CN114601193A - Preparation method and application of antioxidant nicotine salt - Google Patents
Preparation method and application of antioxidant nicotine salt Download PDFInfo
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- CN114601193A CN114601193A CN202210452249.0A CN202210452249A CN114601193A CN 114601193 A CN114601193 A CN 114601193A CN 202210452249 A CN202210452249 A CN 202210452249A CN 114601193 A CN114601193 A CN 114601193A
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 88
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 80
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 38
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229960002715 nicotine Drugs 0.000 claims abstract description 30
- 241000675108 Citrus tangerina Species 0.000 claims abstract description 23
- 238000001816 cooling Methods 0.000 claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 239000011259 mixed solution Substances 0.000 claims abstract description 18
- 150000007524 organic acids Chemical class 0.000 claims abstract description 17
- 239000003960 organic solvent Substances 0.000 claims abstract description 17
- 238000006243 chemical reaction Methods 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 57
- 239000000243 solution Substances 0.000 claims description 42
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 39
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 23
- 239000003571 electronic cigarette Substances 0.000 claims description 20
- 238000010992 reflux Methods 0.000 claims description 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000005711 Benzoic acid Substances 0.000 claims description 14
- 235000010233 benzoic acid Nutrition 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 11
- 238000002386 leaching Methods 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000001630 malic acid Substances 0.000 claims description 6
- 235000011090 malic acid Nutrition 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- 239000002826 coolant Substances 0.000 claims description 4
- 239000004220 glutamic acid Substances 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- 238000000199 molecular distillation Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 239000013557 residual solvent Substances 0.000 claims description 2
- 241001122767 Theaceae Species 0.000 claims 2
- 244000269722 Thea sinensis Species 0.000 abstract description 30
- 241000208125 Nicotiana Species 0.000 abstract description 24
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract description 24
- 230000003647 oxidation Effects 0.000 abstract description 13
- 238000007254 oxidation reaction Methods 0.000 abstract description 13
- 230000006378 damage Effects 0.000 abstract description 4
- 235000013616 tea Nutrition 0.000 description 25
- 235000011187 glycerol Nutrition 0.000 description 18
- 239000003921 oil Substances 0.000 description 15
- 235000019198 oils Nutrition 0.000 description 15
- 238000005303 weighing Methods 0.000 description 9
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 8
- 235000019477 peppermint oil Nutrition 0.000 description 8
- 239000010903 husk Substances 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 235000009569 green tea Nutrition 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010012335 Dependence Diseases 0.000 description 2
- 241000208134 Nicotiana rustica Species 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000779 smoke Substances 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 240000007377 Petunia x hybrida Species 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The application provides a preparation method and application of an antioxidant nicotine salt, which comprises the following steps: adding nicotine, an antioxidant and an organic solvent into a reaction container according to a certain weight ratio, fully stirring under a first preset condition, and uniformly mixing to obtain a first mixed solution; and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the nicotine salt. The nicotine salt with the oxidation resistance is prepared by mixing nicotine, an antioxidant, an organic solvent and an organic acid together under certain conditions, wherein the antioxidant adopts a tea seed green tangerine orange peel extract, and an oil-soluble antioxidant is extracted from the tea seed green tangerine orange peel, so that the oxidation stability of the nicotine salt can be obviously improved, and meanwhile, when the nicotine salt is applied to electronic tobacco tar, the oil-soluble antioxidant can also obviously improve the oxidation resistance of the tobacco tar, enhance the stability of the electronic tobacco tar and reduce the harm of the tobacco tar to human bodies.
Description
Technical Field
The application relates to the technical field of nicotine salt, in particular to a preparation method and application of antioxidant nicotine salt.
Background
Nicotine, 3- [ 1-methylpyrrolidin-2-yl ] pyridine, is a molecular alkaloid naturally produced by some solanaceous plants, commonly known as nicotine, which includes not only tobacco but also capsicum, tomato, potato, eggplant or petunia. Among these plants, tobacco is one of the most abundant plants with nicotine content, accounting for 8% -14%, which is also responsible for its use in cigarettes.
The emergence of electronic cigarettes has changed the fate of millions of smokers, and the emergence of nicotine salt tobacco tar has further promoted the healthy development of small smoke tides. Compared with the traditional nicotine tobacco tar extracted from tobacco, the nicotine salt tobacco tar has higher content of used nicotine salt, can be easily absorbed by human blood, can relieve the nicotine requirement of nicotine addicts, has more comfortable inhalation feeling and addiction relieving capability, can achieve the advantages of quick addiction relieving and no interference of small smoke to other people when being properly applied to low-power equipment, does not resemble the traditional tobacco tar, and can bring unacceptable throat hitting experience when pursuing high nicotine.
However, when the nicotine salt is applied to the electronic cigarette tobacco tar, the defect of low oxidation resistance exists as the nicotine tobacco tar, so that the electronic cigarette tobacco tar is poor in stability and extremely easy to oxidize, the taste of the electronic cigarette tobacco tar is affected, and meanwhile, oxidative decomposition substances generated after the electronic cigarette tobacco tar is inhaled into a human body have certain damage to human organs. Therefore, there is a need to develop a nicotine salt with improved antioxidant properties.
Disclosure of Invention
In view of the above, the present application is proposed to provide a method for preparing and use of an antioxidant nicotine salt that overcomes or at least partially solves the above mentioned problems, comprising:
a preparation method of an antioxidant nicotine salt comprises the following steps:
adding nicotine, an antioxidant and an organic solvent into a reaction container according to a certain weight ratio, fully stirring under a first preset condition, and uniformly mixing to obtain a first mixed solution;
and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the antioxidant nicotine salt.
Preferably, before the step of adding nicotine, an antioxidant and an organic solvent into a reaction vessel according to a certain weight ratio, fully stirring and uniformly mixing under a first preset condition to obtain a first mixed solution, the method further comprises:
preparing an antioxidant, wherein the antioxidant is an extract of green tangerine orange peel of tea seeds.
Preferably, the step of preparing the antioxidant comprises:
mixing the tea seed green tangerine peel particles and n-hexane according to a material-liquid ratio of 1: 1.2-1.4, soaking for 3 times at 50 ℃ for 2 hours each time, filtering and combining to obtain a leaching solution;
heating the combined leaching liquor to 60 ℃ to obtain a concentrated solution;
slowly cooling the concentrated solution to-5 to-7 ℃, controlling the cooling time to be 6 hours, and filtering and removing the wax in the oil after the wax in the concentrated solution is separated out to obtain a purified solution;
and (3) removing the residual solvent from the purified liquid by a molecular distillation method to obtain the antioxidant.
Preferably, the first preset condition is normal temperature, and the second preset condition is: the temperature is 60-150 ℃, the stirring speed is 200-.
Preferably, the organic acid is one or a combination of more of benzoic acid, glutamic acid, malic acid and citric acid.
Preferably, the organic solvent is one or both of propylene glycol and glycerol.
Preferably, the weight ratio of the nicotine, the antioxidant and the organic solvent is 1: 0.1-1: 0.1-1.
Preferably, the weight ratio of the first mixed solution to the organic acid is 1: 0.1-1.
Preferably, the weight ratio of the first mixed solution to the organic acid is 1: 0.3-1.
The application also provides an application of the antioxidant nicotine salt, wherein the antioxidant nicotine salt is used for the electronic cigarette oil, and the electronic cigarette oil comprises the following raw materials in parts by weight: 2-5 parts of antioxidant nicotine salt, 30-50 parts of glycerol, 3-6 parts of cooling agent and 40-60 parts of solvent.
The application has the following advantages:
in the embodiment of the application, nicotine, an antioxidant and an organic solvent are added into a reaction container according to a certain weight ratio, fully stirred under a first preset condition, and uniformly mixed to obtain a first mixed solution; and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the antioxidant nicotine salt. The nicotine salt with the oxidation resistance is prepared by mixing nicotine, an antioxidant, an organic solvent and an organic acid together under certain conditions, wherein the antioxidant adopts a tea seed green tangerine orange peel extract, and an oil-soluble antioxidant is extracted from the tea seed green tangerine orange peel, so that the oxidation stability of the nicotine salt can be obviously improved, and meanwhile, when the nicotine salt is applied to electronic tobacco tar, the oil-soluble antioxidant can also obviously improve the oxidation resistance of the tobacco tar, enhance the stability of the electronic tobacco tar and reduce the harm of the tobacco tar to human bodies; meanwhile, the antioxidant is extracted from the tea seed green husks, so that the tea seed green husks are changed into valuable, and the production cost can be effectively reduced.
Detailed Description
In order to make the objects, features and advantages of the present application more comprehensible, the present application will be described in further detail with reference to the following embodiments. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
An embodiment of the application provides a preparation method of an antioxidant nicotine salt, which comprises the following steps:
adding nicotine, an antioxidant and an organic solvent into a reaction container according to a certain weight ratio, fully stirring under a first preset condition, and uniformly mixing to obtain a first mixed solution;
and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the nicotine salt.
In the embodiment of the application, nicotine, an antioxidant and an organic solvent are added into a reaction container according to a certain weight ratio, fully stirred under a first preset condition, and uniformly mixed to obtain a first mixed solution; and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the antioxidant nicotine salt. The nicotine salt with the oxidation resistance is prepared by mixing nicotine, an antioxidant, an organic solvent and an organic acid together under certain conditions, wherein the antioxidant adopts a tea seed green tangerine orange peel extract, and an oil-soluble antioxidant is extracted from the tea seed green tangerine orange peel, so that the oxidation stability of the nicotine salt can be obviously improved, and meanwhile, when the nicotine salt is applied to electronic tobacco tar, the oil-soluble antioxidant can also obviously improve the oxidation resistance of the tobacco tar, enhance the stability of the electronic tobacco tar and reduce the harm of the tobacco tar to human bodies; meanwhile, the antioxidant is extracted from the tea seed green husks, so that the tea seed green husks are changed into valuable, and the production cost can be effectively reduced.
Hereinafter, a method for preparing an antioxidant nicotine salt and its use in the present exemplary embodiment will be further described.
In an embodiment of the application, the antioxidant is an extract of tea seed green tangerine peels, the used raw material is the waste tea seed green tangerine peels, the raw material source is wide, the antioxidant is prepared from the waste extract of the tea seed green tangerine peels, waste materials are changed into things of value, and the cost can be effectively reduced.
Specifically, the preparation process of the antioxidant comprises the following steps:
collecting ripe tea fruits, drying in the sun to crack the peel, and separating green husks and seeds of tea seeds; taking green tea seed husks, and continuing airing until the water content is reduced to below 15%; crushing the dried green tea seed peel by using a crusher, sieving by using a sieve of 10 meshes to obtain green tea seed peel granules, sealing, bagging and storing; weighing 20kg of the tea seed green tangerine peel particles, adding 24L of n-hexane, soaking at 50 ℃ for 3 times, each time for 2 hours, filtering and combining the leaching liquor; heating the leaching liquor to 60 ℃ to evaporate 80% of the solvent in the leaching liquor to obtain a concentrated solution, and cooling and recycling the evaporated solvent through a condenser; slowly cooling the concentrated solution to-5 to-7 ℃, controlling the cooling time to be 6 hours, and filtering and removing wax in the oil after the wax in the concentrated solution is separated out to obtain a purified solution; the purified solution was subjected to molecular distillation to remove the remaining solvent, and 50g of an oil-soluble antioxidant was obtained.
In one embodiment of the present application, a method for preparing an antioxidant nicotine salt comprises the following steps:
adding nicotine, tea seed green tangerine peel extract and organic solvent into a reaction container according to a certain weight ratio, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution;
adding organic acid into the transparent solution, stirring at 60-150 ℃ at a stirring speed of 200-.
In one embodiment of the present application, the organic acid is one or a combination of several of benzoic acid, glutamic acid, malic acid, and citric acid, preferably benzoic acid; the organic solvent is one or two of propylene glycol or glycerol, and is preferably propylene glycol.
Example 1
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.7:0.5, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: benzoic acid is 1: adding benzoic acid at a ratio of 0.4, heating and stirring at 130 deg.C with stirring speed of 400r/min and reflux ratio of 2:1, refluxing for 2h, and cooling to room temperature to obtain nicotine salt.
Example 2
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.3:0.35, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: benzoic acid is 1: adding benzoic acid at a ratio of 0.7, heating and stirring at 110 deg.C with stirring speed of 400r/min and reflux ratio of 2:1, refluxing for 1h, and cooling to room temperature to obtain nicotine salt.
Example 3
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.6:0.9, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: benzoic acid is 1: adding benzoic acid at a ratio of 0.4, heating and stirring at 90 deg.C with stirring speed of 300r/min and reflux ratio of 2:1, refluxing for 5h, and cooling to room temperature to obtain nicotine salt.
Example 4
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.9:0.2, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: benzoic acid is 1: adding benzoic acid at a ratio of 0.3, heating at 60 deg.C under stirring at a speed of 200r/min and reflux ratio of 2:1, refluxing for 3.6h, and cooling to room temperature to obtain nicotine salt.
Example 5
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.5:0.5, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: benzoic acid is 1: adding benzoic acid at a ratio of 0.7, heating at 70 deg.C under stirring at a speed of 500r/min and reflux ratio of 2:1, refluxing for 1.5h, and cooling to room temperature to obtain nicotine salt.
Example 6
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.8:0.9, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: citric acid is 1: adding citric acid at a ratio of 0.2, heating at 105 deg.C under stirring at 400r/min under reflux ratio of 2:1 for 1 hr, and cooling to room temperature to obtain nicotine salt.
Example 7
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.9:0.1, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: malic acid is 1: adding malic acid at a ratio of 0.2, heating and stirring at 100 deg.C with stirring speed of 300r/min and reflux ratio of 2:1, refluxing for 2.8h, and cooling to room temperature to obtain nicotine salt.
Example 8
Weighing nicotine, a tea seed green tangerine peel extract and propylene glycol according to a weight ratio of 1:0.8:0.8, respectively, fully stirring at normal temperature, and uniformly mixing to obtain a transparent solution; in the obtained transparent solution, the weight ratio of the transparent solution is as follows: malic acid is 1:0.1 of glutamic acid, and adding the transparent solution according to the weight ratio: distilled water is 1: adding water at a ratio of 0.01, heating and stirring at 112 deg.C with stirring speed of 200r/min and reflux ratio of 2:1, refluxing for 5 hr, and cooling to room temperature to obtain nicotine salt.
In the embodiment of the application, the antioxidant nicotine salt prepared by the preparation method is applied to electronic cigarette oil to obtain antioxidant electronic cigarette oil, and the antioxidant electronic cigarette oil comprises the following raw materials in parts by weight: 2-5 parts of antioxidant nicotine salt, 30-50 parts of glycerol, 3-6 parts of cooling agent and 40-60 parts of solvent; wherein the cooling agent is peppermint oil or N-ethyl-p-menthane-3-formamide, preferably peppermint oil, and the solvent is propylene glycol or glycerol, preferably glycerol.
Example 9
The antioxidant electronic cigarette oil comprises the following raw materials in parts by weight: 5 parts of antioxidant nicotine salt, 30 parts of glycerol, 3 parts of peppermint oil and 40 parts of glycerol.
Example 10
The antioxidant electronic cigarette oil comprises the following raw materials in parts by weight: 4 parts of antioxidant nicotine salt, 35 parts of glycerin, 4 parts of peppermint oil and 45 parts of glycerol.
Example 11
The antioxidant electronic cigarette oil comprises the following raw materials in parts by weight: 3 parts of antioxidant nicotine salt, 40 parts of glycerin, 5 parts of peppermint oil and 50 parts of glycerol.
Example 12
The antioxidant electronic cigarette oil comprises the following raw materials in parts by weight: 2 parts of antioxidant nicotine salt, 50 parts of glycerin, 6 parts of peppermint oil and 60 parts of glycerol.
Experiment on Oxidation resistance
The antioxidant electronic cigarette oil prepared by the invention is compared with common electronic cigarette oil without antioxidant, a grease oxidation stability tester is used for measurement, the experimental conditions are that the temperature is 110 ℃/120 ℃, the air flow rate is 20L/h, and the measurement result evaluates the antioxidant performance according to the induction time.
The experimental groups used were the groups of example 9 and example 12.
Comparative example 9
The electronic cigarette oil comprises the following raw materials in parts by weight: 5 parts of nicotine, 30 parts of glycerol, 3 parts of peppermint oil and 40 parts of glycerol.
Comparative example 12
The electronic cigarette oil comprises the following raw materials in parts by weight: 2 parts of nicotine, 50 parts of glycerol, 6 parts of peppermint oil and 60 parts of glycerol.
The experimental data are shown in table one.
Watch 1
Experimental results show that the antioxidant electronic tobacco tar prepared by the method can obviously improve the oxidation stability of the tobacco tar, so that the nicotine salt prepared by the method has higher antioxidant stability.
While preferred embodiments of the present application have been described, additional variations and modifications of these embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including the preferred embodiment and all such alterations and modifications as fall within the true scope of the embodiments of the application.
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, or article that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, or article. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other like elements in a process, method, or article that comprises the element.
The preparation method and the application of the antioxidant nicotine salt provided by the application are described in detail above, and the principle and the implementation mode of the application are explained in the present application by using specific examples, and the description of the above examples is only used to help understand the method and the core idea of the application; meanwhile, for a person skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.
Claims (10)
1. The preparation method of the antioxidant nicotine salt is characterized by comprising the following steps:
adding nicotine, an antioxidant and an organic solvent into a reaction container according to a certain weight ratio, fully stirring under a first preset condition, and uniformly mixing to obtain a first mixed solution;
and adding organic acid into the first mixed solution, placing the mixture under a second preset condition, fully stirring the mixture, and cooling the mixture to room temperature to obtain the antioxidant nicotine salt.
2. The method for preparing an antioxidant nicotine salt as claimed in claim 1, wherein the step of adding nicotine, an antioxidant and an organic solvent into a reaction vessel according to a certain weight ratio, stirring the mixture fully under a first preset condition, and mixing the mixture uniformly to obtain a first mixed solution further comprises:
preparing an antioxidant, wherein the antioxidant is an extract of green tangerine orange peel of tea seeds.
3. The method of preparing an antioxidant nicotine salt of claim 2, wherein the step of preparing an antioxidant comprises:
mixing the tea seed green tangerine peel particles and n-hexane according to a material-liquid ratio of 1: 1.2-1.4, soaking for 3 times at 50 ℃ for 2 hours each time, filtering and combining to obtain a leaching solution;
heating the combined leaching liquor to 60 ℃ to obtain a concentrated solution;
slowly cooling the concentrated solution to-5 to-7 ℃, controlling the cooling time to be 6 hours, and filtering and removing the wax in the oil after the wax in the concentrated solution is separated out to obtain a purified solution;
and (3) removing the residual solvent from the purified liquid by a molecular distillation method to obtain the antioxidant.
4. The method for preparing an antioxidant nicotine salt as in claim 1, wherein the first predetermined condition is normal temperature, and the second predetermined condition is: the temperature is 60-150 ℃, the stirring speed is 200-500r/min, the reflux ratio is 2:1, and the reflux reaction is 0.5-2 h.
5. The method for preparing antioxidant nicotine salt of claim 1, wherein the organic acid is one or more of benzoic acid, glutamic acid, malic acid, and citric acid.
6. The method of claim 1, wherein the organic solvent is one or both of propylene glycol and glycerol.
7. The method of preparing an antioxidant nicotine salt of claim 1, wherein the weight ratio of nicotine, the antioxidant and the organic solvent is 1: 0.1-1: 0.1-1.
8. The method of claim 1, wherein the weight ratio of the first mixed solution to the organic acid is 1: 0.1-1.
9. The method of claim 1, wherein the weight ratio of the first mixed solution to the organic acid is 1: 0.3-1.
10. The use of the antioxidant nicotine salt of claim 1, wherein the antioxidant nicotine salt is used in electronic cigarette liquid, and the electronic cigarette liquid comprises the following raw materials in parts by weight: 2-5 parts of antioxidant nicotine salt, 30-50 parts of glycerol, 3-6 parts of cooling agent and 40-60 parts of solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210452249.0A CN114601193A (en) | 2022-04-27 | 2022-04-27 | Preparation method and application of antioxidant nicotine salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210452249.0A CN114601193A (en) | 2022-04-27 | 2022-04-27 | Preparation method and application of antioxidant nicotine salt |
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Cited By (4)
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| CN115119957A (en) * | 2022-06-28 | 2022-09-30 | 深圳市艾普生物科技有限公司 | Antioxidant electronic cigarette oil and preparation method thereof |
| CN115191635A (en) * | 2022-08-24 | 2022-10-18 | 深圳市恒云生物科技有限公司 | Nicotine salt and preparation method thereof |
| CN115281366A (en) * | 2022-06-28 | 2022-11-04 | 深圳市艾普生物科技有限公司 | Preparation method and application of antioxidant nicotine salt |
| CN116235982A (en) * | 2023-02-28 | 2023-06-09 | 深圳正和生物科技有限公司 | Electronic cigarette oil, preparation method thereof and electronic cigarette |
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| CN113100375A (en) * | 2021-04-14 | 2021-07-13 | 云南省粮油科学研究院（云南省粮油产品质量监督检验测试中心） | Extraction method and application of antioxidant in green tangerine peels of tea seeds |
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| CN115119957A (en) * | 2022-06-28 | 2022-09-30 | 深圳市艾普生物科技有限公司 | Antioxidant electronic cigarette oil and preparation method thereof |
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| CN115191635A (en) * | 2022-08-24 | 2022-10-18 | 深圳市恒云生物科技有限公司 | Nicotine salt and preparation method thereof |
| CN116235982A (en) * | 2023-02-28 | 2023-06-09 | 深圳正和生物科技有限公司 | Electronic cigarette oil, preparation method thereof and electronic cigarette |
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