CN113083193B - Preparation method of ceramide-loaded centella asiatica extract compound - Google Patents

Preparation method of ceramide-loaded centella asiatica extract compound Download PDF

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CN113083193B
CN113083193B CN202110246569.6A CN202110246569A CN113083193B CN 113083193 B CN113083193 B CN 113083193B CN 202110246569 A CN202110246569 A CN 202110246569A CN 113083193 B CN113083193 B CN 113083193B
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ceramide
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CN113083193A (en
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王师亮
龙浩
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Haiyamei Biotechnology Zhuhai Co ltd
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Abstract

The invention relates to a preparation method of a ceramide-loaded centella asiatica extract compound, which comprises a supporting device, a driving device and a driving device, wherein the supporting device is used for supporting the driving device; the reaction kettle is used for containing the ceramide-loaded centella asiatica extract compound; the feed hopper is used for feeding a ceramide-loaded centella asiatica extract compound; the device comprises a solenoid valve, a power device, a stirring device, a sampling device and a detection device, wherein the solenoid valve is used for detecting the particle concentration and the uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract; the control unit is used for adjusting the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles according to the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles obtained by the detection device, and adjusting the stirring speed of the power device according to the uniformity of the obtained ceramide-loaded asiatic pennywort herb extract lipid nanoparticles so that the effectiveness parameters of the produced ceramide-loaded asiatic pennywort herb extract compound reach the preset standard.

Description

Preparation method of ceramide-loaded centella asiatica extract compound
Technical Field
The invention relates to the field of cosmetics, in particular to a preparation method of a ceramide-loaded centella asiatica extract compound.
Background
Ceramide is a phospholipid with ceramide as a skeleton, mainly comprising ceramide phosphorylcholine and ceramide phosphorylethanolamine, is a main component of a cell membrane, has strong water molecule association capacity, and maintains skin moisture by forming a network structure in a horny layer. Therefore, ceramide has the effect of keeping skin moisture. Centella asiatica extract contains various triterpenes, including alpha-resinol structure. The main components are asiaticoside and madecassoside, in the skin care product, the centella asiatica can tighten the connecting part of the epidermis and the dermis, can soften the skin, is beneficial to solving the phenomenon of skin relaxation, and can make the skin smooth and elastic; the collagen in the dermis is promoted to be formed, the fibrin is regenerated and is connected again, and the skin achieves the effects of tightening and smoothing. Can also help the injured tissue to heal and compact the skin. Therefore, the compound formed by combining the centella asiatica extract and the ceramide has the combined effects of moisturizing and firming the skin.
At present, the skin care product taking ceramide and centella as effective components mainly adopts a traditional mixing mode, the content and the uniformity of the ceramide and the centella cannot be accurately controlled, so that the content of effective substances of a single product cannot reach the standard, and the using effect of the skin care product is not uniform.
Disclosure of Invention
Therefore, the invention provides a preparation method of a ceramide-loaded centella asiatica extract compound, which can solve the technical problem that the uniformity of active ingredients of a skin care product taking ceramide and centella asiatica as active ingredients cannot reach a preset standard.
In order to achieve the above object, the present invention provides a preparation method and application of a ceramide-loaded centella asiatica extract complex, comprising:
the supporting device is used for supporting the power device;
the reaction kettle is arranged in the supporting device and is used for containing the ceramide-loaded centella asiatica extract compound;
the feed hopper is arranged at the top of the reaction kettle and used for feeding a ceramide-loaded centella asiatica extract compound;
the electromagnetic valve is arranged at the feed hopper and is used for controlling the adding amount of the ceramide-loaded centella asiatica extract lipid nanoparticles;
the power device is arranged at the top of the supporting device and used for providing power for the stirring device;
the stirring device is connected with the power device and is used for stirring the ceramide-loaded asiatic pennywort herb extract compound;
the sampling device is arranged on the stirring device and is used for extracting a ceramide-loaded asiatic pennywort herb extract compound sample;
the detection device is arranged at the top of the supporting device and is used for detecting the particle concentration and uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract;
the control unit is arranged outside the supporting device and is in wireless connection with the electromagnetic valve, the power device, the detection device and the sampling device, the control unit is used for acquiring the particle concentration of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract according to the detection device and adjusting the adding amount of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract, and the control unit is used for adjusting the stirring speed of the power device according to the acquired uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract so as to enable the validity parameters of the produced ceramide-loaded asiatic pennywort herb extract compound to reach preset standards;
the control unit presets an initial setting A (Xi, Wn, Pq) for preparing the ceramide-loaded asiatic pennywort herb extract composite, wherein Xi is an application direction of the ceramide-loaded asiatic pennywort herb extract composite, Wn is an effectiveness parameter of the ceramide-loaded asiatic pennywort herb extract composite, and Pq is a particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, when the ceramide-loaded asiatic pennywort herb extract composite is prepared by using the preparation method of the ceramide-loaded asiatic pennywort herb extract composite, the control unit adjusts the adding amount parameter Mn of the selected ceramide-loaded asiatic pennywort herb extract lipid nanoparticles according to the obtained particle concentration P 'of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and the control unit adjusts the stirring speed V0' of the power device according to the obtained lipid nanoparticles Y 'in the ceramide-loaded asiatic pennywort herb extract composite' And adjusting to enable the effectiveness parameter W' of the produced ceramide-loaded asiatic pennywort herb extract compound to reach a preset standard.
Further, the control unit initially sets a ceramide-loaded centella asiatica extract complex validity parameter Wn, wherein a first preset ceramide-loaded centella asiatica extract complex validity parameter W1, a second preset ceramide-loaded centella asiatica extract complex validity parameter W2, a third preset ceramide-loaded centella asiatica extract complex validity parameter W3, the control unit presets a ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount M, wherein the first preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M1, the second preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M2, the third preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M3, the control unit initially sets the ceramide-loaded centella asiatica extract complex validity parameter Wn according to the initially set ceramide-loaded centella asiatica extract complex validity parameter Wn, selecting a parameter Mn of the amount of the ceramide-loaded centella asiatica extract compound, wherein n is 1,2 and 3.
Further, the control unit obtains a standard particle concentration Pq of initially set ceramide-loaded centella asiatica extract lipid nanoparticles, wherein a first preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P1, a second preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P2, and a third preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P3, the control unit obtains the product of the obtained ratio of the ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration P 'to the standard particle concentration Pq of initially set ceramide-loaded centella asiatica extract lipid nanoparticles and the obtained ratio of the uniformity of the ceramide-loaded centella asiatica extract lipid nanoparticles Y' to the preset standard ceramide-loaded centella asiatica extract lipid nanoparticle Y0, and obtaining the effectiveness parameters W ', W' ═ P '/Pq × Y'/Y0 of the ceramide-loaded centella asiatica extract compound.
Further, the ceramide-loaded centella asiatica extract compound is wrapped by the separated lipid nanocapsules, the application direction Xi of the ceramide-loaded centella asiatica extract compound is initially set according to the control unit, wherein the skin moisturizing application direction X1 is used for maintaining the skin stable application direction X2, the ratio N of ceramide in the separated lipid nanocapsules to the centella asiatica is selected according to the application direction of the ceramide-loaded centella asiatica extract compound, the first preset ratio N1 is used for selecting the second preset ratio N2, and the control unit selects the preset ratio Ni of the ceramide in the separated lipid nanocapsules to the centella asiatica according to the application direction Xi of the ceramide-loaded centella asiatica extract compound.
Further, the control unit sets a particle concentration error parameter alpha of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, the control unit initially sets a particle concentration parameter Pq of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, the control unit selects a ceramide-loaded asiatic pennywort herb extract lipid nanoparticle adding amount Mn, the control unit obtains the particle concentration P' of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in real time through the detection device, wherein,
when P' is less than or equal to Pq-alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn1, and sets Mn1 ═ Mn x (1+ alpha × Ni);
when the Pq-alpha is more than or equal to Pq' and less than or equal to Pq + alpha, the control unit does not adjust the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles, and the adding amount Mn is set as Mn0 ═ Mn;
when P' is not less than Pq + alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn2, and Mn2 ═ Mn1 ═ Mn x (1- α × Ni).
Further, the control unit sets a particle concentration error parameter α of the ceramide-loaded centella asiatica extract lipid nanoparticle, setting α ═ P' -Pq |/Pq.
Further, the control unit presets a stirring speed of the stirring device V0, the control unit presets a uniformity Y of ceramide-loaded centella asiatica extract lipid nanoparticles in a ceramide-loaded centella asiatica extract complex sample, wherein the first preset sample uniformity Y1, the second preset sample uniformity Y2 and the third preset sample uniformity Y3 are obtained by the control unit through the detection device, wherein,
when Y 'is ≦ Y1, the control unit adjusts the stirring device stirring rate V0 to V1, setting V1 ═ V0 × (1+ (Y1-Y')/Y1);
when Y1 is more than Y' and less than Y2, the control unit adjusts the stirring speed V0 of the stirring deviceSection V2, set V2 ═ V0 × (1+ (Y2-Y')2/Y2)；
When Y2 < Y' ≦ Y3, the control unit does not adjust the stirring speed V0 of the stirring device.
Further, the detection device obtains a distribution image of ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in a ceramide-loaded asiatic pennywort herb extract compound sample, divides the image into e areas in equal proportion, counts the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in each area respectively, and sets the ceramide-loaded asiatic pennywort herb extract lipid nanoparticle uniformity Y' in the ceramide-loaded asiatic pennywort herb extract compound sample as L and the quantity of the sample extracted by the sampling device as L
Figure GDA0003665599190000041
Wherein Gk is the number of lipid nanoparticles of the ceramide-loaded centella asiatica extract in the e-th region, and k is 1,2,3 to e.
Further, the control unit initially sets an effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, the effectiveness parameter W' of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is greater than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, and the control unit judges that the product of the ceramide-loaded asiatic pennywort herb extract compound is qualified and can be produced or subjected to other operations; when the effectiveness parameter W 'of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is not more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, the control unit judges that the ceramide-loaded asiatic pennywort herb extract compound product is unqualified, and the adding amount Mni of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the stirring speed Vj of the stirring device need to be adjusted until the effectiveness parameter W' of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound.
Further, the control unit determines ceramide-loaded centella asiatica extractionThe product complex is not qualified, the control unit adjusts the ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount Mni to Mni ', sets Mni ═ Mni × (1+ (Wn-W')/Wn), wherein i ═ 0,1, 2; while the stirring speed Vj of the stirring apparatus was adjusted to Vj ', Vj ' ═ Vj x (1+ (Wn-W ')2/Wn), wherein j is 0,1, 2.
Compared with the prior art, the method has the beneficial effects that the control unit is arranged to obtain the particle concentration of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract according to the detection device, adjust the adding amount of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract, and adjust the stirring speed of the power device according to the uniformity of the obtained lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract, so that the effectiveness parameters of the produced ceramide-loaded asiatic pennywort herb extract compound reach the preset standard;
in particular, the method sets the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound, divides the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles into three standards, and selects the corresponding adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles according to the initially set effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound so as to enable the effectiveness parameters of the prepared ceramide-loaded asiatic pennywort herb extract compound to reach the preset standards more quickly.
In particular, the invention sets a calculation mode of the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound according to the concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the uniformity of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and in actual production, the evaluation of the application direction of the content and the uniformity of the effective substances in the ceramide-loaded asiatic pennywort herb extract compound has certain influence, so the invention sets the calculation mode of the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound to comprehensively evaluate the ceramide-loaded asiatic pennywort herb extract compound.
In particular, the invention utilizes the separated lipid nanocapsule technology to load ceramide and centella asiatica extract simultaneously, and selects the proportion Ni of the ceramide and the centella asiatica in the separated lipid nanocapsule according to the application direction of the ceramide-loaded centella asiatica extract compound which is initially set, so that the content of effective substances in the ceramide-loaded centella asiatica extract compound is more matched with the application direction of the ceramide-loaded centella asiatica extract compound.
In particular, the particle concentration parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles are set to divide three standards, and the adding amount of the selected ceramide-loaded asiatic pennywort herb extract lipid nanoparticles is adjusted according to the comparison of the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles obtained in real time and the initially set particle concentration parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles within an error range, so that the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles reaches the preset standard.
In particular, the method sets a dynamic acquisition mode of particle concentration error parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and adjusts and controls the particle concentration error range in real time, so that the adjustment of the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles is more accurate.
In particular, the method for obtaining the uniformity of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles adopts a method of dividing regions and counting respectively, so that the obtained uniformity is more accurate, and meanwhile, the method compares the uniformity of the obtained ceramide-loaded asiatic pennywort herb extract lipid nanoparticles with a preset value, and adjusts the stirring speed of a stirring device, so that the uniformity of the adjusted ceramide-loaded asiatic pennywort herb extract lipid nanoparticles reaches a preset standard.
Particularly, the control unit sets a judgment mode for judging whether the ceramide-loaded asiatic pennywort herb extract compound is qualified or not, and simultaneously regulates and controls the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the stirring speed of the stirring device for unqualified products, so that the effectiveness parameters of the finally produced ceramide-loaded asiatic pennywort herb extract compound reach the preset standard.
Drawings
FIG. 1 is a schematic structural diagram of a preparation method of a ceramide-loaded centella asiatica extract complex according to an embodiment of the present invention.
Detailed Description
In order that the objects and advantages of the invention will be more clearly understood, the invention is further described below with reference to examples; it should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only for explaining the technical principle of the present invention, and do not limit the scope of the present invention.
It should be noted that in the description of the present invention, the terms of direction or positional relationship indicated by the terms "upper", "lower", "left", "right", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, which are only for convenience of description, and do not indicate or imply that the device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Referring to fig. 1, a method for preparing a ceramide-loaded centella asiatica extract complex comprises,
a support device 1 for supporting a power device; the reaction kettle 17 is arranged inside the supporting device and used for containing the ceramide-loaded centella asiatica extract compound; the feed hopper 3 is arranged at the top of the reaction kettle and used for feeding a ceramide-loaded centella asiatica extract compound; the electromagnetic valve 4 is arranged at the feed hopper and is used for controlling the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles; the power device is arranged at the top of the supporting device and used for providing power for the stirring device; the stirring device is connected with the power device and is used for stirring the ceramide-loaded asiatic pennywort herb extract compound; the sampling device is arranged on the stirring device and is used for extracting a ceramide-loaded asiatic pennywort herb extract compound sample; the detection device 16 is arranged at the top of the supporting device and is used for detecting the particle concentration and uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract; the control unit is arranged outside the supporting device and is in wireless connection with the electromagnetic valve, the power device, the detection device and the sampling device, the control unit is used for acquiring the particle concentration of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract according to the detection device and adjusting the adding amount of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract, and the control unit is used for adjusting the stirring speed of the power device according to the acquired uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract so as to enable the validity parameters of the produced ceramide-loaded asiatic pennywort herb extract compound to reach preset standards;
the control unit presets initial setting A (Xi, Wn, Pq) for preparing a ceramide-loaded asiatic pennywort herb extract compound, wherein Xi is the application direction of the ceramide-loaded asiatic pennywort herb extract compound, Wn is the effectiveness parameter of the ceramide-loaded asiatic pennywort herb extract compound, and Pq is the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, when the ceramide-loaded asiatic pennywort herb extract compound is used for preparing the preparation method and the ceramide-loaded asiatic pennywort herb extract compound, the control unit adjusts the adding amount parameter Mn of the selected ceramide-loaded asiatic pennywort herb extract lipid nanoparticles according to the obtained particle concentration P 'of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and the control unit adjusts the stirring rate of the power device according to the obtained lipid nanoparticles Y' in the ceramide-loaded asiatic pennywort herb extract compound with uniform degree V0 'is adjusted so that the resulting ceramide-loaded centella asiatica extract complex effectiveness parameter W' meets a predetermined criterion.
Specifically, the stirring device of the embodiment of the invention comprises a plurality of stirring plates 6, which are arranged on the conveying pipe 5 and used for stirring the ceramide-loaded centella asiatica extract compound, and a plurality of stirring plates are arranged and used for uniformly stirring. It will be understood by those skilled in the art that the shape, arrangement position, etc. of the stirring plate in the embodiment of the present invention are not limited as long as the ceramide-loaded centella asiatica extract complex can be sufficiently stirred.
Specifically, the sampling device comprises a conveying pipe 5, wherein the conveying pipe is hollow and is connected with a detection device and a reaction kettle, and a stirring plate is further arranged on the conveying pipe and is used for conveying a ceramide-loaded asiatic pennywort herb extract compound; the first delivery pump is arranged at the position, close to the detection device, of the delivery pipe and is used for pumping a ceramide-loaded asiatic pennywort herb extract compound sample; the device also comprises a second delivery pump 10 which is arranged on the delivery pipe and is positioned in the reaction kettle near the top, and the second delivery pump is connected with a first extraction pipe 7 and is used for extracting a ceramide-loaded asiatic pennywort herb extract compound sample in the reaction kettle near the top; the device also comprises a third delivery pump 11 which is arranged on the delivery pipe and is positioned at the middle position in the reaction kettle, and the third delivery pump is connected with a second extraction pipe 8 and is used for extracting a ceramide-loaded asiatic pennywort herb extract compound sample at the middle position in the reaction kettle; the device also comprises a fourth delivery pump 12 which is arranged on the delivery pipe and is positioned at the bottom position in the reaction kettle, and the fourth delivery pump is connected with a third extraction pipe 9 and is used for extracting a ceramide-loaded centella asiatica extract composite sample at the bottom position in the reaction kettle; second delivery pump, third delivery pump, fourth delivery pump acquire sample volume l respectively, and first delivery pump acquires sample volume 3l, sets up the delivery pump through three different positions in reation kettle, acquires equivalent sample volume respectively, ensures that the ceramide load centella asiatica extract complex correlation parameter that detection device obtained is more accurate.
Specifically, the detection device of the present invention may be a nano detector, a nano laser particle analyzer, a nano flow detector, or the like, and it will be understood by those skilled in the art that the type, arrangement, and arrangement position of the detection device are not limited, as long as the concentration and distribution of ceramide-loaded asiatic pennywort herb extract lipid nanoparticles can be detected.
Specifically, the power device in the embodiment of the present invention may be an oil cylinder or other equipment that can drive the stirring device to stir, and it can be understood by those skilled in the art that the type, installation position, and installation manner of the power device in the embodiment of the present invention are not limited, as long as the power device can provide power for the stirring device.
Specifically, in the embodiment of the invention, the discharge port 13 is arranged at the bottom of the reaction kettle and used for discharging the produced ceramide-loaded asiatic pennywort herb extract compound, and the discharge port is provided with the second electromagnetic valve 14 and used for controlling the output of the produced ceramide-loaded asiatic pennywort herb extract compound and avoiding unqualified output.
The control unit initially sets an effectiveness parameter Wn of a ceramide-loaded centella asiatica extract complex, wherein a first preset ceramide-loaded centella asiatica extract complex effectiveness parameter W1, a second preset ceramide-loaded centella asiatica extract complex effectiveness parameter W2 and a third preset ceramide-loaded centella asiatica extract complex effectiveness parameter W3, the control unit presets a ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount M, wherein the first preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M1, the second preset-ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M2 and the third preset-ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M3, and the control unit initially sets the ceramide-loaded centella asiatica extract complex effectiveness parameter Wn according to the preset ceramide-loaded centella asiatica extract complex effectiveness parameter Wn, selecting a parameter Mn of the amount of the ceramide-loaded centella asiatica extract compound, wherein n is 1,2 and 3.
In particular, the method sets the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound, divides the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles into three standards, and selects the corresponding adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles according to the initially set effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound so as to enable the effectiveness parameters of the prepared ceramide-loaded asiatic pennywort herb extract compound to reach the preset standards more quickly.
The control unit obtains a standard particle concentration Pq of an initially set ceramide-loaded centella asiatica extract lipid nanoparticle, wherein a first preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P1, a second preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P2 and a third preset ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration parameter P3, and the control unit obtains the product of the obtained ratio of the ceramide-loaded centella asiatica extract lipid nanoparticle particle concentration P 'to the initially set standard particle concentration Pq of the ceramide-loaded centella asiatica extract lipid nanoparticle and the obtained ratio of the uniformity Y' of the ceramide-loaded centella asiatica extract lipid nanoparticle to the preset uniformity Y0 of the ceramide-loaded centella asiatica extract lipid nanoparticle, and obtaining the effectiveness parameters W ', W' ═ P '/Pq × Y'/Y0 of the ceramide-loaded centella asiatica extract compound.
In particular, the invention sets a calculation mode of the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound according to the concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the uniformity of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and in actual production, the evaluation of the application direction of the content and the uniformity of the effective substances in the ceramide-loaded asiatic pennywort herb extract compound has certain influence, so the invention sets the calculation mode of the effectiveness parameters of the ceramide-loaded asiatic pennywort herb extract compound to comprehensively evaluate the ceramide-loaded asiatic pennywort herb extract compound.
The ceramide-loaded centella asiatica extract compound is wrapped by a separated lipid nanocapsule, the application direction Xi of the ceramide-loaded centella asiatica extract compound is initially set according to a control unit, the skin moisturizing application direction X1 is the skin stability maintenance application direction X2, the ratio N of ceramide in the separated lipid nanocapsule to the centella asiatica is selected according to the application direction of the ceramide-loaded centella asiatica extract compound, the first preset ratio N1 is the first preset ratio, the second preset ratio N2 is the second preset ratio, and the control unit selects the preset ratio Ni of ceramide in the separated lipid nanocapsule to the centella asiatica according to the application direction Xi of the ceramide-loaded centella asiatica extract compound.
Specifically, the embodiment of the invention adopts an advanced lipid nanocapsule wrapping technology to wrap the ceramide and the centella asiatica extract in one lipid nanocapsule, so that the matching of the proportion of the ceramide and the centella asiatica extract is realized according to the application direction, namely, when the control unit selects the application direction of the compound to moisturize the skin, the proportion of the ceramide and the centella asiatica extract is 1:5, the multiple of the nanocapsule interval number 6 is selected, wherein the proportion 1 is the ceramide content, the proportion 5 is the content of the centella asiatica, the ceramide-loaded centella asiatica extract lipid nanoparticles are formed, if the application direction of the compound is the skin maintenance temperature, the proportion of the ceramide and the centella asiatica extract is 1:10, the multiple of the nanocapsule interval number 11 is selected, the centella asiatica 1 is the ceramide content, and the centella asiatica 10 is the content, the lipid nanoparticles of the ceramide-loaded centella asiatica extract are formed. It will be understood by those skilled in the art that the ratio of ceramide to centella asiatica extract in the present invention is not limited, as long as the ratio satisfies the application direction of the ceramide-loaded centella asiatica extract complex, or the ratio of the effective ingredients of the skin care product.
Specifically, the main component of the ceramide-loaded centella asiatica extract compound prepared by the embodiment of the invention is added with ceramide-loaded centella asiatica extract, and dipotassium glycyrrhizinate and bisabolol are also added, wherein the ceramide content is 0.1-0.5%, the centella asiatica extract content is 0.5-1%, the dipotassium glycyrrhizinate content is 0.1-1%, and the bisabolol content is 0.5-2%, so that the sensitive muscle repairing effect is better.
Specifically, the ceramide loaded with the main component of the centella asiatica extract compound prepared by the embodiment of the invention is beneficial to the improvement and recovery of the barrier function of damaged skin and improves the resistance of the skin to the symptoms of allergy, red swelling, pruritus and the like of sensitive skin caused by external stimulation; the centella asiatica extract has certain inhibiting effect on pseudomonas aeruginosa, staphylococcus aureus, acne bacillus and the like, and simultaneously can reduce the generation of proinflammatory mediators, improve and repair the barrier function of skin, and place and correct the immune dysfunction of the skin; the dipotassium glycyrrhizinate has the functions of nourishing and moistening skin, and the dipotassium glycyrrhizinate has the functions of promoting the absorption of skin on nutrient substances, particularly minerals and trace elements, promoting the metabolism of the skin, enabling the skin to be elastic and glossy and removing wrinkles in the skin care product; the bisabolol is the main active ingredient of the chamomile extract, has good stability and skin compatibility, and has the functions of anti-irritation and repair, so that the skin can be protected and cured. The embodiment of the invention can apply the ceramide-loaded centella asiatica extract compound to cosmetics such as astringent, emulsion, essence, cream, sun cream, facial mask and the like.
In order to further detect the improvement of the skin state of the cosmetics prepared by the ceramide-loaded asiatic pennywort herb extract compound, 10 volunteers are recruited, 8 experimental groups are arranged, 2 control groups are arranged, the cosmetics prepared by the method are added on the basis of daily skin care of the volunteers in the experimental groups, and the control groups only carry out daily skin care. The test period is 7 days, and the water content, the pH value and the acne removal rate of the skin of the volunteers are detected by using a professional detection instrument on the 0 th day, the 3 rd day and the 7 th day respectively.
Tests prove that the skin condition of a volunteer is improved, particularly, the water content is improved by 2.66%, the pH value is kept between 5.5 and 6, and the acne removal rate reaches 82.67%
In particular, the invention utilizes the separated lipid nanocapsule technology to load ceramide and centella asiatica extract simultaneously, and selects the proportion Ni of the ceramide and the centella asiatica in the separated lipid nanocapsule according to the application direction of the ceramide-loaded centella asiatica extract compound which is initially set, so that the content of effective substances in the ceramide-loaded centella asiatica extract compound is more matched with the application direction of the ceramide-loaded centella asiatica extract compound.
The control unit sets a particle concentration error parameter alpha of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, the control unit initially sets a particle concentration parameter Pq of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, the control unit selects the input amount Mn of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and the control unit obtains the particle concentration P' of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in real time through a detection device,
when P' is less than or equal to Pq-alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn1, and sets Mn1 ═ Mn x (1+ alpha × Ni);
when the Pq-alpha is more than or equal to Pq' and less than or equal to Pq + alpha, the control unit does not adjust the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles, and the adding amount Mn is set as Mn0 ═ Mn;
when P' is more than or equal to Pq + alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn2, and Mn2 ═ Mn1 ═ Mn x (1-alpha x Ni);
in particular, the particle concentration parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles are set to divide three standards, and the adding amount of the selected ceramide-loaded asiatic pennywort herb extract lipid nanoparticles is adjusted according to the comparison of the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles obtained in real time and the initially set particle concentration parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles within an error range, so that the particle concentration of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles reaches the preset standard.
The control unit sets a particle concentration error parameter alpha of the ceramide-loaded centella asiatica extract lipid nanoparticles, and sets alpha ═ P' -Pq |/Pq.
In particular, the method sets a dynamic acquisition mode of particle concentration error parameters of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles, and adjusts and controls the particle concentration error range in real time, so that the adjustment of the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles is more accurate.
The stirring speed V0 of the stirring device is preset by the control unit, the uniformity Y of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in the ceramide-loaded asiatic pennywort herb extract compound sample is preset by the control unit, wherein the first preset sample uniformity Y1, the second preset sample uniformity Y2 and the third preset sample uniformity Y3 are preset by the control unit, the control unit obtains the uniformity Y' of the ceramide-loaded asiatic pennywort herb extract compound sample through the detection device,
when Y 'is ≦ Y1, the control unit adjusts the stirring device stirring rate V0 to V1, setting V1 ═ V0 × (1+ (Y1-Y')/Y1);
when Y1 < Y '≦ Y2, the control unit adjusts the stirring speed of the stirring apparatus V0 to V2, setting V2 ═ V0 × (1+ (Y2-Y')2/Y2)；
When Y2 < Y' ≦ Y3, the control unit does not adjust the stirring speed V0 of the stirring device.
In particular, the method for obtaining the uniformity of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles adopts a method of dividing regions and counting respectively, so that the obtained uniformity is more accurate, and meanwhile, the method compares the uniformity of the obtained ceramide-loaded asiatic pennywort herb extract lipid nanoparticles with a preset value, and adjusts the stirring speed of a stirring device, so that the uniformity of the adjusted ceramide-loaded asiatic pennywort herb extract lipid nanoparticles reaches a preset standard.
The detection device obtains the load product of ceramideThe method comprises the steps of sampling a snow grass extract composite sample by using a ceramide-loaded snow grass extract lipid nanoparticle distribution image, dividing the image into e areas in equal proportion, respectively counting the ceramide-loaded snow grass extract lipid nanoparticles in each area, wherein the ceramide-loaded snow grass extract lipid nanoparticle uniformity Y' in the ceramide-loaded snow grass extract composite sample is L, and the sampling device is set to extract a sample amount L
Figure GDA0003665599190000131
Wherein Gk is the number of lipid nanoparticles of the ceramide-loaded centella asiatica extract in the e-th region, and k is 1,2,3 to e.
The control unit initially sets an effective parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, the effective parameter W' of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is larger than the effective parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound initially set, and the control unit judges that a product of the ceramide-loaded asiatic pennywort herb extract compound is qualified and can be produced or subjected to other operations; when the effectiveness parameter W 'of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is not more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, the control unit judges that the ceramide-loaded asiatic pennywort herb extract compound product is unqualified, and the adding amount Mni of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the stirring speed Vj of the stirring device need to be adjusted until the effectiveness parameter W' of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound.
The control unit judges that the ceramide-loaded centella asiatica extract complex product is unqualified, and adjusts the dosage Mni of the ceramide-loaded centella asiatica extract lipid nanoparticles to Mni ', and sets Mni ' ═ Mni x (1+ (Wn-W ')/Wn), wherein i is 0,1, 2; while the stirring speed Vj of the stirring apparatus was adjusted to Vj ', Vj ' ═ Vj x (1+ (Wn-W ')2/Wn), wherein，j＝0,1,2。
Particularly, the control unit sets a judgment mode for judging whether the ceramide-loaded asiatic pennywort herb extract compound is qualified or not, and simultaneously regulates and controls the adding amount of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the stirring speed of the stirring device for unqualified products, so that the effectiveness parameters of the finally produced ceramide-loaded asiatic pennywort herb extract compound reach the preset standard.
So far, the technical solutions of the present invention have been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of the present invention is obviously not limited to these specific embodiments. Equivalent changes or substitutions of related technical features can be made by those skilled in the art without departing from the principle of the invention, and the technical scheme after the changes or substitutions can fall into the protection scope of the invention.

Claims (10)

1. A preparation method of a ceramide-loaded centella asiatica extract compound is characterized by comprising the following steps:
the supporting device is used for supporting the power device;
the reaction kettle is arranged in the supporting device and is used for containing the ceramide-loaded centella asiatica extract compound;
the feed hopper is arranged at the top of the reaction kettle and used for feeding a ceramide-loaded centella asiatica extract compound;
the electromagnetic valve is arranged at the feed hopper and is used for controlling the adding amount of the ceramide-loaded centella asiatica extract lipid nanoparticles;
the power device is arranged at the top of the supporting device and used for providing power for the stirring device;
the stirring device is connected with the power device and is used for stirring the ceramide-loaded asiatic pennywort herb extract compound;
the sampling device is arranged on the stirring device and is used for extracting a ceramide-loaded asiatic pennywort herb extract compound sample;
the detection device is arranged at the top of the supporting device and is used for detecting the particle concentration and the uniformity of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles;
the control unit is arranged outside the supporting device and is in wireless connection with the electromagnetic valve, the power device, the detection device and the sampling device, the control unit is used for obtaining the particle concentration of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract and adjusting the adding amount of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract according to the detection device, and the control unit is used for adjusting the stirring speed of the power device according to the obtained uniformity of the lipid nanoparticles of the ceramide-loaded asiatic pennywort herb extract so as to enable the effectiveness parameter of the produced ceramide-loaded asiatic pennywort herb extract compound to reach a preset standard, wherein the effectiveness parameter of the ceramide-loaded asiatic pennywort herb extract compound is the uniformity of the effective components of the ceramide-loaded asiatic pennywort herb extract compound; ceramide-loaded centella asiatica extract complex effectiveness parameter W '═ P'/pqxy '/Y0, P': particle concentration of ceramide-loaded centella asiatica extract lipid nanoparticles, Pq: standard particle concentration of ceramide-loaded centella asiatica extract lipid nanoparticles, Y': uniformity of ceramide-loaded centella asiatica extract lipid nanoparticles, Y0: the standard uniformity Y0 of the preset ceramide-loaded centella asiatica extract lipid nanoparticles;
the method comprises the steps that a control unit presets an initial setting A (Xi, Wn and Pq) for preparing a ceramide-loaded centella asiatica extract compound, wherein Xi is the application direction of the ceramide-loaded centella asiatica extract compound, Wn is the effectiveness parameter of the ceramide-loaded centella asiatica extract compound, and Pq is the particle concentration of the ceramide-loaded centella asiatica extract lipid nanoparticles, when the ceramide-loaded centella asiatica extract compound is prepared by using the preparation method of the ceramide-loaded centella asiatica extract compound, the control unit adjusts the adding amount parameter Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles according to the particle concentration P ' of the obtained ceramide-loaded centella asiatica extract lipid nanoparticles, and the control unit adjusts the stirring rate V0 ' of a power device according to the lipid nanoparticles Y ' in the obtained ceramide-loaded centella asiatica uniformity extract compound And adjusting to enable the effectiveness parameter W' of the produced ceramide-loaded centella asiatica extract compound to reach a preset standard.
2. The method for preparing the ceramide-loaded centella asiatica extract composition according to claim 1, wherein the control unit initially sets a ceramide-loaded centella asiatica extract composition validity parameter Wn, wherein the first preset ceramide-loaded centella asiatica extract composition validity parameter W1, the second preset ceramide-loaded centella asiatica extract composition validity parameter W2, and the third preset ceramide-loaded centella asiatica extract composition validity parameter W3, and the control unit presets a ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount M, wherein the first preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M1, the second preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M2, and the third preset ceramide-loaded centella asiatica extract lipid nanoparticle dosage amount parameter M3, the control unit selects a parameter Mn of the input amount of the ceramide-loaded asiatic pennywort herb extract compound according to an initially set effective parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, wherein n is 1,2 and 3.
3. The method as claimed in claim 2, wherein the control unit obtains a standard particle concentration Pq of a first predetermined ceramide-loaded centella asiatica extract lipid nanoparticle, wherein the first predetermined ceramide-loaded centella asiatica extract lipid nanoparticle has a particle concentration parameter P1, the second predetermined ceramide-loaded centella asiatica extract lipid nanoparticle has a particle concentration parameter P2, and the third predetermined ceramide-loaded centella asiatica extract lipid nanoparticle has a particle concentration parameter P3, and the control unit obtains a uniformity of the obtained ceramide-loaded centella asiatica extract lipid nanoparticle Y 'and the predetermined ceramide-loaded centella asiatica extract lipid nanoparticle according to a ratio of the obtained particle concentration P' of the ceramide-loaded centella asiatica extract lipid nanoparticle to the standard particle concentration Pq of the first predetermined ceramide-loaded centella asiatica extract lipid nanoparticle And (3) multiplying the ratio of the standard uniformity Y0 of the lipid nanoparticles to obtain the effectiveness parameter W' of the ceramide-loaded centella asiatica extract composite.
4. The preparation method of the ceramide-loaded centella asiatica extract compound according to claim 1, wherein the ceramide-loaded centella asiatica extract compound is wrapped by a partitioned lipid nanocapsule, an application direction Xi of the ceramide-loaded centella asiatica extract compound is initially set according to a control unit, the application direction X1 of skin moisturizing is set, the application direction X2 of skin stabilization is set, a ratio N of partitioned lipid nanocapsule ceramide and centella asiatica is selected according to the application direction of the ceramide-loaded centella asiatica extract compound, the first preset ratio N1 and the second preset ratio N2 are set, and the control unit selects a preset ratio Ni of partitioned lipid nanocapsule ceramide and centella asiatica according to the application direction Xi of the ceramide-loaded centella asiatica extract compound.
5. The method for preparing the ceramide-loaded centella asiatica extract composition according to claim 4, wherein the control unit sets the particle concentration error parameter α of the ceramide-loaded centella asiatica extract lipid nanoparticles, the particle concentration parameter Pq of the ceramide-loaded centella asiatica extract lipid nanoparticles initially set by the control unit, the dosage Mn of the ceramide-loaded centella asiatica extract lipid nanoparticles selected by the control unit, and the particle concentration P' of the ceramide-loaded centella asiatica extract lipid nanoparticles obtained by the control unit via the detection device in real time, wherein,
when P' is less than or equal to Pq-alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn1, and Mn1 is set as Mn x (1+ alpha x Ni);
when the Pq-alpha is more than or equal to Pq' and less than or equal to Pq + alpha, the control unit does not adjust the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles, and the adding amount Mn is set as Mn0 ═ Mn;
when P' is not less than Pq + alpha, the control unit adjusts the adding amount Mn of the selected ceramide-loaded centella asiatica extract lipid nanoparticles to Mn2, and Mn2 ═ Mn1 ═ Mn x (1- α × Ni).
6. The method for preparing the ceramide-loaded centella asiatica extract complex according to claim 5, wherein the control unit sets the particle concentration error parameter α of the ceramide-loaded centella asiatica extract lipid nanoparticle, and sets α ═ P' -Pq |/Pq.
7. The method for preparing the ceramide-loaded asiatic pennywort herb extract complex according to claim 1, wherein the control unit is configured to preset a stirring speed V0 of the stirring device, the control unit is configured to preset a uniformity Y of ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in the ceramide-loaded asiatic pennywort herb extract complex sample, wherein the first preset sample uniformity Y1, the second preset sample uniformity Y2 and the third preset sample uniformity Y3 are obtained, and the control unit is configured to obtain a uniformity Y' of the ceramide-loaded asiatic pennywort herb extract complex sample through the detection device,
when Y 'is ≦ Y1, the control unit adjusts the stirring device stirring rate V0 to V1, setting V1 ═ V0 × (1+ (Y1-Y')/Y1);
when Y1 < Y '≦ Y2, the control unit adjusts the stirring speed of the stirring apparatus V0 to V2, setting V2 ═ V0 × (1+ (Y2-Y')2/Y2)；
When Y2 < Y' ≦ Y3, the control unit does not adjust the stirring speed V0 of the stirring device.
8. The method for preparing the ceramide-loaded centella asiatica extract complex according to claim 7, wherein the detection device is used for acquiring the ceramide-loaded centella asiatica extract lipid from the ceramide-loaded centella asiatica extract complex sampleThe method comprises the steps of distributing images of nanoparticles, dividing the images into e areas in equal proportion, respectively counting ceramide-loaded asiatic pennywort herb extract lipid nanoparticles in each area, wherein the ceramide-loaded asiatic pennywort herb extract lipid nanoparticle uniformity Y' in a ceramide-loaded asiatic pennywort herb extract composite sample is L, and the amount of the sample extracted by a sampling device is set to be L
Figure FDA0003665599180000041
Wherein Gk is the number of lipid nanoparticles of the ceramide-loaded centella asiatica extract in the e-th region, and k is 1,2,3 to e.
9. The method for preparing a ceramide-loaded asiatic pennywort herb extract complex according to claim 2, wherein the control unit initially sets a ceramide-loaded asiatic pennywort herb extract complex effectiveness parameter Wn, the ceramide-loaded asiatic pennywort herb extract complex effectiveness parameter W' obtained by the control unit is greater than the initially set ceramide-loaded asiatic pennywort herb extract complex effectiveness parameter Wn, and the control unit determines that the ceramide-loaded asiatic pennywort herb extract complex product is qualified and can be produced or subjected to other operations; when the effectiveness parameter W 'of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is not more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound, the control unit judges that the ceramide-loaded asiatic pennywort herb extract compound product is unqualified, and the adding amount Mni of the ceramide-loaded asiatic pennywort herb extract lipid nanoparticles and the stirring speed Vj of the stirring device need to be adjusted until the effectiveness parameter W' of the ceramide-loaded asiatic pennywort herb extract compound obtained by the control unit is more than the initially set effectiveness parameter Wn of the ceramide-loaded asiatic pennywort herb extract compound.
10. The method of claim 9, wherein the control unit determines that the product is not qualified and controlsA formulation unit that adjusts the ceramide-supported centella asiatica extract lipid nanoparticle dosage amount Mni to Mni ', setting Mni ═ Mni × (1+ (Wn-W')/Wn), where i ═ 0,1, 2; while the stirring speed Vj of the stirring apparatus was adjusted to Vj ', Vj ' ═ Vj x (1+ (Wn-W ')2/Wn), wherein j is 0,1, 2.
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