CN114502592A - 靶向cldn18.2的抗体及其制备方法和应用 - Google Patents

靶向cldn18.2的抗体及其制备方法和应用 Download PDF

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CN114502592A
CN114502592A CN202080068747.4A CN202080068747A CN114502592A CN 114502592 A CN114502592 A CN 114502592A CN 202080068747 A CN202080068747 A CN 202080068747A CN 114502592 A CN114502592 A CN 114502592A
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seq
amino acid
acid sequence
antibody
variant
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郑明晋
张伟
王杰利
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Heping Pharmaceutical Suzhou Co ltd
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Heping Pharmaceutical Suzhou Co ltd
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Abstract

提供了靶向CLDN18.2的抗体或其抗原结合片段及其制备方法和应用。所述抗体包含轻链可变区和/或重链可变区，所述重链可变区包含HCDRl、HCDR2和HCDR3，所述的轻链可变区包含LCDRl、LCDR2和LCDR3。与现有技术相比，所述抗体的结合亲和力、ADCC、CDC、生长抑制效应、内吞活性等都有明显的优势。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202080068747.4A 2019-09-30 2020-09-29 靶向cldn18.2的抗体及其制备方法和应用 Pending CN114502592A (zh)

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CN2019109413163 2019-09-30
PCT/CN2020/118650 WO2021063336A1 (zh) 2019-09-30 2020-09-29 靶向cldn18.2的抗体及其制备方法和应用

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CN115947851A (zh) * 2022-12-19 2023-04-11 华润生物医药有限公司 结合cldn18.2的抗体及其用途
CN115960229A (zh) * 2022-09-28 2023-04-14 华润生物医药有限公司 一种cldn18.2抗体及其应用
CN115969997A (zh) * 2022-12-19 2023-04-18 华润生物医药有限公司 一种靶向cldn18.2的抗体药物偶联物及其应用

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CN113416260B (zh) * 2021-04-14 2022-02-01 南京凯地医疗技术有限公司 靶向Claudin18.2的特异性嵌合抗原受体细胞及其制备方法和应用
WO2022268200A1 (zh) * 2021-06-25 2022-12-29 信达生物制药(苏州)有限公司 针对密蛋白18.2的抗体及其用途
CN115611983A (zh) * 2021-07-14 2023-01-17 三优生物医药(上海)有限公司 Cldn18.2结合分子及其用途
WO2023025303A1 (zh) * 2021-08-26 2023-03-02 上海君实生物医药科技股份有限公司 抗cldn-18.2抗体药物偶联物及其用途
CN115991784A (zh) * 2021-10-19 2023-04-21 宝船生物医药科技(上海)有限公司 抗cd47-cldn18.2双特异性抗体及其用途
CN116102649A (zh) * 2021-11-11 2023-05-12 上海生物制品研究所有限责任公司 抗cldn18.2单克隆抗体及其应用
TW202333798A (zh) * 2021-12-17 2023-09-01 大陸商信達生物製藥（蘇州）有限公司 靶向ｃｌａｕｄｉｎ １８．２的抗體－藥物偶聯物
CN114316043B (zh) * 2021-12-28 2022-09-20 三优生物医药(上海)有限公司 一种TGFβ1抗原结合分子及其应用
WO2023231942A1 (zh) * 2022-05-31 2023-12-07 石药集团巨石生物制药有限公司 重组抗人cldn18.2单克隆抗体-mmae偶联药物的药物组合物
CN116082523B (zh) * 2022-12-30 2023-10-13 邦恩泰(山东)生物医药科技集团股份有限公司 一种靶向Claudin18.2的嵌合抗原受体及其应用

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN115960229A (zh) * 2022-09-28 2023-04-14 华润生物医药有限公司 一种cldn18.2抗体及其应用
CN115960229B (zh) * 2022-09-28 2024-02-09 华润生物医药有限公司 一种cldn18.2抗体及其应用
CN115947851A (zh) * 2022-12-19 2023-04-11 华润生物医药有限公司 结合cldn18.2的抗体及其用途
CN115969997A (zh) * 2022-12-19 2023-04-18 华润生物医药有限公司 一种靶向cldn18.2的抗体药物偶联物及其应用
CN115947851B (zh) * 2022-12-19 2024-02-13 华润生物医药有限公司 结合cldn18.2的抗体及其用途
CN115969997B (zh) * 2022-12-19 2024-02-13 华润生物医药有限公司 一种靶向cldn18.2的抗体药物偶联物及其应用

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EP4039706A4 (en) 2023-03-01
US20220332814A1 (en) 2022-10-20
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JP7461469B2 (ja) 2024-04-03
TW202126695A (zh) 2021-07-16
EP4039706A1 (en) 2022-08-10
WO2021063336A1 (zh) 2021-04-08
JP2022550952A (ja) 2022-12-06
CN112707965A (zh) 2021-04-27

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