CN114146108A - Formula of eye drop and preparation method thereof - Google Patents
Formula of eye drop and preparation method thereof Download PDFInfo
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- CN114146108A CN114146108A CN202010924436.5A CN202010924436A CN114146108A CN 114146108 A CN114146108 A CN 114146108A CN 202010924436 A CN202010924436 A CN 202010924436A CN 114146108 A CN114146108 A CN 114146108A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention provides a formula of eye drop and a preparation method thereof, wherein the pharmaceutical composition is prepared from the following raw materials in parts by weight: ginseng, astragalus root, white chrysanthemum flower, honeysuckle flower, dandelion and borneol. The formula of the eye drop accords with the monarch, minister, assistant and guide relationship, can promote the growth of eye tissue cells, repair epithelial tissues, promote the growth of granulation tissues, promote the healing of eye wall wounds and stimulate the generation of white blood cells after being dropped into eyelids, and is used for retinopathy, optic neuritis, leukopenia and the like; the connective tissue vascular network is increased, peripheral blood vessels can be expanded, the blood circulation of eyes is improved, and the recovery of pathological change tissues is promoted, so that the visual definition is rapidly improved, the pseudomyopia is improved, the deepening of myopia and astigmatism degrees is relieved, presbyopia is relieved, cataract plays a certain role in preventing, relieving and treating early cataract, and can be used for treating muscae volitantes; restoring and improving lacrimal gland tear secretion, and balancing anterior tear division of cornea, and can be used for treating dry eye, acerbity, sour, and pain; resisting pathogenic microorganism.
Description
Technical Field
The invention belongs to the field of pharmacy, and particularly relates to a formula of eye drops and a preparation method thereof.
Background
The traditional medicine for protecting eyes has large toxic and side effects and is not suitable for long-term use, most medicines only provide nutrition required by human eyes, relieve visual fatigue and only have a health-care effect on visual function, or treat eye diseases in limited types, cannot solve certain inhibition effects on various pathogenic bacteria such as staphylococcus aureus, hemolytic streptococcus, escherichia coli, dysentery bacillus, vibrio cholerae, typhoid bacillus, paratyphoid bacillus and the like, is also effective on pneumococcus, meningococcus, pseudomonas aeruginosa, mycobacterium tuberculosis and is used for treating the problems of blepharitis, dacryocystitis, keratitis conjunctivitis and the like.
Therefore, it is very important to design and manufacture a formulation of eye drops and a preparation method thereof.
Disclosure of Invention
In order to solve the above technical problems, the present invention provides a formulation of an eye drop and a method for preparing the same, which solves the above problems of the background art.
The formula of the eye drop comprises the following raw materials in parts by weight: 55-65 parts of ginseng, 40-55 parts of astragalus root, 155 parts of feverfew, 145 parts of honeysuckle flower, 50-70 parts of dandelion and 5-7 parts of borneol.
The feed is prepared from the following raw materials in parts by weight: 60 parts of ginseng, 47.5 parts of astragalus, 165 parts of white chrysanthemum, 137.5 parts of honeysuckle, 60 parts of dandelion and 6 parts of borneol.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
In the step b, the container comprises a beaker.
Wherein the raw materials also include: 0.5-2 parts of bear gall powder.
Wherein the raw materials also include: bear gall powder 1.2 parts.
The raw materials also comprise:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion, borneol and bear gall powder for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
Compared with the prior art, the invention has the following beneficial effects:
1. the eye drop can promote the growth of eye tissue cells, repair epithelial tissues, promote the growth of granulation tissues and promote the healing of eye wall wounds after being dropped into eyelids, and is used for wounds caused by external forces such as long-time swimming, seawater soaking, sand and stone entering eyes, operation and the like; stimulating the production of leukocytes for retinopathy, optic neuritis, leukopenia, etc.; the connective tissue vascular network is increased, peripheral blood vessels can be expanded, the blood circulation of eyes is improved, and the recovery of pathological change tissues is promoted, so that the visual definition is rapidly improved, the pseudomyopia is improved, the deepening of myopia and astigmatism degrees is relieved, presbyopia is relieved, cataract plays a certain role in preventing, relieving and treating early cataract, and can be used for treating muscae volitantes; restoring and improving lacrimal gland tear secretion, and balancing anterior tear division of cornea, and can be used for treating dry eye, acerbity, sour, and pain; the function of resisting pathogenic microorganisms: has certain inhibiting effect on various pathogenic bacteria such as Staphylococcus aureus, hemolytic streptococcus, Escherichia coli, dysentery bacillus, Vibrio cholerae, typhoid bacillus, and paratyphoid bacillus, also has effect on pneumococcus, meningococcus, Pseudomonas aeruginosa, and tubercle bacillus, and can be used for treating blepharitis, dacryocystitis, keratitis, conjunctivitis, etc.
2. The invention takes ginseng and astragalus root as monarch drugs for promoting the growth of capillary vessels, improving the blood circulation of eyes and promoting granulation, takes white chrysanthemum, honeysuckle and dandelion as ministerial drugs, and the rest drugs are mutually matched.
Detailed Description
The invention is further described below:
example 1:
the formula of the eye drop comprises the following raw materials in parts by weight: 55-65 parts of ginseng, 40-55 parts of astragalus root, 155 parts of feverfew, 145 parts of honeysuckle flower, 50-70 parts of dandelion and 5-7 parts of borneol.
The feed is prepared from the following raw materials in parts by weight: 60 parts of ginseng, 47.5 parts of astragalus, 165 parts of white chrysanthemum, 137.5 parts of honeysuckle, 60 parts of dandelion and 6 parts of borneol.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
In the step b, the container comprises a beaker.
Example 2:
the formula of the eye drop comprises the following raw materials in parts by weight: 55 parts of ginseng, 40 parts of astragalus, 155 parts of white chrysanthemum, 130 parts of honeysuckle, 50 parts of dandelion and 5 parts of borneol.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
In the step b, the container comprises a beaker.
Example 3:
the formula of the eye drop comprises the following raw materials in parts by weight: 65 parts of ginseng, 55 parts of astragalus, 175 parts of white chrysanthemum, 145 parts of honeysuckle, 70 parts of dandelion and 7 parts of borneol.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
In the step b, the container comprises a beaker.
Example four:
the formula of the eye drop comprises the following raw materials in parts by weight: 55 parts of ginseng, 40 parts of astragalus, 155 parts of white chrysanthemum, 130 parts of honeysuckle, 50 parts of dandelion, 5 parts of borneol and 0.5 part of bear gall powder.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
Example five:
the formula of the eye drop comprises the following raw materials in parts by weight: 65 parts of ginseng, 55 parts of astragalus, 175 parts of white chrysanthemum, 145 parts of honeysuckle, 70 parts of dandelion, 7 parts of borneol and 2 parts of bear gall powder.
It comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion, borneol and bear gall powder for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
The functions of the traditional Chinese medicines are as follows:
ginseng: nature, flavor and meridian tropism: slightly warming; sweet and slightly bitter; it enters heart, lung and spleen meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote fluid production, and induce tranquilization. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, asthenia, palpitation, insomnia, sexual impotence, and cold womb; heart failure, cardiogenic shock.
Astragalus root: nature, flavor and meridian tropism: slightly warming; sweet; it enters spleen and lung meridians. Tonify qi, strengthen superficies, induce diuresis, expel pus, heal wound and promote tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes.
White chrysanthemum: nature, flavor and meridian tropism: slightly cold; sweet and bitter; the main indications of the functions of the lung and the liver meridian are as follows: disperse wind-heat, calm liver and improve vision. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, and blurred vision.
Honeysuckle flower: nature, flavor and meridian tropism: cold; sweet; entering lung, heart and stomach meridians; the functional indications are as follows: clear heat and remove toxicity, cool and disperse wind-heat. Can be used for treating carbuncle, swelling, sore, pharyngitis, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever.
Dandelion: nature, flavor and meridian tropism: cold; sweet and bitter; entering liver and stomach meridians, mainly functions: clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with astringency and pain due to heat.
Borneol: nature, flavor and meridian tropism: slightly cold; pungent and bitter; heart, spleen and lung meridians entered; the functional indications are as follows: induce resuscitation and refresh mind, clear heat and alleviate pain. Can be used for treating fever unconsciousness, convulsion syncope, apoplexy with phlegm syncope, qi stagnation and sudden syncope, coma, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.
Bear gall powder: clear heat, pacify liver, improve vision. It can be used for treating conjunctival congestion, swelling and pain of throat.
The clinical medical record part is as follows:
case one:
jin in some, woman, 38 years old.
The medical history: the sand enters eyes to cause red and swollen eyes.
And (3) diagnosis: the eyes are red, swollen and inflamed.
Treatment: the liquid medicine is used for regular coordination treatment. The liquid medicine is dropped into eyes, and is absorbed by massage, so that the vitality of eye cells and optic nerves is improved, and the regeneration is activated.
Case two:
guo in some, female, 12 years old.
The medical history: the main symptoms of cataract are manifested as visual deterioration and blurred vision, and gradually aggravated visual deterioration, and when cataract is severe, blurred vision, light intolerance, dark or yellow object viewing color, etc. may occur.
And (3) diagnosis: early stage cataract.
Treatment: the liquid medicine is used for regular coordination treatment. The liquid medicine is dropped into eyes, and is absorbed by massage, so that the vitality of eye cells and optic nerves is improved, and the regeneration is activated.
Case three:
zhu Chi, woman, age 21.
The medical history: the patients self-state that the mosquitoes fly in front of eyes as if the old mosquitoes can not catch and cannot hit all the time, and the ' mosquitoes fly ' which is if the mosquitoes do not fly is troubled by the patients, especially the ' mosquitoes fly ' after the middle-aged people ' are all suffered by a plurality of people.
And (3) diagnosis: muscae volitantes.
Treatment: the liquid medicine is used for regular coordination treatment. The liquid medicine is dropped into eyes, and is absorbed by massage, so that the vitality of eye cells and optic nerves is improved, and the regeneration is activated.
The technical solutions of the present invention or similar technical solutions designed by those skilled in the art based on the teachings of the technical solutions of the present invention are all within the scope of the present invention.
Claims (7)
1. The formula of the eye drop is characterized in that the pharmaceutical composition is prepared from the following raw materials in parts by weight: 55-65 parts of ginseng, 40-55 parts of astragalus root, 155 parts of feverfew, 145 parts of honeysuckle flower, 50-70 parts of dandelion and 5-7 parts of borneol.
2. The formula of eye drop according to claim 1, which is prepared from the following raw materials in parts by weight: 60 parts of ginseng, 47.5 parts of astragalus, 165 parts of white chrysanthemum, 137.5 parts of honeysuckle, 60 parts of dandelion and 6 parts of borneol.
3. A process for the preparation of an ophthalmic solution according to any one of claims 1 to 2, characterized in that it comprises the following steps:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion and borneol for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
4. The method of claim 3, wherein in step b, the container comprises a beaker.
5. The formulation of claim 1, wherein the ingredients further comprise: 0.5-2 parts of bear gall powder.
6. The formulation of claim 5, wherein the ingredients further comprise: bear gall powder 1.2 parts.
7. The method of claim 5 or 6, wherein the raw materials further comprise:
a. weighing raw material medicines of ginseng, astragalus, white chrysanthemum, honeysuckle, dandelion, borneol and bear gall powder for later use;
b. putting the weighed raw materials into a traditional Chinese medicine decocting machine, decocting to obtain a medicinal liquid mixture, and filtering to obtain medicinal liquid for later use;
c. putting the liquid medicine into a distiller, adding 1000ml of distilled water, sealing and soaking for 24 hours, taking out the liquid medicine, adding the liquid medicine into a container, sterilizing and packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010924436.5A CN114146108A (en) | 2020-09-05 | 2020-09-05 | Formula of eye drop and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010924436.5A CN114146108A (en) | 2020-09-05 | 2020-09-05 | Formula of eye drop and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114146108A true CN114146108A (en) | 2022-03-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010924436.5A Pending CN114146108A (en) | 2020-09-05 | 2020-09-05 | Formula of eye drop and preparation method thereof |
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| CN (1) | CN114146108A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040888A (en) * | 2013-01-13 | 2013-04-17 | 段亚东 | Ophthalmologic external preparation, as well as preparation method and application thereof |
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2020
- 2020-09-05 CN CN202010924436.5A patent/CN114146108A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040888A (en) * | 2013-01-13 | 2013-04-17 | 段亚东 | Ophthalmologic external preparation, as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 金明: "从五脏-五轮辨析眼表炎症", 《中国中医眼科杂志》, vol. 30, no. 3, pages 162 - 165 * |
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