CN111184675A - No-clean disinfection composition, preparation method thereof and no-clean disinfection gel - Google Patents
No-clean disinfection composition, preparation method thereof and no-clean disinfection gel Download PDFInfo
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- CN111184675A CN111184675A CN202010099106.7A CN202010099106A CN111184675A CN 111184675 A CN111184675 A CN 111184675A CN 202010099106 A CN202010099106 A CN 202010099106A CN 111184675 A CN111184675 A CN 111184675A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a no-clean disinfection composition, a preparation method thereof and a no-clean disinfection gel. The no-clean disinfection composition comprises the following components in percentage by mass: 0.1-0.6% of thickening agent, 0.1-0.6% of neutralizing agent, 60-75% of ethanol, 1.29-11.70% of humectant, 0.5-3.0% of first plant extract, 0.3-2.0% of second plant extract and the balance of water; the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 1-3: 2-7: 1-4: 2-5: 1-5. The washing-free disinfection composition has the disinfection and sterilization effects, can be washed without clear water in the using process, and is mild and non-irritant. The effective component of the no-clean disinfection gel comprises the no-clean disinfection composition, and is presented in the form of gel.
Description
Technical Field
The invention relates to the technical field of daily disinfection products, in particular to a no-clean disinfection composition, a preparation method thereof and a no-clean disinfection gel.
Background
In the environment of human life, a large number of bacteria and germs exist, and some of the bacteria and germs can bring serious diseases to human bodies after invading the human bodies, thus seriously threatening the health of the human bodies. Therefore, the cleaning work of individuals and the disinfection work of the environment are well done, bacteria and germs are not allowed to take the opportunity, and the method is an important measure for guaranteeing the health of people.
In the process of personal cleaning, people usually need to wash hands for disinfection, so that bacteria and germs are prevented from remaining on the hands, and the bacteria and germs are effectively prevented from being infected through hand contact. However, the conventional hand washing, sterilizing and disinfecting articles for people have more problems. For example, common alcohol not only has irritation, but also is inflammable and volatile, so that potential safety hazards are easy to exist; the cleaning agent or the hand sanitizer and the like are adopted, a large amount of clear water is needed for washing and cleaning, the cost is greatly increased, the skin is easily damaged by frequent forced kneading in the cleaning process, and in addition, the lasting effect of disinfection and sterilization is not high.
Disclosure of Invention
The invention aims to provide a no-clean disinfection composition aiming at the defects or shortcomings in the prior art. The washing-free disinfection composition has the disinfection and sterilization effects, can be washed without clear water in the using process, and is mild and non-irritant.
The invention also aims to provide a method for preparing the no-clean disinfection composition.
The invention also aims to provide the no-clean disinfection gel containing the no-clean disinfection composition. The washing-free disinfecting gel can be used for cleaning hands, has the efficacy of disinfection and sterilization, does not need to be washed by clear water, is slow and free of stimulation, and has a lasting effect.
The purpose of the invention is realized by the following technical scheme.
A no-clean disinfection composition comprises the following components in percentage by mass:
0.1-0.6% of thickening agent, 0.1-0.6% of neutralizing agent, 60-75% of ethanol, 1.29-11.70% of humectant, 0.5-3.0% of first plant extract, 0.3-2.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 1-3: 2-7: 1-4: 2-5: 1-5.
In a preferred embodiment, the composition comprises the following components in percentage by mass:
0.1-0.3% of thickening agent, 0.1-0.3% of neutralizing agent, 70-75% of ethanol, 2.0-5.0% of humectant, 1.0-2.0% of first plant extract, 0.3-1.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2-3: 3-5: 2-3: 3: 2-4.
In a preferred embodiment, the composition comprises the following components in percentage by mass:
0.2% of thickening agent, 0.2% of neutralizing agent, 75% of ethanol, 4.6% of humectant, 1.0% of first plant extract, 0.8% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2:4:3:3: 3.
In a preferred embodiment, the ethanol is ethanol with the purity of 95%.
In preferred embodiments, the thickening agent comprises carbomer, xanthan gum or carrageenan.
In preferred embodiments, the neutralizing agent comprises triethanolamine or sodium hydroxide.
In a preferred embodiment, the humectant comprises one or more of propylene glycol, glycerin, trehalose, and butylene glycol.
In a more preferable embodiment, the humectant comprises 1.0-10.0% of propylene glycol, 0.15-1.00% of glycerin, 0.05-0.10% of trehalose and 0.09-0.60% of butanediol by mass percentage of the composition.
A process for preparing a leave-on disinfecting composition as claimed in any preceding claim comprising the steps of:
s1, taking part of water, and dissolving and dispersing the neutralizer uniformly for later use;
s2, taking the residual water, and uniformly dispersing the thickening agent for later use;
s3, starting stirring, slowly adding the uniformly dispersed component S2 into the uniformly dispersed component S1, stirring until the mixture is completely transparent and uniform, and defoaming;
s4, adding the ethanol in batches and slowly, and stirring until the mixture is completely transparent and uniform;
s5, sequentially adding the humectant, the first plant extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-clean disinfection composition.
The active ingredient of the no-clean disinfecting gel comprises the no-clean disinfecting composition.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the washing-free disinfection composition can realize the disinfection and sterilization effects and does not need to be washed by clear water; the carbomer component can form a film, so that the ethanol can be reduced to permeate into the skin, and the irritation to the skin can be reduced; and the humectant component is added, so that dryness and irritation caused by ethanol can be effectively relieved; meanwhile, the added first plant extract component can improve and maintain the moisture content for a long time, effectively improve the skin dryness, reduce the roughness of the dry skin and further moisturize the skin, so that the dryness and stimulation caused by ethanol can be further effectively relieved; the added second plant extract component has the effects of moisturizing, nourishing and diminishing inflammation, can relieve itching instantly, prevent skin allergy, further reduce the irritation of the product, make the composition more comfortable, mild and non-irritant, and make the applicable population wider; thereby realizing disinfection and sterilization, protecting human health and effectively taking care of both hands.
According to the preparation method, the raw materials are mixed in sequence according to different properties of the raw materials, so that the raw materials are fully and uniformly dispersed, and the composition obtained by fully dispersing and mixing the components has good effects of disinfection, sterilization, nourishing and caring.
The no-clean disinfection gel disclosed by the invention comprises the no-clean disinfection composition disclosed by the invention, so that the no-clean disinfection composition disclosed by the invention is presented in a gel form, not only has the effects of no-clean disinfection and sterilization, and nourishing and caring, but also can enhance the retention of ethanol active matters and prolong the time of contacting with germs or bacteria, thereby exerting the efficacy as much as possible, and having a more lasting disinfection and sterilization effect; moreover, the jelly-shaped preparation is less prone to burning, volatilization and leakage, and has no inhalation danger and small potential safety hazard compared with spraying.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following specific examples, but the scope and implementation of the present invention are not limited thereto. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Also, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The no-clean disinfection composition comprises the following components in percentage by mass:
0.1-0.6% of thickening agent, 0.1-0.6% of neutralizing agent, 60-75% of ethanol, 1.29-11.70% of humectant, 0.5-3.0% of first plant extract, 0.3-2.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 1-3: 2-7: 1-4: 2-5: 1-5.
The washing-free disinfection composition can realize the disinfection and sterilization effects and does not need to be washed by clear water; and the humectant component is added, so that dryness and irritation caused by ethanol can be effectively relieved; meanwhile, the added first plant extract component can improve and maintain the moisture content for a long time, effectively improve the skin dryness, reduce the roughness of the dry skin and further moisturize the skin, so that the dryness and stimulation caused by ethanol can be further effectively relieved; the added second plant extract component has the effects of moisturizing, nourishing and diminishing inflammation, and can further reduce the irritation of the product, so that the composition is more moderate, mild and non-irritant, and is wider in applicable population; thereby realizing disinfection and sterilization, protecting human health and effectively taking care of both hands.
In a preferred embodiment, the composition comprises the following components in percentage by mass:
0.1-0.3% of thickening agent, 0.1-0.3% of neutralizing agent, 70-75% of ethanol, 2.0-5.0% of humectant, 1.0-2.0% of first plant extract, 0.3-1.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2-3: 3-5: 2-3: 3: 2-4.
In a preferred embodiment, the composition comprises the following components in percentage by mass:
0.2% of thickening agent, 0.2% of neutralizing agent, 75% of ethanol, 4.6% of humectant, 1.0% of first plant extract, 0.8% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2:4:3:3: 3.
In a preferred embodiment, the thickening agent comprises carbomer, xanthan gum or carrageenan;
and/or, the neutralizing agent comprises triethanolamine or sodium hydroxide;
and/or the humectant comprises more than one of propylene glycol, glycerin, trehalose and butanediol.
In a more preferable embodiment, the humectant comprises 1.0-10.0% of propylene glycol, 0.15-1.00% of glycerin, 0.05-0.10% of trehalose and 0.09-0.60% of butanediol by mass percentage of the composition.
The effective component of the no-clean disinfection gel comprises the no-clean disinfection composition. The gel has the effects of no-washing disinfection and sterilization, nourishing and caring, and has more lasting disinfection and sterilization effects; moreover, the jelly-shaped preparation is less prone to burning, volatilization and leakage, and has small potential safety hazard.
The technical solution of the present invention is described in detail by the following embodiments.
In a specific embodiment, the specifically adopted raw materials are as follows:
the second plant extract is composed of an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2:4:3:3: 3.
The ethanol with the purity of 95 percent is adopted.
Example 1
The no-clean disinfection gel comprises the following components in percentage by mass:
carbomer 0.3%, triethanolamine 0.1%, ethanol 65%, propylene glycol 6.0%, glycerol 1.00%, trehalose 0.05%, butylene glycol 0.40%, peach resin extract 1.5%, second plant extract 1.0%, and balance water.
The preparation of the no-clean disinfecting gel of the embodiment comprises the following steps:
s1, taking water with the mass being 10 times that of the triethanolamine, and dissolving and dispersing the triethanolamine uniformly to obtain a component A for later use;
s2, taking the rest water, and uniformly dispersing carbomer to obtain a component B for later use;
s3, starting stirring, slowly adding the component B into the component A, stirring until the component B is completely transparent and uniform, and defoaming to obtain a component C;
s4, dividing the ethanol into 3 batches, slowly adding the ethanol into the component C, and stirring until the mixture is completely transparent and uniform;
s5, adding propylene glycol, glycerol, trehalose and butanediol, sequentially adding the peach resin extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-wash disinfection gel of the embodiment.
Example 2
The no-clean disinfection gel comprises the following components in percentage by mass:
carbomer 0.2%, triethanolamine 0.2%, ethanol 75%, propylene glycol 4.0%, glycerin 0.3%, trehalose 0.10%, butylene glycol 0.24%, peach resin extract 1.0%, second plant extract 0.5%, and water in balance.
The preparation of the no-clean disinfecting gel of the embodiment comprises the following steps:
s1, taking water with the mass being 10 times that of the triethanolamine, and dissolving and dispersing the triethanolamine uniformly to obtain a component A for later use;
s2, taking the rest water, and uniformly dispersing carbomer to obtain a component B for later use;
s3, starting stirring, slowly adding the component B into the component A, stirring until the component B is completely transparent and uniform, and defoaming to obtain a component C;
s4, dividing the ethanol into 3 batches, slowly adding the ethanol into the component C, and stirring until the mixture is completely transparent and uniform;
s5, adding propylene glycol, glycerol, trehalose and butanediol, sequentially adding the peach resin extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-wash disinfection gel of the embodiment.
Example 3
The no-clean disinfection gel comprises the following components in percentage by mass:
carbomer 0.1%, triethanolamine 0.6%, ethanol 60%, propylene glycol 10.0%, glycerol 0.15%, trehalose 0.08%, butylene glycol 0.20%, peach resin extract 2.0%, second plant extract 0.3%, and water in balance.
The preparation of the no-clean disinfecting gel of the embodiment comprises the following steps:
s1, taking water with the mass being 10 times that of the triethanolamine, and dissolving and dispersing the triethanolamine uniformly to obtain a component A for later use;
s2, taking the rest water, and uniformly dispersing carbomer to obtain a component B for later use;
s3, starting stirring, slowly adding the component B into the component A, stirring until the component B is completely transparent and uniform, and defoaming to obtain a component C;
s4, dividing the ethanol into 3 batches, slowly adding the ethanol into the component C, and stirring until the mixture is completely transparent and uniform;
s5, adding propylene glycol, glycerol, trehalose and butanediol, sequentially adding the peach resin extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-wash disinfection gel of the embodiment.
Example 4
The no-clean disinfection gel comprises the following components in percentage by mass:
carbomer 0.6%, triethanolamine 0.2%, ethanol 70%, propylene glycol 5.0%, glycerin 0.50%, trehalose 0.06%, butylene glycol 0.60%, peach resin extract 0.5%, second plant extract 1.2%, and balance water.
The preparation of the no-clean disinfecting gel of the embodiment comprises the following steps:
s1, taking water with the mass being 10 times that of the triethanolamine, and dissolving and dispersing the triethanolamine uniformly to obtain a component A for later use;
s2, taking the rest water, and uniformly dispersing carbomer to obtain a component B for later use;
s3, starting stirring, slowly adding the component B into the component A, stirring until the component B is completely transparent and uniform, and defoaming to obtain a component C;
s4, dividing the ethanol into 3 batches, slowly adding the ethanol into the component C, and stirring until the mixture is completely transparent and uniform;
s5, adding propylene glycol, glycerol, trehalose and butanediol, sequentially adding the peach resin extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-wash disinfection gel of the embodiment.
Example 5
The no-clean disinfection gel comprises the following components in percentage by mass:
carbomer 0.4%, triethanolamine 0.3%, ethanol 75%, propylene glycol 1.0%, glycerol 0.60%, trehalose 0.06%, butylene glycol 0.09%, peach resin extract 3.0%, second plant extract 2.0%, and balance water.
The preparation of the no-clean disinfecting gel of the embodiment comprises the following steps:
s1, taking water with the mass being 10 times that of the triethanolamine, and dissolving and dispersing the triethanolamine uniformly to obtain a component A for later use;
s2, taking the rest water, and uniformly dispersing carbomer to obtain a component B for later use;
s3, starting stirring, slowly adding the component B into the component A, stirring until the component B is completely transparent and uniform, and defoaming to obtain a component C;
s4, dividing the ethanol into 3 batches, slowly adding the ethanol into the component C, and stirring until the mixture is completely transparent and uniform;
s5, adding propylene glycol, glycerol, trehalose and butanediol, sequentially adding the peach resin extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-wash disinfection gel of the embodiment.
Comparative example 1
The no-clean disinfecting gel of this comparative example was the same as example 2 except that no humectant was added.
The no-clean disinfecting gel of the present comparative example was prepared according to the method of example 2.
Comparative example 2
The no-clean disinfecting gel of this comparative example was the same as example 2 except that the first plant extract was not added to this comparative example.
The no-clean disinfecting gel of the present comparative example was prepared according to the method of example 2.
Comparative example 3
The no-clean disinfecting gel of this comparative example was the same as example 2 except that no second plant extract was added to this comparative example.
The no-clean disinfecting gel of the present comparative example was prepared according to the method of example 2.
Comparative example 4
The no-wash disinfecting gel of this comparative example was the same as example 2 except that the first plant extract and the second plant extract were not added to this comparative example.
The no-clean disinfecting gel of the present comparative example was prepared according to the method of example 2.
Comparative example 5
The no-wash disinfecting gel of this comparative example was the same as example 2, except that no moisturizer, first plant extract, and second plant extract were added to this comparative example.
The no-clean disinfecting gel of the present comparative example was prepared according to the method of example 2.
Comparative example 6
The sample of this comparative example was 75% alcohol for disinfection.
Experimental testing
1. Appearance observation and physical and chemical test
Appearance observation and cold and heat resistance tests are carried out on the no-clean disinfection gel prepared in the examples 1-5 and the comparative examples 1-5, and the appearance state and corresponding performance test results of the no-clean disinfection gel prepared in the examples 1-5 and the comparative examples 1-5 are shown in the table 1.
Table 1 appearance status and corresponding physicochemical test results of the no-clean disinfecting gels of examples 1 to 5 and comparative examples 1 to 5
As can be seen from Table 1, the wash-free disinfection gel prepared in the embodiments 1-5 has good cold resistance and heat resistance, and can still keep a stable gel state in an extreme environment, which indicates that the wash-free disinfection gel provided by the invention has good physical and chemical stability, and high use safety and use convenience.
2. Disinfection and sterilization test
The washing-free disinfecting gel of examples 1 to 5 and comparative examples 1 to 5 and the disinfecting alcohol of comparative example 6 were subjected to a sterilization experiment. In the experiment, staphylococcus aureus (ATCC 6538), escherichia coli (8099), staphylococcus albus (8032) and pseudomonas aeruginosa (ATCC 15442) are selected as experimental strains, and bacterial suspensions are prepared for sterilization experiments, wherein the specific experiment operation refers to QB/T2738-. The results of the sterilization test after 30 seconds and 3 minutes are shown in tables 2 and 3, respectively.
Table 2 Sterilization rates 30 seconds after washing-free disinfecting gels of examples 1 to 5 and comparative examples 1 to 5 and disinfecting alcohol of comparative example 6
TABLE 3 Sterilization rates 3 minutes after washing-free disinfecting gels of examples 1 to 5 and comparative examples 1 to 5 and disinfecting alcohol of comparative example 6
As can be seen from tables 2 and 3, the no-wash disinfection gel of the embodiment 1-5 has excellent disinfection and sterilization effects, has good killing effect on pathogenic bacteria commonly existing in the environment, has wide killing application range on bacteria, and has good disinfection and sterilization effect durability. The washing-free disinfection composition can enhance the retention of ethanol active substances and prolong the time of contacting with germs or bacteria when being used in a jelly state, thereby exerting the efficacy as much as possible, having good disinfection and sterilization effects and good durability.
3. Test of use effect
And randomly drawing 50 volunteers, taking 5 volunteers as a group, and respectively carrying out hand disinfection and sterilization on the disinfection products of the trial examples 1-5 and the comparative examples 1-6. In the disinfection and sterilization experiments of the no-clean disinfection gel in the examples 1-5 and the comparative examples 1-5, 5g of sample is taken in the palm, and then the sample is kneaded in a hand washing state by two hands; the disinfecting alcohol of comparative example 6, the spray nozzle for disinfection and sterilization experiments was spray sterilized at the palms and backs of both hands according to the conventional alcohol disinfection method. After every 30 minutes of use and 5 hours of continuous use, the effects of use including the feeling of use and irritation were recorded and scored (10 points were used and averaged) and the results are shown in table 4.
TABLE 4 Disinfection and Sterilization effects of Disinfection products of examples 1 to 5 and comparative examples 1 to 6
Before use and after sterilization for 20 minutes, the moisture content of the hand skin was measured by a skin moisture meter, and the test results are shown in table 5.
TABLE 5 moisturizing Effect test of the disinfecting products of examples 1 to 5 and comparative examples 1 to 6
As can be seen from tables 4 and 5, and by combining the disinfection and sterilization experimental results, the disinfection and sterilization gel of embodiments 1 to 5 has good and durable disinfection and sterilization effects, and simultaneously has good nourishing and caring effects on skin, and can effectively improve skin dryness and reduce and moisturize skin, so that dryness and irritation caused by ethanol can be effectively relieved, and irritation of the product can be reduced. Therefore, the washing-free disinfection gel of the invention can effectively care both hands while realizing disinfection and sterilization and protecting human health.
Various technical features of the above embodiments may be combined arbitrarily, and for the sake of brevity, all possible combinations of the technical features of the above embodiments are not described in this specification. However, as long as there is no contradiction between combinations of these technical features, the scope of the present specification should be considered as being described.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (9)
1. The no-clean disinfection composition is characterized by comprising the following components in percentage by mass:
0.1-0.6% of thickening agent, 0.1-0.6% of neutralizing agent, 60-75% of ethanol, 1.29-11.70% of humectant, 0.5-3.0% of first plant extract, 0.3-2.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 1-3: 2-7: 1-4: 2-5: 1-5.
2. The no-clean disinfection composition as claimed in claim 1, which comprises the following components by mass percent:
0.1-0.3% of thickening agent, 0.1-0.3% of neutralizing agent, 70-75% of ethanol, 2.0-5.0% of humectant, 1.0-2.0% of first plant extract, 0.3-1.0% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2-3: 3-5: 2-3: 3: 2-4.
3. The no-clean disinfection composition as claimed in claim 1, which comprises the following components by mass percent:
0.2% of thickening agent, 0.2% of neutralizing agent, 75% of ethanol, 4.6% of humectant, 1.0% of first plant extract, 0.8% of second plant extract and the balance of water;
the first plant extract comprises a peach resin extract; the second plant extract comprises an astragalus membranaceus root extract, a saposhnikovia divaricata root extract, a calendula officinalis flower extract, an albizia julibrissin flower extract and a gastrodia elata root extract in a mass ratio of 2:4:3:3: 3.
4. A leave-on disinfecting composition according to any one of claims 1 to 3, characterized in that the thickening agent comprises carbomer, xanthan or carrageenan.
5. A leave-on disinfecting composition according to any one of claims 1 to 3, characterized in that the neutralizing agent comprises triethanolamine or sodium hydroxide.
6. A leave-on disinfecting composition according to any one of claims 1 to 3 wherein the humectant comprises one or more of propylene glycol, glycerin, trehalose and butylene glycol, by mass percentage of the composition.
7. A leave-on disinfecting composition according to any one of claims 1 to 3, characterized in that the humectant comprises, in mass percent of the composition, 1.0 to 10.0% of propylene glycol, 0.15 to 1.00% of glycerin, 0.05 to 0.10% of trehalose, and 0.09 to 0.60% of butylene glycol.
8. A process for preparing a leave-on disinfecting composition according to any one of claims 1 to 7 comprising the steps of:
s1, taking part of water, and dissolving and dispersing the neutralizer uniformly for later use;
s2, taking the residual water, and uniformly dispersing the thickening agent for later use;
s3, starting stirring, slowly adding the uniformly dispersed component S2 into the uniformly dispersed component S1, stirring until the mixture is completely transparent and uniform, and defoaming;
s4, adding the ethanol in batches and slowly, and stirring until the mixture is completely transparent and uniform;
s5, sequentially adding the humectant, the first plant extract and the second plant extract, and fully stirring until the mixture is completely transparent and uniform to obtain the no-clean disinfection composition.
9. A no-clean disinfecting gel, which is characterized in that the effective component of the no-clean disinfecting gel comprises the no-clean disinfecting composition of any one of claims 1 to 7.
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CN114522110A (en) * | 2021-12-17 | 2022-05-24 | 安信生物科技有限公司 | Silver ion washing-free disinfectant, and preparation method and application thereof |
CN114617782A (en) * | 2022-04-26 | 2022-06-14 | 舟山市海大科学技术研究院有限责任公司 | Washing-free disinfection gel and preparation method thereof |
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