CN113491716A - Medicine for nursing and treating herpes zoster and preparation method thereof - Google Patents

Medicine for nursing and treating herpes zoster and preparation method thereof Download PDF

Info

Publication number
CN113491716A
CN113491716A CN202110939982.0A CN202110939982A CN113491716A CN 113491716 A CN113491716 A CN 113491716A CN 202110939982 A CN202110939982 A CN 202110939982A CN 113491716 A CN113491716 A CN 113491716A
Authority
CN
China
Prior art keywords
parts
medicine
nursing
herpes zoster
treating herpes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110939982.0A
Other languages
Chinese (zh)
Inventor
任秀云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN202110939982.0A priority Critical patent/CN113491716A/en
Publication of CN113491716A publication Critical patent/CN113491716A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/28Mercury; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/413Gall bladder; Bile
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/65Amphibians, e.g. toads, frogs, salamanders or newts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Insects & Arthropods (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Endocrinology (AREA)

Abstract

The invention discloses a medicine for nursing and treating herpes zoster and a preparation method thereof, wherein the medicine comprises the following raw material medicines: realgar, earthworm, cinnabar, borneol, musk, scorpion, toad venom, plant soot and bezoar. The invention has the beneficial effects that: the medicine of the invention has the main functions of clearing away heat and toxic material, relieving swelling and pain, activating blood and dissolving stasis, and soothing liver and regulating qi, and is used for nursing and treating herpes zoster; the invention takes the traditional Chinese medicine theory as guidance, adopts green and pollution-free pure natural medicines, has no toxic or side effect, and is safe and effective; the formula is simple, and the preparation process is simple and convenient; the medicine is convenient to administer, the price is low, and the medicine is easy to accept by patients; has quick action and short cure time.

Description

Medicine for nursing and treating herpes zoster and preparation method thereof
Technical Field
The invention relates to the technical field of pharmacy, in particular to a medicine for nursing and treating herpes zoster and a preparation method thereof.
Background
Shingles is the most common type of herpes and is a cutaneous infection caused by the infection with varicella-zoster virus. The herpes zoster is mainly manifested as varicella in children, but has the highest prevalence rate of herpes zoster in middle-aged and elderly people, has severe neuralgia although no obvious skin damage, and has the highest prevalence rate of the virus along a nerve running route in spring and autumn, and is mainly caused by the reasons of reduced self resistance and the like.
The herpes zoster is called as herpes zoster or herpes zoster mainly caused by damp-heat fire toxin on skin, qi stagnation and blood stasis, and the key point of the disease is the toxin. The clinical manifestations are mainly pain and skin changes, so it is very important and urgent to stop pain more quickly.
Cause of disease
The human is the only host of varicella-zoster virus, the virus enters blood through respiratory mucosa to form viremia, varicella or recessive infection occurs, and the virus can be hidden in spinal cord posterior root ganglion or cranial nerve sensory ganglion for a long time later. When the body is subjected to certain stimulation (such as trauma, fatigue, malignant tumor or weakness after illness) to cause the resistance of the body to be reduced, latent viruses are activated, and descend along the axis of a sensory nerve to reach the skin of an area dominated by the nerve to reproduce blisters, and meanwhile, the involved nerve is subjected to inflammation and necrosis to generate neuralgia.
Clinical manifestations
The typical manifestations are mild hypodynamia, low fever, anorexia and other general symptoms before eruption, the skin of the affected part feels scorching or neuralgia, the touch has obvious pain sensitivity, lasts for 1-3 days, and eruption can also occur without prodromal symptoms. The good hair part is the intercostal nerve, cervical nerve, trigeminal nerve and lumbosacral nerve innervation area in sequence. The affected part often has firstly moist erythema, quickly has papules from millet grains to soybean sizes, is distributed in clusters without fusion, then quickly becomes blister, the blister wall is tense and shiny, the blister liquid is clear, the periphery is surrounded by the red halo, and the skin among each cluster of blister groups is normal; the skin lesions are arranged in a band along a peripheral nerve, mostly on one side of the body, and generally do not exceed the median line. Neuralgia is one of the characteristics of the disease, can occur before the onset of disease or along with skin damage, and is often severe for the elderly.
Diagnosis of
1. Clustered and clustered blisters appear on the diseased skin and are distributed in a band shape along the peripheral nerve on one side.
2. Has obvious neuralgia and local lymph node swelling.
3. The median skin is normal.
At present, western medicine for treating herpes zoster basically takes antivirus, analgesic and glucocorticoid therapies as main therapies, and acyclovir, valaciclovir or famciclovir are orally taken, and all the drugs have antivirus effect, so that neuralgia caused by herpes can be relieved, analgesic such as ibuprofen is taken severely for pain, water bubbles are broken carelessly and disinfected in time, 78% of calamine lotion can be applied, the treatment course is long, most importantly, postherpetic neuralgia is easy to occur, late-night pain is severe, the rest of a patient is seriously affected, physical and mental fatigue and great pain are caused, long-term administration is needed, tolerance is easy to generate, symptoms and root causes are not treated, the curative effect is not ideal, the price is high, toxic and side effects are large, and the drugs are not easy to be accepted by patients.
Herpes zoster belongs to the categories of spider sore, herpes zoster and herpes zoster in traditional Chinese medicine. The traditional Chinese medicine considers that the disease is mostly caused by liver depression and qi stagnation due to emotional failure, and heat is generated due to long-term depression; or diseases caused by improper diet, dysfunction of the spleen in transportation and transformation, and accumulation of damp-heat. Therefore, the traditional Chinese medicine can make up the defects of western medicines, can comprehensively treat and treat both symptoms and root causes, has wide medicine sources, adopts pollution-free traditional Chinese medicinal materials, has low price, is not easy to generate drug resistance, is safe and effective, controls the illness state in time, improves the cure rate and improves the whole immunity of the organism.
Disclosure of Invention
The invention aims to solve the technical problems that the invention provides a medicine for nursing and treating herpes zoster and a preparation method thereof, the medicine takes the traditional Chinese medicine theory as guidance, adopts green and pollution-free pure natural medicines, is safe and effective, and has no toxic or side effect; the medicine is convenient to administer and easy to accept, and can regulate the immune function of the organism, enhance the disease resistance of the organism and quickly promote the recovery of health by carrying out treatment based on syndrome differentiation on the basis of the overall view.
In order to solve the technical problems, the invention provides a medicine for nursing and treating herpes zoster, which mainly has the functions of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain and soothing liver and regulating qi, and comprises the following raw material medicines: realgar, earthworm, cinnabar, borneol, musk, scorpion, toad venom, plant soot and bezoar.
The medicine comprises the following raw material medicines in parts by weight: 15-25 parts of realgar, 8-15 parts of earthworm, 8-15 parts of cinnabar, 3-10 parts of borneol, 1-5 parts of musk, 0.2-1 part of scorpion, 0.2-1 part of toad venom, 0.5-1.5 parts of plant soot and 0.5-1.5 parts of bezoar.
The medicine comprises the following raw material medicines in parts by weight: 16-24 parts of realgar, 9-14 parts of earthworm, 9-14 parts of cinnabar, 4-9 parts of borneol, 2-4 parts of musk, 0.3-0.9 part of scorpion, 0.3-0.9 part of toad venom, 0.6-1.3 parts of plant soot and 0.6-1.3 parts of bezoar.
The medicine comprises the following raw material medicines in parts by weight: 16 parts of realgar, 14 parts of earthworm, 12 parts of cinnabar, 4 parts of borneol, 2 parts of musk, 0.5 part of scorpion, 0.3 part of toad venom, 1 part of plant soot and 0.8 part of bezoar.
The medicine comprises the following raw material medicines in parts by weight: 20 parts of realgar, 12 parts of earthworm, 9 parts of cinnabar, 9 parts of borneol, 3 parts of musk, 0.9 part of scorpion, 0.6 part of toad venom, 1.3 parts of plant soot and 0.6 part of bezoar.
The medicine comprises the following raw material medicines in parts by weight: 24 parts of realgar, 9 parts of earthworm, 14 parts of cinnabar, 6 parts of borneol, 4 parts of musk, 0.3 part of scorpion, 0.9 part of toad venom, 0.6 part of plant soot and 1.3 parts of bezoar.
A preparation method of a medicine for nursing and treating herpes zoster comprises the following steps:
s1, weighing the traditional Chinese medicine components for later use according to the pharmaceutical formula for nursing and treating herpes zoster of any one of claims;
s2, fully mixing the traditional Chinese medicines weighed in the steps, then crushing the traditional Chinese medicines into fine powder by a traditional Chinese medicine crusher, and then fully mixing the fine powder for later use;
s3, blending the powder obtained in the step S2 into paste by using vinegar.
The using method comprises the following steps:
1. disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed.
2. The cupping jar was pulled out at the place of herpes, and the herpes became black and purple.
3. The paste medicine prepared by the invention is coated on herpes, covered by a sterilized gauze and fixed by an adhesive tape.
The technical scheme provided by the embodiment of the invention has the following beneficial effects: the medicine of the invention has the main functions of clearing away heat and toxic material, relieving swelling and pain, activating blood and dissolving stasis, and soothing liver and regulating qi, and is used for nursing and treating herpes zoster; the invention takes the traditional Chinese medicine theory as guidance, adopts green and pollution-free pure natural medicines, has no toxic or side effect, and is safe and effective; the formula is simple, and the preparation process is simple and convenient; the medicine is convenient to administer, the price is low, and the medicine is easy to accept by patients; has quick action and short cure time.
Detailed Description
The invention provides a medicine for nursing and treating herpes zoster, which is mainly used for clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain and soothing liver and regulating qi, and comprises the following raw material medicines: realgar, earthworm, cinnabar, borneol, musk, scorpion, toad venom, plant soot and bezoar. Wherein the realgar, the cinnabar and the bezoar clear away heat and toxic materials; borneol, musk and plant soot promote blood circulation by removing blood stasis; musk and toad venom have the effects of relieving swelling and pain; earthworm and scorpion soothe the liver and regulate qi; moschus is effective in invigorating spleen and regulating stomach; realgar has effects of promoting diuresis and relieving itching. The whole formula is reviewed, and the compatibility is scientific and strict.
Wherein, the pharmacology of the raw material medicines is as follows:
realgar: pungent and warm, enter large intestine and liver meridians, have the functions of detoxifying and killing parasites, eliminating dampness and phlegm, preventing malaria and arresting convulsion, have good functions of detoxifying, killing parasites and treating sore, and are effective for treating sore and carbuncle pyogenic infections, red swelling and pain caused by wind-heat damp toxin obstruction.
Earthworm: being salty in taste and cold in nature, it is ascribed to liver, spleen and bladder meridians, and has the actions of calming wind and arresting convulsion, so it is suitable for treating coma and delirium, spasm and convulsion, infantile febrile convulsion, etc. caused by extreme heat producing wind.
Cinnabar: sweet in nature and slightly cold in nature, has the efficacies of clearing away heart-fire, relieving convulsion, soothing the nerves and removing toxicity. It is used clinically to treat restlessness, palpitation, insomnia, sore and ulcer, swelling and pain in throat, aphtha and other aphtha. Rhizoma Gynurae Divaricatae, radix Notoginseng, rhizoma Gynurae Divaricatae, and rhizoma Coptidis. Cinnabaris of genus Cinnabaris of family Crassulaceae is used as a whole herb. Returning to the heart; liver; the lung meridian. Stasis dissipating and bleeding stopping; clearing away heat and toxic material. Traumatic injury is mainly caused; sprain; traumatic hemorrhage; laryngopharyngitis; scalding; eczema; carbuncle sore and pyogenic infections; bite by poisonous snake.
Borneol: the property of herbs is pungent, bitter and slightly cold, and they enter heart, spleen and lung meridians. Borneolum has effects in inducing resuscitation, refreshing mind, clearing away heat, relieving pain, removing nebula, improving eyesight, relieving swelling, and removing blood stasis.
Musk: the property of the medicine is pungent and warm, and the medicine belongs to heart and spleen channels, and has the efficacies of inducing resuscitation and refreshing mind, promoting blood circulation and removing obstruction in channels, and relieving swelling and pain.
Scorpion: neutral in nature, mainly belonging to the liver channel, has high medicinal value and edible value, has the efficacies of calming endogenous wind and relieving spasm, counteracting toxic pathogen and dissipating stagnation, dredging collaterals and relieving pain and resisting thrombus, and can calm endogenous wind and relieve spasm: scorpion enters liver meridian and has good property of moving and moving, so it can calm down liver wind, dispel wind and unblock collaterals, and has good effect of extinguishing wind and relieving spasm, so it is the essential herb for treating spasm and convulsion.
And (3) toad venom: detoxicating, relieving pain, inducing resuscitation and refreshing mind, treating carbuncle, cellulitis, furunculosis, scrofula, sore throat, toothache, etc., inducing resuscitation and refreshing mind, treating eruptive abdominal pain, coma, vomiting and diarrhea.
Plant soot: pungent and warm in flavor, has the effects of clearing heat and dissipating blood stasis, detoxifying and dissipating fire, stopping bleeding and removing food retention, and is mainly used for treating throat pain, mouth and tongue sores, ecthyma and alopecia areata.
Bezoar: bitter in nature, sweet and cool, and has the effects: wind extinguishing and convulsion stopping, phlegm reducing and resuscitation inducing, heat clearing and toxicity removing, phlegm reducing and resuscitation inducing is used for fever entering pericardium, or coma and trismus caused by phlegm heat covering the heart orifice, such as stroke, infantile convulsion and epilepsy, can clear heart heat and reduce phlegm and resuscitation inducing, and is used for heat clearing and toxicity removing, and is often used as an essential medicine for heat clearing and toxicity removing, for swelling and pain and rot of throat, carbuncle and furuncle and other symptoms caused by stagnation of heat toxin.
The following embodiments are described in detail to solve the technical problems by applying technical means to the present invention, and the implementation process of achieving the technical effects can be fully understood and implemented.
EXAMPLE 1 drug one of the present invention
The medicine is prepared from realgar 16g, earthworm 14g, cinnabar 12g, borneol 4g, musk 2g, scorpion 0.5g, toad venom 0.3g, plant soot 1g and bezoar 0.8 g.
The method comprises the following steps:
s1, weighing the traditional Chinese medicine components according to the formula of the medicine for nursing and treating herpes zoster for later use;
s2, fully mixing the traditional Chinese medicines weighed in the steps, then crushing the traditional Chinese medicines into fine powder by a traditional Chinese medicine crusher, and then fully mixing the fine powder for later use;
s3, blending the powder obtained in the step S2 into paste by using vinegar.
Example 2 drug two of the present invention
20g of realgar, 12g of earthworm, 9g of cinnabar, 9g of borneol, 3g of musk, 0.9g of scorpion, 0.6g of toad venom, 1.3g of plant soot and 0.6g of bezoar.
The method comprises the following steps:
s1, weighing the traditional Chinese medicine components according to the formula of the medicine for nursing and treating herpes zoster for later use;
s2, fully mixing the traditional Chinese medicines weighed in the steps, then crushing the traditional Chinese medicines into fine powder by a traditional Chinese medicine crusher, and then fully mixing the fine powder for later use;
s3, blending the powder obtained in the step S2 into paste by using vinegar.
Example 3 drug III of the invention
24g of realgar, 9g of earthworm, 14g of cinnabar, 6g of borneol, 4g of musk, 0.3g of scorpion, 0.9g of toad venom, 0.6g of plant soot and 1.3g of bezoar.
The method comprises the following steps:
s1, weighing the traditional Chinese medicine components according to the formula of the medicine for nursing and treating herpes zoster for later use;
s2, fully mixing the traditional Chinese medicines weighed in the steps, then crushing the traditional Chinese medicines into fine powder by a traditional Chinese medicine crusher, and then fully mixing the fine powder for later use;
s3, blending the powder obtained in the step S2 into paste by using vinegar.
Toxicity test:
and (3) allergy test:
15 healthy white guinea pigs with weight of 250-. 2, 4-dinitrochlorobenzene is used as a positive control group, 1% concentration is used for sensitization, and 0.1% concentration is used for excitation; the test group was treated with drug one of example 1 of the present invention. Taking 0.1g of the first medicament of the invention in the example 1, coating the first medicament on the back haired area, covering the area with sterile gauze, and fixing the area with adhesive plaster 1 time every other day for 3 times. Applying the product 0.1g on the same area of back 14 days after the last contact, removing the medicine after 6 hr, and observing whether anaphylaxis exists at 24 hr, 48 hr, and 72 hr. The blank control group and the positive control group were exposed and observed in the same manner. And (3) test results: the positive control group animal skin shows localized erythema and slight edema after 1 hour of sensitization, the allergic reaction symptom is aggravated and hard nodules are formed after 24 hours of sensitization, the sensitization rate is 100%, the test group animal skin and the blank control group animal skin do not show any allergic reaction symptom, and the sensitization rate is 0%.
And (3) allergy test:
15 healthy white guinea pigs with weight of 250-. 2, 4-dinitrochlorobenzene is used as a positive control group, 1% concentration is used for sensitization, and 0.1% concentration is used for excitation; the test group used drug two of example 2 of the present invention. The second medicament of the invention in example 2 is applied to the area of the back where hair is removed, covered with sterile gauze and fixed with adhesive tape 1 time every other day for 3 times. Spraying the product on the same area of back for 1 time 14 days after the last contact, removing the medicine after 6 hr, and observing whether anaphylaxis exists in 24 hr, 48 hr, and 72 hr. The blank control group and the positive control group were exposed and observed in the same manner. And (3) test results: the positive control group animal skin shows localized erythema and slight edema after 1 hour of sensitization, the allergic reaction symptom is aggravated and hard nodules are formed after 24 hours of sensitization, the sensitization rate is 100%, the test group animal skin and the blank control group animal skin do not show any allergic reaction symptom, and the sensitization rate is 0%.
Acute skin irritation test:
the product is characterized in that according to section 6.3 of a skin irritation/corrosion test of the second part of 'cosmetic hygiene Specification' (2002) of the Ministry of health, 4 male white rabbits with big ears in Japan weigh 2 kg-3 kg, the third medicament prepared in the embodiment 3 of the invention is directly coated on the left side skin of an animal (the other side is used as a control), a sterilized gauze is covered and fixed by an adhesive plaster, a sealing test is adopted, the application time is 4 hours, the residual test object is washed by warm water after the test is finished, the skin reactions of a test area and a control area of the animal are respectively observed after the test object is removed for 1 hour, 24 hours, 48 hours and 72 hours, the highest integral mean value is '0', and the product is judged to have no irritation to the skin of the animal.
Clinical data:
selecting 76 patients with herpes zoster for hospital treatment, 41 male patients and 35 female patients, wherein the age is 20-71 years, and the average age is 52 years; wherein, the disease is developed in 36 cases of the hypochondrium, 24 cases of the waist and the abdomen, 4 cases of the chest, 4 cases of the head and the face and 8 cases of the four limbs, and the disease development time is 1-10 days; the four groups are randomly divided into four groups, and the four groups are statistically treated in age, gender and disease course, have no significant difference and are comparable.
Drug one treatment group: 19, 10 men and 9 women.
Drug two treatment groups: 19, 10 men and 9 women.
Three treatment groups of drugs: 19, 10 men and 9 women.
And the western medicine control group comprises: 19, 11 men and 8 women.
Diagnostic criteria:
according to the diagnosis standard of herpes zoster of the traditional Chinese medicine disease diagnosis curative effect standard issued by the State administration of traditional Chinese medicine:
(1) skin damage is generally green gram-sized blisters, clustered and clustered, with tense blister walls and red basal body, which are often distributed on one side and arranged in a strip shape, and severe skin damage can be manifested as hemorrhagic or gangrene damage;
(2) the subjective pain is obvious, and the symptoms of intolerable severe pain and rash relief and residual pain can be caused;
(3) before the rash appears, the skin is usually prickled or burning, which may be accompanied by mild discomfort and fever.
The using method comprises the following steps:
drug one treatment group: disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed; drawing the cupping jar at the herpes place, and taking out the cupping jar when the herpes turns black and purple; the herpes is coated with the first medicament prepared in the embodiment 1 of the invention, covered with a piece of sterile gauze and fixed by an adhesive tape. Every 7 days, 1 course of treatment is given.
Drug two treatment groups: disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed; drawing the cupping jar at the herpes place, and taking out the cupping jar when the herpes turns black and purple; the second medicament prepared in the embodiment 2 of the invention is coated on the herpes, covered by a piece of sterile gauze and fixed by an adhesive tape. Every 7 days, 1 course of treatment is given.
Three treatment groups of drugs: disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed; drawing the cupping jar at the herpes place, and taking out the cupping jar when the herpes turns black and purple; the third medicine prepared in the embodiment 3 of the invention is coated on the herpes, covered by a piece of sterile gauze and fixed by an adhesive tape. Every 7 days, 1 course of treatment is given.
And the western medicine control group comprises: orally taking ribavirin oral liquid 10ml once, 3 times a day; vitamin B12 tablet is orally administered, 1 tablet at a time, 3 times a day; simultaneously, the externally applied acyclovir emulsifiable paste is smeared on the affected part for 4 times a day. 7 days for 1 course of treatment.
The evaluation standard of curative effect is as follows:
and (3) healing: the skin damage disappears, and no clinical symptoms exist;
the effect is shown: the skin lesions subsided 70%, with mild pain;
the method has the following advantages: the skin lesions subsided 30%, moderate pain;
and (4) invalidation: the skin lesions become more severe and severe pain.
The treatment results are as follows:
referring to table 1, it can be seen from table 1 that the treatment of herpes zoster by using the medicine disclosed by the invention has a significant improvement in treatment effect compared with western medicines.
TABLE 1 comparison of clinical efficacy of four groups of drugs after 1 treatment course
Figure DEST_PATH_IMAGE001
According to clinical statistics in the table, the medicine provided by the invention has the advantages of high effective rate, exact curative effect, high safety, quick response and no toxic or side effect.
Typical case one:
in 3 months in 2020, a male is 76 years old, \28390, An villages and towns in Zhou city, when a patient comes for a diagnosis, the face is haggard, the pain is not great, the waist and the belly are painful for one week, the pain is similar to that of a needle prick, particularly, the patient feels severe at later night, the skin rash is raised and looks like a prick, the skin rash is from the waist level of 45 degrees to the belly denseness and numbness, the bottom part is red, a cluster of small blisters appears in some cases, and the typical expression of herpes zoster is finally diagnosed as the herpes zoster through diagnosis. Disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed; drawing the cupping jar at the herpes place, and taking out the cupping jar when the herpes turns black and purple; the herpes is coated with the first medicament prepared in the embodiment 1 of the invention, covered with a piece of sterile gauze and fixed by an adhesive tape. After six days, the scab is removed, and the affected part is well recovered and completely cured. The disease does not relapse after one-year return visit.
Typical case two:
year 2020, month 4, jia chi, maid, age 65, \ 28390, state city, patient dictation: papules ranging from millet to soybean are found on the waist and abdomen of the patient and then become blisters, and the skin of the affected part feels burning and has hard to endure. The test shows that the blisters are distributed in clusters without fusion, the vesicular fluid is clear, the periphery is surrounded by a red halo, and the skin among the blister groups of each cluster is normal. Herpes zoster is diagnosed. Disinfecting the skin around herpes with iodophor and alcohol respectively, and pricking the skin around herpes with plum blossom needle to make the whole periphery of herpes stabbed; drawing the cupping jar at the herpes place, and taking out the cupping jar when the herpes turns black and purple; the third medicine prepared in the embodiment 3 of the invention is coated on the herpes, covered by a piece of sterile gauze and fixed by an adhesive tape. Scabbing and dropping off in one week, the affected part recovers well and is cured completely. The disease does not relapse after one-year return visit.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (7)

1. The medicine for nursing and treating herpes zoster is characterized by comprising the following raw material medicines: realgar, earthworm, cinnabar, borneol, musk, scorpion, toad venom, plant soot and bezoar.
2. The medicine for nursing and treating herpes zoster according to claim 1, wherein the medicine comprises the following raw material medicines in parts by weight: 15-25 parts of realgar, 8-15 parts of earthworm, 8-15 parts of cinnabar, 3-10 parts of borneol, 1-5 parts of musk, 0.2-1 part of scorpion, 0.2-1 part of toad venom, 0.5-1.5 parts of plant soot and 0.5-1.5 parts of bezoar.
3. The medicine for nursing and treating herpes zoster according to claim 1 or 2, wherein the medicine comprises the following raw material medicines in parts by weight: 16-24 parts of realgar, 9-14 parts of earthworm, 9-14 parts of cinnabar, 4-9 parts of borneol, 2-4 parts of musk, 0.3-0.9 part of scorpion, 0.3-0.9 part of toad venom, 0.6-1.3 parts of plant soot and 0.6-1.3 parts of bezoar.
4. The medicine for nursing and treating herpes zoster according to any one of claims 1 to 3, wherein the medicine comprises the following raw material medicines in parts by weight: 16 parts of realgar, 14 parts of earthworm, 12 parts of cinnabar, 4 parts of borneol, 2 parts of musk, 0.5 part of scorpion, 0.3 part of toad venom, 1 part of plant soot and 0.8 part of bezoar.
5. The medicine for nursing and treating herpes zoster according to any one of claims 1 to 4, wherein the medicine comprises the following raw material medicines in parts by weight: 20 parts of realgar, 12 parts of earthworm, 9 parts of cinnabar, 9 parts of borneol, 3 parts of musk, 0.9 part of scorpion, 0.6 part of toad venom, 1.3 parts of plant soot and 0.6 part of bezoar.
6. The medicine for nursing and treating herpes zoster according to any one of claims 1 to 5, wherein the medicine comprises the following raw material medicines in parts by weight: 24 parts of realgar, 9 parts of earthworm, 14 parts of cinnabar, 6 parts of borneol, 4 parts of musk, 0.3 part of scorpion, 0.9 part of toad venom, 0.6 part of plant soot and 1.3 parts of bezoar.
7. The preparation method of the medicine for nursing and treating herpes zoster according to any one of claims 1 to 6, characterized in that the preparation method comprises the following steps:
s1, weighing the traditional Chinese medicine components for later use according to the pharmaceutical formula for nursing and treating herpes zoster of any one of claims;
s2, fully mixing the traditional Chinese medicines weighed in the steps, then crushing the traditional Chinese medicines into fine powder by a traditional Chinese medicine crusher, and then fully mixing the fine powder for later use;
s3, blending the powder obtained in the step S2 into paste by using vinegar.
CN202110939982.0A 2021-08-17 2021-08-17 Medicine for nursing and treating herpes zoster and preparation method thereof Pending CN113491716A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110939982.0A CN113491716A (en) 2021-08-17 2021-08-17 Medicine for nursing and treating herpes zoster and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110939982.0A CN113491716A (en) 2021-08-17 2021-08-17 Medicine for nursing and treating herpes zoster and preparation method thereof

Publications (1)

Publication Number Publication Date
CN113491716A true CN113491716A (en) 2021-10-12

Family

ID=77996913

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110939982.0A Pending CN113491716A (en) 2021-08-17 2021-08-17 Medicine for nursing and treating herpes zoster and preparation method thereof

Country Status (1)

Country Link
CN (1) CN113491716A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032522A (en) * 2007-04-09 2007-09-12 闫芳 Medicine for curing herpes zoster
CN105168286A (en) * 2015-10-28 2015-12-23 吴淑芬 Externally-applied medicine for treating herpes zoster
CN105998172A (en) * 2016-06-02 2016-10-12 温红卫 Topical dressing for treating herpes zoster and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032522A (en) * 2007-04-09 2007-09-12 闫芳 Medicine for curing herpes zoster
CN105168286A (en) * 2015-10-28 2015-12-23 吴淑芬 Externally-applied medicine for treating herpes zoster
CN105998172A (en) * 2016-06-02 2016-10-12 温红卫 Topical dressing for treating herpes zoster and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
宋业强等: "《皮肤疑难病》", 31 May 2000, 中医古籍出版社 *
樊红雨等: "《单味中药巧治病》", 31 October 2018, 中国科学技术出版社 *

Similar Documents

Publication Publication Date Title
CN110393781B (en) Pure traditional Chinese medicine preparation for treating thyroid nodule and preparation method thereof
CN103566199B (en) A kind of Chinese medicine preparation for the treatment of post cerebral traumatic syndrome
CN105030901A (en) Traditional Chinese medicine composition for treatment of skin diseases and application method thereof
CN102274317A (en) Chinese medicinal composition for treating cancers and preparation method thereof
CN102805800B (en) Traditional Chinese medicine composition for treating neurodermatitis
CN102178892A (en) Chinese medicinal composition for treating depression
CN102302559B (en) Medicament for treating respiratory system diseases and application thereof
CN102670945B (en) Prunella vulgaris traditional Chinese medicine oral liquid for adjuvant therapy of pleurisy and preparation method thereof
CN102125678A (en) Chinese medicinal preparation for treating hysteria disease
CN113491716A (en) Medicine for nursing and treating herpes zoster and preparation method thereof
CN1281228C (en) Medicine for hyperplasia of mammary glands and its preparation
CN107137504B (en) Health food for improving sleep and enhancing immunity
CN111920883A (en) External preparation for treating herpes zoster and preparation method thereof
CN105434739A (en) Traditional Chinese medicine composition for treating chalazia and preparation method thereof
CN100411672C (en) A medicinal composition for treatment of psoriasis
CN104524252A (en) Traditional Chinese medicine preparation for treating demented symptom
CN100998744A (en) Chinese patent drug for treating infantile hyperkinetic syndrome
CN109663012A (en) Dispelling wind and heat, removing toxic substances relieving sore-throat Chinese medicine composition and the preparation method and application thereof
CN104666420A (en) A medicine for treating rhinitis
CN103860804A (en) Traditional Chinese medicinal analgesic spray for treating postherpetic neuralgia
CN115463203B (en) Traditional Chinese medicine composition for preventing children influenza
CN104606406B (en) A kind of traditional Chinese medicinal ointment and preparation method thereof of external application prevention of allergic rhinitis
CN114042109B (en) Traditional Chinese medicine composition and patch for inducing resuscitation and stopping nasal discharge, warming yang and strengthening body resistance and preparation method
CN103463517A (en) Medicament for treating asthma
CN102698012B (en) Externally applied traditional Chinese medicine for treating oral lichen planus

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20211012

RJ01 Rejection of invention patent application after publication