CN1132566C - 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 - Google Patents
在胶囊中填充囊芯的方法和由该方法制得的固体剂型 Download PDFInfo
- Publication number
- CN1132566C CN1132566C CN95196811A CN95196811A CN1132566C CN 1132566 C CN1132566 C CN 1132566C CN 95196811 A CN95196811 A CN 95196811A CN 95196811 A CN95196811 A CN 95196811A CN 1132566 C CN1132566 C CN 1132566C
- Authority
- CN
- China
- Prior art keywords
- capsule
- dosage forms
- solid dosage
- core
- moisture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (52)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35813794A | 1994-12-16 | 1994-12-16 | |
US08/358,137 | 1994-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1170346A CN1170346A (zh) | 1998-01-14 |
CN1132566C true CN1132566C (zh) | 2003-12-31 |
Family
ID=23408454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95196811A Expired - Lifetime CN1132566C (zh) | 1994-12-16 | 1995-11-09 | 在胶囊中填充囊芯的方法和由该方法制得的固体剂型 |
Country Status (14)
Country | Link |
---|---|
US (1) | US6080426A (zh) |
EP (1) | EP0797424B1 (zh) |
JP (1) | JP3670016B2 (zh) |
KR (1) | KR100468335B1 (zh) |
CN (1) | CN1132566C (zh) |
AT (1) | ATE194486T1 (zh) |
CA (1) | CA2205553C (zh) |
DE (1) | DE69518006T2 (zh) |
DK (1) | DK0797424T3 (zh) |
ES (1) | ES2150017T3 (zh) |
GR (1) | GR3034491T3 (zh) |
MX (1) | MX9703773A (zh) |
PT (1) | PT797424E (zh) |
WO (1) | WO1996018370A1 (zh) |
Families Citing this family (64)
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---|---|---|---|---|
US6245350B1 (en) | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
JP3670016B2 (ja) * | 1994-12-16 | 2005-07-13 | ワーナー−ランバート・カンパニー | カプレットをカプセル内に封入する方法及びかかる方法により得ることができる固体剤形 |
FR2757173A1 (fr) * | 1996-12-17 | 1998-06-19 | Warner Lambert Co | Compositions polymeres d'origine non-animale pour la formation de films |
US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
JP2004525109A (ja) * | 2001-02-15 | 2004-08-19 | キング・ファーマシューティカルズ・インコーポレイティッド | 安定化された甲状腺ホルモン医薬組成物、及びその製法 |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
US20030072731A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing starch or dextrin |
US20030070584A1 (en) * | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
DE10125883A1 (de) | 2001-05-28 | 2002-12-12 | Serumwerk Bernburg Ag | Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie |
WO2002098403A1 (en) * | 2001-06-01 | 2002-12-12 | Georgetown University | Steroid hormone and non-steroidal anti-inflammatory drug combinations for inducing tumor cell apoptosis |
ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
US8309118B2 (en) * | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US20040146559A1 (en) * | 2002-09-28 | 2004-07-29 | Sowden Harry S. | Dosage forms having an inner core and outer shell with different shapes |
US20040253312A1 (en) | 2001-09-28 | 2004-12-16 | Sowden Harry S. | Immediate release dosage form comprising shell having openings therein |
US20030175337A1 (en) * | 2001-10-29 | 2003-09-18 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
US20030166732A1 (en) * | 2002-02-27 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
US7169450B2 (en) * | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
US6946156B2 (en) * | 2002-05-15 | 2005-09-20 | Mcneil-Ppc, Inc. | Process for enrobing a core |
US7429619B2 (en) * | 2002-08-02 | 2008-09-30 | Mcneil Consumer Healthcare | Polyacrylic film forming compositions |
EP1396263A1 (en) * | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
ES2355233T3 (es) | 2002-09-28 | 2011-03-24 | Mcneil-Ppc, Inc. | Formas de dosificación de liberación modificada con dos núcleos y una abertura. |
US20050079213A1 (en) * | 2003-06-06 | 2005-04-14 | Unilab Pharmatech Ltd | Pharmaceutical compositions |
AU2004261143B2 (en) * | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
EP1648425B1 (en) * | 2003-07-30 | 2007-02-21 | Merrion Research I Limited | Process and Machine for the Automated Manufacture of Gastro-Retentive Capsules |
US7879354B2 (en) | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US8067029B2 (en) | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
US20080102116A1 (en) * | 2004-09-13 | 2008-05-01 | Perrigo Company | Quick Dissolve Medicament and Method of Manufacturing |
AU2006206359B2 (en) * | 2005-01-21 | 2011-03-31 | Allergan Pharmaceuticals International Limited | A tetracycline metal complex in a solid dosage form |
US20060222699A1 (en) * | 2005-03-29 | 2006-10-05 | Jonathan Gilinski | Flavored vegetarian cellulose capsule and methods for producing said capsule. |
US20070072910A1 (en) * | 2005-09-29 | 2007-03-29 | Smith Michael L | Compositions and methods for lowering plasma concentrations of low density lipoproteins in humans |
MX2008012575A (es) * | 2006-03-28 | 2008-12-17 | Mcneil Ppc Inc | Revestimientos no homogeneos de formas de dosificacion. |
EP2433621B1 (en) | 2006-09-15 | 2013-05-01 | Capsugel Belgium NV | Rapidly disintegrating dosage form |
WO2008042802A2 (en) * | 2006-09-29 | 2008-04-10 | Sensient Pharmaceutical Technologies Inc. | Wet edible pearlescent film coatings |
PL2099312T3 (pl) * | 2006-12-14 | 2016-10-31 | Kompozycje pigmentów perłowych oraz sposoby ich wytwarzania i zastosowania | |
US20100172991A1 (en) * | 2007-06-08 | 2010-07-08 | Henry Joseph Horacek | Extended Release Formulation and Methods of Treating Adrenergic Dysregulation |
US20090087490A1 (en) * | 2007-06-08 | 2009-04-02 | Addrenex Pharmaceuticals, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
US20100092548A1 (en) * | 2008-08-28 | 2010-04-15 | Viva Pharmaceuticals Inc. | Chewable softgel capsules |
WO2010065069A2 (en) * | 2008-12-01 | 2010-06-10 | In Vasc Therapeutics, Inc. | Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders |
US20120045510A1 (en) | 2010-08-18 | 2012-02-23 | Joel Waldman | Tablet sleeve for improved performance |
US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
CN102688212B (zh) * | 2012-05-29 | 2013-08-07 | 北京均大高科科技孵化器有限公司 | 一种单硝酸异山梨酯缓释片及其制备方法 |
US20140141075A1 (en) | 2012-11-21 | 2014-05-22 | Warner Chilcott Company, Llc | 5-aminosalicylic acid capsule formulation |
US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
CN103461335B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂的制备方法 |
CN103461336B (zh) * | 2013-09-26 | 2015-08-05 | 卞佳林 | 一种多杀菌素和灰黄霉素复合微囊杀虫剂 |
EP3167869A1 (en) | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof oral dosage form |
EP3167870B1 (en) | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
US11318101B2 (en) | 2016-07-06 | 2022-05-03 | Qualicaps Co., Ltd. | Hard capsule having improved hardness, and method for manufacturing same |
RU2749902C2 (ru) * | 2018-10-31 | 2021-06-18 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Фармацевтическая композиция для лечения инфекционно-воспалительных заболеваний |
CN110279890A (zh) * | 2019-04-15 | 2019-09-27 | 首都医科大学附属北京世纪坛医院 | 基于脂质体的***/米诺环素在peek表面的修饰方法及应用 |
EP3805577A1 (en) * | 2019-10-11 | 2021-04-14 | Hilti Aktiengesellschaft | Threadlike package |
Citations (5)
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---|---|---|---|---|
US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
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US1520940A (en) * | 1922-03-01 | 1924-12-30 | Dulitz August Adolf | Process for the manufacture of sealing caps and for applying them onto the vessels to be sealed |
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US1657982A (en) * | 1926-02-15 | 1928-01-31 | Parke Davis & Co | Process of manufacturing gelatin capsules for use as bottle caps |
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DE2010987C3 (de) * | 1970-03-09 | 1979-03-15 | Ibm Deutschland Gmbh, 7000 Stuttgart | Verfahren zum "Herstellen von Dunnschicht-Magnetköpfen mit magnetischer Anisotropie |
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US5415868A (en) * | 1993-06-09 | 1995-05-16 | L. Perrigo Company | Caplets with gelatin cover and process for making same |
JP3670016B2 (ja) * | 1994-12-16 | 2005-07-13 | ワーナー−ランバート・カンパニー | カプレットをカプセル内に封入する方法及びかかる方法により得ることができる固体剤形 |
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-
1995
- 1995-11-09 JP JP51881996A patent/JP3670016B2/ja not_active Expired - Fee Related
- 1995-11-09 PT PT95939890T patent/PT797424E/pt unknown
- 1995-11-09 DK DK95939890T patent/DK0797424T3/da active
- 1995-11-09 DE DE69518006T patent/DE69518006T2/de not_active Expired - Lifetime
- 1995-11-09 ES ES95939890T patent/ES2150017T3/es not_active Expired - Lifetime
- 1995-11-09 MX MX9703773A patent/MX9703773A/es unknown
- 1995-11-09 KR KR1019970704011A patent/KR100468335B1/ko not_active IP Right Cessation
- 1995-11-09 CA CA002205553A patent/CA2205553C/en not_active Expired - Lifetime
- 1995-11-09 WO PCT/US1995/014651 patent/WO1996018370A1/en active IP Right Grant
- 1995-11-09 EP EP95939890A patent/EP0797424B1/en not_active Expired - Lifetime
- 1995-11-09 AT AT95939890T patent/ATE194486T1/de active
- 1995-11-09 CN CN95196811A patent/CN1132566C/zh not_active Expired - Lifetime
-
1996
- 1996-01-11 US US08/585,549 patent/US6080426A/en not_active Expired - Lifetime
-
2000
- 2000-09-26 GR GR20000402180T patent/GR3034491T3/el unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3258115A (en) * | 1965-05-12 | 1966-06-28 | Scherer Corp R P | Two-piece hard gelatin capsule |
GB1496737A (en) * | 1974-06-12 | 1977-12-30 | Scherer Corp R P | Capsule especially for medicaments |
US4466844A (en) * | 1983-09-19 | 1984-08-21 | Cosden Technology, Inc. | Gripper for capsule welder |
EP0225565A2 (de) * | 1985-12-06 | 1987-06-16 | Boehringer Ingelheim Kg | Teilbare Kapsel |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
Also Published As
Publication number | Publication date |
---|---|
DE69518006D1 (de) | 2000-08-17 |
CN1170346A (zh) | 1998-01-14 |
CA2205553A1 (en) | 1996-06-20 |
PT797424E (pt) | 2000-10-31 |
JPH11500326A (ja) | 1999-01-12 |
DE69518006T2 (de) | 2000-12-21 |
ES2150017T3 (es) | 2000-11-16 |
EP0797424B1 (en) | 2000-07-12 |
DK0797424T3 (da) | 2000-10-23 |
JP3670016B2 (ja) | 2005-07-13 |
KR980700050A (ko) | 1998-03-30 |
WO1996018370A1 (en) | 1996-06-20 |
EP0797424A1 (en) | 1997-10-01 |
MX9703773A (es) | 1997-08-30 |
CA2205553C (en) | 2009-04-07 |
GR3034491T3 (en) | 2000-12-29 |
KR100468335B1 (ko) | 2005-09-02 |
US6080426A (en) | 2000-06-27 |
ATE194486T1 (de) | 2000-07-15 |
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