CN1133635C - 用于结合***受体的氰基吡咯类 - Google Patents
用于结合***受体的氰基吡咯类 Download PDFInfo
- Publication number
- CN1133635C CN1133635C CNB00807139XA CN00807139A CN1133635C CN 1133635 C CN1133635 C CN 1133635C CN B00807139X A CNB00807139X A CN B00807139XA CN 00807139 A CN00807139 A CN 00807139A CN 1133635 C CN1133635 C CN 1133635C
- Authority
- CN
- China
- Prior art keywords
- oxo
- dihydro
- dimethyl
- pyrroles
- benzoxazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18305099P | 1999-05-04 | 1999-05-04 | |
US09/304,550 | 1999-05-04 | ||
US09/552,544 US6407101B1 (en) | 1999-05-04 | 2000-04-19 | Cyanopyrroles |
US09/552,544 | 2000-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1349531A CN1349531A (zh) | 2002-05-15 |
CN1133635C true CN1133635C (zh) | 2004-01-07 |
Family
ID=26878699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB00807139XA Expired - Fee Related CN1133635C (zh) | 1999-05-04 | 2000-05-01 | 用于结合***受体的氰基吡咯类 |
Country Status (15)
Country | Link |
---|---|
US (5) | US6407101B1 (zh) |
EP (1) | EP1173433B1 (zh) |
JP (2) | JP4836331B2 (zh) |
CN (1) | CN1133635C (zh) |
AT (1) | ATE314365T1 (zh) |
AU (1) | AU4980000A (zh) |
CA (1) | CA2372560C (zh) |
CY (1) | CY1105688T1 (zh) |
DE (1) | DE60025189T2 (zh) |
DK (1) | DK1173433T3 (zh) |
ES (1) | ES2256008T3 (zh) |
HK (1) | HK1043990B (zh) |
MX (1) | MXPA01011295A (zh) |
SI (1) | SI1173433T1 (zh) |
WO (1) | WO2000066581A1 (zh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
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US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
US7192956B2 (en) * | 2002-06-25 | 2007-03-20 | Wyeth | Methods of treating hormone-related conditions using cyclothiocarbamate derivatives |
EP1531806A4 (en) * | 2002-06-25 | 2005-09-21 | Wyeth Corp | USE OF THIO-OXINDOLE DERIVATIVES IN THE TREATMENT OF HORMONE-RELATED DISEASES |
CA2489810A1 (en) * | 2002-06-25 | 2003-12-31 | Wyeth | Use of thio-oxindole derivatives in treatment of skin disorders |
KR20050013627A (ko) * | 2002-06-25 | 2005-02-04 | 와이어쓰 | Pr 조절제로서의 사이클로티오카바메이트 유도체 및피부 질환을 치료하기 위한 이의 용도 |
CL2003001544A1 (es) * | 2002-10-11 | 2005-01-07 | Ligand Pharm Inc | Compuestos derivados de 5-cicloalquenil-5h-cromeno[3,4-f]quinolina de formula i, moduladores selectivos del receptor de progesterona; composicion farmaceutica; y su uso en el tratamiento de sangrado uterino disfuncional, dismenorrea, endometriosis, l |
AR040783A1 (es) * | 2002-10-11 | 2005-04-20 | Ligand Pharm Inc | 5-(1',1'-cicloaquil/alquenil) metiliden-1,2 -dihidro-5-h-cromeno [3,4- f] quiinolinas como compuestos moduladores selectivos de receptores de progesterona |
US7247625B2 (en) * | 2003-10-09 | 2007-07-24 | Wyeth | 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators |
US7323455B2 (en) * | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
CA2561014C (en) * | 2004-04-08 | 2013-09-10 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
CN1938298B (zh) | 2004-04-08 | 2013-02-06 | 惠氏公司 | 减少硫代酰胺杂质的方法 |
PL1756095T3 (pl) * | 2004-04-27 | 2008-10-31 | Wyeth Corp | Cyjanopirole zawierające cykliczne karbaminianowe i tiokarbaminianowe biaryle oraz sposoby ich wytwarzania |
PE20060331A1 (es) * | 2004-04-27 | 2006-05-16 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos |
AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
BRPI0512991A (pt) | 2004-07-07 | 2008-04-22 | Wyeth Corp | uso de uma progestina, kit farmaceuticamente útil adaptado para a administração oral diária, e, método de contracepção em uma fêmea em idade de parto |
GT200500186A (es) * | 2004-07-07 | 2006-03-02 | Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits | |
GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
GT200500183A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
JP2008510722A (ja) | 2004-08-20 | 2008-04-10 | ワイス | プロゲステロン受容体構造 |
MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
EP2422796A3 (en) | 2006-03-07 | 2013-03-13 | Geeta Shroff | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation |
US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
US20110237567A9 (en) * | 2006-10-12 | 2011-09-29 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
BRPI0719210A2 (pt) * | 2006-10-12 | 2015-05-05 | Xenon Pharmaceuticals Inc | Uso de compostos espiro-oxindol como agentes terapêuticos |
CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
AU2008341138A1 (en) * | 2007-12-20 | 2009-07-02 | Teva Women's Health, Inc. | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
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EP3266444A1 (en) | 2010-02-26 | 2018-01-10 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
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-
2000
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- 2000-05-01 DE DE60025189T patent/DE60025189T2/de not_active Expired - Lifetime
- 2000-05-01 AU AU49800/00A patent/AU4980000A/en not_active Abandoned
- 2000-05-01 WO PCT/US2000/011844 patent/WO2000066581A1/en active IP Right Grant
- 2000-05-01 JP JP2000615611A patent/JP4836331B2/ja not_active Expired - Fee Related
- 2000-05-01 EP EP00932005A patent/EP1173433B1/en not_active Expired - Lifetime
- 2000-05-01 SI SI200030830T patent/SI1173433T1/sl unknown
- 2000-05-01 CA CA002372560A patent/CA2372560C/en not_active Expired - Fee Related
- 2000-05-01 ES ES00932005T patent/ES2256008T3/es not_active Expired - Lifetime
- 2000-05-01 CN CNB00807139XA patent/CN1133635C/zh not_active Expired - Fee Related
- 2000-05-01 MX MXPA01011295A patent/MXPA01011295A/es active IP Right Grant
- 2000-05-01 AT AT00932005T patent/ATE314365T1/de not_active IP Right Cessation
- 2000-05-01 DK DK00932005T patent/DK1173433T3/da active
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2002
- 2002-01-09 US US10/043,513 patent/US6562857B2/en not_active Expired - Lifetime
- 2002-06-28 HK HK02104856.3A patent/HK1043990B/zh not_active IP Right Cessation
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2003
- 2003-01-15 US US10/342,719 patent/US6982261B2/en not_active Expired - Fee Related
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2005
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2010
- 2010-10-29 US US12/915,211 patent/US8476262B2/en not_active Expired - Fee Related
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2011
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EP1173433B1 (en) | 2005-12-28 |
EP1173433A1 (en) | 2002-01-23 |
US7846924B2 (en) | 2010-12-07 |
JP2002543197A (ja) | 2002-12-17 |
US6562857B2 (en) | 2003-05-13 |
CN1349531A (zh) | 2002-05-15 |
CA2372560C (en) | 2009-09-15 |
DE60025189T2 (de) | 2006-09-07 |
US20030158182A1 (en) | 2003-08-21 |
SI1173433T1 (sl) | 2006-06-30 |
MXPA01011295A (es) | 2003-07-14 |
US8476262B2 (en) | 2013-07-02 |
ES2256008T3 (es) | 2006-07-16 |
CA2372560A1 (en) | 2000-11-09 |
HK1043990B (zh) | 2006-05-04 |
JP2011236225A (ja) | 2011-11-24 |
WO2000066581A1 (en) | 2000-11-09 |
US20050256110A1 (en) | 2005-11-17 |
WO2000066581A8 (en) | 2002-05-30 |
ATE314365T1 (de) | 2006-01-15 |
US6407101B1 (en) | 2002-06-18 |
DK1173433T3 (da) | 2006-05-15 |
US6982261B2 (en) | 2006-01-03 |
AU4980000A (en) | 2000-11-17 |
DE60025189D1 (de) | 2006-02-02 |
JP4836331B2 (ja) | 2011-12-14 |
HK1043990A1 (en) | 2002-10-04 |
US20110039839A1 (en) | 2011-02-17 |
US20020068735A1 (en) | 2002-06-06 |
CY1105688T1 (el) | 2010-12-22 |
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