CN113144032A - Traditional Chinese medicine ointment for treating child anorexia and preparation method thereof - Google Patents
Traditional Chinese medicine ointment for treating child anorexia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine ointment for treating infantile anorexia, which comprises the following raw materials in parts by weight: 2-4 parts of ginseng, 6-8 parts of codonopsis pilosula, 6-8 parts of bighead atractylodes rhizome, 6-8 parts of poria cocos, 6-8 parts of honey-fried licorice root, 12-16 parts of dried orange peel, 6-8 parts of Chinese date, 10-12 parts of medical yellow vaseline, 9-11 parts of stearic acid, 2-2.6 parts of lanolin, 5.5-6.5 parts of glyceryl monostearate, 15-17 parts of glycerol, 802.5-3.5 parts of tween, 50-55 parts of water, 1.5-3.5 parts of azone and 0.05-0.1 part of potassium sorbate. The ointment of the invention can effectively promote digestion and absorption, has no side effect, has lower cost and is suitable for wide consumers.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine ointment for treating child anorexia and a preparation method thereof.
Background
Anorexia is a common disease of children, and is mostly found in children of 1-6 years old. Anorexia children lack appetite for a long time or have anorexia, and are a disease of abnormal eating behaviors of children due to inappetence and even food refusal. If the anorexia can not be improved for a long time, the anorexia can cause malnutrition, physical quality reduction, growth and development retardation and immunity reduction of children, is easy to suffer from various diseases of respiratory system, digestive system and the like, and is a common main disease influencing the growth and development of children at present.
Peripheral and/or central gastrointestinal peptides such as Gastrin (GAS), Motilin (MOT) and other secretory disorders can influence the functional activity of the appetite center, further influence the feeding behavior, and are important links for the development of infantile anorexia. It is believed that feeding behavior is controlled by both the feeding and satiety centers, which are closely related in both anatomy and function, and that it can be considered as a functional unit that controls the initiation and termination of feeding through the feeding and satiety systems. The hypothalamus is the basic site for regulating feeding behavior, and the ventral medial nucleus (VMH) acts as a satiety center to suppress feeding; paraventricular nucleus (PVN) regulates appetite by integrating the relationship between neural and hormonal signals associated with feeding; the lateral region (LH) serves as the feeding center to promote feeding. They cooperate and interact to form a complex "appetite regulating network" (ARN), in which a variety of appetite promoting factors (such as GAS, MOT) and appetite suppressing factors play an important role.
GAS, MOT and NPY before treatment of the child suffering from anorexia are obviously lower than those of normal children, which indicates that the child suffering from anorexia has gastrointestinal hormone change. Gastrin is secreted by G cells distributed in the antrum and duodenum, and also by D cells of human islets. Gastrin has effects of stimulating secretion of gastric acid and pepsin, contracting antrum and pyloric sphincter, promoting digestion, delaying gastric emptying, and promoting mucosal growth, i.e. nourishing effect. Motilin is a gastrointestinal hormone that regulates gastrointestinal motility, the higher the motilin, the faster the gastrointestinal motility and the faster the gastric emptying.
Modern medicine considers that anorexia is a treatment method for treating inappetence center from excitation to inhibition, gastrointestinal function fatigue, gastrointestinal peristalsis slowing, emptying delay, digestive juice secretion reduction and digestive enzyme activity reduction caused by improper feeding, disease factors, drug factors, mental factors, climate factors, trace element deficiency and the like, and pepsin mixture and other digestive aids, morpholine and other gastrokinetic agents, trace element supplementation, hormone and the like are mainly applied in treatment.
The traditional Chinese medicine theory considers that the disease is mainly caused by improper feeding and damages the spleen and stomach or other diseases and dysfunction of the spleen and the stomach, which leads to poor appetite of the stomach. Because of the physiological feature of "frequent insufficiency of the spleen", the child is most commonly suffering from anorexia due to deficiency of spleen-qi and stomach-qi. The dysfunction and transportation mechanism of the spleen of a patient with spleen deficiency is related to the level of gastrointestinal hormone, and some traditional Chinese medicines can influence the secretion and release of the gastrointestinal hormone so as to regulate the gastrointestinal function and the functional state of the whole body, thereby treating anorexia.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provides a traditional Chinese medicine ointment for treating child anorexia and a preparation method thereof. The ointment of the invention can effectively promote digestion and absorption, has no side effect, has lower cost and is suitable for wide consumers.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine ointment for treating child anorexia comprises the following raw materials in parts by weight:
2-4 parts of ginseng, 6-8 parts of codonopsis pilosula, 6-8 parts of bighead atractylodes rhizome, 6-8 parts of poria cocos, 6-8 parts of honey-fried licorice root, 12-16 parts of dried orange peel, 6-8 parts of Chinese date, 10-12 parts of medical yellow vaseline, 9-11 parts of stearic acid, 2-2.6 parts of lanolin, 5.5-6.5 parts of glyceryl monostearate, 15-17 parts of glycerol, 802.5-3.5 parts of tween, 50-55 parts of water, 1.5-3.5 parts of azone and 0.05-0.1 part of potassium sorbate.
Adopt above-mentioned technical scheme's beneficial effect:
because of the physiological feature of "frequent insufficiency of the spleen", the child is most commonly suffering from anorexia due to deficiency of spleen-qi and stomach-qi. In the formula, the ginseng and the codonopsis pilosula are monarch drugs, are sweet and warm, tonify qi, strengthen spleen and nourish stomach. The bitter and warm white atractylodes rhizome is used as a ministerial drug, strengthens spleen and dries dampness, and supplements qi and assists transportation. Poria cocos, sweet and bland in flavor, is used as an adjuvant drug for invigorating spleen and eliminating dampness. Poria cocos and rhizoma Atractylodis Macrocephalae are combined to achieve the effect of invigorating spleen and eliminating dampness. The dried orange peel is used for promoting the circulation of qi and harmonizing the stomach, and eliminating dampness and strengthening the spleen. And the prepared licorice and the Chinese date can tonify qi, regulate the middle warmer and harmonize the other drugs. The whole formula can tonify qi, invigorate spleen, promote qi circulation, and remove qi stagnation, so as to achieve the effects of promoting the transportation and transformation of spleen and stomach functions and enhancing digestion and absorption.
Preferably, the traditional Chinese medicine ointment for treating infantile anorexia comprises the following raw materials in parts by weight: 2 parts of ginseng, 8 parts of codonopsis pilosula, 6 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 6 parts of honey-fried licorice root, 12 parts of dried orange peel, 6 parts of Chinese date, 10 parts of medical yellow vaseline, 2.5 parts of lanolin, 11 parts of stearic acid, 6 parts of glyceryl monostearate, 16 parts of glycerol, 802.8 parts of tween, 54 parts of water, 2 parts of azone and 0.05 part of potassium sorbate.
The invention also provides a preparation method of the traditional Chinese medicine ointment for treating child anorexia, which comprises the following steps:
step (1), extracting volatile oil: extracting volatile oil from pericarpium Citri Tangerinae by steam distillation, and separating pericarpium Citri Tangerinae volatile oil;
step (2), preparing an extract: mixing the solid-liquid mixture obtained in the step (1) after removing the pericarpium citri reticulatae volatile oil with ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date, decocting with water, and concentrating the obtained water decoction into paste to obtain an extract;
step (3), preparing a matrix oil phase: mixing medical yellow vaseline, lanolin, stearic acid and glyceryl monostearate, heating in water bath to molten state, keeping the temperature, and stirring to mix uniformly to obtain a matrix oil phase for later use;
step (4), preparing a matrix water phase: mixing glycerol, tween 80 and water, heating in water bath to 79-81 deg.C, maintaining the temperature, and stirring to mix well to obtain matrix water phase;
step (5), matrix preparation: slowly adding the matrix oil phase obtained in the step (3) into the matrix water phase obtained in the step (4) for mixing, heating in a water bath to 79-81 ℃, preserving heat, and stirring until the oil phase and the water phase are dissolved into uniform emulsion to obtain a matrix;
and (6) adding the extract obtained in the step (2) into the matrix obtained in the step (5), heating the mixture to 79-81 ℃ in a water bath, preserving the heat, stirring the mixture until the mixture is uniformly mixed, adding azone, potassium sorbate and the dried orange peel volatile oil prepared in the step (1), continuously stirring the mixture until the mixture is uniformly mixed, and naturally cooling the mixture to room temperature to obtain the traditional Chinese medicine ointment or plaster for treating infantile anorexia.
Adopt above-mentioned technical scheme's beneficial effect: the powder or decoction is difficult to be taken orally, and even if the powder or decoction is fed forcibly, the absorption of the powder or decoction is limited by the functions of the spleen and the stomach. The invention combines the modern Chinese medicine pharmacology and the cream preparation process to prepare the Chinese medicine composition into the cream. Aims at using it as the medium of massage and applying the tonifying massage method of tuina manipulations on Pishu and Weishu to achieve the dual effects of both medicine and manipulations, and exploring a new method for solving the problems of medicine taking and absorption of premature infant.
The cream friction agent used by the invention is prepared by adopting an oil-in-water (O/W) cream process, has better skin permeability, and is a natural traditional Chinese medicine penetration enhancer with pungent and sweet taste in the prescription, so the cream friction agent has the function of transdermal absorption.
Preferably, when the volatile oil in the dried orange peel is extracted by the steam distillation method, the mass ratio of the dried orange peel to the water is 1: 8-10.
Preferably, the mass of the extract obtained by the concentration in the step (2) is 0.4 time of the total mass of the dried orange peel, the ginseng, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the honey-fried licorice root and the Chinese date.
Preferably, the stirring in step (3) and step (4) is performed using a round-head glass stirring rod.
Preferably, the stirring in the step (5) and the step (6) is manual stirring at a speed of 150-.
Preferably, the preparation method of the traditional Chinese medicine ointment for treating infantile anorexia comprises the following steps:
step (1), extracting volatile oil: extracting volatile oil from pericarpium Citri Tangerinae by steam distillation, and separating pericarpium Citri Tangerinae volatile oil to obtain pericarpium Citri Tangerinae-water mass ratio of 1: 8;
step (2), preparing an extract: mixing the solid-liquid mixture obtained in the step (1) after removing the pericarpium citri reticulatae volatile oil with ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date, decocting for 2 times, soaking for 30min for the first time, decocting for 1 hour, adding water for the second time, decocting for 40min, combining water decoctions, and concentrating the obtained water decoction into a paste to obtain an extract; the mass of the extract is 0.4 times of the total mass of the dried orange peel, the ginseng, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the honey-fried licorice root and the Chinese date;
step (3), preparing a matrix oil phase: mixing medical yellow vaseline, stearic acid, lanolin and glyceryl monostearate, heating in a water bath to a molten state, preserving heat, stirring for 10min by using a round-head glass stirring rod, and rotating/dividing at 150-;
step (4), preparing a matrix water phase: mixing glycerol, Tween 80 and water, heating in water bath to 80 ℃, preserving heat, and stirring for 10min by using a round-head glass stirring rod at the speed of 150-;
step (5), matrix preparation: mixing the matrix oil phase obtained in the step (3) with the matrix water phase obtained in the step (4), heating in a water bath to 80 ℃, preserving heat, and then stirring clockwise at the speed of 150-;
and (6) adding the extract obtained in the step (2) into the matrix obtained in the step (5), wherein the dosage ratio of the matrix to the extract is 1:0.25, heating the mixture to 80 ℃ in a water bath, preserving the heat, clockwise stirring the mixture for 15min at the speed of 150 plus 220 rpm, then adding azone, potassium sorbate and the ethanol solution for dissolving the dried orange peel volatile oil prepared in the step (1), continuously clockwise stirring the mixture for 5min at the speed of 150 plus 220 rpm, and naturally cooling the mixture to room temperature to obtain the traditional Chinese medicine ointment molar agent for treating the infantile anorexia.
Compared with the prior art, the invention has the beneficial effects that:
(1) the ointment of the invention can effectively promote the secretion of motilin GAS and gastrin MOT, promote digestion and absorption, has no toxic or side effect, has low cost and is suitable for being used by vast families;
(2) the invention overcomes the problem that children are difficult to take traditional Chinese medicine decoction and granules, and the ointment of the invention is used as a massage medium to be combined with painless and noninvasive massage which is easy to accept by children for treatment, thereby having considerable economic benefit and certain social benefit.
(3) The pediatric plaster-massage therapy is an excellent traditional Chinese medicine external treatment method, and is not effectively inherited and widely popularized and applied since the modern times. The modern pharmaceutical preparation technology is combined with the traditional Chinese medicine therapy, the advantages of the traditional Chinese medicine ointment-massage therapy can be developed again, excellent medicine formulation innovation is creatively carried out, and the method has great scientific research exploration significance and subject development significance.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A traditional Chinese medicine ointment for treating child anorexia comprises the following raw materials in parts by weight:
2 parts of ginseng, 8 parts of codonopsis pilosula, 6 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 6 parts of honey-fried licorice root, 12 parts of dried orange peel, 6 parts of Chinese date, 10 parts of medical yellow vaseline, 2.5 parts of lanolin, 11 parts of stearic acid, 6 parts of glyceryl monostearate, 16 parts of glycerol, 802.8 parts of tween, 54 parts of water, 2 parts of azone and 0.05 part of potassium sorbate.
The preparation method of the traditional Chinese medicine ointment for treating child anorexia comprises the following steps:
step (1), extracting volatile oil: extracting volatile oil from pericarpium Citri Tangerinae by steam distillation, and separating pericarpium Citri Tangerinae volatile oil; when volatile oil in the dried orange peel is extracted by a steam distillation method, the mass ratio of the dried orange peel to water is 1: 8;
step (2), preparing an extract: mixing the solid-liquid mixture obtained in the step (1) after removing the pericarpium citri reticulatae volatile oil with ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date, decocting with water, and concentrating the obtained water decoction into paste to obtain an extract; the mass of the extract is 0.4 time of the total mass of the dried orange peel, the ginseng, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the honey-fried licorice root and the Chinese date;
step (3), preparing a matrix oil phase: mixing medical yellow vaseline, lanolin, stearic acid and glyceryl monostearate, heating in water bath to molten state, keeping the temperature, stirring with round-head glass pestle to mix uniformly to obtain a matrix oil phase for later use;
step (4), preparing a matrix water phase: mixing glycerol, tween 80 and water, heating in water bath to 79 ℃, keeping the temperature, and stirring with a round-head glass pestle until the mixture is uniformly mixed to obtain a matrix water phase;
step (5), matrix preparation: mixing the matrix oil phase obtained in the step (3) with the matrix water phase obtained in the step (4), heating the mixture to 79 ℃ in a water bath, preserving the heat, and stirring the mixture at the speed of 180 revolutions per minute until the oil phase and the water phase are dissolved into uniform emulsion to obtain a matrix;
and (6) adding the extract obtained in the step (2) into the matrix obtained in the step (5), heating in a water bath to 79 ℃, preserving heat, then stirring at the speed of 180 revolutions per minute until the mixture is uniformly mixed, then adding azone, potassium sorbate and 0.923 ml of ethanol solution 923 dissolved with the pericarpium citri reticulatae volatile oil prepared in the step (1), continuously stirring at the speed of 180 revolutions per minute until the mixture is uniformly mixed, and naturally cooling to room temperature to obtain the traditional Chinese medicine ointment molar preparation for treating infantile anorexia.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. The traditional Chinese medicine ointment-mol agent for treating child anorexia is characterized by comprising the following raw materials in parts by weight:
2-4 parts of ginseng, 6-8 parts of codonopsis pilosula, 6-8 parts of bighead atractylodes rhizome, 6-8 parts of poria cocos, 6-8 parts of honey-fried licorice root, 12-16 parts of dried orange peel, 6-8 parts of Chinese date, 10-12 parts of medical yellow vaseline, 2-2.6 parts of lanolin, 9-11 parts of stearic acid, 5.5-6.5 parts of glyceryl monostearate, 15-17 parts of glycerol, 802.5-3.5 parts of tween, 50-55 parts of water, 1.5-3.5 parts of azone and 0.05-0.1 part of potassium sorbate.
2. The traditional Chinese medicine ointment for treating infantile anorexia according to claim 1, which comprises the following raw materials in parts by weight: 2 parts of ginseng, 8 parts of codonopsis pilosula, 6 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 6 parts of honey-fried licorice root, 12 parts of dried orange peel, 6 parts of Chinese date, 10 parts of medical yellow vaseline, 2.5 parts of lanolin, 11 parts of stearic acid, 6 parts of glyceryl monostearate, 16 parts of glycerol, 802.8 parts of tween, 54 parts of water, 2 parts of azone and 0.05 part of potassium sorbate.
3. The preparation method of the traditional Chinese medicine ointment for treating infantile anorexia according to claim 1 or 2, which comprises the following steps:
step (1), extracting volatile oil: extracting volatile oil from pericarpium Citri Tangerinae by steam distillation, and separating pericarpium Citri Tangerinae volatile oil;
step (2), preparing an extract: mixing the solid-liquid mixture obtained in the step (1) after removing the pericarpium citri reticulatae volatile oil with ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date, decocting with water, and concentrating the obtained water decoction into paste to obtain an extract;
step (3), preparing a matrix oil phase: mixing medical yellow vaseline, lanolin, stearic acid and glyceryl monostearate, heating in water bath to molten state, keeping the temperature, and stirring to mix uniformly to obtain a matrix oil phase for later use;
step (4), preparing a matrix water phase: mixing glycerol, tween 80 and water, heating in water bath to 79-81 deg.C, maintaining the temperature, and stirring to mix well to obtain matrix water phase;
step (5), matrix preparation: slowly adding the matrix oil phase obtained in the step (3) into the matrix water phase obtained in the step (4) for mixing, heating in a water bath to 79-81 ℃, preserving heat, and stirring until the oil phase and the water phase are dissolved into uniform emulsion to obtain a matrix;
and (6) adding the extract obtained in the step (2) into the matrix obtained in the step (5), heating the mixture to 79-81 ℃ in a water bath, preserving the heat, stirring the mixture until the mixture is uniformly mixed, adding azone, potassium sorbate and the dried orange peel volatile oil prepared in the step (1), continuously stirring the mixture until the mixture is uniformly mixed, and naturally cooling the mixture to room temperature to obtain the traditional Chinese medicine ointment or plaster for treating infantile anorexia.
4. The preparation method of the traditional Chinese medicine ointment for treating infantile anorexia according to claim 3, wherein the mass ratio of the dried orange peel to the water is 1:8-10 when the volatile oil in the dried orange peel is extracted by steam distillation.
5. The preparation method of the traditional Chinese medicine ointment for treating infantile anorexia according to claim 3, wherein the mass of the extract obtained by concentration in step (2) is 0.4 times of the total mass of dried orange peel, ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date.
6. The process for preparing a Chinese medicinal electuary according to claim 3, wherein the stirring in steps (3) and (4) is performed with a round glass stirring rod.
7. The method for preparing a Chinese medicinal ointment for treating infantile anorexia as claimed in claim 3, wherein the stirring in steps (5) and (6) is performed by manual stirring at a speed of 150 and 220 rpm.
8. The preparation method of the traditional Chinese medicine ointment for treating infantile anorexia according to claim 3, which comprises the following steps:
step (1), extracting volatile oil: extracting volatile oil from pericarpium Citri Tangerinae by steam distillation, and separating pericarpium Citri Tangerinae volatile oil; during extraction, the mass ratio of the dried orange peel to water is 1: 8;
step (2), preparing an extract: mixing the solid-liquid mixture obtained in the step (1) after removing the pericarpium citri reticulatae volatile oil with ginseng, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, honey-fried licorice root and Chinese date, decocting for 2 times, soaking for 30min for the first time, decocting for 1 hour, adding water for the second time, decocting for 40min, combining water decoctions, and concentrating the obtained water decoction into a paste to obtain an extract; the mass of the extract is 0.4 times of the total mass of the dried orange peel, the ginseng, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the honey-fried licorice root and the Chinese date;
step (3), preparing a matrix oil phase: mixing medical yellow vaseline, lanolin, stearic acid and glyceryl monostearate, heating in a water bath to a molten state, preserving heat, stirring for 10min by adopting a glass pestle, and rotating/dividing at 150-;
step (4), preparing a matrix water phase: mixing glycerol, Tween 80 and water, heating in water bath to 80 ℃, preserving heat, and stirring for 10min by using a round-head glass stirring rod at the speed of 150-;
step (5), matrix preparation: mixing the matrix oil phase obtained in the step (3) with the matrix water phase obtained in the step (4), heating in a water bath to 80 ℃, preserving heat, and then clockwise stirring for 10min at the speed of 150-;
and (6) adding the extract obtained in the step (2) into the matrix obtained in the step (5), wherein the mass ratio of the matrix to the extract is 1:0.25, heating the mixture to 80 ℃ in a water bath, preserving the heat, clockwise stirring the mixture for 15min at the speed of 150-.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116870067A (en) * | 2023-08-10 | 2023-10-13 | 上海纳米技术及应用国家工程研究中心有限公司 | Traditional Chinese medicine composition for relieving VB12 malabsorption and preparation method thereof |
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| CN116870067A (en) * | 2023-08-10 | 2023-10-13 | 上海纳米技术及应用国家工程研究中心有限公司 | Traditional Chinese medicine composition for relieving VB12 malabsorption and preparation method thereof |
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