CN112842924A - Squalane-embedded high-viscosity moisturizing amino acid facial cleanser and preparation method and application thereof - Google Patents
Squalane-embedded high-viscosity moisturizing amino acid facial cleanser and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides squalane-embedded high-viscosity moisturizing amino acid facial cleanser and a preparation method and application thereof, wherein the raw materials of the facial cleanser comprise: glycerol, butylene glycol, potassium cocoyl glycinate, sodium cocoyl malate, alkyl glycoside, cocamidopropyl betaine, cetostearyl alcohol, ethylene glycol stearate, citric acid, glyceryl stearate, collagen, squalane liposome, disodium edetate, p-hydroxyacetophenone, vitamin E acetate and water. The invention also provides a preparation method of the squalane liposome. According to the invention, through increasing the amino acid surface active aggregation groups, the squalane-embedded high-viscosity moisturizing amino acid facial cleanser solves the problems of high dosage and difficult thickening of amino acid surface living body products, so that the temperature, viscosity and mildness of the facial cleanser are greatly improved in the cleaning effect on skin dirt and the moisturizing degree after use; meanwhile, the surface activity dosage of the facial cleanser and the usage amount of the product in use are reduced.
Description
Technical Field
The invention belongs to the technical field of cosmetic production, and particularly relates to squalane-embedded high-viscosity moisturizing amino acid facial cleanser as well as a preparation method and application thereof.
Background
With the updating of the cosmetic formula framework, the requirements of people on the cosmetic quality are improved, and daily chemical products are in endless. At present, the facial cleansing products in China are various in types, and it is not difficult to discover that in over 200 million of the cosmetics already put on record, the main cleansing products for the face mainly use facial cleanser as main agents, and the facial cleanser products on the market use soap base, anionic activator and amphoteric surfactant as main agents, so that the surfactant has abundant foams, strong detergency contrast, large degreasing property, and particularly has strong feeling after use due to large irritation of the soap base, and even in some formulas which are declared to be amino acid facial cleansers, a large amount of thickening agent and auxiliary surfactant are required to be added. The original safe and mild properties of the amino acid surfactant are destroyed by the formula structure.
The amino acid facial cleanser with amino acid as main surface activity has small micelle particle size, high critical micelle concentration and extremely difficult thickening, and the amino acid facial cleanser in the market is a thickening agent which basically increases the dosage of amino acid surfactant and assists various macromolecules and various thickening agents to increase the viscosity and stability of products. However, the price of amino acid surfactants is more expensive than soap base and anionic surfactants. This results in higher cost of amino acid facial cleanser and difficult mass production of the formula of the product.
Such as: CN106726698A discloses an amino acid type facial cleanser and a preparation method thereof, the amino acid type facial cleanser comprises: 0-30 wt% of amino acid surfactant, 1-15 wt% of non-amino acid surfactant, 0.5-2 wt% of thickening agent, 5-30 wt% of humectant, 0.2-2.5 wt% of neutralizer, 0.1-1 wt% of conditioner and deionized water, the skin-care cleanser is neutral, mild, skin-friendly, safe and non-irritant, can deeply clean skin, is thickened into paste mainly by adding high-content amino acid surfactant, non-amino acid surfactant and 0.5-2 wt% of thickening agent, is high in manufacturing cost and high in degreasing force, can bring water shortage and tightness after skin cleaning, hyaluronic acid and the like are added to solve the problem of moisturizing capability of the formula, and the high-content surfactant in the amino acid type cleanser and the cationic polyquaternium containing the surfactant are used as skin conditioners, so that the skin-care cleanser has obvious irritation and the characteristic of destroying the mildness of the amino acid surfactant. When the facial cleanser containing substantially all the amino acid surfactants is used in the market, the characteristic skin feeling of pseudo-smooth oil film feeling caused by long-time washing of the amino acid surfactants is difficult to overcome.
Disclosure of Invention
The invention aims to provide a squalane-embedded high-viscosity moisturizing amino acid facial cleanser as well as a preparation method and application thereof, solves the problem that a thickening agent is used for increasing the viscosity of the facial cleanser with amino acid as a main surfactant in the prior art, reduces/avoids the addition of a non-amino acid surfactant for an apparent living system, and gives consideration to safety and mildness.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the invention provides squalane-embedded high-viscosity moisturizing amino acid facial cleanser, which comprises the following components in parts by weight:
the invention also provides a preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser, which comprises the following steps:
(1) adding the first part of the glycerol, the butanediol, the potassium cocoyl glycinate, the sodium cocoyl malic acid, the alkyl glycoside, the cocamidopropyl betaine, the cetostearyl alcohol, the ethylene glycol stearate, the glyceryl stearate, the disodium ethylene diamine tetraacetate, the vitamin E acetate, the p-hydroxyacetophenone and the deionized water with the above dosage, vacuumizing, heating and stirring for reaction to obtain a phase A;
(2) adding citric acid into the second part of the deionized water, and stirring and dissolving to obtain a citric acid aqueous solution as a phase B;
(3) adding collagen into the third part of the deionized water, and stirring and dissolving to obtain a phase C;
(4) adding the phase B obtained in the step (2) into the phase A obtained in the step (1), heating and stirring, and cooling to obtain a phase D;
(5) adding the phase C obtained in the step (3) into the phase D obtained in the step (4), keeping the temperature, stirring, cooling and obtaining a phase E;
(6) and (3) adding the squalane liposome into the phase E obtained in the step (5), keeping the temperature, stirring, cooling, standing and aging to obtain the squalane-embedded high-viscosity moisturizing amino acid facial cleanser.
Further: the squalane liposome is prepared by the method a or the method b:
method a, (a 1): after cleaning and disinfecting the emulsifying kettle, adding 20-28 parts of squalane, 3-8 parts of caprylic/capric triglyceride and 5-6 parts of phytosterol into the emulsifying kettle, heating, stirring, cooling and discharging to a raw material barrel;
(a2) the method comprises the following steps Placing the raw material barrel of (a1) in a refrigerator for cooling and storing, taking out for heating and preserving, cooling and storing again, and performing cold-hot alternate circulation for 3-6 periods for later use;
(a3) the method comprises the following steps After cleaning and disinfecting the emulsifying kettle, adding 8-12 parts of deionized water, adding 10-15 parts of hydrogenated lecithin into the emulsifying kettle, starting sealed stirring, introducing nitrogen and stirring;
(a4) the method comprises the following steps Adding the raw materials treated in the step (a2) into the emulsifying kettle in the step (a3), vacuumizing, stirring, heating and preserving heat; adding 3 parts of 1, 2-hexanediol and deionized water, vacuumizing an emulsifying kettle, increasing the stirring speed, opening the homogenizing shear for 8-12 min, reducing the stirring speed, cooling and discharging to obtain squalane liposome;
or method b, (b 1): after cleaning and disinfecting the emulsifying kettle, adding 8-12 parts of deionized water, adding 10-15 parts of hydrogenated lecithin into the emulsifying kettle, starting sealed stirring, introducing nitrogen and stirring;
(b2) the method comprises the following steps Adding 20-28 parts of squalane, 3-8 parts of caprylic/capric triglyceride and 5-6 parts of phytosterol into an emulsifying kettle, vacuumizing, stirring, heating and preserving heat; and adding 3 parts of 1, 2-hexanediol and deionized water, increasing the stirring speed, opening the homogenizing shear for 8-12 min, reducing the stirring speed, and discharging after cooling to obtain the squalane liposome.
Further, the reaction temperature in the step (1) is 71-80 ℃, and the stirring rotation speed is 300-500 rpm.
Further, the temperature rise temperature in the step (4) is 76-85 ℃, and the temperature drop temperature is 56-65 ℃; the stirring speed is 300-500 rpm.
Further, the weight of the first part of the deionized water, the weight of the second part of the deionized water and the weight of the third part of the deionized water are respectively 60-90%, 5-20% and 5-20% of the total weight of the deionized water.
Further, the temperature reduction temperature in the step (5) is 36-45 ℃.
Further, the cooling speed in the cooling in the steps (4) and (5) is 0.5-1.5 ℃/min.
Further, the total amount of the deionized water of the steps (a3) and (a4) is 20-28 parts; the total amount of the deionized water in the steps (b1) and (b2) is 20-28 parts.
Further, the air pressure for vacuumizing in the step (1) is below-0.05 MP.
Further, the B phase, the C phase and the squalane liposome in the steps (4) to (6) are added dropwise at a speed of 50-100 ml/min.
Further, the stirring time in the step (1) is 26-35 min; the stirring time in the step (4) is 26-35 min; the stirring time in the step (5) is 16-55 min; and (4) stirring time in the step (6) is 16-25 min.
Further, in the step (a1), the temperature is raised to 58-65 ℃, the temperature is lowered to room temperature, and the stirring time is 18-25 min.
Further, in the step (a2), the temperature is reduced to below 0 ℃, the temperature is increased to 21-30 ℃, the temperature reduction and preservation time is 16-50 h, and the temperature increase and preservation time is 16-50 h.
Further, in the steps (a3) and (b1), the nitrogen gas is introduced for 3-6 min, the stirring speed is 200-300 rpm, and the stirring time is 6-12 min.
Further, in the step (a4), the stirring speed is 200-300 rpm, the temperature rise and preservation temperature is 70-75 ℃, and the preservation time is 18-25 minutes; the stirring speed is increased to 400-500 rpm, and the stirring speed is decreased to 150-200 rpm.
The invention also provides application of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser in preparation of cosmetics.
Compared with the prior art, the invention has the advantages and beneficial effects that:
the invention has low cost, simple production and no thickener, and is suitable for mass production. The invention is prepared by raw materials such as squalane liposome, deionized water and the like. The invention is extremely mild, no thickener is added, but can have extremely high viscosity. Can protect and supplement skin barrier, is easy to clean, has no special pseudo-slippery feeling of common amino acid surfactant, and has long water locking time. All the raw materials have good biodegradability and are environment-friendly.
The people who select the product with the amino acid framework formula mainly have sensitive skin and sensitive skin consumers. The amino acid facial cleanser disclosed by the invention is extremely high in mildness, does not have the characteristic that the dosage of an activator product in an amino acid surface-activated facial cleanser system is high or a large amount of thickening agent needs to be added to realize thickening, so that the temperature, the viscosity, the temperature, the skin dirt cleaning effect and the humidity after use of the facial cleanser are greatly improved.
The facial cleanser disclosed by the invention is free of the addition of the thickening agent, the particle size of the amino acid surface active aggregation group micelle is increased for thickening, the liposome microcapsule formed after the squalane double-layer wrapping is embedded in the gap of the increased amino acid surface active micelle group, and the squalane is subjected to denaturation treatment, so that the dissipation of squalane is increased, a good skin nourishing effect can be quickly achieved by using the liposome microspheres, and the irritation of the facial cleanser to the skin is greatly reduced. The skin permeability is increased by the squalane encapsulated by the microcapsules, and the skin barrier can be supplemented, protected and repaired. The low-irritation alkyl glycoside, the cocamidopropyl betaine and the amino acid are compounded in the formula, so that the foaming degree can be increased, the skin cleaning use feeling can be improved, and the surface activity use amount of the facial cleanser system and the use amount of the product in use are reduced. Meanwhile, the invention carries out denaturation treatment on the squalane, and can quickly achieve good skin nourishing effect by utilizing the liposome microspheres through improving the dissipation of the squalane after the denaturation treatment.
Detailed Description
The following embodiments better illustrate the present invention. However, the present invention is not limited to the following examples.
The squalane-embedded high-viscosity moisturizing amino acid facial cleanser comprises the following components in parts by weight:
the raw materials for embedding the squalane liposome structure are as follows according to parts by weight:
according to the formula disclosed by the invention, no thickening agent is added, and system thickening is carried out by increasing the micelle particle size of the potassium cocoyl glycinate and the sodium cocoyl malate. The liposome microcapsule formed after the squalane double-layer coating is embedded between the enlarged gaps of the amino acid surface active micelle groups of the potassium cocoyl glycinate and the sodium cocoyl malate. Can reduce the stimulation brought by the surfactant, and simultaneously can ensure that the coated squalane quickly permeates skin, supplements and repairs skin barriers and achieves the effect of lasting moisture preservation.
Example 1: two preparation methods of squalane liposome
The preparation method a of the squalane liposome comprises the following steps:
1. after a 100L pilot-scale emulsion kettle (hereinafter referred to as an emulsion kettle for short) is cleaned and disinfected, adding 28 parts of squalane, 8 parts of caprylic/capric triglyceride and 5 parts of phytosterol into the emulsion kettle, stirring at 200-300 rpm, heating to 60 ℃, stirring for 20min, cooling, naturally cooling to room temperature, and discharging to a raw material barrel.
2. Placing the raw material barrel in the step 1 in a refrigerator, cooling to-5 ℃, preserving for 48h, taking out, heating to 25 ℃, and preserving for 48 h; after the heat preservation is finished, the mixture is put into a refrigerator to be cooled to-5 ℃ and stored for 48 hours, and the cold and hot alternate circulation is carried out for 5 periods for standby.
3. After the emulsification kettle is cleaned and disinfected, 10 parts of deionized water is added, 12 parts of hydrogenated lecithin is added into the emulsification kettle, stirring is started by inching, valves of the emulsification kettle are closed, nitrogen is introduced for 5min, and the rotation speed is controlled to be 200-300 rpm and kept for 10 min.
4. Adding the raw materials treated in the step 2 into the emulsifying kettle in the step 3 through an oil phase pot, vacuumizing to be below-0.05 MP, controlling the rotating speed to be 200-300 rpm, heating to 70-75 ℃, and preserving heat for 20 minutes; adding 1, 2-hexanediol and the rest deionized water into an aqueous phase pot, vacuumizing an emulsifying kettle to be below-0.05 MP, preserving the temperature at 70-75 ℃, increasing the stirring speed to 400-500 rpm, opening the homogenizing shear, controlling the homogenizing shear speed to 20000rpm, and keeping for 10 min. Reducing the stirring speed, controlling the rotation speed to be 150-200 rpm, cooling to 40 ℃, controlling the cooling speed to be 1 ℃/min and 40 ℃, introducing nitrogen, exhausting and discharging to obtain the squalane liposome.
Secondly, the preparation method b of the squalane liposome comprises the following steps:
1. after the emulsification kettle is cleaned and disinfected, 10 parts of deionized water is added, 12 parts of hydrogenated lecithin is added into the emulsification kettle, stirring is started by inching, valves of the emulsification kettle are closed, nitrogen is introduced for 5min, and the rotation speed is controlled to be 200-300 rpm and kept for 10 min.
2. Adding 28 parts of squalane, 8 parts of caprylic/capric triglyceride and 5 parts of phytosterol into an emulsifying kettle through an oil phase pot, vacuumizing to be below-0.05 MP, controlling the rotating speed to be 200-300 rpm, heating to 70-75 ℃, and preserving heat for 20 minutes; adding 1, 2-hexanediol and the rest deionized water into an aqueous phase pot, vacuumizing an emulsifying kettle to be below-0.05 MP, preserving the temperature at 70-75 ℃, increasing the stirring speed to 400-500 rpm, opening the homogenizing shear, controlling the homogenizing shear speed to 20000rpm, keeping for 10min, reducing the stirring speed, controlling the rotation speed to 150-200 rpm, reducing the temperature to 40 ℃, controlling the cooling speed to 1 ℃/min and 40 ℃, introducing nitrogen, evacuating and discharging to obtain the undenatured squalane liposome.
Example 2: preparation of squalane-embedded high-viscosity moisturizing amino acid facial cleanser
The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser comprises the following steps:
1. adding 90% of the total weight of glycerol, butanediol, potassium cocoyl glycinate, sodium cocoyl malate, alkyl glycoside, cocamidopropyl betaine, cetostearyl alcohol, glyceryl stearate, p-hydroxyacetophenone, ethylene glycol stearate, disodium ethylene diamine tetraacetate, vitamin E acetate and deionized water into a 150L pilot scale reaction kettle (hereinafter referred to as a reaction kettle) in sequence, stirring by inching, adjusting the revolution to 300rpm, heating to 75 ℃, vacuumizing to-0.05 MP, and stirring for 30min to obtain a phase A.
2. Adding citric acid into 5% of deionized water, stirring to obtain citric acid aqueous solution, and getting phase B.
3. Adding collagen into the residual 5% of deionized water, stirring and dissolving to obtain protein dispersed colloid phase C.
4. And (3) dropwise adding the phase B obtained in the step (2) into the phase A obtained in the step (1) at 50ml/min, controlling the temperature to be increased to 80 ℃ after dropwise adding is finished, stirring at the speed of 500rpm, keeping the pressure in the reaction kettle to be less than-0.05 MP, cooling to 60 ℃ by introducing cooling water after heat preservation is carried out for 30min, and controlling the cooling speed to be 1 ℃/min to obtain a phase D.
5. And (3) dropwise adding the phase C obtained in the step (3) into the phase D obtained in the step (4) at a speed of 100ml/min, controlling the temperature to be 60 ℃ and the rotation speed to be 500rpm after the dropwise adding is finished, controlling the pressure in the reaction kettle to be less than-0.05 MP, stirring for 20min, then introducing cooling water to be cooled to 40 ℃, controlling the cooling speed to be 0.5 ℃/min, and obtaining the phase E (adjusting the rotation speed to be 300rpm after the temperature is cooled to 50 ℃).
6. And (3) dropwise adding the squalane liposome into the phase E obtained in the step (5) at a rate of 100ml/min, controlling the temperature to be 40 ℃ after the dropwise adding is finished, rotating at the speed of 300rpm, controlling the pressure in the reaction kettle to be less than-0.05 MP, stirring for 20min, cooling to room temperature, discharging, standing at room temperature, and aging for 24 hours to obtain the squalane-embedded high-viscosity moisturizing amino acid facial cleanser which is a qualified finished product.
Example 3: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
First, formula
The raw material formula and the weight parts of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser are shown in table 1;
table 1 formula of amino acid facial cleanser of the present invention
| Formulation A | Formulation B | Formulation C | Formulation D | |
| Glycerol | 40 portions of | 35 portions of | 30 portions of | 25 portions of |
| Butanediol | 5 portions of | 5 portions of | 8 portions of | 8 portions of |
| Coconut oil acyl potassium glycinate | 14 portions of | 12 portions of | 10 portions of | 8 portions of |
| Sodium cocoyl malate | 4 portions of | 4 portions of | 6 portions of | 2 portions of |
| Alkyl glycosides | 10 portions of | 8 portions of | 6 portions of | 5 portions of |
| Cocoamidopropyl betaine | 5 portions of | 5 portions of | 5 portions of | 8 portions of |
| Cetostearyl alcohol | 2 portions of | 2 portions of | 1 part of | 1 part of |
| Ethylene glycol stearate | 4 portions of | 4 portions of | 2 portions of | 1.5 parts of |
| Citric acid | 2 portions of | 2 portions of | 1.5 parts of | 1.5 parts of |
| Glycerol stearate | 1 part of | 1 part of | 0.5 portion | 0.5 portion |
| Collagen protein | 1 part of | 1 part of | 1 part of | 0.5 portion |
| Squalane liposome | 8 portions of | 6 portions of | 6 portions of | 4 portions of |
| Ethylenediaminetetraacetic acid disodium salt | 0.05 part | 0.05 part | 0.05 part | 0.1 part |
| P-hydroxyacetophenone | 0.5 portion | 0.5 portion | 0.5 portion | 0.5 portion |
| Vitamin E acetate | 1 part of | 1 part of | 1 part of | 1 part of |
| Deionized water | 22.45 portions | 33.45 parts | 41.45 parts | 53.4 parts |
| Total up to | 120 portions of | 120 portions of | 120 portions of | 120 portions of |
The raw material formula and the parts by weight of the squalane liposome are shown in table 2;
TABLE 2 formulation of squalane liposomes of the invention
The raw materials used in the present invention are all commercially available.
Second, preparation method
1. Squalane liposome prepared according to the preparation method described in example 1, formulation E in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is 10 nm-50 nm squalane liposome.
2. The facial cleanser was prepared according to the preparation method described in example 3, and the formula was formula a in example 3.
(1) The obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 4, 12 rpm;
41 (pointer reading) × 500 (coefficient) ═ 20500 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 125 + -3 mm (3 measurements are averaged);
foam height after 10 min: 116. + -.3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 31 subjects, wherein the age of the subjects is 23-38 years old;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 17;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: the skin moisture content is one of main indexes for detecting the moisture retention of a formula and influencing the skin barrier, and the facial cleanser with an amino acid formula with a large sale amount on the market and the facial cleanser disclosed by the invention are selected for reference; under the test conditions of constant temperature and constant relative humidity (25 ℃, 35 ℃) in an organoleptic test laboratory, a skin moisture content test probe is used to select 11 human subjects with the ages of 25-38 years from CK company (Courage + Khazaka company, Germany) Comemeter CM825 for testing, and the test results are shown in the following table 3;
TABLE 3 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 27.31±1.97 | 23.15±1.65 | 31.38±3.35 |
| 1h | 27.55±2.18 | 23.19±2.51 | 33.49±3.43 |
| 7h | 28.63±3.31 | 27.89±2.64 | 31.15±2.57 |
The high-viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
Example 4: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
1. Squalane liposome prepared according to the preparation method described in example 1, formulation E in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is the squalane liposome with the particle diameter of 30 nm-60 nm.
2. The facial cleanser is prepared according to the preparation method of the example 3, and the formula is the formula A in the example 3;
(1) the obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 4, 12 rpm;
40 (pointer reading) × 500 (coefficient) ═ 20000 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 120 + -3 mm (3 measurements are averaged);
foam height after 10 min: 111 + -3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 32 testees, wherein the age of the testees is 23-38 years old;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 18;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: under the constant temperature and constant relative humidity (25 ℃, 35 ℃) test conditions of an organoleptic test laboratory, 11 human subjects aged 25-38 years were selected by a tester CM825 of CK company (Courage + Khazaka, germany) using a skin moisture content test probe and tested, and the test results are shown in table 4 below.
TABLE 4 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 27.21±1.75 | 23.06±1.59 | 30.35±2.65 |
| 1h | 27.38±2.05 | 23.03±2.51 | 32.19±3.22 |
| 7h | 28.54±3.28 | 27.88±2.56 | 30.56±2.85 |
The high viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
Example 5: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
1. Squalane liposomes were prepared according to the preparation method described in example 1, formulation F in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is the squalane liposome with the particle diameter of 30 nm-60 nm.
2. The facial cleanser is prepared according to the preparation method of the example 3, and the formula is the formula B in the example 3;
(1) the obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 3, 6 rpm;
84.0 (pointer reading) 200 (coefficient) 16800 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 118 ± 3mm (3 measurements averaged);
foam height after 10 min: 114. + -.3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 33 subjects, wherein the age of the subjects is 23-38 years old;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 19;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: under the test conditions of constant temperature and constant relative humidity (25 ℃, 35 ℃) in an organoleptic test laboratory, a skin moisture content test probe is used to select 9 human subjects with the ages of 25-38 years from a Comemeter CM825 of Germany CK company (Courage + Khazaka company, Germany) for testing, and the test results are shown in the following table 5;
TABLE 5 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 28.55±1.52 | 24.25±1.18 | 36.38±3.85 |
| 1h | 28.95±2.42 | 25.26±2.91 | 38.72±2.36 |
| 7h | 29.21±3.15 | 27.18±3.25 | 32.50±2.42 |
The high viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
Example 6: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
1. Squalane liposomes were prepared according to the preparation method described in example 1, formulation F in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is 10 nm-50 nm squalane liposome.
2. The facial cleanser is prepared according to the preparation method of the example 3, and the formula is the formula B in the example 3;
(1) the obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 3, 6 rpm;
88.0 (pointer reading) 200 (coefficient) 17600 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 125 + -3 mm (3 measurements are averaged);
foam height after 10 min: 120 + -3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 33 subjects, wherein the age of the subjects is 23-38 years old;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 19;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: under the test conditions of constant temperature and constant relative humidity (25 ℃, 35 ℃) of an organoleptic test laboratory, a skin moisture content test probe is used to select 10 subjects with the ages of 25-38 years from a Cornemeter CM825 of Germany CK company (Courage + Khazaka company, Germany) for testing, and the test results are shown in the following table 6;
TABLE 6 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 28.05±1.88 | 24.11±1.58 | 37.88±1.65 |
| 1h | 28.40±2.84 | 25.31±2.63 | 39.42±2.62 |
| 7h | 29.21±3.30 | 27.83±3.66 | 33.80±3.48 |
The high viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
Example 7: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
1. Squalane liposome prepared according to the preparation method described in example 1, formulation G in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is 10 nm-50 nm squalane liposome.
2. The facial cleanser was prepared according to the preparation method described in example 3, and the formula was formula C in example 3;
(1) the obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 3, 6 rpm;
76.5 (pointer reading) 200 (coefficient) 15300 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 133 + -3 mm (3 measurements are averaged);
foam height after 10 min: 116. + -.3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 28 subjects, wherein the age of the subjects is 23-35 years;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 17;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: under the test conditions of constant temperature and constant relative humidity (25 ℃, 35 ℃) of an organoleptic test laboratory, a skin moisture content test probe is used to select 10 subjects with the ages of 25-38 years from a Cornemeter CM825 of Germany CK company (Courage + Khazaka company, Germany) for testing, and the test results are shown in the following table 7;
TABLE 7 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 27.31±1.97 | 23.15±1.65 | 33.54±2.25 |
| 1h | 27.55±2.18 | 23.19±2.51 | 35.44±3.65 |
| 7h | 28.63±3.31 | 26.89±2.64 | 32.19±2.56 |
The high viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
Example 8: testing of squalane-embedded high viscosity moisturizing amino acid facial cleanser
1. Squalane liposome was prepared according to the preparation method described in example 1, formulation H in example 3; sampling, selecting emulsified particles with different sizes by microscopic image control analysis under a high power microscope, and measuring the particle diameter by a three-point method, wherein the measured particle diameter is 20 nm-60 nm squalane liposome.
2. The facial cleanser was prepared according to the preparation method described in example 3, and the formula was formula D in example 3;
(1) the obtained facial cleanser is high-viscosity moisturizing amino acid facial cleanser embedded with squalane, and the viscosity of the facial cleanser is tested after the facial cleanser is stood and aged for 24 hours at room temperature;
the NDJ-1 type rotary viscometer is selected to test conditions: rotor No. 3, 6 rpm;
74.5 (pointer reading) × 200 (coefficient) ═ 14900 mpa.s.
(2) And (3) performing foam test after the squalane-embedded high-viscosity moisturizing amino acid facial cleanser is stood and aged for 24 hours at room temperature, wherein the test method is measured by using a Roche foamer according to GB/17173:
and (3) testing mass concentration: 2 percent;
and (3) testing temperature: 40 ℃;
the initial foam height was: 128 + -3 mm (3 measurements are averaged);
foam height after 10 min: 115. + -.3 mm (3 measurements are averaged).
(3) Spot-pasting experiment: selecting 31 subjects, wherein the age of the subjects is 23-38 years old;
the number of sensitive muscles is required to be at least 50 percent of the total number (the number of sensitive muscle screening rolls is measured by 5 percent lactic acid solution), and the number of actual sensitive muscles is 17;
applying spots of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser to the curved side of the forearm of a subject, lightly pressing with hands to uniformly apply the patches to the skin for 24 hours, removing the spots, and recording reaction results for 30min, 24 hours and 48 hours after the indentations disappear;
all the testers had negative reaction. No weak erythema, edema, infiltration, pimple, etc.
(4) Moisture content of skin: under the test conditions of constant temperature and constant relative humidity (25 ℃, 35 ℃) of an organoleptic test laboratory, a skin moisture content test probe is used to select 10 subjects with the ages of 25-38 years from a Cornemeter CM825 of Germany CK company (Courage + Khazaka company, Germany) for testing, and the test results are shown in the following table 8;
TABLE 8 test results
| Time | Blank space | Commercial facial cleanser | High-viscosity moisturizing amino acid facial cleanser |
| 30min | 27.55±1.60 | 24.00±1.82 | 31.38±3.35 |
| 1h | 27.90±2.20 | 24.85±2.90 | 33.49±3.43 |
| 7h | 28.63±3.88 | 27.00±3.57 | 32.15±2.57 |
The high viscosity moisturizing amino acid facial cleanser can protect and supplement skin barrier. Under a stable environment, the measured data shows that the water locking and moisturizing time is still higher than a blank value.
The comparison of the test results of the examples 5 to 8 shows that the squalane-coated liposome microcapsule prepared in the example 1 and denatured at high and low temperatures has obvious advantages in both the viscosity of the facial cleanser and the moisturizing effect compared with the undenatured squalane liposome microcapsule prepared in the example 2.
The amino acid facial cleanser mainly takes amino acid surfactants as main materials, has fine foams, moderate cleaning force, soft and mild skin feel when in use, has weak acidity in the whole formula, and is close to the pH value of healthy skin of a human body.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the technical solutions described in the foregoing embodiments, or some of the technical features may be substituted equally; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. A squalane-embedded high-viscosity moisturizing amino acid facial cleanser is characterized in that: the facial cleanser comprises the following components in parts by weight:
2. the method for preparing squalane-embedded high-viscosity moisturizing amino acid facial cleanser of claim 1, comprising the steps of:
(1) adding the first part of the glycerol, the butanediol, the potassium cocoyl glycinate, the sodium cocoyl malic amino acid, the alkyl glycoside, the cocamidopropyl betaine, the cetostearyl alcohol, the ethylene glycol stearate, the glyceryl stearate, the disodium ethylene diamine tetraacetate, the vitamin E acetate, the p-hydroxyacetophenone and the deionized water with the above dosage, vacuumizing, heating and stirring for reaction to obtain a phase A;
(2) adding citric acid into the second part of the deionized water, and stirring and dissolving to obtain a citric acid aqueous solution as a phase B;
(3) adding collagen into the third part of the deionized water, and stirring and dissolving to obtain a phase C;
(4) adding the phase B obtained in the step (2) into the phase A obtained in the step (1), heating and stirring, and cooling to obtain a phase D;
(5) adding the phase C obtained in the step (3) into the phase D obtained in the step (4), keeping the temperature, stirring, cooling and obtaining a phase E;
(6) and (3) adding the squalane liposome into the phase E obtained in the step (5), keeping the temperature, stirring, cooling, standing and aging to obtain the squalane-embedded high-viscosity moisturizing amino acid facial cleanser.
3. The method for producing a squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 1 or 2, wherein the squalane liposomes are produced by method a or method b:
method a, (a 1): after cleaning and disinfecting the emulsifying kettle, adding 20-28 parts of squalane, 3-8 parts of caprylic/capric triglyceride and 5-6 parts of phytosterol into the emulsifying kettle, heating, stirring, cooling and discharging to a raw material barrel;
(a2) the method comprises the following steps Placing the raw material barrel of (a1) in a refrigerator for cooling and storing, taking out for heating and preserving, cooling and storing again, and performing cold-hot alternate circulation for 3-6 periods for later use;
(a3) the method comprises the following steps After cleaning and disinfecting the emulsifying kettle, adding 8-12 parts of deionized water, adding 10-15 parts of hydrogenated lecithin into the emulsifying kettle, starting sealed stirring, introducing nitrogen and stirring;
(a4) the method comprises the following steps Adding the raw materials treated in the step (a2) into the emulsifying kettle in the step (a3), vacuumizing, stirring, heating and preserving heat; adding 3 parts of 1, 2-hexanediol and deionized water, vacuumizing an emulsifying kettle, increasing the stirring speed, opening the homogenizing shear for 8-12 min, reducing the stirring speed, and discharging after cooling to obtain the squalane liposome;
or method b, (b 1): after cleaning and disinfecting the emulsifying kettle, adding 8-12 parts of deionized water, adding 10-15 parts of hydrogenated lecithin into the emulsifying kettle, starting sealed stirring, introducing nitrogen and stirring;
(b2) the method comprises the following steps Adding 20-28 parts of squalane, 3-8 parts of caprylic/capric triglyceride and 5-6 parts of phytosterol into an emulsifying kettle, vacuumizing, stirring, heating and preserving heat; and adding 3 parts of 1, 2-hexanediol and deionized water, increasing the stirring speed, opening the homogenizing shear for 8-12 min, reducing the stirring speed, and discharging after cooling to obtain the squalane liposome.
4. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 2, wherein the reaction temperature in the step (1) is 71-80 ℃, and the stirring rotation speed is 300-500 rpm.
5. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 2, wherein the temperature rise temperature in the step (4) is 76-85 ℃, and the temperature drop temperature is 56-65 ℃; the stirring speed is 300-500 rpm.
6. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 2, wherein the weight of the first part of deionized water, the weight of the second part of deionized water and the weight of the third part of deionized water are respectively 60-90%, 5-20% and 5-20% of the total weight of deionized water.
7. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 2, wherein the temperature reduction temperature in the step (5) is 36-45 ℃.
8. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 2, wherein the cooling rate in cooling in steps (4) and (5) is 0.5-1.5 ℃/min.
9. The preparation method of the squalane-embedded high-viscosity moisturizing amino acid facial cleanser according to claim 3, wherein the total amount of deionized water in the steps (a3) and (a4) is 20-28 parts; the total amount of the deionized water in the steps (b1) and (b2) is 20-28 parts.
10. Use of the squalane-embedded high viscosity moisturizing amino acid facial cleanser of claim 1 in the preparation of cosmetics.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267124A (en) * | 2015-11-18 | 2016-01-27 | 陈洁娣 | Whitening and hydrating cleansing milk and method for manufacturing same |
| CN107997996A (en) * | 2017-12-12 | 2018-05-08 | 广州市仙婷贸易有限公司 | A kind of bilayer mildy wash and preparation method thereof |
| CN108815083A (en) * | 2018-08-24 | 2018-11-16 | 广州市美驰化妆品有限公司 | A kind of nourishing moisturizing mildy wash and preparation method thereof |
| CN108992368A (en) * | 2018-08-21 | 2018-12-14 | 上海儿童营养中心有限公司 | A kind of liposome of bionical vernix caseosa, preparation method and application |
| CN110151578A (en) * | 2019-07-05 | 2019-08-23 | 广东天源生物科技有限公司 | A kind of clean face cream of amino acid skin-active and preparation method thereof of mild cleaning moisturizing |
| CN110251452A (en) * | 2019-07-03 | 2019-09-20 | 森锐健康科技(广州)有限公司 | A kind of moist mild amino acid bath foam and preparation method thereof |
| CN110604703A (en) * | 2019-09-17 | 2019-12-24 | 广州市衡拓贸易有限公司 | Efficient amino acid thickener and preparation method thereof |
| CN110693747A (en) * | 2019-10-30 | 2020-01-17 | 广州留今科学研究有限公司 | Surfactant composition, female fragrance shower gel containing surfactant composition and preparation method of shower gel |
-
2020
- 2020-12-22 CN CN202011524606.7A patent/CN112842924B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267124A (en) * | 2015-11-18 | 2016-01-27 | 陈洁娣 | Whitening and hydrating cleansing milk and method for manufacturing same |
| CN107997996A (en) * | 2017-12-12 | 2018-05-08 | 广州市仙婷贸易有限公司 | A kind of bilayer mildy wash and preparation method thereof |
| CN108992368A (en) * | 2018-08-21 | 2018-12-14 | 上海儿童营养中心有限公司 | A kind of liposome of bionical vernix caseosa, preparation method and application |
| CN108815083A (en) * | 2018-08-24 | 2018-11-16 | 广州市美驰化妆品有限公司 | A kind of nourishing moisturizing mildy wash and preparation method thereof |
| CN110251452A (en) * | 2019-07-03 | 2019-09-20 | 森锐健康科技(广州)有限公司 | A kind of moist mild amino acid bath foam and preparation method thereof |
| CN110151578A (en) * | 2019-07-05 | 2019-08-23 | 广东天源生物科技有限公司 | A kind of clean face cream of amino acid skin-active and preparation method thereof of mild cleaning moisturizing |
| CN110604703A (en) * | 2019-09-17 | 2019-12-24 | 广州市衡拓贸易有限公司 | Efficient amino acid thickener and preparation method thereof |
| CN110693747A (en) * | 2019-10-30 | 2020-01-17 | 广州留今科学研究有限公司 | Surfactant composition, female fragrance shower gel containing surfactant composition and preparation method of shower gel |
Non-Patent Citations (1)
| Title |
|---|
| 郑依等: "胎脂成分与功效及仿生应用展望", 《日用化学工业》 * |
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