CN114159348B - Skin care matrix and moisturizing skin care product suitable for edible bird's nest acid - Google Patents
Skin care matrix and moisturizing skin care product suitable for edible bird's nest acid Download PDFInfo
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- CN114159348B CN114159348B CN202111452981.XA CN202111452981A CN114159348B CN 114159348 B CN114159348 B CN 114159348B CN 202111452981 A CN202111452981 A CN 202111452981A CN 114159348 B CN114159348 B CN 114159348B
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 54
- 239000002253 acid Substances 0.000 title claims abstract description 51
- 244000000626 Daucus carota Species 0.000 title claims abstract description 25
- 235000005770 birds nest Nutrition 0.000 title claims abstract description 25
- 235000005765 wild carrot Nutrition 0.000 title claims abstract description 25
- 239000011159 matrix material Substances 0.000 title abstract description 31
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940032094 squalane Drugs 0.000 claims abstract description 17
- 239000004359 castor oil Substances 0.000 claims abstract description 14
- 235000019438 castor oil Nutrition 0.000 claims abstract description 14
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 14
- 229920002545 silicone oil Polymers 0.000 claims abstract description 14
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- MRIXVKKOHPQOFK-UHFFFAOYSA-N 4-methoxysalicylic acid Chemical compound COC1=CC=C(C(O)=O)C(O)=C1 MRIXVKKOHPQOFK-UHFFFAOYSA-N 0.000 claims description 16
- 239000004475 Arginine Substances 0.000 claims description 13
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 13
- 229920001577 copolymer Polymers 0.000 claims description 12
- 229940078492 ppg-17 Drugs 0.000 claims description 12
- 239000000230 xanthan gum Substances 0.000 claims description 12
- 229920001285 xanthan gum Polymers 0.000 claims description 12
- 229940082509 xanthan gum Drugs 0.000 claims description 12
- 235000010493 xanthan gum Nutrition 0.000 claims description 12
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 10
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 9
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- IZZIWIAOVZOBLF-UHFFFAOYSA-N 5-methyloxysalicylic acid Natural products COC1=CC=C(O)C(C(O)=O)=C1 IZZIWIAOVZOBLF-UHFFFAOYSA-N 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 229960005323 phenoxyethanol Drugs 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- 229960002446 octanoic acid Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 abstract description 11
- 239000003995 emulsifying agent Substances 0.000 abstract description 4
- 239000003906 humectant Substances 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 239000002562 thickening agent Substances 0.000 abstract description 4
- 229940087068 glyceryl caprylate Drugs 0.000 abstract description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 18
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 6
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 5
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- 238000002360 preparation method Methods 0.000 description 5
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- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 3
- 235000019799 monosodium phosphate Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 3
- CERZMXAJYMMUDR-QBTAGHCHSA-N 5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid Chemical class N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-QBTAGHCHSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
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- 210000000245 forearm Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- -1 antiseptic Substances 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000005859 cell recognition Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000013400 design of experiment Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000030363 nerve development Effects 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000001301 oxygen Chemical group 0.000 description 1
- 229910052760 oxygen Chemical group 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a skin care matrix and a moisturizing skin care product suitable for bird's nest acid, wherein the skin care matrix comprises water-soluble silicone oil, squalane, caprylic/capric glyceride, hydrogenated castor oil, a humectant, an emulsifier, a thickener and water; wherein the sum of the mass ratio of the water-soluble silicone oil, squalane, glyceryl caprylate and hydrogenated castor oil in the skin care matrix is 3.5-4.2%, and the mass ratio of water in the skin care matrix is 88-92%. According to the invention, the skin care matrix with specific composition is compounded with the nidus Collocaliae acid, so that a synergistic moisturizing effect can be generated, and the level equivalent to that of the nidus Collocaliae acid skin care product added with higher concentration can be still reached under the conditions that the concentration of the nidus Collocaliae acid is low (0.1-1%) and the integral concentration of the matrix is lower.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a skin care matrix and a moisturizing skin care product suitable for bird's nest acid.
Background
The Sialic Acid (SA), also known as Sialic acid, N-acetylneuraminic acid, is a group of nitrogen or oxygen substituted derivatives of neuraminic acid, which are all negatively charged nine-carbon-sugar neuraminic acid. The bird's nest acid is widely existing in mammal tissues, is an important component of glycoprotein, oligosaccharide and glycolipid, and participates in cell recognition, survival, reproduction and other functions. Researches show that the nidus Collocaliae acid has the functions of promoting nerve development, resisting virus and inflammation, whitening and moisturizing, etc.
In view of the multiple effects of the bird's nest acid, the skin care products added with the bird's nest acid are more and more on the market at present, but the higher the adding amount of the bird's nest acid is, the better the effect is based on the existing cognition of people. For example, CN111743810a discloses a moisturizing skin care product containing N-acetylneuraminic acid, wherein the addition amount of N-acetylneuraminic acid is 5% or more, in order to provide good moisturizing effect to the product. In addition, in the previous studies by the inventors, the higher the concentration of the nidus Collocaliae acid, the better the moisture retention. As in CN104083291A, the content of the cubilose acid monomer in mass percent is 0.5-2.0%, and the moisture retention rate of the cubilose acid monomer is positively related to the content of the cubilose acid monomer in moisture retention rate measurement of short time of 4 hours and long time of 24 hours and 48 hours.
Disclosure of Invention
The invention provides a skin care matrix and a moisturizing skin care product suitable for nidus Collocaliae acid, and the skin care matrix can achieve the moisturizing effect equivalent to that of the skin care product with higher nidus Collocaliae acid addition under the conditions of lower nidus Collocaliae acid concentration and lower matrix overall concentration.
The invention adopts the following technical scheme:
the invention provides a skin care matrix suitable for bird's nest acid, which comprises water-soluble silicone oil, squalane, caprylic/capric glyceride, hydrogenated castor oil, a humectant, an emulsifier, a thickener and water;
wherein the sum of the mass ratio of the water-soluble silicone oil, squalane, glyceryl caprylate and hydrogenated castor oil in the skin care matrix is 3.5-4.2%, and the mass ratio of water in the skin care matrix is 88-92%.
Based on previous researches of the inventor and related contents disclosed in the prior art, the inventor considers that the higher the adding amount of the bird's nest acid in the moisturizing skin care product is, the better the adding amount is, and after a certain effect is achieved, the economic benefit is considered comprehensively, the content of the bird's nest acid is not increased uniformly, and the good moisturizing effect and low cost are achieved. However, the inventor obtains the specific skin care matrix in the research and development process, and the specific skin care matrix is matched with the nidus Collocaliae acid, so that the synergistic effect can be achieved, the use amount of the nidus Collocaliae acid is reduced, and the level equivalent to the moisturizing effect of the skin care product added with the nidus Collocaliae acid with higher concentration can be still achieved under the conditions that the concentration of the nidus Collocaliae acid is lower and the overall concentration of the matrix is lower. The inventor speculates that the compatibility of the oil phase components of water-soluble silicone oil, squalane, caprylic/capric glyceride and hydrogenated castor oil with higher content in the skin care matrix is key to realizing better moisturizing effect by using less moisturizing component.
Further, the skin care matrix comprises the following components in weight percent: 1.5 to 1.8 percent of water-soluble silicone oil, 0.8 to 1 percent of squalane, 0.8 to 1 percent of caprylic/capric glyceride, 0.2 to 0.4 percent of hydrogenated castor oil, 2 to 3 percent of humectant, 0.5 to 0.8 percent of emulsifying agent, 0.4 to 0.7 percent of thickening agent and 88 to 92 percent of water.
Further, in the above technical scheme, the humectant is glycerin or ethylhexyl glycerin; the emulsifier is PEG/PPG-17/6 copolymer; the thickener is xanthan gum.
Further, the skin care matrix also comprises one or more of skin feel regulator, antiallergic agent, antiseptic, chelating agent, essence, pigment and other auxiliary agents, and the total addition amount of the skin care matrix is not more than 1%; wherein the skin feel modulator is arginine.
Based on the skin care matrix suitable for the nidus Collocaliae acid, the invention also provides a moisturizing skin care product which consists of the nidus Collocaliae acid and the skin care matrix.
Further, the mass fraction of the cubilose acid in the moisturizing skin care product is 0.1-1%. Due to the synergistic effect of the skin care matrix and the bird's nest acid, the added amount of the bird's nest acid is in the range of 0.1-1%, and the moisturizing effect equivalent to that of skin care products with higher added amount of the bird's nest acid in the prior art can be realized.
In a preferred embodiment of the present invention, the moisturizing skin care product is composed of the following components in weight percent: 0.1 to 1 percent of bird's nest acid, 1.5 to 1.6 percent of water-soluble silicone oil, 0.8 to 1 percent of synthesized squalane, 0.6 to 0.7 percent of PEG/PPG-17/6 copolymer, 0.8 to 0.9 percent of caprylic/capric glyceride, 1 to 1.2 percent of glycerin, 1 to 1.2 percent of ethylhexyl glycerin, 0.2 to 0.3 percent of 4-methoxy salicylic acid, 0.1 to 0.3 percent of xanthan gum, 0.1 to 1 percent of arginine, 0.2 to 0.3 percent of hydrogenated castor oil, 0.01 to 0.1 percent of EDTA-disodium, 0.1 to 0.5 percent of phenoxyethanol, 0.01 to 0.06 percent of cellulose powder and the balance of water.
Further preferably, the invention can achieve better moisturizing effect at smaller application concentration of the bird's nest acid, wherein the content of the bird's nest acid can be as low as 0.1-0.2%.
In a specific application embodiment, the oil phase and the moisturizing ingredient in the moisturizing skin care product may be: 0.1% of bird's nest acid, 1.6% of water-soluble silicone oil, 1% of synthesized squalane, 0.6% of PEG/PPG-17/6 copolymer, 0.9% of caprylic/capric glyceride, 1.1% of glycerin, 1.2% of ethylhexyl glycerin, 0.3% of 4-methoxysalicylic acid, 0.2% of xanthan gum, 0.5% of arginine and 0.3% of hydrogenated castor oil.
The invention also provides a preparation method of the moisturizing skin care product, which comprises the following steps: uniformly mixing the components except the nidus Collocaliae acid and the arginine at 75-80 ℃, cooling to 40-45 ℃, adding the nidus Collocaliae acid and the arginine, and uniformly mixing again.
The invention also provides application of the moisturizing skin care product in human skin care, and in particular, the moisturizing skin care product can be directly used, coated on a part required by a human body or further processed into other forms of skin care products for use. Preferably, the moisturizing skin care product of the present invention is suitable for application as a product in the form of an emulsion, essence, or the like. When the product is directly coated, the dosage of the moisturizing skin care product is 2.0+/-0.1 mg/cm 2 。
The invention provides a skin care matrix and a moisturizing skin care product suitable for bird's nest acid, which can generate a synergistic moisturizing effect by compounding the skin care matrix with the bird's nest acid, so that the moisturizing effect equivalent to that of the skin care product with higher bird's nest acid addition in the prior art is still obtained under the conditions that the concentration of the bird's nest acid is lower (0.1-1%) and the integral concentration of the matrix is lower.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The raw materials and auxiliary materials used in the following examples were commercially available unless otherwise specified.
Example 1
The present embodiment provides a skin care matrix suitable for use with cubilose acid, comprising the following components:
arginine 0.5g, water-soluble silicone oil 1.6g, synthesized squalane 1g, PEG/PPG-17/6 copolymer 0.6g, caprylic/capric glyceride 0.9g, glycerin 1.1g, ethylhexyl glycerin 1.2g, 4-methoxy salicylic acid 0.3g, xanthan gum 0.2g, hydrogenated castor oil 0.3g, EDTA-disodium 0.05g, phenoxyethanol 0.5g, cellulose powder 0.04g, and the balance of water to 100g.
Example 2
The embodiment provides a moisturizing skin care product, which comprises the following components:
0.1g of bird's nest acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthesized squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerin, 1.2g of ethylhexyl glycerin, 0.3g of 4-methoxy salicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder and the balance of water to 100g.
The embodiment also provides a preparation method of the moisturizing skin care product, which comprises the following steps:
heating weighed water-soluble silicone oil, synthesized squalane, PEG/PPG-17/6 copolymer, caprylic/capric glyceride, glycerin, ethylhexyl glycerin, 4-methoxysalicylic acid, xanthan gum, hydrogenated castor oil, EDTA-disodium, phenoxyethanol, cellulose powder and water in a constant-temperature water bath at 78 ℃, stirring and mixing uniformly after high-speed shearing, then cooling to 40 ℃, adding nidus Collocaliae acid and arginine, stirring and mixing uniformly again, and discharging.
Example 3
The embodiment provides a moisturizing skin care product, which comprises the following components:
0.5g of bird's nest acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthesized squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerin, 1.2g of ethylhexyl glycerin, 0.3g of 4-methoxy salicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder and the balance of water to 100g. The preparation method is the same as in example 2.
Example 4
The embodiment provides a moisturizing skin care product, which comprises the following components:
1.0g of cubilose acid, 0.5g of arginine, 1.6g of water-soluble silicone oil, 1g of synthesized squalane, 0.6g of PEG/PPG-17/6 copolymer, 0.9g of caprylic/capric glyceride, 1.1g of glycerin, 1.2g of ethylhexyl glycerin, 0.3g of 4-methoxy salicylic acid, 0.2g of xanthan gum, 0.3g of hydrogenated castor oil, 0.05g of EDTA-disodium, 0.5g of phenoxyethanol, 0.04g of cellulose powder and the balance of water to 100g. The preparation method is the same as in example 2.
Comparative example 1
The comparative example provides a moisturizing skin care product which comprises the following specific components:
5g of N-acetylneuraminic acid, 6.6g of 1, 3-butanediol, 0.4g of p-hydroxyacetophenone, 0.6g of PEG/PPG-17/6 copolymer, 0.15g of synthesized squalane, 0.15g of allantoin, 0.04g of EDTA-disodium, 0.3g of xanthan gum, disodium hydrogen phosphate and sodium dihydrogen phosphate, pH adjustment to 6.8 and 85g of deionized water.
Heating the weighed 1, 3-butanediol, synthesized squalane, allantoin, PEG/PPG-17/6 copolymer, EDTA-disodium and deionized water in a constant-temperature water bath at 75 ℃, stirring and mixing for 1h by using a high-speed dispersing homogenizer, emulsifying uniformly, adding p-hydroxyacetophenone and xanthan gum, continuously stirring for 30min by using the high-speed dispersing homogenizer at 75 ℃, and standing for 12h after stirring. And then placing the mixed solution in a constant-temperature water bath at 40 ℃, adding the weighed N-acetylneuraminic acid, stirring for 30min, adding disodium hydrogen phosphate and sodium dihydrogen phosphate to adjust the pH to 6.8 after stirring is completed, and discharging.
Comparative example 2
The comparative example provides a moisturizing skin care product which comprises the following specific components:
2g of cubilose acid, 6.6g of 1, 3-butanediol, 0.4g of p-hydroxyacetophenone, 0.6g of PEG/PPG-17/6 copolymer, 0.15g of synthesized squalane, 0.15g of allantoin, 0.04g of EDTA-disodium, 0.3g of xanthan gum, and disodium hydrogen phosphate and sodium dihydrogen phosphate, wherein the balance of deionized water is added to 100g. The preparation method is the same as that of comparative example 1.
Experimental example 1 in vitro experiments
The skin care matrix/moisturizing skin care product provided in each example and comparative example was tested for in vitro moisturizing effect.
And (3) placing a sample containing a certain amount of moisture in a dryer for drying by a weighing method, weighing the mass of the sample after a certain period of time, and analyzing the moisturizing effect of the moisturizing skin care product by reducing the moisture.
1. And respectively taking 0.5g of each sample to be measured, putting the samples into a glass dish, wherein the specification of the glass dish is that the upper cover diameter is 95mm, the lower bottom diameter is 90m, the dish height is 15m, putting the glass dish in a drying oven with the relative humidity of 60%, weighing and recording every 40min, and calculating the moisture retention rate. The test results are shown in the following table.
TABLE 1 moisturizing effect of samples at 60% relative humidity
2. And respectively taking 0.5g of each sample to be measured, putting the samples into a glass dish with the same specification, putting the glass dish in a drying oven with the relative humidity of 30%, weighing and recording every 40min, and calculating the moisture retention rate. The test results are shown in the following table.
TABLE 2 moisturizing effect of samples at 30% relative humidity
From the above results, it is clear that the moisturizing skin care product provided in the examples of the present invention has good moisturizing rate in the environment with 30% and 60% relative humidity, which is comparable to comparative example 1.
Test example 2 clinical trials
1. Test information
(1) Test sample: the skin care matrix of example 1, the moisturizing skin care products of examples 2-4 and comparative example 2;
(2) Test purpose: the moisturizing effect of the product in 8 hours is evaluated by skin moisture content test;
(3) The testing method comprises the following steps: QB/T4256-2011 in the guidelines for evaluating moisturizing efficacy of cosmetics;
(4) Test instrument: corneometer (CM 825, courage+khazaka)
Electronic balance (ME 104E/02,Mettler Toledo)
A pipette (10-100. Mu.l, eppendorf Research);
(5) Reagents and materials: dry facial tissues, latex finger sleeves, alcohol, dust-free paper and a pipette tip;
(6) Subject information: women, 25 persons (26 subjects who were eligible to participate in the test, 1 subject was withdrawn for personal reasons during the test), ages 23-56 years;
(7) Test area: the inner side of the forearm;
(8) Test time point: initial value, 2 hours, 4 hours and 8 hours after the product is used.
2. Design of experiment
Based on a random, double-blind experimental design. 26 eligible female volunteers were tested, and 5 test products and blank control were randomly distributed in 6 areas (3.0X4.0 cm) on the inner side of the left and right forearms of the volunteers 2 ). The product is used for the subject by technicians on site at a time, and the dosage of the product is (2.0+/-0.1) mg/cm 2 . Skin moisture content testing (Corneometer) was performed on each test area before product use, 2 hours, 4 hours, and 8 hours after single use of the product.
3. Adverse reaction recording
During the test, no adverse skin reaction was observed in the subjects.
4. Test results
TABLE 3 moisturizing effect of samples in clinical experiments
Note that: the statistical method comprises the following steps: dunnett-t test, which shows that the moisture content of each time point of the same sample has a significant difference from the initial value, and P is less than or equal to 0.05; * And compared with a blank, a certain sample has a significant difference from the initial value, and P is less than or equal to 0.05.
From the results, the moisturizing skin care product provided by the invention has good moisturizing effect in 8 hours of single use of a human body.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (3)
1. The moisturizing skin care product is characterized by comprising the following components in percentage by weight: 0.1-0.2% of bird's nest acid, 1.5-1.6% of water-soluble silicone oil, 0.8-1% of synthesized squalane, 0.6-0.7% of PEG/PPG-17/6 copolymer, 0.8-0.9% of caprylic acid glyceride, 1-1.2% of glycerin, 1-1.2% of ethylhexyl glycerin, 0.2-0.3% of 4-methoxy salicylic acid, 0.1-0.3% of xanthan gum, 0.1-1% of arginine, 0.2-0.3% of hydrogenated castor oil, 0.01-0.1% of EDTA-disodium, 0.1-0.5% of phenoxyethanol, 0.01-0.06% of cellulose powder and the balance of water.
2. The method for preparing the moisturizing skin care product according to claim 1, which is characterized by comprising the following steps: and uniformly mixing the components except the nidus Collocaliae acid and the arginine at 75-80 ℃, cooling to 40-45 ℃, adding the nidus Collocaliae acid and the arginine, and uniformly mixing again.
3. The use of the moisturizing skin care product according to claim 1 for non-therapeutic purposes in human skin care, wherein the moisturizing skin care product is used in an amount of 2.0.+ -. 0.1mg/cm 2 。
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| CN106361665A (en) * | 2015-07-22 | 2017-02-01 | 广生堂国际有限公司 | Edible bird nest extract extraction method |
| CN110433127A (en) * | 2019-07-26 | 2019-11-12 | 李和伟 | It is a kind of high to remove scar ink-jet ink and its facial mask surely |
| CN111743810A (en) * | 2020-06-29 | 2020-10-09 | 合肥中科华燕生物技术有限公司 | Moisturizing skin care product containing N-acetylneuraminic acid and preparation method thereof |
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| CN104083291A (en) * | 2014-06-16 | 2014-10-08 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics |
| CN106361665A (en) * | 2015-07-22 | 2017-02-01 | 广生堂国际有限公司 | Edible bird nest extract extraction method |
| CN110433127A (en) * | 2019-07-26 | 2019-11-12 | 李和伟 | It is a kind of high to remove scar ink-jet ink and its facial mask surely |
| CN111743810A (en) * | 2020-06-29 | 2020-10-09 | 合肥中科华燕生物技术有限公司 | Moisturizing skin care product containing N-acetylneuraminic acid and preparation method thereof |
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