CN111388341A - Washing-free hand protection disinfectant and preparation method thereof - Google Patents
Washing-free hand protection disinfectant and preparation method thereof Download PDFInfo
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- CN111388341A CN111388341A CN202010231259.2A CN202010231259A CN111388341A CN 111388341 A CN111388341 A CN 111388341A CN 202010231259 A CN202010231259 A CN 202010231259A CN 111388341 A CN111388341 A CN 111388341A
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- disinfectant
- ethanol
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- benzalkonium chloride
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 52
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 23
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 23
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 23
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 23
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 23
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 23
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 23
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 21
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960001631 carbomer Drugs 0.000 claims abstract description 21
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical group [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 33
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 22
- 235000011187 glycerol Nutrition 0.000 claims description 18
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 18
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 5
- 229960004756 ethanol Drugs 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 230000000857 drug effect Effects 0.000 abstract description 4
- 230000002045 lasting effect Effects 0.000 abstract description 4
- 231100000252 nontoxic Toxicity 0.000 abstract description 4
- 230000003000 nontoxic effect Effects 0.000 abstract description 4
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 17
- 239000008367 deionised water Substances 0.000 description 10
- 229910021641 deionized water Inorganic materials 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 235000005979 Citrus limon Nutrition 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 244000248349 Citrus limon Species 0.000 description 6
- 230000003385 bacteriostatic effect Effects 0.000 description 5
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 4
- 229960003260 chlorhexidine Drugs 0.000 description 4
- 239000003599 detergent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 229940035535 iodophors Drugs 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- -1 easy to sublimate Substances 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a no-clean hand protection disinfectant and a preparation method thereof, wherein the disinfectant comprises the following components: the composition comprises, by weight, 30-75% of ethanol, 0.01-0.5% of benzalkonium chloride, 0.2-0.7% of carbomer, 0.3-3% of glycerol, 0.001-0.005% of hydroxypropyl cellulose, 0.001-0.005% of hydroxyethyl cellulose and 0.1-0.8% of aminomethyl propanol. The disinfectant has quick and lasting drug effect, is nontoxic and residue-free, and is an ecological green preparation; the skin care product integrates disinfection and skin care, is fresh and cool, is not sticky, is convenient to use, has aromatic smell and comfortable hand feeling; the bacteriostasis rate reaches more than 90 percent.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a no-clean hand-protecting disinfectant and a preparation method thereof.
Background
The current disinfectants for hand skin disinfection comprise iodophor, 75% alcohol, chlorhexidine (chlorhexidine), chlorine-containing disinfectant and other compound disinfectant, and the main components of the disinfectants are iodine, alcohol, quaternary ammonium salt, surfactant and the like. Although the hand disinfectants on the market are various, the hand disinfectants have the advantages and the disadvantages: iodophors are complexes of iodine and surfactants, and overcome the defects that iodine is difficult to dissolve in water, easy to sublimate, irritant, not stable enough, easy to color and the like, but although iodophors have good disinfection effect, iodophors are greatly influenced by organic matters, and have unpleasant sticky feeling due to long drying time after disinfection. 75% ethanol is quick in disinfection, but is volatile, so that the disinfection is very irritant to skin, and if the ethanol is frequently used for hand washing disinfection, the skin is dry and rough due to degreasing. Chlorhexidine is a biguanide compound, and is not suitable for use with detergents such as soap because it is a cationic disinfectant and has antagonistic action with anionic detergents. Most of the main components of disinfection products in the market are chlorhexidine, quaternary ammonium salt and the like, and the disinfection products have the common disinfection effect, the skin moistening and moisturizing effects, but the price is high.
Accordingly, the prior art is deficient and needs improvement.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a no-clean hand-protection disinfectant and a preparation method thereof, wherein the disinfectant has quick and lasting drug effect, is nontoxic and has no residue, and is an ecological green preparation; disinfection and skin care are integrated, and the skin is fresh and cool without stickiness; the use is convenient, the smell is fragrant, and the hand feeling is comfortable; the antibacterial rate reaches more than 90%, and the disinfection and sterilization effect is good.
The technical scheme of the invention is as follows: provides a no-clean hand protection disinfectant, which comprises the following components: the composition comprises, by weight, 30-75% of ethanol, 0.01-0.5% of benzalkonium chloride, 0.2-0.7% of carbomer, 0.3-3% of glycerol, 0.001-0.005% of hydroxypropyl cellulose, 0.001-0.005% of hydroxyethyl cellulose and 0.1-0.8% of aminomethyl propanol.
Further, by weight percentage, the content of ethanol is 50-75%, the content of benzalkonium chloride is 0.03-0.5%, the content of carbomer is 0.2-0.7%, the content of glycerol is 0.5-2%, the content of hydroxypropyl cellulose is 0.002-0.005%, the content of hydroxyethyl cellulose is 0.002-0.005%, and the content of aminomethyl propanol is 0.2-0.8%.
Further, by weight percentage, the content of ethanol is 60-75%, the content of benzalkonium chloride is 0.05-0.5%, the content of carbomer is 0.3-0.7%, the content of glycerol is 0.5-1.5%, the content of hydroxypropyl cellulose is 0.002-0.005%, the content of hydroxyethyl cellulose is 0.002-0.005%, and the content of aminomethyl propanol is 0.3-0.8%.
Further, by weight percentage, the content of ethanol is 70%, the content of benzalkonium chloride is 0.1%, the content of carbomer is 0.5%, the content of glycerol is 1%, the content of hydroxypropyl cellulose is 0.003%, the content of hydroxyethyl cellulose is 0.003%, and the content of aminomethyl propanol is 0.3%.
Furthermore, the disinfectant also comprises ionized water, essence and an acid-base regulator, wherein the balance is the content of the ionized water, the essence and the acid-base regulator.
Further, the pH regulator is potassium hydroxide or hydrochloric acid.
Further, the pH value of the disinfectant is 6.2-8.5.
Further, the pH value of the disinfectant is 7.0.
The invention also provides a method for preparing the washing-free hand-protection disinfectant, which adopts a normal-temperature mixing method to prepare the disinfectant.
Further, ethanol, benzalkonium chloride, carbomer, hydroxypropyl cellulose, hydroxyethyl cellulose, and aminomethyl propanol may be added in any order.
Compared with the prior art, the invention has the beneficial effects that:
1. the disinfectant contains alcohol and benzalkonium chloride simultaneously, so that the bacteriostatic and bactericidal effects are enhanced, and the bacteriostatic efficiency reaches over 90 percent;
2. film forming agents such as hydroxypropyl cellulose, hydroxyethyl cellulose and the like are added in the disinfectant, so that the sterilization effect is prolonged, the moisturizing effect of glycerin can be promoted, and the disinfectant has a good hand protection effect;
3. the disinfectant has quick and lasting drug effect, is nontoxic and residue-free, and is an ecological green preparation;
4. the skin care product integrates disinfection and skin care, is fresh, cool and not sticky, is convenient to use, has aromatic smell and comfortable hand feeling.
Detailed Description
In order to more clearly understand the technical features, objects, and effects of the present invention, specific embodiments of the present invention will now be described in detail. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a no-clean hand protection disinfectant, which comprises the following components: the composition comprises 30-75% by weight of ethanol, benzalkonium chloride, carbomer, hydroxypropyl cellulose, hydroxyethyl cellulose, aminomethyl propanol, deionized water, essence and an acid-base regulator, preferably 50-75% by weight of ethanol, and further preferably 60-75% by weight of ethanol; the content of benzalkonium chloride is 0.01% -0.5%, preferably 0.03% -0.5%, and more preferably 0.05% -0.5%; the content of carbomer is 0.2-0.7%, preferably 0.3-0.7%; the content of glycerin is 0.3-3%, preferably 0.5-2%, and more preferably 0.5-1.5%; the content of hydroxypropyl cellulose is 0.001-0.005%, preferably 0.002-0.005%; the content of hydroxyethyl cellulose is 0.001-0.005%, preferably 0.002-0.005%; the content of aminomethyl propanol is 0.1-0.8%, preferably 0.2-0.8%, and more preferably 0.3-0.8%; the balance of deionized water, essence and an acid-base regulator, wherein the acid-base regulator is potassium hydroxide or hydrochloric acid. The pH value of the disinfectant is 6.2-8.5, and the preferable pH value is 7.0.
The invention also provides a method for preparing the no-clean hand-protection disinfectant, which comprises the steps of adding ethanol, benzalkonium chloride, carbomer, hydroxypropyl cellulose, hydroxyethyl cellulose and aminomethyl propanol into a container in any sequence at normal temperature, adding deionized water essence, uniformly mixing, and finally adjusting the pH value to 7.0 by using potassium hydroxide or hydrochloric acid.
The following specific examples are further illustrated:
example 1, preparation of a no-clean hand sanitizer comprises the following components in percentage by weight:
30 percent of ethanol
Benzalkonium chloride 0.02%
0.2 percent of carbomer
0.4 percent of glycerin
Hydroxypropyl cellulose 0.001%
0.001 percent of hydroxyethyl cellulose
Aminomethyl propanol 0.1%
0.005 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 2, preparation of a no-clean hand sanitizer comprises the following components in percentage by weight:
50 percent of ethanol
0.05 percent of benzalkonium chloride
0.2 percent of carbomer
0.5 percent of glycerin
Hydroxypropyl cellulose 0.002%
Hydroxyethyl cellulose 0.002%
Aminomethyl propanol 0.2%
0.005 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 3 preparation of a no-clean hand sanitizer, the following components were taken in weight percent:
60 percent of ethanol
0.1 percent of benzalkonium chloride
Carbomer 0.4%
1% of glycerol
Hydroxypropyl cellulose 0.003%
Hydroxyethyl cellulose 0.003%
Aminomethyl propanol 0.4%
Lemon essence 0.006%
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 4 preparation of a no-clean hand sanitizer, the following components were taken in weight percent:
70 percent of ethanol
0.15 percent of benzalkonium chloride
Carbomer 0.6%
1.5 percent of glycerin
Hydroxypropyl cellulose 0.004%
Hydroxyethyl cellulose 0.004%
Aminomethyl propanol 0.6%
0.008 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 5 preparation of a no-clean hand sanitizer, the following components were taken in weight percent:
65 percent of ethanol
0.2 percent of benzalkonium chloride
Carbomer 0.6%
1.5 percent of glycerin
Hydroxypropyl cellulose 0.005%
0.005 percent of hydroxyethyl cellulose
Aminomethyl propanol 0.6%
0.008 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 6 preparation of a no-clean hand sanitizer, the following components were taken in weight percent:
70 percent of ethanol
0.2 percent of benzalkonium chloride
Carbomer 0.5%
1.5 percent of glycerin
Hydroxypropyl cellulose 0.005%
0.005 percent of hydroxyethyl cellulose
Aminomethyl propanol 0.6%
0.008 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Example 7 preparation of a no-clean hand sanitizer, the following components were taken in weight percent:
72 percent of ethanol
0.13 percent of benzalkonium chloride
Carbomer 0.6%
1.5 percent of glycerin
Hydroxypropyl cellulose 0.006%
Hydroxyethyl cellulose 0.006%
Aminomethyl propanol 0.6%
0.008 percent of lemon essence
The balance of deionized water, and adding potassium hydroxide or hydrochloric acid to adjust the pH value to 7 after mixing.
Experiment for inhibiting bacteria
The antibacterial experiment is carried out according to a suspension quantitative method provided by QB/T2738-:
TABLE 1
| Formula of washing-free hand protection disinfectant | Escherichia coli inhibitory rate (%) | Staphylococcus aureus inhibitory rate (%) |
| Example 1 | 90 | 91 |
| Example 2 | 93 | 94 |
| Example 3 | 95 | 94 |
| Example 4 | 99 | 99 |
| Example 5 | 99 | 99 |
| Example 6 | 99 | 99 |
| Example 7 | 99 | 99 |
As can be seen from Table 1, the hand protection disinfectant has good antibacterial effect, and meets the standards of light industry standard GB/T2850-2007 antibacterial and bacteriostatic detergent that the antibacterial property reaches more than 90%.
Hand protection effect experiment
The experimental test subjects had 20 persons, 10 men and 10 women, and had good hand skin feeling, moisturized skin, reduced hand dryness, and restored and maintained skin elasticity after using the hand protection disinfectant of the present invention in example 4 for 1 week. 16 of the 20 test persons had a greater preference for using the hand sanitizer of the present invention.
In conclusion, the beneficial effects of the invention are as follows:
1. the disinfectant contains alcohol and benzalkonium chloride simultaneously, so that the bacteriostatic and bactericidal effects are enhanced, and the bacteriostatic efficiency reaches over 90 percent;
2. film forming agents such as hydroxypropyl cellulose, hydroxyethyl cellulose and the like are added in the disinfectant, so that the sterilization effect is prolonged, the moisturizing effect of glycerin can be promoted, and the disinfectant has a good hand protection effect;
3. the disinfectant has quick and lasting drug effect, is nontoxic and residue-free, and is an ecological green preparation;
4. the skin care product integrates disinfection and skin care, is fresh, cool and not sticky, is convenient to use, has aromatic smell and comfortable hand feeling.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A no-clean hand protection disinfectant is characterized by comprising the following components: the composition comprises, by weight, 30-75% of ethanol, 0.01-0.5% of benzalkonium chloride, 0.2-0.7% of carbomer, 0.3-3% of glycerol, 0.001-0.005% of hydroxypropyl cellulose, 0.001-0.005% of hydroxyethyl cellulose and 0.1-0.8% of aminomethyl propanol.
2. The no-clean hand and disinfectant solution as claimed in claim 1, wherein the content of ethanol is 50-75%, the content of benzalkonium chloride is 0.03-0.5%, the content of carbomer is 0.2-0.7%, the content of glycerol is 0.5-2%, the content of hydroxypropyl cellulose is 0.002-0.005%, the content of hydroxyethyl cellulose is 0.002-0.005%, and the content of aminomethyl propanol is 0.2-0.8%.
3. The no-clean hand and disinfectant solution as claimed in claim 1, wherein the content of ethanol is 60-75%, the content of benzalkonium chloride is 0.05-0.5%, the content of carbomer is 0.3-0.7%, the content of glycerol is 0.5-1.5%, the content of hydroxypropyl cellulose is 0.002-0.005%, the content of hydroxyethyl cellulose is 0.002-0.005%, and the content of aminomethyl propanol is 0.3-0.8%.
4. The no-clean hand and disinfectant solution according to claim 3, wherein the ethanol content is 70%, benzalkonium chloride content is 0.1%, carbomer content is 0.5%, glycerin content is 1%, hydroxypropyl cellulose content is 0.003%, hydroxyethyl cellulose content is 0.003%, and aminomethyl propanol content is 0.3%.
5. The no-clean hand and disinfection solution of claim 1, further comprising ionized water, essence, and acid-base modifier, wherein the balance of the ionized water, essence, and acid-base modifier.
6. The no-clean hand and disinfectant solution as recited in claim 5, wherein said pH modifier is potassium hydroxide or hydrochloric acid.
7. The no-clean hand and disinfectant solution as claimed in any one of claims 1 to 6, wherein the pH value of the disinfectant solution is 6.2-8.5.
8. The no-clean hand and disinfectant solution as claimed in claim 7, wherein the pH of the disinfectant solution is 7.0.
9. A method for preparing the no-clean hand sanitizer of any one of claims 1 to 8, wherein the sanitizer is prepared by mixing at room temperature.
10. The method according to claim 9, wherein the ethanol, benzalkonium chloride, carbomer, hydroxypropyl cellulose, hydroxyethyl cellulose and aminomethyl propanol are added in any order.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010231259.2A CN111388341A (en) | 2020-03-27 | 2020-03-27 | Washing-free hand protection disinfectant and preparation method thereof |
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| CN202010231259.2A CN111388341A (en) | 2020-03-27 | 2020-03-27 | Washing-free hand protection disinfectant and preparation method thereof |
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| CN202010231259.2A Pending CN111388341A (en) | 2020-03-27 | 2020-03-27 | Washing-free hand protection disinfectant and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023121603A1 (en) * | 2021-12-24 | 2023-06-29 | Eczacibasi Tuketim Urunleri Sanayi Ve Ticaret Anonim Sirketi | Product enabling disinfection and protection of the skin |
Citations (10)
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