CN103566199B - A kind of Chinese medicine preparation for the treatment of post cerebral traumatic syndrome - Google Patents
A kind of Chinese medicine preparation for the treatment of post cerebral traumatic syndrome Download PDFInfo
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- CN103566199B CN103566199B CN201310549449.9A CN201310549449A CN103566199B CN 103566199 B CN103566199 B CN 103566199B CN 201310549449 A CN201310549449 A CN 201310549449A CN 103566199 B CN103566199 B CN 103566199B
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Abstract
The present invention relates to a kind of Chinese medicine for the treatment of post cerebral traumatic syndrome, belong to tcm field.Raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 10-20 part, Flos Chrysanthemi 3-5 part, Radix Polygalae 3-5 part, Semen Ziziphi Spinosae (parched) 10-20 part, Dens Draconis 10-20 part, Concha Ostreae 10-20 part, Concha Margaritifera 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Angelicae Sinensis 10-20 part, Semen Persicae 10-20 part, Radix Paeoniae Rubra 10-20 part, Poria 10-20 part, Caulis Polygoni Multiflori 20-30 part, Rhizoma Gastrodiae 5-10 part.Described preparation is said dosage form on any one pharmaceutics, as capsule preparations, dissolved granule, tablet, decoction, pill, oral liquid formulations etc., utilizes the routine techniques of pharmaceutical industry to make.The present invention has that beneficial brain is calmed the nerves, calmness is nourished heart, effect of blood circulation promoting and blood stasis dispelling.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of post cerebral traumatic syndrome, belong to tcm field.
Background technology
Post-traumatic brain syndrome, the traditional Chinese medical science belongs to the scope of traumatic headache.Because current traffic accident, wound increase, so primary disease is day by day common clinically.Be mainly extraneous violence to clash into suddenly caused by head.Due to unexpected concussion, brains baffle, and have upset the house of intelligence of head, therefore namely occur momentary loss of consciousness or staring spells in early days; If blood stasis violates brain, stay in intracranial, ecchymoma swelling pressure compels brains, then occur the symptoms such as headache, dizziness, Nausea and vomiting, severe patient continued for several weeks is more than.Therefore need to take effective measures to intervene.
In prior art, the treatment of post cerebral traumatic syndrome comprises measures such as reducing intracranial pressure, scavenging free radicals, hyperbaric oxygen, nutrition cranial nerve, although the medicine for the treatment of this disease is at present more, but the less-than-ideal problem of ubiquity curative effect, and existing medicine great majority are Western medicine, although these Western medicine have certain curative effect, it is also obvious to there is toxic and side effects in it.
The advantage of the further performance traditional Chinese medical science, can treat post cerebral traumatic syndrome.But the existing Chinese medicine effectively can treating post cerebral traumatic syndrome lacks still very much, and effective percentage is not high.
Summary of the invention
The present invention is directed to above-mentioned the deficiencies in the prior art, provide a kind of therapeutic effect good, have no side effect, the Chinese medicine preparation of the treatment post cerebral traumatic syndrome of determined curative effect.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of Chinese medicine preparation for the treatment of post cerebral traumatic syndrome, and raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 10-20 part, Flos Chrysanthemi 3-5 part, Radix Polygalae 3-5 part, Semen Ziziphi Spinosae (parched) 10-20 part, Dens Draconis 10-20 part, Concha Ostreae 10-20 part, Concha Margaritifera 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Angelicae Sinensis 10-20 part, Semen Persicae 10-20 part, Poria 10-20 part, Radix Paeoniae Rubra 10-20 part, Caulis Polygoni Multiflori 20-30 part, Rhizoma Gastrodiae 5-10 part.
Further, the best raw material composition making effective ingredient and weight proportion are: Ramulus Uncariae Cum Uncis 10 parts, Flos Chrysanthemi 3 parts, Radix Polygalae 5 parts, Semen Ziziphi Spinosae (parched) 10 parts, Caulis Polygoni Multiflori 20 parts, Dens Draconis 10 parts, Concha Ostreae 10 parts, Concha Margaritifera 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Semen Persicae, Radix Paeoniae Rubra 10 parts, 10 parts, Poria, Caulis Polygoni Multiflori 20 parts, 5 parts, Rhizoma Gastrodiae.
Described preparation is said dosage form on any one pharmaceutics, as capsule preparations, dissolved granule, tablet, decoction, pill, oral liquid formulations etc., utilizes the routine techniques of pharmaceutical industry to make.
Traditional medicine thinks that post cerebral traumatic syndrome system is by cranial traumas tumbling down, undermine top, mountain peak, upset gods, clear sun is obstructed, QI and blood is not smooth, check network road, therefore often cause headache, dizziness, nausea and vomiting, forgetful insomnia, have a dream vexed wait series of symptoms, benefit with beneficial brain calm the nerves, calmness is nourished heart, the method for blood circulation promoting and blood stasis dispelling, recover to make function.This is dialectical basis of the present invention.
The present invention is made up of 14 taste Chinese medicines, wherein Ramulus Uncariae Cum Uncis endogenous wind stopping relieving convulsion, kind controls headache, feeling of fullness in the head, tinnitus, dizzy; Flos Chrysanthemi refresh oneself, treats dizzy; Papillary can fall apart the mansion of sun clearly.Poria promoting diuresis with drugs of tasteless flavour is with the intracranial swelling that disappears, and energy mind tranquilizing and the heart calming; Radix Polygalae calming heart for resuscitation, Semen Ziziphi Spinosae tranquilizing by nourishing the heart, Dens Draconis, Concha Ostreae tranquillizing and allaying excitement, three medicines share plays beneficial brain benefit marrow, effect of mind tranquilizing and the heart calming, calmness altogether.Be aided with that Caulis Polygoni Multiflori can treat malaise, palpitation with fear insomnia, staring spells, irritability be afraid of that frightened, the state of mind is anticipated the diseases such as unrest, forgetful dreaminess.Concha Margaritifera kind peace soul, arresting convulsion is throbbed with fear.Rhizoma Chuanxiong blood-activating and qi-promoting, can priming up, be aided with Rhizoma Gastrodiae and can treat headache again.Radix Angelicae Sinensis, Semen Persicae, Radix Paeoniae Rubra blood circulation promoting and blood stasis dispelling, be apt to control traumatic injury, blood stasis is had a pain.Nourish heart medicine with beneficial brain mind tranquilizing and the heart calming with calmness, uses drug for invigorating blood circulation and eliminating stasis reducing swelling and alleviating pain, help with refresh oneself, inducing diuresis and reducing edema product dizzy to treat headache, full side plays beneficial brain altogether and calms the nerves, effect of blood circulation promoting and blood stasis dispelling.
The present invention carries out developing, process, develop and obtaining according to the traditional proved recipe in locality, medicine itself does not have toxic and side effects, more safe and reliable, medicine successful, its production method is simple simultaneously, Conventional processing methods is used for, in the production of crude drug provided by the invention, can not causing the loss of effective ingredient; And in this invention preparation, raw material easily obtains.
Instructions of taking is as follows, wherein
The instructions of taking of capsule preparations: raw material of the present invention is weighed according to weight proportion, kilogram to be processed into fine powder for unit of weight, cross 100 mesh sieves, mix homogeneously, ozone sterilization 20 minutes, technique makes capsule routinely, every heavy 0.5 gram, and every day respectively takes 1 time, each 4-6 grain sooner or later, warm water delivery service, takes 1 month continuously.
The instructions of taking of dissolved granule: raw material of the present invention is weighed according to weight proportion, be 1:(4-5 with water with weight ratio by formula of the present invention again) mix, getting formula 110g of the present invention at this joins in 500mL water, after being fully mixed into medicinal liquid, medicinal liquid is decocted into cream, be condensed into granule, pack, respectively takes 1 bag sooner or later by every bag heavy 3 grams, warm water delivery service, takes 1 month continuously.
The instructions of taking of tablet: raw material of the present invention is weighed according to weight proportion, kilogram to be processed into fine powder for unit of weight, then tablet processing technology routinely, medicated powder is pressed into the tablet of 0.3 gram every, every day respectively takes 1 time, each 3-4 sheet sooner or later, warm water delivery service, takes 1 month continuously.
The instructions of taking of decoction: weighed according to weight proportion by raw material of the present invention, routinely decoction processing technology, be fried into decoction and take, every day potion, every day sooner or later respectively takes 1 time, takes 1 month continuously.
The instructions of taking of pill: weighed according to weight proportion by raw material of the present invention, fried concentrated, the honey of technique is smelt ball routinely, and every ball weighs 0.5 gram, and every day respectively takes 1 time sooner or later, and each 6 balls, take 1 month continuously.
The instructions of taking of oral liquid formulations: raw material of the present invention is weighed according to weight proportion, be 1:(9-10 with water with weight ratio by formula of the present invention again) mix, getting formula 110g of the present invention at this joins in 1000mL water, after being fully mixed into medicinal liquid, then oral liquid processing technology routinely, medicinal liquid is decocted and is concentrated into 200ml, every day respectively takes 1 time sooner or later, each 10-20ml, warm water delivery service, takes 1 month continuously.
1 clinical data:
1.1 physical data
Case is selected from the 132 routine post cerebral traumatic syndrome patients that in March, 2011 to 2012, year Haiyang City the People's Hospital of Shandong Province in February accepted for medical treatment, age 18-65 year.When being admitted to hospital, GCS scoring 5 ~ 12 points, is clearly post cerebral traumatic syndrome through neurologic check, head CT clinical diagnosis.132 routine post cerebral traumatic syndrome patients are divided into treatment group 66 example at random, matched group 66 example.The concrete typing of two groups of patient ages, sex ratio, craniocerebral trauma, whether accept the equal not statistically significants of aspect difference (p>0.05) such as emergency operation with or without after combined injury, wound, there is comparability, in table 1.
The patient clinical data of table 1 treatment group and matched group compares
Note: treatment group is statistics zero difference compared with matched group.
1.2 Therapeutic Method
Matched group gives every conventional therapy, comprises hemostasis, dewaters, falls cranium pressure, antiinflammatory, nutrition, prevention epilepsy, surgical operation and other symptomatic treatments, do not use decoct of the present invention.The same matched group for the treatment of group conventional therapy, separately gives formula decoction of the present invention, fried by systematic unity of boiling medicine during clinical application, 250mL decocted into by every agent medicine, point two bags of packagings, sooner or later respectively takes 1 bag, can not take food if any patient, use stomach tube nasal feeding, within one month, be 1 course for the treatment of, observe 6 months.
1.3 observation index
(1) mortality rate.(2) stupor index score (being called for short GCS).(3) convalescence appraisal of life quality (being called for short KPS).(4) auxiliary examination, comprises blood, routine urinalysis, Liver and kidney function inspection.
The situation of record patient weekly.6 months are followed up a case by regular visits to after leaving hospital.Require that patient at least monthly accepts 1 state of an illness and follows up a case by regular visits to.Observe in medication process and record various Drug side reaction that may be relevant with medication simultaneously. comprise erythra, hepatic and renal function injure etc.
1.4 statistical method
SPSS13.0 software is adopted to carry out statistical analysis to data.All data all with
represent, compare contrast t inspection before and after adopting in group, comparing employing one factor analysis of variance between group, is that difference has statistical significance with P<0.05.
2 results
Efficacy analysis during 2.1 mortality rates and medication
Treatment group death totally 4 examples, account for 6.1%, matched group altogether dead 5 examples, account for 7.6%, two groups of mortality difference not statistically significant (χ
2=0.0000, P=1.000).After medication the 14th day, treatment group GCS scoring started higher than matched group, and two group differences have statistical significance (P<0.05), in table 2.
2.2 convalescence efficacy analysis
Follow-up results shows: the KPS for the treatment of group patient is obviously better than matched group, and difference has statistical significance, in table 2.
Table 2 liang group patient GCS scoring, KPS scoring are compared
| Group | 1st day | 7th day | 14th day | 21st day | 6 months |
| Treatment group (n=66) | 9.09±1.63 | 11.48±2.65 | 14.36±1.91 | 14.79±1.26 | 91.3±10.9 |
| Matched group (n=66) | 9.19±1.59 | 11.57±2.52 | 13.67±2.01 | 13.64±1.31 | 85.5±10.3 |
| T value | 0.3568 | 0.1119 | 2.0217 | 5.1401 | 3.142 |
| P value | 0.7218 | 0.8418 | 0.0453 | 0.0000 | 0.0021 |
Note: treatment group statistics compared with matched group has notable difference.
The safety of 2.3 medications: blood, routine urinalysis, Liver and kidney function inspection
At treatments period, treatment group has 3 examples and finds after medication, occur that slight routine blood test, hepatic and renal function are abnormal, but also no evidence thinks relevant with medication, and all takes a turn for the better after symptomatic treatment.Other patients all do not find the obvious side reaction because medication causes.
Therapeutic effect:
Can be drawn by above experimental data, therapeutic effect of the present invention is significantly higher than matched group, proves treatment hundreds post cerebral traumatic syndrome patient, obtains good curative effect.The present invention has that beneficial brain is calmed the nerves, calmness is nourished heart, effect of blood circulation promoting and blood stasis dispelling.
Detailed description of the invention
Be described principle of the present invention and feature below, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
Treat a Chinese medicine preparation for post cerebral traumatic syndrome, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 10 parts, Flos Chrysanthemi 3 parts, Radix Polygalae 5 parts, Semen Ziziphi Spinosae (parched) 10 parts, Dens Draconis 10 parts, Concha Ostreae 10 parts, Concha Margaritifera 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Semen Persicae, Radix Paeoniae Rubra 10 parts, 10 parts, Poria, Caulis Polygoni Multiflori 20 parts, Caulis Polygoni Multiflori 20 parts, 5 parts, Rhizoma Gastrodiae.
Embodiment 2
Treat a Chinese medicine preparation for post cerebral traumatic syndrome, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 15 parts, Flos Chrysanthemi 4 parts, Radix Polygalae 4 parts, Semen Ziziphi Spinosae (parched) 15 parts, Dens Draconis 15 parts, Concha Ostreae 15 parts, Concha Margaritifera 15 parts, Rhizoma Chuanxiong 15 parts, Radix Angelicae Sinensis 15 parts, 15 parts, Semen Persicae, 15 parts, Poria, Radix Paeoniae Rubra 15 parts, Caulis Polygoni Multiflori 25 parts, 7 parts, Rhizoma Gastrodiae.
Embodiment 3
Treat a Chinese medicine preparation for post cerebral traumatic syndrome, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 20 parts, Flos Chrysanthemi 5 parts, Radix Polygalae 5 parts, Semen Ziziphi Spinosae (parched) 20 parts, Dens Draconis 20 parts, Concha Ostreae 20 parts, Concha Margaritifera 20 parts, Rhizoma Chuanxiong 20 parts, Radix Angelicae Sinensis 20 parts, 20 parts, Semen Persicae, 20 parts, Poria, Radix Paeoniae Rubra 20 parts, Caulis Polygoni Multiflori 30 parts, 10 parts, Rhizoma Gastrodiae.
Embodiment 4
Treat a Chinese medicine preparation for post cerebral traumatic syndrome, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 13 parts, Flos Chrysanthemi 4 parts, Radix Polygalae 3 parts, Semen Ziziphi Spinosae (parched) 15 parts, Dens Draconis 12 parts, Concha Ostreae 18 parts, Concha Margaritifera 18 parts, Rhizoma Chuanxiong 12 parts, Radix Angelicae Sinensis 15 parts, 14 parts, Semen Persicae, 13 parts, Poria, Radix Paeoniae Rubra 12 parts, Caulis Polygoni Multiflori 25 parts, 7 parts, Rhizoma Gastrodiae.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from which point, above-mentioned embodiment of the present invention all can only be thought explanation of the present invention and can not limit the present invention, claims indicate scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, any change in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (3)
1. treat the Chinese medicine preparation of post cerebral traumatic syndrome for one kind, it is characterized in that, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 10-20 part, Flos Chrysanthemi 3-5 part, Radix Polygalae 3-5 part, Semen Ziziphi Spinosae (parched) 10-20 part, Dens Draconis 10-20 part, Concha Ostreae 10-20 part, Concha Margaritifera 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Angelicae Sinensis 10-20 part, Semen Persicae 10-20 part, Radix Paeoniae Rubra 10-20 part, Poria 10-20 part, Caulis Polygoni Multiflori 20-30 part, Rhizoma Gastrodiae 5-10 part.
2. the Chinese medicine preparation for the treatment of post cerebral traumatic syndrome according to claim 1, it is characterized in that, raw material composition and the weight proportion of making effective ingredient are: Ramulus Uncariae Cum Uncis 10 parts, Flos Chrysanthemi 3 parts, Radix Polygalae 5 parts, Semen Ziziphi Spinosae (parched) 10 parts, Dens Draconis 10 parts, Concha Ostreae 10 parts, Concha Margaritifera 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Semen Persicae, Radix Paeoniae Rubra 10 parts, 10 parts, Poria, Caulis Polygoni Multiflori 20 parts, 5 parts, Rhizoma Gastrodiae.
3. the Chinese medicine preparation for the treatment of post cerebral traumatic syndrome according to claim 1 and 2, is characterized in that, described preparation is said dosage form on any one pharmaceutics.
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| CN104665413B (en) * | 2014-12-26 | 2016-05-18 | 郭巍 | A kind of traditional Chinese medicine medical pillow of having a headache after after craniocerebral injury or operation of intracranial tumor for the treatment of |
| CN104815253A (en) * | 2015-05-15 | 2015-08-05 | 徐德玲 | Traditional Chinese medicine preparation for treating head injury sequela |
| CN106860709A (en) * | 2017-03-28 | 2017-06-20 | 华北理工大学 | A kind of Chinese medicine preparation for treating post cerebral traumatic syndrome |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102631579A (en) * | 2012-04-18 | 2012-08-15 | 中国人民解放军第三医院 | Oral Chinese herbal preparation for treating post-traumatic brain syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102631579A (en) * | 2012-04-18 | 2012-08-15 | 中国人民解放军第三医院 | Oral Chinese herbal preparation for treating post-traumatic brain syndrome |
Non-Patent Citations (3)
| Title |
|---|
| 中西医结合治疗外伤性低颅压综合征20例;鄢明东;《湖南中医杂志》;20000930;第16卷(第5期);34 * |
| 脑外伤后综合征的辨证治疗探讨;李逊;《陕西中医》;20091231;第30卷(第6期);702-703 * |
| 脑外伤综合征辨证论治;彭本旭;《中医正骨》;19961231;第8卷(第3期);33-34 * |
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