CN114181781B - Detergent and bactericide, preparation method and application thereof - Google Patents
Detergent and bactericide, preparation method and application thereof Download PDFInfo
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- CN114181781B CN114181781B CN202111602315.XA CN202111602315A CN114181781B CN 114181781 B CN114181781 B CN 114181781B CN 202111602315 A CN202111602315 A CN 202111602315A CN 114181781 B CN114181781 B CN 114181781B
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 43
- 239000003899 bactericide agent Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000003599 detergent Substances 0.000 title claims description 18
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 22
- 150000001408 amides Chemical class 0.000 claims abstract description 20
- 125000003147 glycosyl group Chemical group 0.000 claims abstract description 20
- 238000005406 washing Methods 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 16
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 14
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 14
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 14
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 13
- CBFCDTFDPHXCNY-UHFFFAOYSA-N octyldodecane Natural products CCCCCCCCCCCCCCCCCCCC CBFCDTFDPHXCNY-UHFFFAOYSA-N 0.000 claims description 13
- 229940123208 Biguanide Drugs 0.000 claims description 12
- 239000008367 deionised water Substances 0.000 claims description 12
- 229910021641 deionized water Inorganic materials 0.000 claims description 12
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 11
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 11
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 10
- 239000001632 sodium acetate Substances 0.000 claims description 10
- 235000017281 sodium acetate Nutrition 0.000 claims description 10
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 9
- 244000060011 Cocos nucifera Species 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims 3
- 230000000855 fungicidal effect Effects 0.000 claims 2
- 239000000417 fungicide Substances 0.000 claims 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- 239000006260 foam Substances 0.000 abstract description 9
- 206010059866 Drug resistance Diseases 0.000 abstract description 5
- 238000011010 flushing procedure Methods 0.000 abstract description 2
- 150000002500 ions Chemical class 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 18
- 230000001954 sterilising effect Effects 0.000 description 13
- 238000004659 sterilization and disinfection Methods 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000001590 oxidative effect Effects 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- PBLNBZIONSLZBU-UHFFFAOYSA-N 1-bromododecane Chemical compound CCCCCCCCCCCCBr PBLNBZIONSLZBU-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- UIKUBYKUYUSRSM-UHFFFAOYSA-N 3-morpholinopropylamine Chemical compound NCCCN1CCOCC1 UIKUBYKUYUSRSM-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- -1 alcohols (alcohols) Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-O morpholinium Chemical compound [H+].C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-O 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000008234 soft water Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/65—Mixtures of anionic with cationic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2079—Monocarboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
- C11D3/323—Amides; Substituted amides urea or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/58—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/62—Quaternary ammonium compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a washing efficient bactericide, a preparation method and application thereof, wherein the washing efficient bactericide adopts the combination of yin and yang ions, has the concentration lower than that of the bactericide commonly used in the market, has a broad-spectrum antibacterial effect, can improve the drug resistance problem faced by the products in the market at present, and has the characteristics of strong detergency, low foam and easiness in flushing. The invention also provides glycosyl amide morpholine cationic surfactant and a preparation method thereof, and indicates the application of the glycosyl amide morpholine cationic surfactant as a component in a washing bactericide.
Description
Technical Field
The invention belongs to the technical field of daily chemical product washing, and particularly relates to an anion-cation synergistic efficient bactericide, a preparation method and application thereof.
Background
The detergent industry not only plays an indispensable role in good life, but also is indispensable in major social disasters and sudden public health events.
The disinfectant and bactericide can be classified into an oxidizing bactericide and a non-oxidizing bactericide according to their mechanism of action. The main products of the oxidative bactericide are generally chlorine-containing and peroxide preparations, and the conventional products comprise sodium hypochlorite (84 disinfectant), chlorine dioxide, peracetic acid and the like, so that the oxidative bactericide has the advantages of strong bactericidal power, easily available raw materials and simplicity in use. However, firstly, the preparation can generate strong stimulation and oxidation corrosion to skin, respiratory tract mucous membrane and eyes of human body in the production and use process, and secondly, the preparation is generally used independently and is difficult to be used for preparing the washing products with sterilization function, and the preparation has the problems of short shelf life, expiration failure, how to treat and the like when being used as a commodity. The non-oxidizing bactericide includes non-oxidizing compounds such as alcohols (alcohols), organic aldehydes, quaternary ammonium salts, and biguanides. Alcohol is a flammable and volatile liquid at normal temperature, and its vapor can form an explosive mixture with air. Quaternary ammonium salts are becoming more and more important as a bactericide which is safe, efficient, colorless, odorless, nonflammable and nonvolatile. However, the conventional quaternary ammonium salt bactericide has drug resistance after long-term use and has single type of bacteria killing. Therefore, it is important to develop a novel high-efficiency bactericide which has long sterilization period, broad-spectrum antibiosis, low use concentration and capability of preventing bacteria from generating drug resistance.
Disclosure of Invention
The invention aims to provide a washing efficient bactericide which is capable of preventing drug resistance, long in sterilization period, broad-spectrum in antibacterial property and low in use concentration and a preparation method thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
the invention provides a washing bactericide which comprises the following components in parts by weight:
2-3 parts of glycosyl amide morpholine cationic surfactant, 0.5-1 part of sodium dodecyl benzene sulfonate, 2-3 parts of hydroxyethyl didecyl quaternary ammonium salt, 2-3 parts of dodecyl dimethyl benzyl ammonium chloride, 1-2 parts of ammonium poise Li Lv (polyquaternium-1), 2-3 parts of cocoanut biguanide acetate, 3-4 parts of sodium acetate and the balance of deionized water.
Preferably, the total amount of parts by weight is 100 parts.
The invention provides a glycosyl amide morpholine cationic surfactant, which has the structural formula:
wherein n is 8-12.
A process for the preparation of glycosyl amide morpholinium cationic surfactant (n=10):
into a 500mL three-necked round bottom flask equipped with a thermometer and bulb condenser was charged 21.7g (151 mmol) of N-aminopropylmorpholine, 26.7g (150 mmol) of gluconolactone, and 200mL of methanol. Reflux reaction, reaction for 5h, and standing and cooling. The solvent was distilled off by a rotary evaporator, and the obtained product was washed with diethyl ether 3 times to obtain 46.81g of an intermediate in 96.69% yield.
16.1g (0.05 mol) of intermediate, 12.7g (0.051 mol) of bromododecane and 150mL of acetone are introduced into an autoclave and reacted at 120℃for 48h. Cooled to room temperature, the solvent was distilled off by a rotary evaporator, and the obtained product was washed with diethyl ether 3 times to obtain 26.5g of the product in 92.01% yield.
When n is 8, 9, 11 and 12, the reactant is replaced by bromododecane to obtain the corresponding bromoalkane, and other conditions are unchanged, so that the corresponding glycosylamide morpholine cationic surfactant can be obtained.
The general cationic surfactant and the anionic surfactant can generate precipitate after being compounded, so that the respective effects are lost, and the glycosyl amide morpholine cationic surfactant breaks through the common knowledge in the prior art and has good compatibility with the anionic surfactant. The following table shows:
transmittance of different mole ratio compound system
n 1 Glycosyl amide morpholine cationic surfactant; n is n 2 Sodium dodecyl benzene sulfonate
Further, the structural formula of the hydroxyethyl didecyl quaternary ammonium salt is as follows:
the invention provides a preparation method of a washing bactericide, which is characterized by comprising the following steps:
1) Preparation of liquid a: uniformly mixing the glycosyl amide morpholine cationic surfactant with water, adding sodium dodecyl benzene sulfonate, and stirring to form uniform and transparent liquid A;
2) Preparation of liquid B: uniformly mixing hydroxyethyl didecyl quaternary ammonium salt with water, adding dodecyl dimethyl benzyl ammonium chloride, uniformly mixing, then adding poise Li Lv ammonium and cocoanut biguanide acetate, and stirring to form transparent liquid B;
3) Preparation of a detergent and bactericide: adding the liquid A into the liquid B, adding sodium acetate, and stirring uniformly to obtain the washing bactericide.
Further, the preparation method of the detergent and the bactericide comprises the following specific steps:
at 50-60 ℃, deionized water accounting for 50% of the total water content of the bactericide and glycosyl amide morpholine cationic surfactant are uniformly mixed, sodium dodecyl benzene sulfonate is added under stirring, and uniform and transparent liquid A is formed under stirring.
At 50-60 ℃, deionized water accounting for 50% of the total water content of the bactericide and hydroxyethyl didecyl quaternary ammonium salt are uniformly mixed, dodecyl dimethyl benzyl ammonium chloride is added under stirring to be uniformly mixed, then, the poise Li Lv ammonium (polyquaternium-1) and cocoanut biguanide acetate are added, and transparent liquid B is formed after uniform stirring. And then slowly adding the liquid A into the liquid B under the stirring condition to form uniform and transparent liquid, finally adding sodium acetate, stirring uniformly, and cooling to room temperature to obtain the anion-cation synergistic efficient washing bactericide.
The invention provides an application of a washing bactericide in washing and/or sterilization.
The invention provides an application of glycosyl amide morpholine cationic surfactant in washing and/or sterilization.
The beneficial effects are that:
compared with the prior art, the invention has the following advantages:
1. the invention adopts the synergistic effect of the combination of anions and cations, thereby improving the sterilization effect of the washing sterilizing agent.
2. The use concentration of the anion-cation synergistic efficient detergent bactericide is lower than that of the common bactericides in the market, so that the product is safer and more environment-friendly.
3. The anionic and cationic synergistic efficient detergent and bactericide has broad-spectrum antibacterial effect and good bactericidal rate on various common bacteria.
4. The anion-cation synergistic efficient detergent and bactericide has a long sterilization period, and can improve the drug resistance problem of products in the current market.
5. The anionic and cationic synergistic efficient detergent and bactericide has the advantages of high-efficiency sterilization effect, strong detergency, low foam and easy flushing.
Drawings
FIG. 1 is a foam performance chart;
fig. 2 is a 1HNMR diagram of a glycosyl amide morpholine cationic surfactant (n=10).
The specific embodiment is as follows:
the present invention is further illustrated below with reference to examples, which are provided only to illustrate the present invention and are not intended to limit the scope of the present invention.
Embodiment 1:
deionized water and glycosyl amide morpholine cationic surfactant (n=10) in an amount of 50% of the total water were mixed uniformly at 50 ℃, sodium dodecyl benzene sulfonate was added under stirring, and a uniform transparent liquid a was formed under stirring.
At 50 ℃, deionized water with 50% of total water and hydroxyethyl didecyl quaternary ammonium salt are uniformly mixed, dodecyl dimethyl benzyl ammonium chloride is added under stirring to uniformly mix, then, poise Li Lv ammonium (polyquaternary ammonium salt-1) and cocoanut biguanide acetate are added, and transparent liquid B is formed after uniform stirring. Then slowly adding the liquid A into the liquid B under the stirring condition to form uniform and transparent liquid, finally adding sodium acetate, uniformly stirring, cooling to room temperature, and discharging.
Embodiment 2:
deionized water and glycosyl amide morpholine cationic surfactant (n=10) in an amount of 50% of the total water were mixed uniformly at 60 ℃, sodium dodecyl benzene sulfonate was added under stirring, and a uniform transparent liquid a was formed under stirring.
At 60 ℃, deionized water with 50% of total water and hydroxyethyl didecyl quaternary ammonium salt are uniformly mixed, dodecyl dimethyl benzyl ammonium chloride is added under stirring to uniformly mix, then, poise Li Lv ammonium (polyquaternary ammonium salt-1) and cocoanut biguanide acetate are added, and transparent liquid B is formed after uniform stirring. Then slowly adding the liquid A into the liquid B under the stirring condition to form uniform and transparent liquid, finally adding sodium acetate, uniformly stirring, cooling to room temperature, and discharging.
Embodiment 3:
deionized water and glycosyl amide morpholine cationic surfactant (n=10) in an amount of 50% of the total water were mixed uniformly at 55 ℃, sodium dodecylbenzenesulfonate was added with stirring, and a uniform transparent liquid a was formed with stirring.
At 55 ℃, deionized water with 50% of total water and hydroxyethyl didecyl quaternary ammonium salt are uniformly mixed, dodecyl dimethyl benzyl ammonium chloride is added under stirring to uniformly mix, then, the poise Li Lv ammonium (polyquaternary ammonium salt-1) and cocoanut biguanide acetate are added, and transparent liquid B is formed after uniform stirring. Then slowly adding the liquid A into the liquid B under the stirring condition to form uniform and transparent liquid, finally adding sodium acetate, uniformly stirring, cooling to room temperature, and discharging.
The results of the sterilization rate test at a sample concentration of 20ppm prepared in the above example are shown in Table 1:
table 1 table of bactericidal properties
The sterilization result is obtained according to the evaluation method of the antibacterial and bacteriostatic effects of the daily chemical products of the national standard QB/T2738-2005 of the people's republic of China. Therefore, as can be seen from the experimental results of the above table, the samples obtained in the examples can achieve high-efficiency sterilization.
Wherein the addition of sodium acetate has the effect of counter ion, so that the product can kill bacteria at lower concentration, and the sterilization rates of staphylococcus aureus and escherichia coli are 88.3% and 79.5% respectively when the concentration of the product of the example 1 is 20ppm without sodium acetate.
If sodium dodecyl benzene sulfonate is not added in example 1, the sterilization rates for staphylococcus aureus and escherichia coli at the product concentration of example 1 of 20ppm are 93.4% and 92.1% respectively, with the other formulations being the same. It is shown that the addition of anionic surfactant also works synergistically and also improves the detergency of the product (Table 2). This is probably because the system of the combination of the anions and the cations can lead the product to form micelle under lower concentration, thereby being easier to gather around bacteria, leading the concentration of the bactericide around the bacteria to be locally increased and being more beneficial to killing the bacteria.
According to the national standard GB/T13174-2008, the three kinds of dirt cloth test pieces of carbon black, protein and sebum are respectively washed, and compared with standard powder, the decontamination ratio P is calculated. As can be seen from the table, the detergency is higher than that of the conventional bactericide dodecyldimethylbenzyl ammonium chloride, although the washing effect is good without the standard powder. Has better decontamination effect.
Table 2 detergency ratio table
The foam performance of the above products in soft water was tested using the modified Ross-Miles method, with the foam height at 0.5min being the foaming force and the ratio of the foam height at 5min to the foam height at 30s being the foam stability (FIG. 1). As can be seen from fig. 1, the foaming capacity and foam stabilizing capacity of the three examples products were much lower than those of the commercially available detergents (sodium dodecylbenzenesulfonate, LAS), which are almost bubble-free products. Easy rinsing in the washing process.
Claims (6)
1. The detergent bactericide is characterized by comprising the following components in 100 parts by weight:
2-3 parts of glycosyl amide morpholine cationic surfactant, 0.5-1 part of sodium dodecyl benzene sulfonate, 2-3 parts of hydroxyethyl didecyl quaternary ammonium salt, 2-3 parts of dodecyl dimethyl benzyl ammonium chloride, 1-2 parts of ammonium poise chloride, 2-3 parts of coco biguanide acetate, 3-4 parts of sodium acetate and the balance of water;
the structural formula of the glycosyl amide morpholine cationic surfactant is as follows:
wherein n is 10;
the structural formula of the hydroxyethyl didecyl quaternary ammonium salt is as follows:
。
2. the detergent disinfectant as set forth in claim 1, which is composed of the following 100 parts by weight:
3 parts of glycosyl amide morpholine cationic surfactant
Sodium dodecyl benzene sulfonate 1 part
Hydroxyethyl didecyl quaternary ammonium salt 3 parts
Dodecyl dimethyl benzyl ammonium chloride 2 parts
Po Li Lv ammonium 1 part
2 parts of coco biguanide acetate
Sodium acetate 3 parts
And the balance of deionized water.
3. The detergent disinfectant as set forth in claim 1, which is composed of the following 100 parts by weight:
2 parts of glycosyl amide morpholine cationic surfactant
Sodium dodecyl benzene sulfonate 0.9 part
Hydroxyethyl didecyl quaternary ammonium salt 2 parts
Dodecyl dimethyl benzyl ammonium chloride 2.1 parts
2 parts of poise Li Lv ammonium
3 parts of cocoanut biguanide acetate
Sodium acetate 4 parts
And the balance of deionized water.
4. The detergent disinfectant as set forth in claim 1, which is composed of the following 100 parts by weight:
2.5 parts of glycosyl amide morpholine cationic surfactant
Sodium dodecyl benzene sulfonate 0.5 part
2.5 parts of hydroxyethyl didecyl quaternary ammonium salt
Dodecyl dimethyl benzyl ammonium chloride 3 parts
Po Li Lv ammonium 1.5 parts
2.5 parts of cocoanut biguanide acetate
Sodium acetate 3.5 parts
And the balance of deionized water.
5. The method for preparing the detergent and bactericidal agent as set forth in claim 1, comprising the steps of:
1) Preparation of liquid a: uniformly mixing the glycosyl amide morpholine cationic surfactant with water, adding sodium dodecyl benzene sulfonate, and stirring to form uniform and transparent liquid A;
2) Preparation of liquid B: uniformly mixing hydroxyethyl didecyl quaternary ammonium salt with water, adding dodecyl dimethyl benzyl ammonium chloride, uniformly mixing, then adding poise Li Lv ammonium and cocoanut biguanide acetate, and stirring to form transparent liquid B;
3) Preparation of a detergent and bactericide: adding the liquid A into the liquid B, adding sodium acetate, and stirring uniformly to obtain the washing bactericide.
6. Use of a detergent fungicide according to claim 1 in the preparation of a detergent and/or fungicide.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103013687A (en) * | 2012-12-24 | 2013-04-03 | 中国船舶重工集团公司第七一八研究所 | Foam cleaning disinfectant and preparation method thereof |
| CN103555450A (en) * | 2013-11-05 | 2014-02-05 | 中国日用化学工业研究院 | Antibacterial decontaminating liquid detergent and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103013687A (en) * | 2012-12-24 | 2013-04-03 | 中国船舶重工集团公司第七一八研究所 | Foam cleaning disinfectant and preparation method thereof |
| CN103555450A (en) * | 2013-11-05 | 2014-02-05 | 中国日用化学工业研究院 | Antibacterial decontaminating liquid detergent and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 新型糖基酰胺类表面活性剂的合成与性能研究;智丽飞;《中国博士学位论文全文数据库 工程科技Ⅰ辑》;20160115(第1期);第B016-78页 * |
| 新型糖基酰胺阳离子表面活性剂的动态表面张力研究;智丽飞等;《中国化学会第十六届胶体与界面化学会议论文摘要集》;20170731;第33-34页 * |
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