CN115010860A - Formula and preparation method of medical soft hydrophilic contact lens - Google Patents
Formula and preparation method of medical soft hydrophilic contact lens Download PDFInfo
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- CN115010860A CN115010860A CN202210444269.3A CN202210444269A CN115010860A CN 115010860 A CN115010860 A CN 115010860A CN 202210444269 A CN202210444269 A CN 202210444269A CN 115010860 A CN115010860 A CN 115010860A
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- 238000009472 formulation Methods 0.000 title claims description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 66
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 43
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 43
- 241001122767 Theaceae Species 0.000 claims abstract description 42
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 41
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 39
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 39
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims abstract description 6
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims abstract description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 6
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims abstract description 6
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims abstract description 6
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 40
- 238000003756 stirring Methods 0.000 claims description 27
- 229960003080 taurine Drugs 0.000 claims description 20
- 238000004140 cleaning Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 12
- 230000001954 sterilising effect Effects 0.000 claims description 12
- 230000036571 hydration Effects 0.000 claims description 8
- 238000006703 hydration reaction Methods 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 239000001045 blue dye Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 4
- 238000003754 machining Methods 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 238000005498 polishing Methods 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
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- 238000000034 method Methods 0.000 claims description 3
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- 238000002834 transmittance Methods 0.000 claims description 2
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- 239000000203 mixture Substances 0.000 claims 3
- WDZKHTCGONVORD-UHFFFAOYSA-N (2-hydroxyphenyl)-phenylmethanone;prop-2-enoic acid Chemical compound OC(=O)C=C.OC1=CC=CC=C1C(=O)C1=CC=CC=C1 WDZKHTCGONVORD-UHFFFAOYSA-N 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 abstract description 2
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 238000004061 bleaching Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 description 6
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- 230000002401 inhibitory effect Effects 0.000 description 3
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
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- 210000001508 eye Anatomy 0.000 description 1
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- 239000003228 hemolysin Substances 0.000 description 1
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- 230000000968 intestinal effect Effects 0.000 description 1
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- 210000004243 sweat Anatomy 0.000 description 1
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- 229940118696 vibrio cholerae Drugs 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention relates to a formula of a medical soft hydrophilic contact lens and a preparation method thereof in the technical field of ophthalmic medical treatment, the medical soft hydrophilic contact lens comprises a comonomer consisting of hydroxyethyl methacrylate, methyl methacrylate, ethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate, ethylene glycol dimethacrylate, a UV absorbent, azodiisoheptonitrile and a vat blue-bleaching dye, and also comprises a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution.
Description
Technical Field
The invention relates to the technical field of ophthalmic medical treatment, in particular to a medical soft hydrophilic contact lens.
Background
Tea polyphenols have been recognized by researchers in many countries around the world as a broad-spectrum, potent, low-toxicity antimicrobial. In a plurality of antibacterial tests, the antibacterial agent has inhibitory and killing effects on a plurality of pathogenic bacteria such as ordinary proteus, staphylococcus aureus, staphylococcus epidermidis, streptococcus mutans, clostridium botulinum, lactobacillus, vibrio cholerae, oral mutans bacteria and the like, especially on intestinal pathogenic bacteria to different degrees. At the same time, it can effectively prevent antibiotic-resistant staphylococcus infection and has inhibitory activity on hemolysin. In addition, tea polyphenols have strong inhibitory effect on pathogenic fungi causing human body dermatosis, such as parasitic fungi of tinea alba of head, tinea alba of macula, tinea alba of sweat, and intractable tinea.
Soft hydrophilic contact lens materials are generally composed of hydrophilic organic monomers, hydrophobic organic monomers, and cross-linking agents. Hydroxyethyl methacrylate, N-vinyl pyrrolidone and glycidyl methacrylate are selected as hydrophilic organic monomers; the hydrophobic organic monomer is methyl methacrylate or ethyl methacrylate; the cross-linking agent is ethylene glycol dimethacrylate. The hydrophilic organic monomer mainly plays a role in increasing the water content of the material in the material, the hydrophobic organic monomer plays a role in enhancing the mechanical strength of the material, and the cross-linking agent mainly plays a role in maintaining the dimensional stability of the material.
In general, a soft hydrophilic contact lens is worn on a eyeball by a user directly contacting the soft hydrophilic contact lens, which is a medical vision correction tool worn on a daily basis, and therefore, the eyeball of the user is easily infected with bacteria, and inflammation and other symptoms are caused to the eyeball of the user.
Disclosure of Invention
The invention aims to solve the defects and provides a formula of a medical soft hydrophilic contact lens and a preparation method thereof.
In order to solve the technical problem, the invention adopts the following technical scheme:
the formula of the medical soft hydrophilic contact lens comprises a comonomer, a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution, wherein the comonomer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate, methyl methacrylate, glycol dimethacrylate, 2-hydroxybenzophenone ethylene glycol acrylate, azo-diisoheptonitrile and a vat blue dye, the sodium hyaluronate aqueous solution comprises sodium hyaluronate and pure water, the tea polyphenol aqueous solution comprises tea polyphenol and pure water, and the formula comprises the following components in percentage by weight:
the volume concentration of the sodium hyaluronate aqueous solution is 0.1-0.2%, and the dosage of the sodium hyaluronate aqueous solution is 2.5-7.5% of the total weight of the comonomers
The volume concentration of the tea polyphenol water solution is 0.01-0.05%, and the dosage of the tea polyphenol water solution is 2-7% of the total weight of the comonomer.
In the above description, as a further scheme, the formula further includes a taurine aqueous solution, wherein the taurine aqueous solution has a volume concentration of 0.01-0.05%, and the amount of the taurine aqueous solution is 0.1-1% of the total weight of the comonomers.
In the above description, as a further scheme, the comonomer further includes ethyl methacrylate, and the addition amount of the ethyl methacrylate is 0-5% of the comonomer by weight percentage.
In the above description, as a further mode, the medical soft hydrophilic contact lens contains 42 to 55% of water and 90% or more of average transmittance in the visible light wavelength range.
The preparation method of the medical soft hydrophilic contact lens comprises the following steps:
step one, preparation: adding sodium hyaluronate into pure water, stirring at 5-10 ℃ overnight, and preparing a sodium hyaluronate aqueous solution with the volume concentration of 0.10-0.2%; adding tea polyphenol into pure water, stirring overnight at 5-10 ℃, and preparing a tea polyphenol water solution with the volume concentration of 0.01-0.05%; accurately weighing each comonomer according to the formula, and mechanically stirring for 0.5-1 h until all materials are uniformly mixed; adding a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution into a mixed comonomer, and stirring for 2-3 h;
step two, polymerization: adding the mixed solution obtained in the step one into a mold, putting the mold into a precise program control oven, polymerizing for 60-90 min at 60-65 ℃, vulcanizing for 20-60 min at 90-105 ℃, naturally cooling to room temperature, and standing for more than 3h in an environment with relative humidity lower than 55% for later use;
step three, machining: placing the obtained polymer blank on a precise lathe, turning, polishing the surface, and cleaning the dry sheet and the die by using an organic solvent after the dry sheet is separated from the die;
step four, hydration and cleaning: putting the dry sheet into phosphate buffered normal saline for hydration for more than 8 hours to ensure that the dry sheet is fully swelled and balanced, and cleaning;
step five, quality inspection and sterilization: and (3) checking the surface quality, curvature, diameter, central thickness and back vertex power of the cleaned wet sheet, packaging in bottles, and sterilizing to obtain the finished soft hydrophilic contact lens.
In the above description, as a further scheme, the first step is to add sodium hyaluronate into pure water, stir at 5-10 ℃ overnight, and prepare a sodium hyaluronate aqueous solution with a volume concentration of 0.10-0.2%; adding tea polyphenol into pure water, stirring overnight at 5-10 ℃, and preparing a tea polyphenol water solution with the volume concentration of 0.01-0.05%; adding taurine into pure water, stirring at 5-10 ℃ overnight, and preparing a taurine aqueous solution with the volume concentration of 0.01-0.05%; accurately weighing each comonomer according to the formula, and mechanically stirring for 0.5-1 h until all materials are uniformly mixed; and adding the sodium hyaluronate aqueous solution, the tea polyphenol aqueous solution and the taurine aqueous solution into the mixed comonomer, and stirring for 2-3 h.
In the above description, as a further scheme, the cleaning in the fourth step is to clean the lens after swelling equilibrium with a cleaning solution containing 2% tween-80 by weight.
In the above description, the sterilization treatment in the fifth step is a sterilization treatment at 126 ℃ for 30min as a further embodiment.
The beneficial effects produced by the invention are as follows:
(1) by adding sodium hyaluronate aqueous solution with the weight of 0.1-0.2% of the weight of the comonomer, the water content of the lens material can be increased, so that the water content of the soft hydrophilic contact reaches 42-55% (by mass);
(2) by adding the sodium hyaluronate aqueous solution with the weight of 0.1-0.2% of the weight of the comonomer, the wettability of the lens can be changed, the friction coefficient of the surface is reduced, the soft hydrophilic contact texture is soft, and the lens is not broken after being stretched by 200%;
(3) by adding the tea polyphenol aqueous solution, the lens can effectively inhibit bacteria such as bacillus proteus vulgaris, staphylococcus aureus, staphylococcus epidermidis and the like from breeding on the surface, and has a certain effect on the bacterial proliferation of the eyes of a patient.
Drawings
Fig. 1 is a flow chart of a method for manufacturing a medical soft hydrophilic contact lens according to the present invention.
Detailed Description
The present invention will be further described with reference to the following examples for facilitating understanding of those skilled in the art, and the description of the embodiments is not intended to limit the present invention. The present invention is described in detail below.
The first embodiment is as follows:
the formula of the medical soft hydrophilic contact lens comprises a comonomer, a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution, wherein the comonomer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate, methyl methacrylate, glycol dimethacrylate, 2-hydroxybenzophenone ethylene glycol acrylate, azo-diisoheptonitrile and a vat blue dye, the sodium hyaluronate aqueous solution comprises sodium hyaluronate and pure water, the tea polyphenol aqueous solution comprises tea polyphenol and pure water, and the formula comprises the following components in percentage by weight:
the volume concentration of the sodium hyaluronate aqueous solution is 0.2 percent, the dosage is 7.5 percent of the total weight of the comonomer, the volume concentration of the tea polyphenol aqueous solution is 0.03 percent, and the dosage is 2.5 percent of the total weight of the comonomer.
The addition amount of the hyaluronic acid sodium water solution and the tea polyphenol water solution is calculated when the total amount of the comonomer is 100%.
The preparation method of the medical soft hydrophilic contact lens comprises the following steps:
step one, preparation: adding sodium hyaluronate into pure water, stirring at 6 ℃ overnight, and preparing into 0.2% sodium hyaluronate aqueous solution; adding tea polyphenols into pure water, stirring at 6 deg.C overnight to obtain 0.03% tea polyphenols water solution; accurately weighing each comonomer according to the formula, and mechanically stirring for 1h until all materials are uniformly mixed; adding a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution into a mixed comonomer, and stirring for 3 hours;
step two, polymerization: adding the mixed solution obtained in the step one into a mold, putting the mold into a precise program-controlled oven, polymerizing for 70min at 60 ℃, vulcanizing for 50min at 95 ℃, naturally cooling to room temperature, and standing for 3.5h in an environment with relative humidity lower than 55% for later use;
step three, machining: placing the polymer blank obtained in the step two on a precise lathe, turning, polishing the surface, and cleaning the dry sheet and the die by using an organic solvent after the dry sheet is separated from the die;
step four, hydration and cleaning: putting the dry sheet into phosphate buffered normal saline for hydration for more than 8 hours to fully swell and balance the dry sheet, and cleaning the swelled and balanced lens by using cleaning solution containing 2% of tween-80 in parts by weight;
step five, quality inspection and sterilization: and (3) checking the surface quality, curvature, diameter, central thickness and back vertex power of the cleaned wet sheet, packaging in bottles, and sterilizing at the temperature of 126 ℃ for 30min to obtain the finished soft hydrophilic contact lens.
Example two:
the formula of the medical soft hydrophilic contact lens comprises a comonomer, a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution, wherein the comonomer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate, ethyl methacrylate, glycol dimethacrylate, 2-hydroxybenzophenone ethylene glycol acrylate, azo-diisoheptonitrile and a vat blue dye, the sodium hyaluronate aqueous solution comprises sodium hyaluronate and pure water, the tea polyphenol aqueous solution comprises tea polyphenol and pure water, and the formula comprises the following components in percentage by weight:
the volume concentration of the sodium hyaluronate aqueous solution is 0.2 percent, the dosage is 7.5 percent of the total weight of the comonomer,
the volume concentration of the tea polyphenol aqueous solution is 0.03 percent, the dosage of the tea polyphenol aqueous solution is 2 percent of the total weight of the comonomer, the volume concentration of the taurine aqueous solution is 0.02 percent, and the dosage of the taurine aqueous solution is 0.5 percent of the total weight of the comonomer.
The volumes of the hyaluronic acid sodium aqueous solution and the tea polyphenol aqueous solution and the addition amount of the taurine aqueous solution are calculated when the total amount of the comonomer is 100 percent.
The preparation method of the medical soft hydrophilic contact lens comprises the following steps:
step one, preparation: adding sodium hyaluronate into pure water, stirring at 6 ℃ overnight, and preparing into 0.2% sodium hyaluronate aqueous solution; adding tea polyphenols into pure water, stirring at 6 deg.C overnight to obtain 0.03% tea polyphenols water solution; adding taurine into pure water, stirring overnight at 6 ℃ to prepare a taurine aqueous solution with the volume concentration of 0.02%; accurately weighing each comonomer according to the formula, and mechanically stirring for 1h until all materials are uniformly mixed; adding a sodium hyaluronate aqueous solution, a tea polyphenol aqueous solution and a taurine aqueous solution into the mixed comonomer, and stirring for 3 hours;
step two, polymerization: adding the mixed solution obtained in the step one into a mold, putting the mold into a precise program-controlled oven, polymerizing for 70min at 60 ℃, vulcanizing for 50min at 95 ℃, naturally cooling to room temperature, and standing for 3.5h in an environment with relative humidity lower than 55% for later use;
step three, machining: placing the polymer blank obtained in the second step on a precise lathe, turning, polishing the surface, and cleaning with an organic solvent after the dry sheet is separated from the die;
step four, hydration and cleaning: putting the dry sheet into phosphate buffered normal saline for hydration for more than 8 hours to fully swell and balance the dry sheet, and cleaning the swelled and balanced lens by using cleaning solution containing 2% of Tween-80 by weight;
step five, quality inspection and sterilization: and (3) checking the surface quality, curvature, diameter, central thickness and back vertex power of the cleaned wet sheet, packaging in bottles, and sterilizing at the temperature of 126 ℃ for 30min to obtain the finished soft hydrophilic contact lens.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (8)
1. The formula of the medical soft hydrophilic contact lens is characterized in that: the dye consists of a comonomer, a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution, wherein the comonomer comprises hydroxyethyl methacrylate, N-vinyl pyrrolidone, glycidyl methacrylate, methyl methacrylate, glycol dimethacrylate, 2-hydroxybenzophenone acrylic acid diethyl ether, azodiisoheptanonitrile and a reduction blue dye, the sodium hyaluronate aqueous solution comprises sodium hyaluronate and pure water, the tea polyphenol aqueous solution comprises tea polyphenol and pure water, and the formula comprises the following components in percentage by weight:
the volume concentration of the sodium hyaluronate aqueous solution is 0.1-0.2%, the dosage of the sodium hyaluronate aqueous solution is 2.5-7.5% of the total weight of the comonomer,
the volume concentration of the tea polyphenol water solution is 0.01-0.05%, and the dosage of the tea polyphenol water solution is 2-7% of the total weight of the comonomer.
2. The formulation of a medical soft hydrophilic contact lens according to claim 1, wherein: the formula also comprises a taurine aqueous solution, wherein the taurine aqueous solution comprises taurine and pure water, the volume concentration of the taurine aqueous solution is 0.01-0.05%, and the dosage of the taurine aqueous solution is 0.1-1% of the total weight of the comonomer.
3. The formulation of a medical soft hydrophilic contact lens according to any one of claims 1 to 2, wherein: the comonomer also comprises ethyl methacrylate, and the addition amount of the ethyl methacrylate is 0-5% of the comonomer in percentage by weight.
4. The formulation of a medical soft hydrophilic contact lens according to any one of claims 1 to 2, wherein: the medical soft hydrophilic contact lens has a water content of 42-55% and an average transmittance of 90% or more in a visible light wavelength range.
5. The preparation method of the medical soft hydrophilic contact lens is characterized by comprising the following steps: the method is used for the medical soft hydrophilic contact lens according to any one of claims 1 to 4, and comprises the following steps:
step one, preparation: adding sodium hyaluronate into pure water, stirring at 5-10 ℃ overnight, and preparing a sodium hyaluronate aqueous solution with the volume concentration of 0.10-0.2%; adding tea polyphenol into pure water, stirring overnight at 5-10 ℃, and preparing a tea polyphenol water solution with the volume concentration of 0.01-0.05%; accurately weighing each comonomer according to the formula, and mechanically stirring for 0.5-1 h until all materials are uniformly mixed; adding a sodium hyaluronate aqueous solution and a tea polyphenol aqueous solution into a mixed comonomer, and stirring for 2-3 h;
step two, polymerization: adding the mixed solution obtained in the step one into a mold, putting the mold into a precise program control oven, polymerizing for 60-90 min at 60-65 ℃, vulcanizing for 20-60 min at 90-105 ℃, naturally cooling to room temperature, and standing for more than 3h in an environment with relative humidity lower than 55% for later use;
step three, machining: placing the obtained polymer blank on a precise lathe, turning, polishing the surface, and cleaning the dry sheet and the die by using an organic solvent after the dry sheet is separated from the die;
step four, hydration and cleaning: putting the dry sheet into phosphate buffer normal saline for hydration for more than 8 hours to fully swell and balance, and washing:
step five, quality inspection and sterilization: and (3) checking the surface quality, curvature, diameter, central thickness and back vertex power of the cleaned wet sheet, packaging in bottles, and sterilizing to obtain the finished soft hydrophilic contact lens.
6. A method for producing the medical soft hydrophilic contact lens according to claim 5, characterized in that:
adding sodium hyaluronate into pure water, stirring at 5-10 ℃ overnight, and preparing a sodium hyaluronate aqueous solution with the volume concentration of 0.10-0.2%; adding tea polyphenol into pure water, stirring overnight at 5-10 ℃, and preparing a tea polyphenol water solution with the volume concentration of 0.01-0.05%; adding taurine into pure water, stirring overnight at 5-10 ℃, and preparing a taurine aqueous solution with volume concentration of 0.01-0.05%; accurately weighing each comonomer according to the formula, and mechanically stirring for 0.5-1 h until all materials are uniformly mixed; and adding the sodium hyaluronate aqueous solution, the tea polyphenol aqueous solution and the taurine aqueous solution into the mixed comonomer, and stirring for 2-3 h.
7. A method for producing a medical soft hydrophilic contact lens according to any one of claims 5 to 6, wherein: and the cleaning in the fourth step is to clean the lens after swelling balance by using cleaning solution containing 2% of Tween-80 in parts by weight.
8. A method for preparing a medical soft hydrophilic contact lens according to any one of claims 5 to 6, wherein: the sterilization treatment in the fifth step is sterilization treatment at 126 ℃ for 30 min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115710329A (en) * | 2022-11-30 | 2023-02-24 | 江苏视准医疗器械有限公司 | Soft hydrophilic contact lens containing ectoin and preparation method thereof |
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| CN1748024A (en) * | 2002-12-23 | 2006-03-15 | 眼力健有限公司 | Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity |
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| CN1748024A (en) * | 2002-12-23 | 2006-03-15 | 眼力健有限公司 | Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity |
| CN101482625A (en) * | 2009-02-13 | 2009-07-15 | 广州科甫眼镜有限公司 | Sodium hyaluronate contained flexible hydrophilic contact lens and method for producing the same |
| CN106929181A (en) * | 2015-12-29 | 2017-07-07 | 青岛智通四海家具设计研发有限公司 | A kind of contact lens care solution containing green tea elite |
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| CN115710329A (en) * | 2022-11-30 | 2023-02-24 | 江苏视准医疗器械有限公司 | Soft hydrophilic contact lens containing ectoin and preparation method thereof |
| CN115710329B (en) * | 2022-11-30 | 2023-09-19 | 江苏视准医疗器械有限公司 | Flexible hydrophilic contact lens containing ectoin and preparation method thereof |
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