CN112842936A - Eye cleaning solution and preparation method thereof - Google Patents
Eye cleaning solution and preparation method thereof Download PDFInfo
- Publication number
- CN112842936A CN112842936A CN202110273199.5A CN202110273199A CN112842936A CN 112842936 A CN112842936 A CN 112842936A CN 202110273199 A CN202110273199 A CN 202110273199A CN 112842936 A CN112842936 A CN 112842936A
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- Prior art keywords
- cleaning solution
- eye
- eye cleaning
- polyethylene glycol
- castor oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses an eye cleaning solution and a preparation method thereof, wherein the eye cleaning solution is prepared from the following raw materials: the eye mask comprises sodium hyaluronate, polyethylene glycol, hydroxypropyl methylcellulose, ethylene oxide-propylene oxide copolymer, castor oil, ethylene diamine tetraacetic acid disodium, tea polyphenol and deionized water, contains various moisture retention components and antibacterial and anti-inflammatory active ingredients, can effectively remove foreign matters, and also has the effects of resisting bacteria, diminishing inflammation, relieving eye pressure and resisting sensitivity.
Description
Technical Field
The invention relates to the technical field of eye cleaning, in particular to an eye cleaning solution and a preparation method thereof.
Background
In modern society, electronic products are continuously updated and more fit for the aesthetic and entertainment interests of the public. People use electronic products excessively no matter work or entertainment life, so that eyes are tired; on the other hand, allergens, dirt, bacteria and the like in the air further burden the eyes, and in addition, many people prefer to wear contact lenses or cosmetic pupil contact lenses, and each time the lenses are taken off, the inner concave surfaces of the contact lenses are found to have a lot of dirt and are extremely difficult to clean. Moreover, women and children frequently make up for eyes, make up and remove makeup and make up the process and all easily cause the eye dirty, easily infect and induce eye disease for a long time accumulation. Even when people go out, people can easily attach pollutants to the surfaces of eyeballs when meeting an unclean water body or a dust environment, and further eyes are dry, itchy or red and swollen.
Disclosure of Invention
The invention mainly aims to solve the problems and provides an eye cleaning solution, which comprises the following raw materials: sodium hyaluronate, polyethylene glycol, hydroxypropyl methyl cellulose, ethylene oxide-propylene oxide copolymer, castor oil, ethylene diamine tetraacetic acid disodium, tea polyphenol and deionized water.
Preferably, the eye cleaning solution contains the following raw materials in parts by mass: 1-3% of sodium hyaluronate, 0.5-2% of polyethylene glycol, 0.3-1% of hydroxypropyl methyl cellulose, 0.01-0.05% of ethylene oxide-propylene oxide copolymer, 0.05-0.2% of castor oil, 0.02-0.2% of disodium ethylene diamine tetraacetate, 0.02-0.1% of tea polyphenol and the balance of deionized water.
Preferably, the eye cleaning solution contains the following raw materials in parts by mass: 2% of sodium hyaluronate, 1% of polyethylene glycol, 0.6% of hydroxypropyl methylcellulose, 0.03% of ethylene oxide-propylene oxide copolymer, 0.1% of castor oil, 0.05% of disodium ethylene diamine tetraacetate, 0.04% of tea polyphenol and the balance of deionized water.
The invention also provides a preparation method of the eye cleaning solution, which comprises the following steps:
the preparation method comprises the following steps:
(1) dissolving sodium hyaluronate and polyethylene glycol in deionized water, stirring uniformly, transferring to a water bath kettle, heating, gradually adding hydroxypropyl methylcellulose under slow stirring, continuously stirring to cool the mixed slurry to a clear liquid, adding disodium ethylene diamine tetraacetate, stirring uniformly, and naming the mixture as L1 for later use;
(2) dispersing ethylene oxide-propylene oxide copolymer in castor oil, ultrasonic heating for 5-20min, adding L1, mixing the test solution, cooling to 40-50 deg.C, adding tea polyphenols, dissolving, sterilizing, and packaging.
Preferably, the water bath heating in step (1) is heating at 80-100 ℃.
Preferably, the stirring in step (1) is performed at a rotation speed of 100-200 rpm/min.
Preferably, the ultrasonic heating in step (2) is carried out at a temperature of 60-80 ℃ and a frequency of 60-100 kHz.
Compared with the prior art, the technical scheme of the invention has the following beneficial effects:
(1) the eye lotion prepared by the invention is designed for people suffering from eye infection and foreign matters existing in eyes, contains various moisturizing components and antibacterial and anti-inflammatory active ingredients, and can effectively remove foreign matters, resist bacteria and diminish inflammation and relieve eye pressure.
(2) The eye cleaning solution prepared by the invention takes sodium hyaluronate, polyethylene glycol and hydroxypropyl methyl cellulose as moisture-preserving components and castor oil as an oil component. The sodium hyaluronate is an inherent component of a human body, reduces the stimulation to eyes, prolongs the retention time of various components on the surface of the eyes through good wettability of the sodium hyaluronate, and improves the cleaning effect. Similarly, the polyethylene glycol and the hydroxypropyl methyl cellulose can also help to change tension, so that a water locking layer can be formed on the surface of an eyeball when eyes are cleaned, and the eyes are kept moist and comfortable; in addition, the castor oil can also prevent and treat various virus, bacteria and fungal infections, and has good effect by combining with tea polyphenol for antibiosis; the tea polyphenol also has the effects of radiation protection and oxidation resistance, provides the green tea with faint scent for the cleaning solution, and enhances the comfort of use.
(3) The eye lotion prepared by the invention is also added with ethylene oxide-propylene oxide copolymer, which can remove eye stains and enhance eye moist feeling; the added disodium ethylene diamine tetraacetate can also remove protein sediments secreted in eyes, and the added sodium chlorite is used as a stable component of the eye lotion and can keep the safe storage and use of the reagent.
Detailed Description
To further clarify the disclosure, features and advantages of the present invention, reference will now be made to the following examples and to the accompanying drawings.
Example 1
A preparation method of the eye cleaning solution specifically comprises the following steps:
(1) dissolving 3% sodium hyaluronate and 2% polyethylene glycol in deionized water, stirring uniformly, transferring to a water bath kettle, heating at 85 ℃, then gradually adding 0.8% hydroxypropyl methyl cellulose at the rotation speed of 200rpm/min, continuously stirring, cooling the mixed slurry to a clear liquid, then adding 0.2% disodium ethylenediamine tetraacetic acid and 0.02% sodium chlorite, stirring uniformly, and naming the mixture as L1 for later use;
(2) dissolving 0.1% tea polyphenols in 0.2% oleum ricini, adding 0.05% ethylene oxide-propylene oxide copolymer, ultrasonically stirring at 80 deg.C and 90kHz for 20min, adding L1, mixing the test solutions, sterilizing, and packaging.
Example 2
A preparation method of the eye cleaning solution specifically comprises the following steps:
(1) dissolving 2% sodium hyaluronate and 1% polyethylene glycol in deionized water, stirring uniformly, transferring to a water bath kettle, heating at 80 ℃, then gradually adding 0.6% hydroxypropyl methyl cellulose at the rotation speed of 200rpm/min, continuously stirring, cooling the mixed slurry to a clear liquid, then adding 0.2% disodium ethylenediamine tetraacetic acid and 0.02% sodium chlorite, stirring uniformly, and naming the mixture as L1 for later use;
(2) dissolving 0.07% tea polyphenols in 0.1% oleum ricini, adding 0.05% ethylene oxide-propylene oxide copolymer, ultrasonically stirring at 80 deg.C and 80kHz for 20min, adding L1, mixing the test solutions, sterilizing, and packaging.
Example 3
A preparation method of the eye cleaning solution specifically comprises the following steps:
(1) dissolving 2% sodium hyaluronate and 0.5% polyethylene glycol in deionized water, stirring uniformly, transferring to a water bath kettle, heating at 90 ℃, then gradually adding 0.4% hydroxypropyl methyl cellulose at the rotation speed of 200rpm/min, continuously stirring, cooling the mixed slurry to a clear liquid, then adding 0.2% disodium ethylene diamine tetraacetate and 0.04% sodium chlorite, stirring uniformly, and naming the mixture as L1 for later use;
(2) dissolving 0.02% tea polyphenols in 0.05% oleum ricini, adding 0.05% ethylene oxide-propylene oxide copolymer, ultrasonically stirring at 80 deg.C and 80kHz for 20min, adding L1, mixing the test solutions, sterilizing, and packaging.
Comparative example 1
Comparative example 1 of the present invention is different from example 1 in that tea polyphenol and castor oil are not added.
(1) And (3) antibacterial experiment: an eye cleansing solution prepared in examples 1 to 3 and comparative example 1 of the present invention was tested for antibacterial activity, and the experimental strains were selected from staphylococcus, pseudomonas aeruginosa, escherichia coli, and candida albicans, and the test environment of the strains was 1mL of eye cleansing solution per 1mL of strains, and the effects are shown in table 1.
Table 1: antibacterial ratio test results
| Item | Example 1 | Example 2 | Example 3 | Comparative example 1 |
| Staphylococcus aureus | 98％ | 95％ | 92％ | 25％ |
| Pseudomonas aeruginosa | 97％ | 92％ | 92％ | 21％ |
| Escherichia coli | 97％ | 93％ | 88％ | 20％ |
| Candida albicans | 95％ | 90％ | 85％ | 16％ |
As can be observed from the data in table 1, compared to comparative example 1, the eye washing solutions prepared in examples 1 to 3 of the present invention have good antibacterial effects, which are obtained by adding tea polyphenols and castor oil, while the eye washing solutions prepared in comparative example 1 still have low antibacterial ability, probably because other adjuvants in the eye washing solutions have certain chemical antibacterial effects.
(2) Evaluation test: and 8 volunteers to be made up (including eye makeup) for 12h are selected to perform experience tests on the eye cleaning solution prepared by the technical scheme of the example 1 and the comparative example 1, the volunteers are required to uniformly use the product to clean eyes and soak the eyes for 30s, and the specific use effect is shown in table 2.
Table 2: eye cleaning effect feedback meter
As can be seen from table 2, the volunteers fed back good results after performing the eye cleansing test using the eye lotion prepared in example 1 of the present invention.
While the foregoing is directed to the preferred embodiment of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. Such modifications and variations are considered to be within the scope of the invention.
Claims (7)
1. The eye cleaning solution is characterized by comprising the following raw materials: sodium hyaluronate, polyethylene glycol, hydroxypropyl methyl cellulose, ethylene oxide-propylene oxide copolymer, castor oil, ethylene diamine tetraacetic acid disodium, tea polyphenol and deionized water.
2. The eye cleaning solution according to claim 1, wherein the eye cleaning solution comprises the following raw materials in parts by mass: 1-3% of sodium hyaluronate, 0.5-2% of polyethylene glycol, 0.3-1% of hydroxypropyl methyl cellulose, 0.01-0.05% of ethylene oxide-propylene oxide copolymer, 0.05-0.2% of castor oil, 0.02-0.2% of disodium ethylene diamine tetraacetate, 0.02-0.1% of tea polyphenol and the balance of deionized water.
3. The eye cleaning solution according to claim 1, wherein the eye cleaning solution comprises the following raw materials in parts by mass: 2% of sodium hyaluronate, 1% of polyethylene glycol, 0.6% of hydroxypropyl methylcellulose, 0.03% of ethylene oxide-propylene oxide copolymer, 0.1% of castor oil, 0.05% of disodium ethylene diamine tetraacetate, 0.04% of tea polyphenol and the balance of deionized water.
4. The method for preparing an eye cleaning solution according to any one of claims 1 to 3, comprising the steps of:
(1) dissolving sodium hyaluronate and polyethylene glycol in deionized water, stirring uniformly, transferring to a water bath kettle, heating, gradually adding hydroxypropyl methylcellulose under slow stirring, continuously stirring to cool the mixed slurry to a clear liquid, adding disodium ethylene diamine tetraacetate, stirring uniformly, and naming the mixture as L1 for later use;
(2) dispersing ethylene oxide-propylene oxide copolymer in castor oil, ultrasonic heating for 5-20min, adding L1, mixing the test solution, cooling to 40-50 deg.C, adding tea polyphenols, dissolving, sterilizing, and packaging.
5. The method for preparing an eye cleaning solution according to claim 4, wherein the water bath heating in step (1) is performed at 80-100 ℃.
6. The method as claimed in claim 4, wherein the stirring in step (1) is performed at a speed of 100-200 rpm/min.
7. The method of claim 4, wherein the ultrasonic heating of step (2) is performed at a temperature of 60-80 ℃ and a frequency of 60-100 kHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110273199.5A CN112842936A (en) | 2021-03-15 | 2021-03-15 | Eye cleaning solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110273199.5A CN112842936A (en) | 2021-03-15 | 2021-03-15 | Eye cleaning solution and preparation method thereof |
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| Publication Number | Publication Date |
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| CN112842936A true CN112842936A (en) | 2021-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110273199.5A Pending CN112842936A (en) | 2021-03-15 | 2021-03-15 | Eye cleaning solution and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115010860A (en) * | 2022-04-25 | 2022-09-06 | 深圳市都市健康药业有限公司 | Formula and preparation method of medical soft hydrophilic contact lens |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1390606A (en) * | 2002-06-20 | 2003-01-15 | 上海卫康光学有限公司 | Composition for treaitng contact lens and its application |
| WO2004082625A2 (en) * | 2003-03-18 | 2004-09-30 | Advanced Medical Optics, Inc. | Self-emulsifying compositions, methods of use and preparation |
| CN101151038A (en) * | 2005-04-04 | 2008-03-26 | 眼力健有限公司 | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CN106176335A (en) * | 2016-07-05 | 2016-12-07 | 马香 | A kind of solution promoting eyelashes to grow |
| CN107456508A (en) * | 2017-01-19 | 2017-12-12 | 山东福瑞达生物工程有限公司 | A kind of eye care solution and preparation method and application |
| CN108102803A (en) * | 2017-12-24 | 2018-06-01 | 洛阳名力科技开发有限公司 | A kind of contact lenses multifunction nursing liquid |
| CN109010375A (en) * | 2018-09-11 | 2018-12-18 | 厦门阿欧客健康科技有限公司 | A kind of collyrium |
| CN111295169A (en) * | 2017-08-18 | 2020-06-16 | 阿克里维斯塔有限责任公司 | Methods of diagnosing and treating dry eye syndrome and compositions for treating human eyes |
-
2021
- 2021-03-15 CN CN202110273199.5A patent/CN112842936A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1390606A (en) * | 2002-06-20 | 2003-01-15 | 上海卫康光学有限公司 | Composition for treaitng contact lens and its application |
| WO2004082625A2 (en) * | 2003-03-18 | 2004-09-30 | Advanced Medical Optics, Inc. | Self-emulsifying compositions, methods of use and preparation |
| CN101151038A (en) * | 2005-04-04 | 2008-03-26 | 眼力健有限公司 | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| CN106176335A (en) * | 2016-07-05 | 2016-12-07 | 马香 | A kind of solution promoting eyelashes to grow |
| CN107456508A (en) * | 2017-01-19 | 2017-12-12 | 山东福瑞达生物工程有限公司 | A kind of eye care solution and preparation method and application |
| CN111295169A (en) * | 2017-08-18 | 2020-06-16 | 阿克里维斯塔有限责任公司 | Methods of diagnosing and treating dry eye syndrome and compositions for treating human eyes |
| CN108102803A (en) * | 2017-12-24 | 2018-06-01 | 洛阳名力科技开发有限公司 | A kind of contact lenses multifunction nursing liquid |
| CN109010375A (en) * | 2018-09-11 | 2018-12-18 | 厦门阿欧客健康科技有限公司 | A kind of collyrium |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115010860A (en) * | 2022-04-25 | 2022-09-06 | 深圳市都市健康药业有限公司 | Formula and preparation method of medical soft hydrophilic contact lens |
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Application publication date: 20210528 |