol into a stirring pot, and stirring for 10-20 minutes until the plant extract and the dihydric alcohol are uniform; (2) adding organic acid, isoprene glycol, an auxiliary agent and glycerol into a stirring pot, and mixing and stirring for 40-60 minutes to obtain the composition.

Has the advantages that:

1. the composition disclosed by the invention has the advantages of few formula components, more beneficial skin components, simple preparation process, and mutual matching of the components in the formula, so that the composition has good effects of moisturizing, whitening and the like, has good affinity in the use process, does not irritate the skin, and has good applicability to skin types such as sensitive muscles.

2. According to the invention, the plant extracts such as turmeric root and the like are added, so that the effects of moisturizing and the like of the composition are further improved, the composition has a good mild skin moisturizing effect, skin wrinkles can be reduced, the skin is effectively and uniformly moisturized, and the softness and the glossiness of the skin are improved.

3. According to the invention, the composition has an excellent whitening effect through the synergistic effect of the added beneficial substances such as the undecylenoyl phenylalanine, the tetrahydro-methylpyrimidine carboxylic acid and the like, and the composition is ensured not to irritate the skin while having a good whitening effect, and has the characteristics of being mild and not irritating.

4. According to the invention, through the blending of the polyhydric compound alcohol, the solubility of components such as ascorbic acid in the composition system is effectively improved, and the effect of active components such as ascorbic acid in the composition is effectively ensured through the free radical scavenging effect of the active components in the turmeric root extract.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; no other elements are excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

The dihydric alcohol is at least one of 1, 3-propylene glycol, methyl propylene glycol and dipropylene glycol.

In some preferred embodiments, the organic acid is at least one of ascorbic acid, ferulic acid, tranexamic acid.

In some preferred embodiments, the organic acid is ascorbic acid.

In some preferred embodiments, the plant extract is at least one of turmeric root extract, withania extract, centella asiatica extract, aloe vera extract.

In some preferred embodiments, the plant extract is turmeric root extract.

In some preferred embodiments, the mass ratio of the turmeric root extract to the auxiliary agent is 1: 4.

in some preferred embodiments, the adjuvant is undecylenoyl phenylalanine, tetrahydromethyl pyrimidine carboxylic acid.

In some preferred embodiments, the mass ratio of the undecylenoyl phenylalanine to the tetrahydro-methyl pyrimidine carboxylic acid is 1-2: 1.

in some preferred embodiments, the mass ratio of undecylenoyl phenylalanine to tetrahydro-methyl pyrimidine carboxylic acid is 1: 1.

the applicant finds that the addition of turmeric root extract, undecylenoyl phenylalanine and tetrahydro-methyl pyrimidine carboxylic acid to the composition species simultaneously effectively improves the whitening and skin-softening effects of the composition, and is mild and non-irritating. Furthermore, especially when the mass ratio of the turmeric root extract to the auxiliary agent is 1: 4, and the mass ratio of the undecylenoyl phenylalanine to the tetrahydromethyl pyrimidine carboxylic acid is 1: 1, the composition has optimal whitening and moisturizing effects, good affinity, and no irritation to skin. The applicant speculates that: when the mass ratio of the turmeric root extract to the auxiliary agent is 1: 4, when the tetrahydro-methyl pyrimidine carboxylic acid in the auxiliary agent is used, the tetrahydro-methyl pyrimidine carboxylic acid can regulate and control the osmotic pressure of cells in skin cells, can be used as a chemical transfer bridge of flavonoid substances in the turmeric root extract, stabilizes an enzyme protein structure in the cells, and promotes the absorption of the turmeric root extract; at the moment, flavonoid substances in the turmeric root extract can effectively exert the inhibiting effect on the cerebral amidase in skin cells, stably maintain the content of the cerebral amidase in skin epidermal cells, and simultaneously, the unique molecular structure of the tetrahydro-methyl pyrimidine carboxylic acid can further promote the water molecule complexing ability of the skin cells, so that free water in the cells is structured, the inhibiting effect of the turmeric root extract on skin elastase is promoted, and the decomposition phenomenon of proteins in the skin cells is effectively inhibited. Further, when the mass ratio of the undecylenoyl phenylalanine to the tetrahydro-methylpyrimidine carboxylic acid is 1: 1, the good moisturizing effect provided by the tetrahydro-methyl pyrimidine carboxylic acid can further promote the effect of the undecylenoyl phenylalanine on blocking receptor agonist mediation of skin melanin, so that the transmission of generation signals of each stage of melanin generation is intercepted, and good combination efficiency of melanin stimulin and melanin factors is achieved.

In some preferred embodiments, the glycol is 1, 3-propanediol, methyl propanediol.

In some preferred embodiments, the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 7-9: 10 to 12.

In some preferred embodiments, the mass ratio of methyl propylene glycol, 1, 3-propanediol is 8: 11.375.

the applicant finds that the effect of moisturizing, whitening and the like of the composition can be effectively improved by adding the methyl propylene glycol and the 1, 3-propylene glycol mixed diol into the composition system. The applicant speculates that: the anhydrous polyalcohol system in the system can effectively avoid the electron losing reaction of the ascorbic acid in the composition and effectively reserve the active ingredients of the ascorbic acid in the composition. At the same time, however, the solubility of ascorbic acid in alcoholic systems is low, and the applicant has found that, surprisingly, when the mass ratio of methylpropanediol to 1, 3-propanediol is 8: 11.375, the solubility of the ascorbic acid in the polyol complex system can be obviously improved, and the ascorbic acid can be effectively combined with other components in the composition, so that the synergistic effect of enhancing the performance of the composition is achieved.

When the composition is used, the high solubility of the ascorbic acid can effectively ensure that the ascorbic acid can play a good skin care effect, and the free radical scavenging effect of active ingredients such as flavonoid in the turmeric root extract in the raw materials can further ensure the activity of the ascorbic acid in the composition.

In some preferred embodiments, the mass ratio of the organic acid to the glycol is 2 to 3: 15 to 16.

In some preferred embodiments, the mass ratio of the organic acid to the glycol is 3: 15.5.

the invention provides a preparation method of the mild non-irritant moisturizing and whitening composition, which comprises the following steps: (1) putting the plant extract and the dihydric alcohol into a stirring pot, and stirring for 10-20 minutes until the mixture is uniform; (2) adding organic acid, isoprene glycol, an auxiliary agent and glycerol into a stirring pot, and mixing and stirring for 40-60 minutes to obtain the composition.

Examples

The technical solution of the present invention is described in detail by the following examples, but the scope of the present invention is not limited to all of the examples. The starting materials of the present invention are all commercially available unless otherwise specified.

Example 1

The embodiment 1 provides a mild and non-irritant moisturizing and whitening composition in a first aspect, and the raw materials comprise the following components in percentage by mass: turmeric root extract 0.1%, ascorbic acid 15%, isoprene glycol 2%, glycerol 5%, undecylenoyl phenylalanine 0.2%, tetrahydromethyl pyrimidine carboxylic acid 0.2%, methyl propylene glycol and 1, 3-propylene glycol supplement the rest (the mass ratio of methyl propylene glycol to 1, 3-propylene glycol is 8: 11.375).

In this example, the turmeric root extract is a product of turmeric root extract sold by Sabinsa corporation, india.

In a second aspect, this embodiment provides a method for preparing a mild non-irritating, moisturizing and whitening composition, comprising the following steps: (1) placing the turmeric root extract, methyl propylene glycol and 1, 3-propylene glycol into a stirring pot, and stirring for 10 minutes until the mixture is uniform; (2) adding ascorbic acid, isoprene glycol, undecylenoyl phenylalanine, tetrahydro-methyl pyrimidine carboxylic acid and glycerol into a stirring pot, and continuously mixing and stirring for 50 minutes to obtain the composition.

Example 2

The embodiment of the present invention is different from embodiment 1 in that: 0.4 percent of undecylenoyl phenylalanine, and the balance of methyl propanediol and 1, 3-propanediol (the mass ratio of methyl propanediol to 1, 3-propanediol is 8: 11.375).

Example 3

The embodiment of the present invention is different from embodiment 1 in that: the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 9: 10.

comparative example 1

The embodiment of this comparative example is the same as example 1 except that: the turmeric root extract is 0.01 percent, and the balance of methyl propylene glycol and 1, 3-propylene glycol is supplemented (the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 8: 11.375).

Comparative example 2

The embodiment of this comparative example is the same as example 1 except that: 0.4 percent of undecylenoyl phenylalanine, 0.1 percent of tetrahydro-methyl pyrimidine carboxylic acid, and the balance of methyl propylene glycol and 1, 3-propylene glycol (the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 8: 11.375).

Comparative example 3

The embodiment of this comparative example is the same as example 1 except that: the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 2: 1.

comparative example 4

The embodiment of this comparative example is the same as example 1 except that: the ascorbic acid content was 5%.

Evaluation of Performance

1. Radical scavenging effect: (1) test samples: all the compositions prepared in the examples and the comparative examples were mixed and diluted with pure water to form a test solution with a mass fraction of 1 wt%; (2) the test method comprises the following steps: hydroxyl radical scavenging experiments: taking 0.5mL of absolute ethanol solution of o-diazaphenanthrene with the concentration of 0.75mmol/L into a test tube with a plug, respectively adding 2mL and 1mL of phosphate buffer solution with the pH value of 7.4 and the concentration of 0.2mol/L into the test tube, fully and uniformly mixing the test samples, adding 0.5mL of FeSO with the concentration of 0.75mmol/L into the test tube₄·7H₂O solution, mixed again and then added with 0.5mL of 0.01% (v/v) H₂O₂After being put in a constant-temperature water bath at 37 ℃ for 60min, the absorbance values of all groups of mixed solutions are respectively measured at 536nm and recorded As As, the absorbance values are measured by using distilled water instead of sample solution As a blank group and recorded As Ab, and the distilled water instead of H₂O₂And measuring the absorbance value An of the damage group, and calculating the hydroxyl radical clearance of the test sample according to the following formula: hydroxyl radical clearance (%) - (As-An)/(Ab-An)]100%, the test results are tabulated by taking the average of 5 tests, 5 specimens are tested for each example comparative example, and the average of the measured values is tabulated in table 1.

2. Protein synthesis promoting effect: (1) test samples: all emulsion products prepared in examples and comparative examples were mixed and diluted with pure water to give a test solution having a mass fraction of 1 wt%; (2) the test method comprises the following steps: the method comprises the steps of determining the content of collagen I in fibroblasts by an enzyme-linked immunosorbent assay, transferring the fibroblasts into a 96-well culture plate after being digested by trypsin, filling the marginal holes with a sterile phosphate buffer solution, transferring the cells into an incubator to be continuously cultured, sequentially adding 30 mu L/hole of sample solutions of examples and comparative examples by using a microsyringe when the cells are completely attached to the walls and grow, determining the content of the collagen I according to the instruction of a kit after adding the samples for 48 hours, taking 5 multiple holes in each group, taking a common essence milk product without the samples of the examples and the comparative examples on the market as a control group, taking the average value of the collagen synthesis amount as 100 percent, recording the average value into a table, testing 5 samples in each example comparative example, and recording the average value of the measured value into the table 1.

TABLE 1

Examples	Free radical scavenging effect%	Protein promoting effect%
			Example 1	80.4	144.3
Example 2	79.5	141.5
			Example 3	78.8	141.6
Comparative example 1	44.2	104.2
			Comparative example 2	64.3	119.1
Comparative example 3	66.4	121.5
			Comparative example 4	64.8	120.4

The compositions which are mild, non-irritating, moisturizing and whitening and the preparation method thereof have good effects of moisturizing, whitening, free radical removal, skin softening and the like, are mild and non-irritating in the using process, do not damage the skin, are suitable for being popularized in the field of skin care products, and have wide development prospects. Wherein, the example 1 obtains the best performance index under the factors of the best raw material proportion, the best preparation process and the like.

Finally, it should be understood that the above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the present invention, and any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The mild non-irritant moisturizing and whitening composition is characterized by comprising the following components in parts by weight: the raw materials comprise the following components in percentage by mass: 0.05-0.2% of plant extract, 10-15% of organic acid, 1-4% of isoprene glycol, 3-8% of glycerol, 0.2-0.8% of auxiliary agent and the balance of dihydric alcohol.

2. The mild non-irritating, moisturizing and whitening composition according to claim 1, characterized in that: the dihydric alcohol is at least one of 1, 3-propylene glycol, methyl propylene glycol and dipropylene glycol.

3. The mild non-irritating, moisturizing and whitening composition according to claim 1, characterized in that: the organic acid is at least one of ascorbic acid, ferulic acid and tranexamic acid.

4. The mild non-irritating, moisturizing and whitening composition according to claim 1, characterized in that: the plant extract is at least one of Curcuma rhizome extract, Withania Somnifera extract, herba Centellae extract, and Aloe extract.

5. The mild non-irritating, moisturizing and whitening composition according to claim 1, characterized in that: the auxiliary agent is undecylenoyl phenylalanine and tetrahydro-methyl pyrimidine carboxylic acid.

6. The mild non-irritating, moisturizing and whitening composition according to claim 5, characterized in that: the mass ratio of the undecylenoyl phenylalanine to the tetrahydro-methyl pyrimidine carboxylic acid is 1-2: 1.

7. the mild non-irritating, moisturizing and whitening composition according to claim 2, characterized in that: the dihydric alcohol is 1, 3-propylene glycol or methyl propylene glycol.

8. The mild non-irritating, moisturizing and whitening composition according to claim 7, characterized in that: the mass ratio of the methyl propylene glycol to the 1, 3-propylene glycol is 7-9: 10 to 12.

9. The mild non-irritating, moisturizing and whitening composition according to claim 1, characterized in that: the mass ratio of the organic acid to the dihydric alcohol is 2-3: 15-16.

10. A method for preparing a mild non-irritating, moisturizing and whitening composition according to any one of claims 1-9, characterized in that: the method comprises the following steps: (1) putting the plant extract and the dihydric alcohol into a stirring pot, and stirring for 10-20 minutes until the mixture is uniform; (2) and adding organic acid, isoprene glycol, an auxiliary agent and glycerol into a stirring pot, and mixing and stirring for 40-60 minutes to obtain the composition.