CN113412263A - 氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途 - Google Patents

氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途 Download PDF

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Publication number
CN113412263A
CN113412263A CN202180001692.XA CN202180001692A CN113412263A CN 113412263 A CN113412263 A CN 113412263A CN 202180001692 A CN202180001692 A CN 202180001692A CN 113412263 A CN113412263 A CN 113412263A
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CN
China
Prior art keywords
alkyl
compound
formula
membered saturated
pharmaceutically acceptable
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Pending
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CN202180001692.XA
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English (en)
Inventor
胡斌
谢婧
张凯
杨文�
石晓永
关慧平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yangtze River Pharmaceutical Group Co Ltd
Shanghai Haiyan Pharmaceutical Technology Co Ltd
Original Assignee
Yangtze River Pharmaceutical Group Co Ltd
Shanghai Haiyan Pharmaceutical Technology Co Ltd
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Application filed by Yangtze River Pharmaceutical Group Co Ltd, Shanghai Haiyan Pharmaceutical Technology Co Ltd filed Critical Yangtze River Pharmaceutical Group Co Ltd
Publication of CN113412263A publication Critical patent/CN113412263A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

Abstract

提供了氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途。具体地，提供了式(I)和式(Ⅱ)化合物或其药学上可接受的盐、立体异构体或溶剂化物，及其制备方法和应用。

Description

PCT国内申请，说明书已公开。

Claims (51)

  1. PCT国内申请，权利要求书已公开。
CN202180001692.XA 2020-01-17 2021-01-15 氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途 Pending CN113412263A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020100520393 2020-01-17
CN202010052039 2020-01-17
PCT/CN2021/072015 WO2021143801A1 (zh) 2020-01-17 2021-01-15 氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途

Publications (1)

Publication Number Publication Date
CN113412263A true CN113412263A (zh) 2021-09-17

Family

ID=76863582

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180001692.XA Pending CN113412263A (zh) 2020-01-17 2021-01-15 氮杂双环取代的氧杂螺环衍生物、其制法与医药上的用途

Country Status (8)

Country Link
US (1) US20230128062A1 (zh)
EP (1) EP4092031A4 (zh)
JP (1) JP7442652B2 (zh)
KR (1) KR20220128428A (zh)
CN (1) CN113412263A (zh)
AU (1) AU2021208113B2 (zh)
CA (1) CA3164577A1 (zh)
WO (1) WO2021143801A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819171A (zh) * 2022-07-25 2023-03-21 成都苑东生物制药股份有限公司 一种mor受体激动剂合成路线中关键中间体的手性拆分方法

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* Cited by examiner, † Cited by third party
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WO2022143715A1 (zh) * 2020-12-29 2022-07-07 上海海雁医药科技有限公司 氧杂螺环取代的吡咯并吡唑衍生物及其中间体和制备方法
CN117529481A (zh) * 2021-07-13 2024-02-06 上海海雁医药科技有限公司 Mor受体激动剂的药学上可接受的盐、其多晶型物及其用途
WO2023284775A1 (zh) * 2021-07-14 2023-01-19 上海海雁医药科技有限公司 吡唑衍生物及其中间体和制备方法
WO2023011422A1 (zh) * 2021-08-02 2023-02-09 上海枢境生物科技有限公司 氧杂螺环类衍生物、制备方法及其用途

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WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用
WO2018188641A1 (zh) * 2017-04-14 2018-10-18 江苏恒瑞医药股份有限公司 一种mor激动剂与kor激动剂的药物组合物及其用途
WO2019052557A1 (zh) * 2017-09-18 2019-03-21 上海华汇拓医药科技有限公司 μ-阿片受体激动剂及其制备方法和在医药领域的应用
WO2019205983A1 (zh) * 2018-04-28 2019-10-31 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途

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JP5912169B2 (ja) 2011-03-23 2016-04-27 トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． オピオイド受容体リガンド並びにそれらの使用方法及び製造方法
CN108366997A (zh) 2015-12-14 2018-08-03 特维娜有限公司 治疗痛觉过敏的方法
US20190008803A1 (en) 2015-12-17 2019-01-10 Trevena, Inc. Combinations of opioid receptor ligands and cytochrome p450 inhibitors
CN111662284B (zh) * 2019-03-06 2021-08-10 上海海雁医药科技有限公司 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途

Patent Citations (4)

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WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用
WO2018188641A1 (zh) * 2017-04-14 2018-10-18 江苏恒瑞医药股份有限公司 一种mor激动剂与kor激动剂的药物组合物及其用途
WO2019052557A1 (zh) * 2017-09-18 2019-03-21 上海华汇拓医药科技有限公司 μ-阿片受体激动剂及其制备方法和在医药领域的应用
WO2019205983A1 (zh) * 2018-04-28 2019-10-31 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819171A (zh) * 2022-07-25 2023-03-21 成都苑东生物制药股份有限公司 一种mor受体激动剂合成路线中关键中间体的手性拆分方法

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Publication number Publication date
JP7442652B2 (ja) 2024-03-04
AU2021208113B2 (en) 2023-11-30
JP2023510622A (ja) 2023-03-14
KR20220128428A (ko) 2022-09-20
CA3164577A1 (en) 2021-07-22
EP4092031A1 (en) 2022-11-23
EP4092031A4 (en) 2024-02-21
WO2021143801A1 (zh) 2021-07-22
US20230128062A1 (en) 2023-04-27
AU2021208113A1 (en) 2022-09-08

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