CN114569568A - Dendrobium buccal tablet and preparation method thereof - Google Patents
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Abstract
The invention discloses a dendrobium buccal tablet and a preparation method thereof, wherein the dendrobium buccal tablet comprises 20-80 parts of dendrobium or dendrobium officinale powder, 10-60 parts of lactose, 5-50 parts of mannitol, 2-6 parts of PVP and 0.5-5 parts of magnesium stearate. The preparation method comprises the following steps: slicing fresh herba Dendrobii or herba Dendrobii, blanching, inactivating enzyme, protecting color, lyophilizing, and pulverizing; uniformly mixing the dendrobium or dendrobium officinale powder with a specific mesh with the rest components, preparing a soft material by using 50-70% ethanol, and sieving and granulating; and after drying, uniformly mixing the dendrobium granules with magnesium stearate, and tabletting to obtain the dendrobium buccal tablet. The invention can obviously improve the poor quality of the current commercially available dendrobe buccal tablets such as poor color, rough mouthfeel, excessive stickiness and the like, and the obtained buccal tablets are bright light green and have better mouthfeel.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation processes, and particularly relates to dendrobium buccal tablets and a preparation method thereof.
Background
Herba Dendrobii is a plant of Dendrobium of Orchidaceae, and can be used as both medicine and food. The method is mainly distributed in places such as Guangxi, Guizhou, Yunnan, Anhui, Hubei, Hainan, Taiwan and the like in China. The first treatise on pharmacology in China, Shen nong Ben Cao Jing, listed dendrobe as the top grade. In the monograph of the Taoist treatise on the Collection, dendrobe is located at the head of the Chinese "Jiudaoxiancao". In the Ming Dynasty Li Shizhen Ben Cao gang mu, it records that "Dendrobii nobile is mild in smell, sweet, bland, slightly salty in taste, descending and descending of yin-middle yang". The dendrobium and the dendrobium officinale are listed separately in the pharmacopoeia of the people's republic of China (2020), have sweet and slightly cold properties, enter stomach and kidney channels, benefit stomach, promote fluid production, nourish yin and clear heat, and are used for treating fever body fluid deficiency, thirst, stomach yin deficiency, anorexia, retching, deficiency heat after illness, yin deficiency and fire excess, bone steaming, fatigue and fever, dim and unclear eyes and flaccidity of bones and muscles. Modern medical research shows that the dendrobium contains rich alkaloids such as dendrobine, dendrobine and the like, and functional components such as saponins, flavonoids, polysaccharide mucilaginous substances and the like, and has various pharmacological effects of reducing blood pressure, reducing blood sugar, resisting oxidation, resisting tumors, enhancing immunity, resisting fatigue and the like.
The dendrobium has unique medicinal and health care functions and is widely applied to the industries of medicines and health care products, and main products of the dendrobium comprise dendrobium powder, Chinese maple, dry strips, buccal tablets, raw juice drinks thereof and the like. The buccal tablet is convenient to apply, but the dendrobium contains more fibers, is difficult to crush to uniform granularity, and is easy to have sticking, cracking, surface spots and the like in the tabletting process, so that the existing finished dendrobium buccal tablet has the defects of rough mouthfeel, gritty feeling or over-sticky feeling, poor color and the like.
Disclosure of Invention
In order to solve the problems, the invention firstly aims to provide the dendrobium buccal tablet which is bright and light green and has better mouthfeel.
The invention also aims to provide the preparation method of the dendrobium buccal tablet, which can effectively reduce the damage of the traditional preparation method to the color, the appearance and the effective components of the original medicinal material dendrobium, and effectively improve the color, the taste and the functionality of the finished product of the dendrobium buccal tablet.
The invention is realized by the following technical scheme:
a dendrobe buccal tablet comprises the following components in parts by weight: 20-80 parts of dendrobium or dendrobium officinale powder, 10-60 parts of lactose, 5-50 parts of mannitol, 2-6 parts of PVP and 0.5-5 parts of magnesium stearate.
As a preferable mode of the invention, the dendrobium buccal tablet comprises the following components in parts by weight: 40-60 parts of dendrobium or dendrobium officinale powder
25-40 parts of lactose, 10-15 parts of mannitol, 3-4 parts of PVP and 1-2 parts of magnesium stearate.
Preferably, the granularity of the dendrobium or dendrobium officinale powder is 100-200 meshes. Granularity of dendrobium or dendrobium officinale powder
The taste of the dendrobium nobile buccal tablet is greatly influenced, the granularity of the dendrobium nobile or dendrobium officinale powder is controlled to be 200 meshes through screening, the taste of the dendrobium nobile buccal tablet can be obviously improved, and preferably 180 meshes are selected.
According to the invention, researches show that the addition of the dendrobium powder also has certain influence on the quality of the dendrobium buccal tablets, therefore, the invention screens the addition of the dendrobium powder, and the specific process is as follows:
| dendrobium powder | Lactose | Mannitol | PVP | Sensory evaluation | |
| 1 | 20% | 60% | 15% | 3% | Herba Dendrobii has weak fragrance and low viscosity |
| 2 | 40% | 40% | 10% | 2% | The herba Dendrobii has faint scent, moderate sweetness and moderate viscosity |
| 3 | 60% | 28% | 7% | 1.4% | Herba Dendrobii with faint scent, low sweetness and slightly high viscosity |
| 4 | 80% | 12% | 3% | 0.6% | The dendrobium nobile has faint scent, weak sweetness and excessively sticky and greasy taste |
Through comparison, the addition amount of the dendrobium powder is in the range of 40% -60%, and the dendrobium buccal tablets have the best score.
The invention also provides a preparation method of the dendrobium buccal tablet, which comprises the following steps:
(1) cleaning fresh dendrobium or dendrobium officinale, slicing, shaping, then soaking in a citric acid solution with the mass concentration of 0.15-0.30% for color protection for 1-2h, blanching with hot water to inactivate enzymes, and draining to obtain fresh dendrobium or dendrobium officinale slices;
(2) freeze-drying fresh dendrobium or dendrobium officinale slices to obtain freeze-dried dendrobium or dendrobium officinale slices;
(3) pulverizing the freeze-dried dendrobium or dendrobium officinale slices, and taking the powder with the granularity of 100 meshes and 200 meshes to obtain dendrobium or dendrobium officinale powder;
(4) and fully mixing the dendrobium or dendrobium officinale powder with lactose, mannitol and PVP, adding a proper amount of 50-70% ethanol, uniformly dispersing to obtain a soft material, sieving and granulating, drying, uniformly mixing the dendrobium granules with magnesium stearate, and tabletting to obtain the dendrobium buccal tablet.
According to the invention, the enzyme is killed by hot water blanching, so that the catalytic action of oxidase, amylase and the like can be reduced, the color is protected, and the nutrient loss is reduced, preferably, in the step (1), the temperature of the enzyme is 65-80 ℃, and the time is 4-7 min.
Preferably, in the step (2), the freeze drying comprises a pre-freezing treatment stage, a sublimation drying stage and an analysis drying stage, wherein the pre-freezing treatment stage is a quick-freezing mode, the pre-freezing temperature is-40 to-80 ℃, and the pre-freezing time is 3 to 12 hours; in the sublimation drying stage, the vacuum degree is 50-70pa, the temperature of the heating plate is 15-30 ℃, and the drying time is 7-12 h; and (3) analyzing and drying stage, wherein the vacuum degree is 40-50pa, the temperature of the heating plate is 30-45 ℃, and the drying time is 10-16 h.
Compared with the prior art, the invention has the following advantages:
according to the invention, through pretreatment and freeze-drying of fresh dendrobium or dendrobium officinale, the brittleness of dendrobium cellulose can be effectively improved while the color is protected, so that the uniformity of granularity of the crushed dendrobium is improved; meanwhile, the dendrobium or dendrobium officinale powder with the proper granularity is screened, so that the rough taste caused by a common crushing method and the sticky taste caused by single ultrafine crushing are improved, and the prepared dendrobium buccal tablet is bright and light green and has better taste.
Detailed Description
In order to better understand the present invention, the following examples are further provided to illustrate the present invention, which should be construed as limiting the scope of the present invention.
Example 1
A dendrobe buccal tablet comprises, by weight, dendrobe powder 40, lactose 40, mannitol 15 parts, PVP 3 parts and magnesium stearate 2 parts;
the preparation method comprises the following steps:
(1) cleaning fresh dendrobium, slicing (1.5-2.5 cm), shaping, soaking in 0.25% citric acid solution for color protection for 2h, blanching with hot water to inactivate enzyme (80 ℃, 5 min), and draining to obtain fresh dendrobium slices;
(2) freeze-drying fresh dendrobium slices to obtain freeze-dried dendrobium slices; comprises a pre-freezing treatment stage, a sublimation drying stage and an analysis drying stage, wherein the pre-freezing treatment stage is a quick-freezing mode, the pre-freezing temperature is-80 ℃, and the pre-freezing time is 3-5 hours; in the sublimation drying stage, the vacuum degree is 50-70pa, the temperature of the heating plate is 15-30 ℃, and the drying time is 7-12 h; analyzing and drying stage with vacuum degree of 40-50pa, heating plate temperature of 30-45 deg.C, and drying time of 10-16 h;
(3) crushing the freeze-dried dendrobium slices, and taking the granularity of the freeze-dried dendrobium slices to be 180 meshes to obtain dendrobium powder;
(4) and fully mixing the dendrobium powder with lactose, mannitol and PVP, adding a proper amount of 50-70% ethanol, uniformly dispersing to obtain a soft material, sieving and granulating, drying, uniformly mixing the dendrobium granules with magnesium stearate, and tabletting to obtain the dendrobium buccal tablet.
Example 2
A dendrobe buccal tablet comprises 50 parts of dendrobe powder, 32 parts of lactose, 13 parts of mannitol, 3.5 parts of PVP and 2 parts of magnesium stearate in parts by weight;
in the step (3), the freeze-dried dendrobium slices are crushed, and the granularity of the crushed dendrobium slices is 150 meshes, so that dendrobium powder is obtained;
the rest of the procedure was the same as in example 1.
Example 3
A dendrobium buccal tablet comprises 60 parts of dendrobium officinale powder, 25 parts of lactose, 10 parts of mannitol, 4 parts of PVP and 1.5 parts of magnesium stearate by weight;
in the step (3), the freeze-dried dendrobium officinale slices are crushed, and the granularity of the freeze-dried dendrobium officinale slices is 200 meshes, so that dendrobium officinale powder is obtained;
the rest of the procedure was the same as in example 1.
Comparative example 1
In the step (3), the freeze-dried dendrobium slices are crushed, and the granularity of the crushed dendrobium slices is 50 meshes to obtain dendrobium powder;
the rest is the same as example 2.
Comparative example 2
And (2) wherein the pre-freezing treatment stage is a quick-freezing mode, the pre-freezing temperature is-20 ℃, and the pre-freezing time is 48 hours.
The rest is the same as example 2.
Comparative example 3
Step (2), drying fresh dendrobium slices for 36 hours at 60 ℃ by using an oven;
the rest is the same as example 2.
The dendrobium buccal tablets of examples 1-3 and comparative examples 1-3 are evaluated in color and taste, and the evaluation results are shown in table 1.
Table 1 evaluation results of dendrobe buccal tablets prepared in examples and comparative examples
| Color | Taste of the product | Composite score (score) | |
| Example 1 | Light green | Smooth taste and moderate viscosity | 9.5 |
| Example 2 | Light green | Smooth taste and moderate viscosity | 8.5 |
| Example 3 | Light green | Smooth taste and slightly high viscosity | 8.0 |
| Comparative example 1 | Light green | Has coarse taste and moderate viscosity | 5.5 |
| Comparative example 2 | Grayish green | Has slightly coarse taste and moderate viscosity | 7.0 |
| Comparative example 3 | Close to gray | Has slightly coarse taste and moderate viscosity | 6.0 |
Claims (6)
1. The dendrobe buccal tablet is characterized by comprising the following components in parts by weight: 20-80 parts of dendrobium or dendrobium officinale powder, 10-60 parts of lactose, 5-50 parts of mannitol, 2-6 parts of PVP and 0.5-5 parts of magnesium stearate.
2. The dendrobium buccal tablet according to claim 1, which is characterized by comprising the following components in parts by weight: 40-60 parts of dendrobium or dendrobium officinale powder, 25-40 parts of lactose, 10-15 parts of mannitol, 3-4 parts of PVP and 1-2 parts of magnesium stearate.
3. The dendrobe buccal tablet as claimed in claim 1 or 2, wherein the particle size of the dendrobe or dendrobium officinale powder is 100-200 meshes, preferably 150-180 meshes.
4. The preparation method of the dendrobium buccal tablet according to any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) cleaning fresh dendrobium or dendrobium officinale, slicing, shaping, soaking in a citric acid solution with the mass concentration of 0.15-0.30% for color protection for 1-2h, blanching with hot water to inactivate enzymes, and draining to obtain fresh dendrobium or dendrobium officinale slices;
(2) freezing and drying fresh dendrobium or dendrobium officinale slices to obtain freeze-dried dendrobium or dendrobium officinale slices;
(3) pulverizing the freeze-dried dendrobium or dendrobium officinale slices, and taking the powder with the granularity of 100 meshes and 200 meshes to obtain dendrobium or dendrobium officinale powder;
(4) and fully mixing the dendrobium or dendrobium officinale powder with lactose, mannitol and PVP, adding a proper amount of 50-70% ethanol, uniformly dispersing to obtain a soft material, sieving and granulating, drying, uniformly mixing the dendrobium granules with magnesium stearate, and tabletting to obtain the dendrobium buccal tablet.
5. The preparation method of the dendrobium buccal tablet according to claim 4, wherein in the step (1), the temperature of the enzyme deactivation by hot water blanching is 65-80 ℃ and the time is 4-7 min.
6. The preparation method of the dendrobium buccal tablet according to claim 4, wherein in the step (2), the freeze drying comprises a pre-freezing treatment stage, a sublimation drying stage and an analysis drying stage, wherein the pre-freezing treatment stage is a quick-freezing mode, the pre-freezing temperature is-40 to-80 ℃, and the pre-freezing time is 3 to 12 hours; in the sublimation drying stage, the vacuum degree is 50-70pa, the temperature of the heating plate is 15-30 ℃, and the drying time is 7-12 h; and (3) analyzing and drying stage, wherein the vacuum degree is 40-50pa, the temperature of the heating plate is 30-45 ℃, and the drying time is 10-16 h.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101015649A (en) * | 2006-11-23 | 2007-08-15 | 天津市轩宏医药技术有限公司 | Dendrobium candidum polysaccharide extractive, medicine composition thereof and its preparation and use |
| CN102908531A (en) * | 2012-11-06 | 2013-02-06 | 广州中医药大学 | Dendrobium candidum chewable tablet |
| CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
| CN106473143A (en) * | 2016-10-19 | 2017-03-08 | 南京希元生物医药科技有限公司 | A kind of Herba Dendrobii lyophilized powder buccal tablet |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101015649A (en) * | 2006-11-23 | 2007-08-15 | 天津市轩宏医药技术有限公司 | Dendrobium candidum polysaccharide extractive, medicine composition thereof and its preparation and use |
| CN102908531A (en) * | 2012-11-06 | 2013-02-06 | 广州中医药大学 | Dendrobium candidum chewable tablet |
| CN103285242A (en) * | 2013-05-23 | 2013-09-11 | 重庆市中药研究院 | Dendrobium buccal tablets and preparation method for same |
| CN106473143A (en) * | 2016-10-19 | 2017-03-08 | 南京希元生物医药科技有限公司 | A kind of Herba Dendrobii lyophilized powder buccal tablet |
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| Title |
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| 张雨婷等: "不同干燥方法对铁皮石斛多糖和甘露糖含量的影响", 《安徽中医药大学学报》 * |
| 辛明等: "不同干燥工艺对铁皮石斛多糖及石斛碱的影响", 《南方农业学报》 * |
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