CN112825859B - Bactericidal composition and application thereof - Google Patents

Bactericidal composition and application thereof Download PDF

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Publication number
CN112825859B
CN112825859B CN202011314120.0A CN202011314120A CN112825859B CN 112825859 B CN112825859 B CN 112825859B CN 202011314120 A CN202011314120 A CN 202011314120A CN 112825859 B CN112825859 B CN 112825859B
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active component
composition
halo
activity
disease
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CN112825859A (en
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王军锋
李志念
刘君丽
关爱莹
兰杰
刘长令
孙芹
单忠刚
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Priority to CN202310611109.8A priority Critical patent/CN116711727A/en
Priority to CN202310611255.0A priority patent/CN117016551A/en
Priority to CN202310611195.2A priority patent/CN117016550A/en
Priority to CN202210553242.8A priority patent/CN114903046B/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the field of agricultural bactericides, and particularly relates to a bactericidal composition and application thereof. The composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99: 1; the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof, and the active component B is selected from a bactericide. The bactericidal composition is particularly suitable for preventing and treating various plant pathogenic fungi and bacterial diseases.

Description

Bactericidal composition and application thereof
Technical Field
The invention belongs to the field of agricultural bactericides, and particularly relates to a pyrimidine-containing substituted pyrazole compound and a bactericidal composition of a bactericide and application thereof.
Background
WO2016184378 discloses a pyrimidine-containing substituted pyrazole compound and its use, wherein the compound shown in the following general formula I-A, I-B is reported to have good activity on various diseases.
Figure BDA0002790774720000011
The bactericide of the respiratory inhibitor class, the bactericide of the nucleic acid metabolism inhibitor class, the bactericide of the cell wall synthesis inhibitor class, the bactericide of the signal transduction inhibitor class, the bactericide of the cytoskeleton and the kinetin inhibitor class, the bactericide of the sterol biosynthesis inhibitor class, the bactericide of the phospholipid synthesis inhibitor class, the bactericide of the cell wall synthesis inhibitor class and the bactericide of the methionine biosynthesis inhibitor class are bactericides which are widely used in agricultural production and have outstanding prevention and treatment effects. Due to the single action site, the field efficacy of part of varieties is obviously reduced after long-term repeated use. The multi-site inhibitor bactericide is a broad-spectrum protective bactericide, but the bactericide has poor therapeutic activity and large field dosage.
In the practice of applying bactericides, people often find that one medicament has a good disease prevention effect in the initial stage, but the dosage is gradually increased along with the increase of the use times, the medicament effect is slightly improved, and sometimes the disease prevention effect is even completely lost. The main reason is that the pathogenic bacteria population changes, namely part of pathogenic bacteria obtain drug-resistant plasmids through mutation to generate drug resistance, and the dominant population is gradually formed in natural selection, so that the drug effect of the bactericide is reduced. Meanwhile, it is also recognized that after the pesticide is applied, a part of the pesticide may be scattered on the soil or dissipated into the air, or may flow into rivers and lakes along with rainwater and farmland drainage, causing environmental pollution. Therefore, pesticide products which have high pesticide effect, small dosage and less environmental pollution and can delay the drug resistance of pathogenic bacteria are urgently needed.
The pesticide combination application is an important means for delaying the generation of drug resistance of pathogenic bacteria and is also an effective method for reducing the pesticide dosage. The scientificity of the combined application of the bactericides depends on not only the control objects and the action mechanism, but also the combined action property after the medicaments are mixed. Therefore, the development of a high-efficiency bactericide composition with complementary action and remarkable synergism has a plurality of restriction factors and has extremely low success rate.
Disclosure of Invention
The invention aims to provide a synergistic bactericidal composition of a pyrimidine-containing substituted pyrazole compound and a bactericide and application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a bactericidal composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:99-99: 1;
wherein, the active component A is one or more of substituted pyrazole compounds containing pyrimidine or salts thereof; the active component B is selected from a bactericide.
The active component A is a compound shown as a general formula I-A or I-B or a salt thereof:
Figure BDA0002790774720000021
in the formula:
R1selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C1-C4Alkylthio, halo C1-C4Alkylthio radical, C1-C4Alkylsulfinyl radical, C1-C4Alkylsulfonyl radical, C2-C4Alkenyl, halo C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkynyl, C3-C4Alkenyloxy, halogeno C3-C4Alkenyloxy radical, C3-C4Alkynyloxy, halo C3-C4Alkynyloxy, C1-C4Alkylamino radical, di (C)1-C4Alkyl) amino, C1-C4Alkylaminocarbonyl, halogeno C1-C4Alkylaminocarbonyl radical, C1-C4Alkoxycarbonyl, halo C1-C4Alkoxycarbonyl group, C1-C4Alkoxy radical C1-C4Alkyl or C1-C4Alkylthio group C1-C4An alkyl group;
R2selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group;
R3selected from hydrogen, hydroxy, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylthio radical, C2-C4Alkenylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkenyl, halo C2-C4Alkynyl, C1-C4Alkoxy radical C1-C4Alkyl, halo C1-C4Alkoxy radical C1-C4Alkyl radical, C1-C4Alkylthio group C1-C4Alkyl, halo C1-C4Alkylthio group C1-C4Alkyl radical, C1-C4Alkylsulfinyl, halogeno C1-C4Alkylsulfinyl radical, C1-C4Alkylsulfonyl, halo C1-C4Alkylsulfonyl radical, C1-C4Alkylaminosulfonyl, di (C)1-C4Alkyl) aminosulfonyl, C1-C4Alkylsulfonylaminocarbonyl group, C1-C4Alkylcarbonylaminosulfonyl radical, C3-C4Cycloalkyloxycarbonyl radical, C1-C4Alkylcarbonyl, halo C1-C4Alkylcarbonyl group, C1-C4Alkoxycarbonyl, halo C1-C4Alkoxycarbonyl group, C1-C4Alkyl carbonyl radical C1-C4Alkyl radical, C1-C4Alkoxycarbonyl radical C1-C4Alkyl radical, C1-C4Alkylaminocarbonyl, di (C)1-C4Alkyl) aminocarbonyl, C2-C4Alkenyloxycarbonyl radical, C2-C4Alkynyloxycarbonyl group, C1-C4Alkoxy radical C1-C4Alkoxycarbonyl group, C1-C4Alkylaminosulfenyl, di (C)1-C4Alkyl) aminosulfanyl, arylcarbonyl C1-C4Alkyl, arylcarbonyl, aryloxycarbonyl, aryl C1-C4Alkyloxycarbonyl, aryl C1-C4Alkyl, heteroaryl carbonyl C1-C4Alkyl, heteroarylcarbonyl, heteroaryloxycarbonyl, heteroaryl C1-C4Alkyloxycarbonyl or heteroaryl C1-C4An alkyl group;
R4、R5can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; wherein R is4、R5C attached thereto may also form C3-C4A ring of (a);
R6、R7can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; wherein R is6、R7C attached thereto may also form C3-C4A ring of (a);
R8、R9can be the same or different and are respectively selected from hydrogen, cyano, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxycarbonyl, halo C1-C4Alkoxycarbonyl, unsubstituted or substituted by 1 to 5R11Substituted aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroarylmethyl, heteroarylcarbonyl, heteroarylmethylcarbonyl, or heteroaryloxycarbonyl;
R11selected from halogen, hydroxy, amino, cyano, nitro, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylamino, halogeno C1-C4Alkylamino radical, di (C)1-C4Alkyl) amino, halo-di (C)1-C4Alkyl) amino, C1-C4Alkylthio, halo C1-C4Alkylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, C2-C4Alkenyloxy, halogeno C2-C4Alkenyloxy radical, C2-C4Alkynyloxy, halo C2-C4Alkynyloxy, C1-C4Alkylsulfonyl, halo C1-C4Alkylsulfonyl radical, C1-C4Alkylcarbonyl, halo C1-C4Alkylcarbonyl group, C1-C4Alkoxycarbonyl, halo C1-C4Alkoxycarbonyl group, C1-C4Alkoxy radical C1-C4Alkyl, halo C1-C4Alkoxy radical C1-C4Alkyl radical, C1-C4Alkylthio group C1-C4Alkyl, halo C1-C4Alkylthio group C1-C4Alkyl radical, C1-C4Alkoxycarbonyl radical C1-C4Alkyl, halo C1-C4Alkoxycarbonyl radical C1-C4Alkyl radical, C1-C4Alkylthio carbonyl group C1-C4Alkyl, halo C1-C4Alkylthio carbonyl group C1-C4Alkyl radical, C1-C4Alkylcarbonyloxy, halo C1-C4Alkylcarbonyloxy, C1-C4Alkoxycarbonyloxy, haloGeneration C1-C4Alkoxycarbonyloxy, C1-C4Alkylsulfonyloxy, halo C1-C4Alkylsulfonyloxy, C1-C4Alkoxy radical C1-C4Alkoxy or halo C1-C4Alkoxy radical C1-C4An alkoxy group; n is an integer of 0 to 5, and when n is greater than 1, R11May be the same or different;
R14、R15、R16or R17Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy or C3-C4A cycloalkyl group;
w is selected from hydrogen, halogen, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl, C1-C4Alkoxy radical, C1-C4Alkylthio or C1-C4An alkylsulfonyl group;
the salt of the pyrimidine-containing substituted pyrazole compound is formed by a compound shown in a general formula I-A or I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
the active component B is selected from one or more of a respiratory inhibitor bactericide, a nucleic acid metabolism inhibitor bactericide, a cell wall synthesis inhibitor bactericide, a signal transduction inhibitor bactericide, a cytoskeleton and kinetin inhibitor bactericide, a sterol biosynthesis inhibitor bactericide, a phospholipid synthesis inhibitor bactericide, a methionine biosynthesis inhibitor bactericide, a multi-site inhibitor bactericide and an action mechanism unknown bactericide.
When the active component A is a compound in the general formula I-A or a salt thereof, the composition is preferably composed of the active component A and the active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula: r3Selected from hydrogen, hydroxy, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl, C1-C4Alkylthio radical, C2-C4Alkenylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkenyl or halogeno C2-C4An alkynyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxycarbonyl or halo C1-C4An alkoxycarbonyl group; r11Selected from halogen, hydroxy, amino, cyano, nitro, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylamino, halogeno C1-C4Alkylamino radical, di (C)1-C4Alkyl) amino, halo-di (C)1-C4Alkyl) amino or C1-C4An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; r14、R15、R16Or R17Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C1-C4Alkyl, halo C1-C4Alkyl or C1-C4An alkoxy group; w is selected from hydrogen, halogen, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy or C1-C4An alkylthio group;
the salt of the compound shown in the general formula I-A is formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from benzovindiflupyr B1, fluxapyroxad B2, isopyrazam B3, fluxapyroxad B4, flupyrazamide B5, flunisolide B6, flutolanil B7, fluthiavalicarb B8, boscalid B9, diphenoxyhydramine B10, flutolanil B11, flutriafol B12, fluthiavalimide B13, fluquinconazole B13, flufenamide B13, fluquinconazole B, Cyazofamid (cyazofamid) B30, ametoctradin B31, fluazinam (fluazinam) B32, fenpicoamid B33, florylpicoxamid B34, amisulbrom (amisulbactam) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, triphenyltin chloride (triphenotinchloride) B38, dicrotonate (cinconazole) B39, dinocap (dinocap) B40, flumorph (flumorph) B41, dimethomorph (dimorphoh) B42, mandipropamid (manisop) B42, difenoconazole (difenoconazole) B42, cyazofamid (cyazofamid) B42, cyazofamid (pyrimethanamide) B42, cyazofamid (pyrimethanamide) B42), cyazofamid B42, cyazofamid (pyrimethanamide (42), cyazofamid B42), cyazofamid (fosfamid B42), cyazofamid B42, cyazofamid (fosfamid B42), cyazofamid B42, cyazofamid (fosfamid B-cyazofamid B42, cyazofamid (fosfamid B42, cyazofamid B-5, cyazofamid B-isopropyl (fosfamid B42, cyazofamid B-5, cyazofamid B42, cyazofamid B-cyazofamid B42, cyazofamid B-ethimide B-pyrimethanamide (fosfamid B42, cyazofamid B-5, cyazofamid B42, cyazofamid B-5, cyazofamid B42, cyazofamid B-5, cyazofamid B42, cyazofamid B-5, cyazofamid B42, cyazofamid B-B42, cyazofamid B-5, cyazofamid B-cy, Hymexazol B59, octhiophenone B60, furosemide B61, quinconazole B62, oxadixyl B62, furalaxyl B62, fludioxonil B62, fenpiclonil B62, iprodione B62, procymidone B62, metrazolidol B62, metrazolidone B62, procymidone B62, metrazolidol B62, procymidone B62, meclozolin B62, chlozolinate B62, dimethachlon B62, dimethachiazolin B62, procymidone B62, ethiprole B62, diethylfenfenamidopropyl B62, pyrimethanpyrimethan B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethan B62, pyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethan B62, pyrimethanil B62, pyrimethan B62, pyrimethanil B685, Chlorofluoromethoate (mefenthifluzole) B91, nuarimol B92, oxaziridine (oxypolyzole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyrisoxazole (pyrisoxazole) B97, tridemorph (tridemorph) B98, triforine (triforine) B99, dodemorph (dodemorph) B100, bromuconazole (broconazol) B101, imazalil (triafol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumzofe) B105, pyriproxyfluazol B106, tetrazofenozide B106, pyrifenozide B108, propineb (propineb) B121, pyrifenoxathiobac (thiofenozide) B115, pyrifenoxathiofenozide B108, pyrifenozide B119, pyriproxyfen (propineb) B108, pyrifenozide B110, pyrifenoxathiobac (propineb B110, pyrifenozide B110, pyrifenoxathiobac (thiobac (propineb B110, pyrifenozide B110, pyrifenoxad (propineb B110, pyrifenozide B110, pyrifenoxathiobac (propineb B110, pyrifenoxaprop-ethyl) B110, pyrifenozide B110, pyrifenozide B (propineb B, pyrifenozide B (propineb B110, pyrifenozide B110, pyrifenozide B (propineb B110, pyrifenozide B (propineb B110, pyrifenozide B110, pyrifenozide B (propineb B110, pyrifenozide B110, pyrifenoxad (propineb B110, pyrifenoxad (propineb B110, pyrifenozide B, pyrifenoxad (propineb B110, pyrifenoxad B110, pyrifenozide B (propineb B110, pyrifenoxad B (propineb B110, pyri, Tolclofos-methyl B122, benthiavalicarb-isopyramid B123, polyoxin B124, valicarb-125, pyrimorph B126, blasticidin B127, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, oxytetracycline B133, zineb B134, mancozeb B135, metiram B136, propineb B149, fenbuconazole B150, fenpropathrin B145, fenfluramine B148, fenfluramine B137, fenflurane B148, fenfluramine B142, fenfluramine B145, fenfluramine B131, streptomycin B137, streptomycin B133, zineb B134, fenfluramine B147, fenfluramine B150, fenfluramine B145, fenfluramine B150, fenfluramine B, flupyr B, fenfluramine B, flupyr B, flufenozide B, flufenofos, flufenoxathim, flufenofos, flufenoxaprop-B, flufenofos, benfluram B, flufenofos, benfluramine B, flufenofos, benfluram B, flufenoxaprop-B, benfluram B, benfluride B, benfluramine B, benfluram B, thim, benfluram B, benfluram, Dithianon B152, fluimide B153, sulfocarb B154, captafol B155, folpet B156, iminoctadine B157, guazatine B158, zinc thiazole B159, oxine-copper B160, thiodiazole-copper B161, nonylphthalate B162, picrylbutox B163, aminopyriferon B164, metetrazole B165, polypyridazine B166, pyridoxamyl B167, omerazone B168, jindoxazone B168, jindox B169, flumethrin B175, flumethrin B171, flumethrin B175, flumethrin B172, flumethrin B175, flumethrin B171, flumethrin B175, flumethrin B170 or flumethrin B175.
Further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein the active component A is one or more compounds shown in a general formula I-A or salts thereof;
in the formula, R3Selected from hydrogen, hydroxy, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylthio radical, C2-C4Alkenylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkenyl or halogeno C2-C4An alkynyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxycarbonyl or halo C1-C4An alkoxycarbonyl group; r11Selected from halogen, hydroxy, amino, cyano, nitro, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylamino or halogeno C1-C4An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; r14、R15、R16Or R17Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; w selectsFrom hydrogen, halogen, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy or C1-C4An alkylthio group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula I-A and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from benzovindiflupyr B1, fluxapyroxad B2, isopyrazam B3, fluxapyroxad B4, flupyrad B5, flubeneamide B6, fluxapyroxad B7, fluthiavalicarb B6852, boscalid B6855, diphenoxylate B10, flutolanil B10, furametpyramide B10, furametpyr B10, thifluzamide B10, flufluzamide B10, fluquinamide B10, fluquinamine B10, fluquinamide B10, fluquinconazole B10, Amisulbrom (amisulbactam) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manipropamid) B43, zoxamide (zoxamide) B44, mefenoxam (metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cymoxanil (cymoxanil) B48, benalaxyl (benazolyl-M) B48, tiadinil (tiadinil) B48, ethaboxam (pyrimethanil) B48, ethazine) B48, pyrimethanil (pium) B48, flupyrromolate (pibutralimate) B48, dimethomofenol (dimethomorph) B48, pyrimethanil (pyrimethanil) B48, silthiophanate (silthiophanate B48), pyrimethanil (pyrimethanil) B48, pyrimethanil B48, thione B48, pyrimethanil B48, thione B48, pyrimethanil B48, thione B48, pyrimethanil B48, 48B 48, thione B48, thione B48, thione B48, thione B48, thione B48, thiophanate-methyl B77, phenamacril B78, benomyl B79, pyribenzoxim B85, fenarimol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpyrazamine (fenpyrazamine) B90, fluroxypyr (mefenthifluzazole) B91, nuarimol B92, oxpoconazole (oxpoconazole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine B96, pyrithiobac (silazole) B120, pyribenzoxim B120, pyrifenoxathiobac (pyra) B119, pyrithiobac (pyrazone) B104, pyrithiobac-methyl (phenazophos) B35108, pyrithiobac (pyrazofos) B35108, pyrithiobac (fenthiobac) B35104, pyrithiobac (pyrazofos) B3552, pyrithiobac (pyrazofos) B96, pyrithiobac (pyrazofos) B63104, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B63104, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B78, pyrithiobac (pyrazofos) B97, pyrithiobac (pyrithiopyrazofos) B78, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B63104, pyrithiopyrazofos) B97, pyrithiopyrazofos (pyrithiopyrazofos) B123, pyrithiopyrazofos B104, pyrithiopyrazofos (pyrithiopyrazofos B104, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofos (pyrithiopyrazofos) B104, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofenofos (pyrithiofenofos) B, pyrithiofenofos) B104, pyrithiofenofos (pyrithiopyrazofenofos) B108, pyrithiopyrazofenofos (pyrithiofenofos) B108, pyrithiofenofos (pyrithiofenofos) B123, pyrithiofenofos B104, pyrithiofenofos B123, pyrithiofenofos B104, pyrithiofenoxathiofenofos B104, pyrithiofenofos B104, pyrithiofenoxathiofenoxathiofenofos B104, pyrithiofenofos B, pyrithiofenoxathiofenofos B, pyrithiofenofos B104, pyrithiofenoxathiofenoxathiofenoxathiofenoxathiofenofos B123, pyrithiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofeno, Valienamine B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, ambam B139, mancozeb B142, manocopper B143, sulpiride B145, trichloram B146, captoprene B147, carboline B156, carboline B162, carboline B154, carboline B150, carboline B154, carboline B150, carboline B, carboline B, one or more of pyridachloromethyl B167, validamycin B169, pyrizonone B170, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175 and teclofthalam B176.
Still further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-A or salts thereof;
in the formula, R3Selected from hydrogen, hydroxy, formyl or C1-C4An alkyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen or C1-C4An alkyl group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen or C1-C4An alkyl group; r8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C1-C4An alkyl group; r11Selected from halogen, hydroxy, amino, cyano, nitro or C1-C4An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; r14、R15、R16Or R17Can be the same or different and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro or C1-C4An alkyl group; w is selected from hydrogen, halogen or C1-C4An alkyl group;
the salt of the compound shown in the general formula I-A is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxad (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyrad) B5, fluphenetole (fluphenateram) B6, fluxapyroxad (sedaxane) B7, fluthiavalicarb (penthiopyrad) B7, boscalid (boscalid) B7, difenoconazole (bixafen) B7, thifluzamide (thifluzamide) B7, fluxapyroxad (pyfluxofenamide) B7, fluazinam (flusilazole) B7, fluazinam (fluazinam) B7, fluazinam (fluazinam B7, fluazinam (fluazinam B7, fluazinam B, Zoxamide (zoxamide) B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, tiadinil B51, ethaboxam B52, bupirimate B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinazone (chinomethionat) B52, fludioxonil (fludioxonil) B65, iprodione (iprodione) B64772, procymidone (procymidone) B68, diethofencunf B73, metiramide (metryxol) B936, isophthonol B91, pyrimethanil B6858, pyrimethanil B91, pyrimethanil B6858, pyrimethanil B91, pyrimethanil B6858, pyrimethanil B, Fluothiazole pyriproxyfen B116, fluxapriroline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B149, propiconazole B160, pyrimethanil B161, pyrimethanil B162, pyrimethanil B150, pyrimethanil B162, pyrimethanil B150, pyrimethanil B (bencarb B, pyrimethanil B (bensulbencarb B (ben B, pyrimethanil, One or more of pyridachlorometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175, and teclofthalam B176.
When the active component A is a compound in the general formula I-B or a salt thereof, the composition is preferably the active component A and the active component B in a weight ratio of 1:50-50: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R1Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C1-C4Alkylthio, halo C1-C4Alkylthio radical, C1-C4Alkylsulfinyl radical, C1-C4Alkylsulfonyl radical, C2-C4Alkenyl, halo C2-C4Alkenyl radical, C2-C4Alkynyl or halo C2-C4An alkynyl group; r2Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4Alkyl or halo C1-C4An alkyl group; r3Selected from hydrogen, hydroxy, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylthio radical, C2-C4Alkenylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkenyl or halogeno C2-C4An alkynyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r is8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxycarbonyl or halo C1-C4An alkoxycarbonyl group; r11Selected from halogen, hydroxy, amino, cyano, nitro, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylamino, halogeno C1-C4Alkylamino radical, di (C)1-C4Alkyl) amino, halo-di (C)1-C4Alkyl) amino or C1-C4An alkylthio group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; w is selected from hydrogen, halogen, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy or C1-C4An alkylthio group;
the salt of the compound shown in the general formula I-B is formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid;
the active component B is selected from benzovinfluxazole (benzovindifluppy) B1, fluxapyroxafen (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxamide (fluxapyroxad) B4, flupyrazamide (flupyram) B5, flubeneamide (flubeneteram) B6, flutriafol (sedaxane) B7, penthiopyrad (penthiopyrad) B8, boscalid (boscalid) B9, diphenoxyamide (bixafen) B8, flutolamide (flutolnil) B11, furflupyrad (furametpyr) B4975, thifluzamide (thifluzamide) B13, flufenamide (fluflufenamide B13), flufenamidoylfluzamide (flufenapyr) B13, fluquinconazole B13, flufenamidothiopyrazamide (flufenamidothiopyrazamide B13), flufenamidone (flufenamide B13), flufenamide B13, flufenamidone (flufenamide B13) B13, flufenamide B13, flufenamidone (flufenamidone B13, flufenamide B13, flufenamidone B13, flufenamide B13, flufenamidothiopyraflufenamide B13, flufenamide B13, flufenamidone B13, flufenamide B13, flufenamide B13, flufenamidone B13, flufenamidothiopyraflufenamide B13, flufenamide B13, flufenamidothiopyraflufenamide B13, flufenamide B13, flufenapyr B13, Cyazofamid (cyazofamid) B30, ametoctradin B31, fluazinam (fluazinam) B32, fenpicoamid B33, florylpicoxamid B34, amisulbrom (amisulbrom) B35, silthiopham (silthiopham) B466, pyribencarb (pyribencarb) B37, triphenyltin chloride (triphenotinum chloride) B38, diniconite (cincoxap) B39, dinocap (dinocap) B40, flumorph (flumorph) B41, dimethomorph (dimorphohomoh) B42, diynodiamide (propamid) B42, fenhexamid (zoxam) B42, fenpyrazamide B42, cyazofamid B42, cyhalofamid B, Hymexazol B59, octhiophenone B60, furosemide B61, quinconazole B62, oxadixyl B62, furalaxyl B62, fludioxonil B62, fenpiclonil B62, iprodione B62, procymidone B62, metrazolidol B62, metrazolidone B62, procymidone B62, metrazolidol B62, procymidone B62, meclozolin B62, chlozolinate B62, dimethachlon B62, dimethachiazolin B62, procymidone B62, ethiprole B62, diethylfenfenamidopropyl B62, pyrimethanpyrimethan B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethanpyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethanpyrimethanil B62, pyrimethan B62, pyrimethanpyrimethanil B62, pyrimethanil B62, pyrimethan B62, pyrimethanil B62, pyrimethan B62, pyrimethanil B685, Chlorofloxacin (mefenthifluzole) B91, nuarimol B92, oxaziridine (oxazicloconazole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine (spiroxamine) B96, pyrisoxazole (pyrisoxazole) B97, tridemorph (tridemorph) B98, triforine (triforine) B99, dodemorph B100, bromuconazole (brofenazol) B101, imazalil (triafol) B102, naftifine (naftifine) B103, simeconazole (simeconazole) B104, triflumizole (triflumzole) B105, pyrithionazole B106, pyrifenozide B120, pyrifenozide (fenapyr-methyl) B108, pyrifenozide B, pyrifeno, Tolclofos-methyl B122, benthiavalicarb-isopyramid B123, polyoxin B124, valicarb-125, pyrimorph B126, blasticidin B127, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, oxytetracycline B133, zineb B134, mancozeb B135, metiram B136, propineb B149, fenbuconazole B150, fenpropathrin B145, fenfluramine B148, fenfluramine B137, fenflurane B148, fenfluramine B142, fenfluramine B145, fenfluramine B131, streptomycin B137, streptomycin B133, zineb B134, fenfluramine B147, fenfluramine B150, fenfluramine B145, fenfluramine B150, fenfluramine B, flupyr B, fenfluramine B, flupyr B, flufenozide B, flufenofos, flufenoxathim, flufenofos, flufenoxaprop-B, flufenofos, benfluram B, flufenofos, benfluramine B, flufenofos, benfluram B, flufenoxaprop-B, benfluram B, benfluride B, benfluramine B, benfluram B, thim, benfluram B, benfluram, Dithianon B152, fluimide B153, sulfocarb B154, captafol B155, folpet B156, iminoctadine B157, guazatine B158, zinc thiazole B159, oxine-copper B160, thiodiazole-copper B161, nonylphthalate B162, picrylbutox B163, aminopyriferon B164, metetrazole B165, polypyridazine B166, pyridoxamyl B167, omerazone B168, jindoxazone B168, jindox B169, flumethrin B175, flumethrin B171, flumethrin B175, flumethrin B172, flumethrin B175, flumethrin B171, flumethrin B175, flumethrin B170 or flumethrin B175.
Further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:20-20: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R1Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, C1-C4Alkyl or halo C1-C4An alkyl group; r2Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl, C1-C4Alkyl or halo C1-C4An alkyl group; r3Selected from hydrogen, hydroxy, formyl, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylthio radical, C2-C4Alkenylthio radical, C2-C4Alkenyl radical, C2-C4Alkynyl, halo C2-C4Alkenyl or halogeno C2-C4An alkynyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy or halo C1-C4An alkoxy group; r is8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen and C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxycarbonyl or halo C1-C4An alkoxycarbonyl group; r11Selected from halogen, hydroxy, amino, cyano, nitro, C1-C4Alkyl, halo C1-C4Alkyl radical, C1-C4Alkoxy, halo C1-C4Alkoxy radical, C3-C4Cycloalkyl radical, C1-C4Alkylamino or halogeno C1-C4An alkylamino group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; w is selected from hydrogen, halogen, C1-C4Alkyl, halo C1-C4Alkyl radical, C3-C4Cycloalkyl radical, C1-C4Alkoxy or C1-C4An alkylthio group;
the salt of the compound shown in the general formula I-B is formed by the compound shown in the general formula I-B and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrim) B1, fluxapyroxad (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyram) B5, flunisolide (flubeneram) B6, fluxapyroxadine (sedaxane) B7, fluthiavalicarb (penthiopyrad) B2, boscalid (boscalid) B9, biphenylpyrad (bixafen) B10, flutolamide (flutolanil) B10, fluquinamide (furametpyr) B10, flufluflufluvalide (fluquinamide) B10, flufluquinamide (fluquinamide) B10, flufenpyrafluquinamide (diflubenzpyrazamide) B10, fluquinconazole B10, flufenapyr (flufenamide B10), flufenamidone B10, flufenamide B10, flufenamidone (10), flufenamide B10, flufenamidone (flufenamide B10, flufenamidone B10, flufenamide B10, flufenamido B10, flufenamide B10, flufenamidoflufenamidoflufenamide B10, flufenamide B10, flufenamido B10, flufenamide B10, flufenamido B10, flufenamidoflufenamido B10, flufenamide B10, flufenamido B10, flufenamidoflufenamide B10, flufenamido B10, flufenamide B10, flufenamido B10, flufenamidoflufenamidoflufenamide B10, flufenamido B10, flufenamide B10, flufenamidoflufenamidoflufenamide B10, flufenamido B10, flufenamide B10, flufenamido B10, flufenamide B10, flufenamido B10, flufenamide B10, flufenamidoflufenamido B10, flufenamide B10, Amisulbrom (amisulbrom) B35, silthiopham (silthiopham) B36, pyribencarb (pyribencarb) B37, flumorph (flumorph) B41, dimethomorph (dimethomorph) B42, mandipropamid (manisopamide) B43, zoxamide (zoxamide) B44, mefenoxam (metalaxyl-M) B46, iprovalicarb (iprovalicarb) B47, cyanamide (momoxamyl) B48, benalaxyl (benaxyl-M) B48, tiadinil (tiadinil) B48, ethaboxam (ethanamine) B48, ethirimol sulfonate (pyrimethanlate) B48, dimethenamid (dimethomorph) B48, thifluzamide (diethylcarbaminate) B48, thiflufen B48, thifluzamide (diethylcarbamazepine) B48, thifludioxonil (48), pyrimethanpyrimethanil) B48, thifludioxonil (48), pyrimethanil) B48, pyrimethanil (pyrimethanil B48, pyrimethanil B48, Thiophanate-methyl B77, phenamacril B78, benomyl B79, pyribenzoxim B85, fenarimol (fenarimol) B86, fenbuconazole (fenbuconazole) B87, fenpropidine (fenpropidine) B88, fenpyrazamine (fenpyrazamine) B90, fluroxypyr (mefenthifluzazole) B91, nuarimol B92, oxpoconazole (oxpoconazole) B93, pefurazoate (pefurazoate) B94, prochloraz (prochloraz) B95, spiroxamine B96, pyrithiobac (silazole) B120, pyribenzoxim B120, pyrifenoxathiobac (pyra) B119, pyrithiobac (pyrazone) B104, pyrithiobac-methyl (phenazophos) B35108, pyrithiobac (pyrazofos) B35108, pyrithiobac (fenthiobac) B35104, pyrithiobac (pyrazofos) B3552, pyrithiobac (pyrazofos) B96, pyrithiobac (pyrazofos) B63104, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B63104, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B78, pyrithiobac (pyrazofos) B97, pyrithiobac (pyrithiopyrazofos) B78, pyrithiobac (pyrazofos) B123, pyrithiobac (pyrazofos) B63104, pyrithiopyrazofos) B97, pyrithiopyrazofos (pyrithiopyrazofos) B123, pyrithiopyrazofos B104, pyrithiopyrazofos (pyrithiopyrazofos B104, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofos (pyrithiopyrazofos) B104, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofenofos (pyrithiopyrazofenofos) B123, pyrithiopyrazofenofos (pyrithiofenofos) B, pyrithiofenofos) B104, pyrithiofenofos (pyrithiopyrazofenofos) B108, pyrithiopyrazofenofos (pyrithiofenofos) B108, pyrithiofenofos (pyrithiofenofos) B123, pyrithiofenofos B104, pyrithiofenofos B123, pyrithiofenofos B104, pyrithiofenoxathiofenofos B104, pyrithiofenofos B104, pyrithiofenoxathiofenoxathiofenofos B104, pyrithiofenofos B, pyrithiofenoxathiofenofos B, pyrithiofenofos B104, pyrithiofenoxathiofenoxathiofenoxathiofenoxathiofenofos B123, pyrithiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofenoxathiofeno, Valienamine B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, mepanipyrim B130, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B136, propineb B137, maneb B138, ambam B139, mancozeb B142, manocopper B143, sulpiride B145, trichloram B146, captoprene B147, carboline B156, carboline B162, carboline B154, carboline B150, carboline B154, carboline B150, carboline B, carboline B, one or more of pyridachloromethyl B167, validamycin B169, pyrizonone B170, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175 and teclofthalam B176.
Still further preferably, the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1;
wherein, the active component A is selected from one or more compounds in a general formula I-B or salts thereof;
in the formula, R1Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl or C1-C4An alkyl group; r2Selected from hydrogen, halogen, cyano, nitro, amino, carboxyl, formyl or C1-C4An alkyl group; r3Selected from hydrogen, hydroxy, formyl or C1-C4An alkyl group; r4、R5Can be the same or different and are respectively selected from hydrogen, halogen or C1-C4An alkyl group; r6、R7Can be the same or different and are respectively selected from hydrogen, halogen or C1-C4An alkyl group; r8、R9Can be the same or different and are respectively selected from hydrogen, cyano, halogen or C1-C4An alkyl group; r11Selected from halogen, hydroxy, aminoCyano, nitro or C1-C4An alkyl group; n is an integer of 0 to 5, and when n is 0, no substituent is arranged on a benzene ring; when n is greater than 1, R11May be the same or different; w is selected from hydrogen, halogen or C1-C4An alkyl group;
the salt of the compound shown in the general formula I-B is a salt formed by the compound shown in the general formula and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
the active component B is selected from benzovindiflupyr (benzovindifiupyrir) B1, fluxapyroxad (penflufen) B2, isopyrazam (isopyrazam) B3, fluxapyroxad (fluxapyroxad) B4, flupyrad (flupyrad) B5, fluphenetole (fluphenateram) B6, fluxapyroxad (sedaxane) B7, fluthiavalicarb (penthiopyrad) B7, boscalid (boscalid) B7, difenoconazole (bixafen) B7, thifluzamide (thifluzamide) B7, fluxapyroxad (pyfluxofenamide) B7, fluazinam (flusilazole) B7, fluazinam (fluazinam) B7, fluazinam (fluazinam B7, fluazinam (fluazinam B7, fluazinam B, Zoxamide (zoxamide) B44, metalaxyl-M B46, iprovalicarb B47, cymoxanil (cymoxanil) B48, tiadinil B51, ethaboxam B52, bupirimate B56, ethirimol (ethirimol) B58, hymexazol (hymexazol) B59, octhiolone (octhiazolinone) B60, quinazone (chinomethionat) B52, fludioxonil (fludioxonil) B65, iprodione (iprodione) B64772, procymidone (procymidone) B68, diethofencunf B73, metiramide (metryxol) B936, isophthonol B91, pyrimethanil B6858, pyrimethanil B91, pyrimethanil B6858, pyrimethanil B91, pyrimethanil B6858, pyrimethanil B, Fluothiazole pyriproxyfen B116, fluxapriroline B117, propamocarb B118, quintozene B121, tolclofos-methyl B122, benthiavalicarb-isopropyl B123, polyoxin B124, valinate B125, pyrimorph B126, cyprodinil B128, kasugamycin B129, pyrimethanil B131, streptomycin B132, zineb B134, mancozeb B135, metiram B149, propiconazole B160, pyrimethanil B161, pyrimethanil B162, pyrimethanil B150, pyrimethanil B162, pyrimethanil B150, pyrimethanil B150, pyrimethanil B (bencarb B, pyrimethanil B (bencarb B (bensulbensulbensulbensulbensulbensulbensulbensulbensulbensulbencarb B, pyrimethanil B (bensulben B (ben B (bencarb B (bensulben B, pyrimethanil B (ben B, pyrimethanil B (bensulbensulben B, pyrimethanil B (ben B (bensulben B, pyrimethanil B (ben B, pyrimethanil B (bensulben B (ben B (bencarb B, pyrimethanil, One or more of pyridachlorometyl B167, validamycin B169, tebufloquin B171, quinofumelin B173, ipflufenoquin B174, dipyrometrone B175, and teclofthalam B176.
Application of bactericidal composition in preparation of medicines for preventing and treating plant pathogenic fungi and bacterial diseases
The plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, leaf mold, banded sclerotial blight, damping off, black nevus, smut, powdery mildew, downy mildew, late blight, epidemic disease, downy mildew, black shank, soft rot, damping-off, phytophthora blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, gummy stem blight, gray mold, sclerotinia, rot, root rot, gibberellic disease, soft rot, bacterial blight, leaf blight, angular leaf spot, circular leaf spot, bacterial leaf blight, bacterial wilt, ulcer disease or yellow dragon disease.
The bactericidal preparation comprises the effective component of the bactericidal composition, and the weight percentage of the bactericidal composition is 0.1-95%.
The composition of the present invention is used at a concentration of 5 to 500mg/L (content of active ingredient, the same shall apply hereinafter) in the area where crops are grown, preferably 50 to 200mg/L, depending on the degree of occurrence of crop diseases.
The active component A and at least one active component B in the composition are prepared in advance or prepared on the site of use or the two components are separately and sequentially used according to a proper proportion provided by the invention.
The composition is suitable for the application of trees (apples, rubber, pears, oranges, hawthorns, chestnuts, pepper, medlar, mangoes, pawpaw, lychees, bananas, peach trees and the like), vine plants (grapes and the like), cucurbits (tomatoes, eggplants, hot peppers, cucumbers, melons, white gourds, watermelons, pumpkins, balsam pears, luffa, chayords, cucurbits, pumpkin, lettuce, potatoes and carrots), beans (peas, beans and cowpeas), cereals (wheat, rice, corns, sorghum and the like), oil crops (rapes, soybeans, peanuts, sesames and the like), onions and garlics (shallots, garlic and onions), economic crops (tobaccos and the like), fungal and bacterial diseases control of flower plants and lawns, seed treatment, fruit preservation and the like.
The bactericidal composition is particularly suitable for preventing and treating the following plant diseases: apple powdery mildew, rubber powdery mildew, citrus powdery mildew, hawthorn powdery mildew, Chinese chestnut powdery mildew, pepper powdery mildew, medlar powdery mildew, mango powdery mildew, papaya powdery mildew, club powdery mildew, grape powdery mildew, tomato powdery mildew, eggplant powdery mildew, pepper powdery mildew, cucumber powdery mildew, melon powdery mildew, wax gourd powdery mildew, watermelon powdery mildew, pumpkin powdery mildew, balsam pear powdery mildew, towel gourd powdery mildew, finger citron powdery mildew, gourd powdery mildew, pumpkin powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew, wheat powdery mildew, barley powdery mildew, monthly rose powdery mildew, chrysanthemum powdery mildew, lawn grass powdery mildew, carrot powdery mildew, apple rust, pear rust, soybean rust, pea rust, bean rust, cowpea rust, wheat rust, barley rust, corn rust, onion powdery mildew, grape powdery mildew, tomato powdery mildew, cucumber powdery mildew, Garlic rust, onion rust, turf grass rust, apple anthracnose, rubber tree anthracnose, pear anthracnose, citrus anthracnose, hawthorn anthracnose, Chinese chestnut anthracnose, Chinese prickly ash anthracnose, Chinese wolfberry anthracnose, mango anthracnose, papaya anthracnose, hazel anthracnose, grape anthracnose, tomato anthracnose, eggplant anthracnose, hot pepper anthracnose, melon anthracnose, white gourd anthracnose, watermelon anthracnose, pumpkin anthracnose, bitter gourd anthracnose, towel gourd anthracnose, chayote anthracnose, cucurbit, pumpkin anthracnose, lettuce anthracnose, cucumber downy mildew, grape downy mildew, melon downy mildew, balsam pear downy mildew, towel gourd downy mildew, tomato late blight, potato late blight, pepper blight, cucumber damping-off, eggplant damping-off, pepper damping-off, pear brown spot, cucumber brown spot, pear black spot, rose black spot, pear black spot, pepper anthracnose, grape anthracnose, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow pepper yellow spot, tomato yellow leaf spot, tomato yellow pepper yellow leaf spot, tomato yellow leaf spot, tomato leaf spot, rose black spot, chrysanthemum black spot, soybean brown spot, cowpea red spot, apple alternaria leaf spot, kidney bean round spot, eggplant rod spore leaf spot, potato black nevus, wheat sharp eyespot, rice sheath blight, rice bakanae disease, soybean damping off, pea damping off, kidney bean damping off, onion damping off, turf grass damping off, citrus canker, citrus yellow shoot, rice bacterial leaf blight, rice bacterial streak, tomato bacterial wilt, cucumber bacterial angular leaf spot, and crop gray mold and sclerotinia rot caused by botrytis and sclerotinia pathogenic bacteria.
The invention has the advantages that:
the invention combines the active component A and the bactericide active component B according to different proportions, the observation effect is larger than the calculation effect, the synergistic effect is very obvious, the dosage of the medicament can be reduced, and the environmental pollution is reduced. The bactericide with different action mechanisms is mixed, which is beneficial to delaying the generation of drug resistance of pathogenic bacteria, provides an effective solution for the problem of bactericide resistance in agricultural production and pesticide industry, and prolongs the service life of the bactericide.
Detailed Description
The synergistic effect of the compositions according to the invention on harmful fungal and bacterial diseases is further illustrated by the following examples, to which the invention is in no way restricted. Wherein the active components are the compound A and the bactericide B in the bactericidal composition;
the preparation of the compound A is described in WO2016184378, and the bactericide B is one or more of respiratory inhibitor bactericide, nucleic acid metabolism inhibitor bactericide, cell wall synthesis inhibitor bactericide, signal transduction inhibitor bactericide, cytoskeleton and kinetin inhibitor bactericide, sterol biosynthesis inhibitor bactericide, phospholipid synthesis inhibitor bactericide, cell wall synthesis inhibitor bactericide, methionine biosynthesis inhibitor bactericide, multi-site inhibitor bactericide, and bactericide with unknown action mechanism.
The test method and the evaluation method are as follows:
the active samples to be detected are respectively active component A, active component B, and the composition of active component A and active component B.
The active component A is one or more of an active component A1, an active component A2, an active component A3 and an active component A4;
wherein the active component A1 is a compound A1 shown in a general formula I-A;
the active component A2 is a salt formed by the compound A1 and sulfuric acid;
compound A1 is
Figure BDA0002790774720000181
In the formula, R3Selected from hydrogen, R4、R5Are each selected from hydrogen, R6、R7Are each selected from hydrogen, R8、R9Are each selected from hydrogen, R11Selected from 4-chloro, n ═ 1, R14、R15、R16Or R17Are respectively selected from hydrogen, W is selected from hydrogen, namely the compound A1;
the active component A3 is a compound A3 shown in a general formula I-B;
active ingredient a4 is a salt formed from compound A3 and sulfuric acid:
compound A3 is
Figure BDA0002790774720000191
In the formula:
R3selected from hydrogen, R4、R5Are respectively selected from hydrogen R6、R7Are each selected from hydrogen, R8、R9Are each selected from hydrogen, R11Selected from 4-chloro, n ═ 1, R14、R15、R16Or R17Respectively selected from hydrogen, W is selected from hydrogen, namely the compound A3.
The active component B is benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctradin B31, fluazinam B32, fenpicoxamide B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, phenamacystron B78, fluroxypyr B91, prochloraz B95, fluthiazopyr B116, fluxapriproline B137, polyoxin B124, kasugamycin B129, zineb B134, mancozeb B149, propineb B135, propineb B159, fenpyrenozide B159, propineb B159.
The composition to be detected is active component A1, each active component B, active component A1 and each active component B respectively; wherein the active component B is a composition consisting of benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, fluopyram B27, ametoctrad B31, fluazinam B32, fenpicoamid B33, flumorph B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxam B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, phenamacystron B78, fluroxypyr B91, prochloraz B95, fluthiazopyr B116, fluxaprop-roline B117, polyoxin B124, kasugamycin B129, zinokinomycin B149, mancozeb B137, propineb B163, propineb B159, and propineb B159.
The composition to be detected is a composition which consists of an active component A2 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, flupyraclostrobin B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhalothrin B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxapridine B117, polyoxin B149, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The composition to be detected is a composition which consists of an active component A3 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, flupyraclostrobin B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhalothrin B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxapridine B117, polyoxin B149, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The composition to be detected is a composition which consists of an active component A4 and/or benzovindiflupyr B1, fluxapyroxad B4, fluopyram B5, boscalid B9, thifluzamide B13, fluxapyroxad B14, flupyraclostrobin B27, ametoctradin B31, fluazinam B32, fenpicoxamid B33, flumorphine B41, dimethomorph B42, mandipropamid B43, zoxamide B44, mefenoxamine B46, bupirimate B56, ethirimol B58, fludioxonil B65, diethofencarb B73, metrafenone B74, cyhalothrin B78, difenoconazole B91, prochloraz B95, fluthiazopyr B116, fluxapridine B117, polyoxin B149, kasugamycin B149, zinokiflavon B129, propineb B159, propineb B.
The specific mode is as follows:
dissolving the above active components or compositions in acetone (volume ratio of acetone amount to liquid spray amount is equal to or less than 0.05), diluting with water containing 0.1% Tween 80 to obtain solution to be tested with desired concentration, and preparing the solution to be tested according to a set proportion. The solution to be tested is sprayed on neat and uniform host plants (which are not inoculated before pesticide application and are not used with other medicines) cultured in a greenhouse on a crop sprayer, and disease inoculation is carried out 24 hours later. According to the characteristics of diseases, inoculating the disease plants to be cultured by temperature and moisture control, culturing in a climatic chamber, and transferring into a greenhouse for culturing after the diseases are infected; the disease plants which do not need to be subjected to moisturizing culture are inoculated and then directly transferred into a greenhouse for culture. And (5) after the contrast is fully developed, carrying out disease investigation, and recording the total leaf number, the diseased leaf number and the diseased grade number of the investigation.
The disease grading method comprises the following steps:
level 0: the whole plant is disease-free;
level 1: the area of the lesion spots is less than 5% of the whole leaf area;
and 3, stage: the area of the lesion spots is 6-10% of the whole leaf area;
and 5, stage: the area of the whole leaf of the lesion spot is 11-20%;
and 7, stage: the area of the lesion spots is 21-50% of the whole leaf area;
and 9, stage: the area of the lesion spots is more than 51 percent of the whole leaf area.
Observed efficacy of active ingredients or compositions (C)obs) The pesticide effect evaluation common formula (correction control effect calculation formula) is used for calculation:
Figure BDA0002790774720000211
Figure BDA0002790774720000212
an efficacy of "0" indicates that the level of infestation of the treated crop is the same as the level of infestation of the untreated control crop; an efficacy of "100" indicates that the treated crop is not infested.
Expected efficacy of the composition (C)exp) Determined by using Abbott method (see Liu Ching et al, synergistic effect of bactericide mixture, pesticide science and management, 2002, 23(5), 12-15).
Cexp＝X+Y–XY/100
In the formula:
x: the efficacy of active ingredient a at the concentration a used;
y: the efficacy of active component B at the concentration B is used.
Observed efficacy of synergistic Effect of compositions (C)obs) And expected efficacy (C)exp) And (4) evaluating the ratio of (A) to (B). Ratio (synergy ratio)>1, the composition exhibits a synergistic effect; when the ratio (synergy ratio) is 1, the composition shows an additive effect; ratio (synergy ratio)<1, indicating that the composition is antagonistic.
Example 1 control of cucumber powdery mildew test 1
Spraying aqueous solution (effective component concentration is shown in the following table) of each active component or composition on potted cucumber seedlings of two-leaf stage of Jinzhan-4 variety, spraying spores of Ustilago virens on leaves after 24 hours, culturing in a greenhouse, and performing disease investigation after 10 days and full control disease.
The activity data and the synergistic effect of the individual active components and the composition of the invention for controlling cucumber powdery mildew are shown in tables 1 and 2.
The results in Table 2 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on cucumber powdery mildew in a test proportioning range.
TABLE 1 Activity of the Individual active ingredients
Figure BDA0002790774720000221
TABLE 2 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000222
Figure BDA0002790774720000231
Figure BDA0002790774720000241
Example 2 control of cucumber powdery mildew test 2
The seedling of the cucumber in the two-leaf period cultivated in a pot with the variety of 'Xintai Mici' is treated by spraying water solution (the concentration of active ingredients is shown in the following table) of each active component or composition, after 24 hours, spores of the yellow powdery mildew germs are sprayed on leaves by using an inoculating device and cultured in a greenhouse, and after 10 days, disease condition investigation is carried out after full control disease occurrence.
The activity data and synergistic effect of the individual active components and the composition of the invention for controlling cucumber powdery mildew are shown in tables 3 and 4.
The results in Table 4 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on cucumber powdery mildew in a test proportioning range.
TABLE 3 Activity of the Individual active Components
Figure BDA0002790774720000242
Figure BDA0002790774720000251
TABLE 4 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000252
Example 3 test for controlling powdery mildew of melon
Potted four-leaf sweet melon seedlings (1-2 leaves are cut off before the test and only 3-4 leaves are reserved) of the variety 'sweet melon' are sprayed with aqueous solutions (the concentration is shown in the table below) of various active components or compositions, after 24 hours, the spore suspension of the powdery mildew of the melon is inoculated on the leaves and cultured in a greenhouse, and after 15 days, disease investigation is carried out after the control is fully developed.
The activity data of the individual active ingredients of the invention for controlling powdery mildew of melon are shown in table 5.
The activity data and the synergistic effect of the composition for preventing and treating powdery mildew of melons are shown in table 6.
The results in Table 6 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on melon powdery mildew in a test proportioning range.
TABLE 5 Activity of the Individual active Components
Figure BDA0002790774720000261
TABLE 6 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000262
Figure BDA0002790774720000271
Example 4 test for controlling powdery mildew of Capsicum
Spraying the potted six-leaf stage pepper seedlings of 'green round pepper' with aqueous solutions (effective component concentrations are shown in the following table) of active components or compositions, inoculating pepper powdery mildew spores on the back surfaces of the leaves after 24 hours, culturing in a climate chamber, transplanting the leaves into a greenhouse for culturing after the diseases are infected, and performing disease investigation after the diseases are fully developed in contrast after 20-25 days.
The activity data of each individual active component for controlling powdery mildew of pepper of the invention are shown in tables 7 and 8.
The activity data and synergistic effect of the composition of the invention for controlling powdery mildew of capsicum are shown in tables 9 and 10.
The results in tables 9 and 10 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on pepper powdery mildew in a test proportioning range.
TABLE 7 Activity of Individual active Components
Figure BDA0002790774720000272
TABLE 8 Activity of the Individual active Components
Figure BDA0002790774720000281
TABLE 9 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000282
TABLE 10 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000283
Example 5 test for controlling powdery mildew of beans
Spraying aqueous solution (effective component concentration shown in the following table) of active components or compositions on potted two-leaf kidney bean seedling of Fenggao No. 1, air drying naturally after spraying, and suspending spore water suspension (5 × 10) of pathogenic bacteria of powdery mildew of kidney bean for 24 hr6Individual/ml) on the leaf of kidney bean, naturally drying, transferring into a greenhouse for culture, and culturing under the conditions (temperature: the disease condition is investigated after the contrast is fully developed at the temperature of 23-28 ℃ in the day and 18-20 ℃ in the night.
The activity data of the individual active ingredients of the invention for controlling powdery mildew of kidney beans are shown in table 11.
The activity data and synergistic effect of the composition of the invention for preventing and treating powdery mildew of kidney beans are shown in Table 12.
The results in Table 12 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the powdery mildew of kidney beans in a test proportioning range.
TABLE 11 Activity of the Individual active Components
Figure BDA0002790774720000291
TABLE 12 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000292
Example 6 tobacco powdery mildew control test
The tobacco seedling in six-leaf period cultivated in a pot of variety CN89 is treated by spraying with aqueous solution (concentration is shown in the table below) of each active component or composition, after 24 hours, the tobacco powdery mildew spore suspension is inoculated on the tobacco seedling leaf, and is directly transplanted into a greenhouse for culture, and after 20 days, disease condition investigation is carried out after full control disease.
The activity data of the individual active ingredients of the invention for controlling tobacco powdery mildew are shown in table 13.
The activity data and synergistic effect of the composition of the invention for preventing and treating powdery mildew of tobacco are shown in Table 14.
The results in Table 14 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the powdery mildew of tobacco in the range of the experimental mixture ratio.
TABLE 13 Activity of the Individual active Components
Figure BDA0002790774720000301
TABLE 14 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000302
Figure BDA0002790774720000311
Example 7 corn rust control test
Spraying the potted two-leaf corn seedlings of the variety 'golden yellow glutinous' with aqueous solutions (the concentration of active ingredients is shown in the following table) of the active components or the compositions, inoculating the corn rust germ spore suspension on the corn leaves after 24 hours, culturing in a climatic chamber, transferring the corn rust germ spore suspension into a greenhouse for culturing after the infection of diseases is finished, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data of the activity of the individual active ingredients of the invention against corn rust are shown in table 15.
The activity data and synergistic effect of the composition of the invention for controlling corn rust are shown in table 16.
The results in Table 16 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the corn rust in a test mixture ratio range.
TABLE 15 Activity of Individual active Components
Figure BDA0002790774720000312
Figure BDA0002790774720000321
TABLE 16 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000322
Figure BDA0002790774720000331
Example 8 control of cucumber downy mildew test 1
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 17.
The activity data and synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 18.
The results in table 18 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 17 Activity of the Individual active Components
Figure BDA0002790774720000332
TABLE 18 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000341
Figure BDA0002790774720000351
Figure BDA0002790774720000361
Example 9 control of cucumber downy mildew test 2
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The activity data for controlling cucumber downy mildew of the individual active ingredients of the invention are given in table 19.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in table 20.
The results in table 20 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 19 Activity of the Individual active Components
Figure BDA0002790774720000362
Figure BDA0002790774720000371
TABLE 20 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000372
Figure BDA0002790774720000381
Figure BDA0002790774720000391
Example 10 control of cucumber downy mildew test 3
The test is carried out according to the national standard GB/T17980.26-2000: pesticide field efficacy test criterion (I) -related content execution of the bactericide for preventing and treating cucumber downy mildew. The test site is arranged in Bayizhen protected area of Suzhongyuan region of Shenyang city, the cucumber variety is Sinomei thorn, the management level is middle, during the test, the cucumber is in the cucumber forming period, downy mildew slightly occurs, and the area of the cell is about 25m2(ii) a Carrying out medicament spraying treatment on the cucumbers according to the set dosage of the experiment; the test is carried out for 2 times, the application intervals are 7 days, and the attack condition of cucumber downy mildew in each cell is investigated 10 days after the second application. Sampling is carried out at 4 points in each cell, 8 plants are taken at each point, and the disease condition of the whole plant leaf is investigated from top to bottom of each plant.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 21.
The activity data and the synergistic effect of the composition for preventing and treating cucumber downy mildew are shown in Table 22.
The results in table 22 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested ratios.
TABLE 21 Activity of the Individual active Components
Figure BDA0002790774720000392
Figure BDA0002790774720000401
TABLE 22 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000402
Example 11 control of cucumber downy mildew test 4
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on cucumber seedlings of two-leaf period in a pot plant of a variety 'Xintai Mici', inoculating a cucumber downy mildew pathogen sporangium suspension on cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, and carrying out disease investigation after the diseases are fully developed in contrast after 7 days.
The data on the activity of the individual active ingredients of the invention against cucumber downy mildew are given in table 23.
The activity data and synergistic effect of the composition of the invention for controlling cucumber downy mildew are shown in Table 24.
The results in table 24 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the composition is greater than 1, indicating that the composition exhibits a synergistic effect on cucumber downy mildew in the range of the tested proportions.
TABLE 23 Activity of the Individual active Components
Figure BDA0002790774720000411
TABLE 24 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000412
Figure BDA0002790774720000421
Example 12 control of grape downy mildew test 1
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in Table 25.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in Table 26.
The results in Table 26 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 25 Activity of Individual active Components
Figure BDA0002790774720000422
TABLE 26 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000431
Figure BDA0002790774720000441
Example 13 control of grape downy mildew test 2
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients according to the invention against grape downy mildew are given in Table 27.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in Table 28.
The results in Table 28 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 27 Activity of Individual active Components
Figure BDA0002790774720000442
Figure BDA0002790774720000451
TABLE 28 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000452
Figure BDA0002790774720000461
Example 14 control of grape downy mildew test 3
The grape seedlings in five-leaf period potted plant of 'seedless white chicken heart' are treated by spraying with aqueous solution (the concentration of active ingredients is shown in the table) of each active component or composition, 24 hours later, the grape downy mildew pathogenic bacteria sporangium suspension is inoculated on the grape leaves, the grape seedlings are placed in a climatic chamber for culture, after the infection of the diseases is completed, the grape seedlings are moved into a greenhouse for culture, and after 7 days, the grape seedlings are subjected to disease investigation after full control disease attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in table 29.
The activity data and synergistic effect of the composition for preventing and treating grape downy mildew are shown in Table 30.
The results in Table 30 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 29 Activity of the Individual active Components
Figure BDA0002790774720000462
Figure BDA0002790774720000471
TABLE 30 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000472
Figure BDA0002790774720000481
Example 15 control of grape downy mildew test 4
The method comprises the steps of carrying out spray treatment on potted five-leaf grape seedlings of 'seedless white heart' varieties by using aqueous solutions (effective component concentrations are shown in the table below) of active components or compositions, inoculating grape downy mildew pathogen sporangium suspension on grape leaves after 24 hours, placing the grape seedlings in a climatic chamber for culture, moving the grape seedlings into a greenhouse for culture after diseases are infected, and carrying out disease investigation after 7 days and full control attack.
The data of the activity of the individual active ingredients of the invention against grape downy mildew are given in table 31.
The activity data and synergistic effect of the composition of the invention for controlling grape downy mildew are shown in table 32.
The results in Table 32 below show that the ratio between the observed efficacy (Cobs) and the expected efficacy (Cexp) of the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on grapevine downy mildew in the range of the ratios tested.
TABLE 31 Activity of Individual active Components
Figure BDA0002790774720000482
TABLE 32 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000491
Example 16 control of Chinese cabbage downy mildew test
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf Chinese cabbage seedling of 'four-season Chinese cabbage', inoculating peronospora pelagi sporangium on the back of leaf after 24 hours, culturing in climate chamber, culturing in greenhouse after infection of disease is completed, and performing disease investigation after disease is fully developed in contrast after 5-7 days.
The activity data of each single active component for preventing and treating the Chinese cabbage downy mildew is shown in a table 33.
The activity data and the synergistic effect of the composition for preventing and treating Chinese cabbage downy mildew are shown in Table 34.
The results in Table 34 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the cabbage downy mildew in a test proportioning range.
TABLE 33 Activity of Individual active Components
Figure BDA0002790774720000501
TABLE 34 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000502
Figure BDA0002790774720000511
Example 17 sunflower downy mildew control test
A potted sunflower seedling with the variety of 'three-header' and the six-leaf period (1-4 leaves are cut off and only 5-6 leaves are reserved before the test) is sprayed with aqueous solution (the concentration of active ingredients is shown in the following table) of each active component or composition, after 24 hours, sunflower downy mildew pathogen sporangium suspension is inoculated on leaves and cultured in a climatic chamber, after the infection of the disease is completed, the sunflower downy mildew pathogen sporangium suspension is moved into a greenhouse for culture, and after 12 days, the disease investigation is carried out after the contrast is fully developed.
The data on the activity of the individual active ingredients of the invention against downy mildew of sunflower are shown in Table 35.
The activity data and synergistic effect of the composition of the invention for controlling sunflower downy mildew are shown in table 36.
The results in Table 36 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of (A to B)>1, the composition shows a synergistic effect on sunflower downy mildew in a test proportioning range.
TABLE 35 Activity of Individual active Components
Figure BDA0002790774720000512
Figure BDA0002790774720000521
TABLE 36 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000522
Example 18 control of tomato late blight test 1
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf stage tomato seedlings of 'Pingtai ', inoculating tomato late blight pathogen sporangium suspension on tomato leaves after 24 hours, placing the tomato seedlings in a climatic chamber for culture, transferring the tomato seedlings into a greenhouse for culture after infection of diseases is completed, and carrying out disease investigation after 7 days and full control disease.
The activity data of each single active component for preventing and treating the tomato late blight of the invention are shown in a table 37.
The activity data and the synergistic effect of the composition for preventing and treating the tomato late blight are shown in a table 38.
The results in table 38 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on late blight of tomato over the range of the tested ratios.
TABLE 37 Activity of Individual active Components
Figure BDA0002790774720000531
TABLE 38 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000532
Figure BDA0002790774720000541
Example 19 test for controlling tomato late blight 2
Spraying aqueous solution (effective component concentration is shown in the table below) of each active component or composition on potted five-leaf stage tomato seedlings of 'Pingtai ', inoculating tomato late blight pathogen sporangium suspension on tomato leaves after 24 hours, placing the tomato seedlings in a climatic chamber for culture, transferring the tomato seedlings into a greenhouse for culture after infection of diseases is completed, and carrying out disease investigation after 7 days and full control disease.
The activity data of each single active component for preventing and treating the tomato late blight of the invention are shown in a table 39.
The activity data and the synergistic effect of the composition for preventing and treating the tomato late blight are shown in a table 40.
The results in table 40 below show that the ratio of observed potency (Cobs) to expected potency (Cexp) for the composition is greater than 1, indicating that the composition exhibits a synergistic effect on late blight of tomato over the range of the tested ratios.
TABLE 39 Activity of the Individual active Components
Figure BDA0002790774720000551
TABLE 40 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000552
Figure BDA0002790774720000561
Example 20 test for controlling cucumber anthracnose 1
Spraying the cucumber seedlings of two-leaf period potted plant with Xintai Mici with water solution of each active component or composition, naturally drying after spraying, inoculating the cucumber anthracnose pathogen spore water suspension on the cucumber leaves after 24 hours, culturing in a climatic chamber, transferring into a greenhouse for culturing after the infection of diseases is completed, carrying out disease investigation after 7 days, grading the leaves according to the development degree of the pathogen infection on the leaves, recording the total leaf number, the diseased leaf number and the disease grade number of the investigation, and calculating the efficacy of the medicament according to a formula.
The activity data of the individual active components of the invention for controlling cucumber anthracnose are shown in table 41.
The activity data and synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 42.
The results in table 42 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose in the range of the tested ratios.
TABLE 41 Activity of Individual active Components
Figure BDA0002790774720000562
Figure BDA0002790774720000571
TABLE 42 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000572
EXAMPLE 21 test for controlling cucumber anthracnose 2
Spraying the potted two-leaf stage cucumber seedling of Xintai Mici with water solution of active components or compositions, naturally drying after spraying, inoculating the cucumber anthracnose pathogenic bacteria spore water suspension on the cucumber leaf after 24 hours, culturing in a climate chamber, moving into a greenhouse for culturing after the disease infection is finished, carrying out disease investigation after 7 days, grading the leaf according to the development degree of the germ infection on the leaf, recording the total leaf number, the diseased leaf number and the disease grade number of the investigation, and calculating the medicament effect according to a formula.
The activity data of each single active component for preventing and treating cucumber anthracnose are shown in a table 43.
The activity data and synergistic effect of the composition for preventing and treating cucumber anthracnose are shown in Table 44.
The results in table 44 below show that the ratio of observed efficacy (Cobs) to expected efficacy (Cexp) for the compositions is greater than 1, indicating that the compositions exhibit a synergistic effect on cucumber anthracnose in the range of the tested ratios.
TABLE 43 Activity of Individual active Components
Figure BDA0002790774720000573
Figure BDA0002790774720000581
TABLE 44 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000582
EXAMPLE 22 test for controlling Pepper anthracnose
Spraying potted six-leaf stage pepper seedlings of 'green round pepper' with aqueous solutions (effective component concentrations are shown in the following table) of active components or compositions, inoculating pepper anthracnose pathogen spore suspension on the back of leaves after 24 hours, culturing in a climate chamber, transplanting into a greenhouse for culturing after infection of diseases is completed, and performing disease investigation after full control disease occurs after 5-7 days.
The activity data of each single active component for preventing and treating the pepper anthracnose are shown in a table 45.
The activity data and synergistic effect of the composition for preventing and treating pepper anthracnose are shown in Table 46.
The results in Table 46 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on pepper anthracnose in a test proportioning range.
TABLE 45 Activity of Individual active Components
Figure BDA0002790774720000583
Figure BDA0002790774720000591
TABLE 46 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000592
Figure BDA0002790774720000601
Example 23 test for controlling eggplant cercospora brown spot
Spraying the eggplant seedlings in five-leaf period potted in Liaoqie No. 1 with aqueous solution (concentration is shown in the table below) of each active component or composition, inoculating the eggplant phomopsis alternata spore suspension on eggplant leaves after 24 hours, culturing in a climatic chamber, transplanting into a greenhouse for culturing after the diseases are infected, and performing disease investigation after 10 days and fully developing diseases in contrast.
The activity data of the individual active components of the invention for controlling eggplant cercospora brown spot are shown in table 47.
The activity data and the synergistic effect of the composition for preventing and treating the eggplant cercospora brown spot are shown in a table 48.
The results in Table 48 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on eggplant cercospora brown spot in a test proportioning range.
TABLE 47 Activity of Individual active Components
Figure BDA0002790774720000602
Figure BDA0002790774720000611
TABLE 48 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000612
Example 24 test for controlling leaf spot disease of eggplant
Spraying the eggplant seedlings in five-leaf period potted in Liaoqie No. 1 with aqueous solutions (the concentration is shown in the table below) of the active components or the compositions, inoculating the eggplant corymbose spodoptera spore suspension on eggplant leaves after 24 hours, culturing in a climate chamber, transplanting into a greenhouse for culturing after the diseases are infected, and performing disease investigation after 8 days and full disease control.
The activity data of the individual active ingredients of the invention for controlling eggplant solanum melongena leaf spot are shown in table 49.
The activity data and the synergistic effect of the composition for preventing and treating the leaf spot disease of eggplant, namely the corynespora solani, are shown in a table 50.
The results in Table 50 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the leaf spot of eggplant, namely the corynespora solanacearum in a test proportioning range.
TABLE 49 Activity of Individual active Components
Figure BDA0002790774720000621
TABLE 50 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000622
Figure BDA0002790774720000631
EXAMPLE 25 Pear Blackspot control test
Taking the tender leaves of potted seedlings of 'bergamot pears', disinfecting the surfaces, washing the leaves clean with sterile water and drying in the shade for later use. Soaking with water solution (concentration shown in the table below) of each active component or composition, inoculating leaf blade with Pyricularia nivalis spore suspension after 24 hr, placing in culture dish (containing 2% water agar) and culturing under constant temperature illumination, and after 14 days, performing disease investigation after control fully attacks disease.
The data of the activity of each individual active ingredient of the invention for controlling pear black spot are shown in table 51.
The activity data and synergistic effect of the composition for preventing and treating pear black spot are shown in table 52.
The results in Table 52 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on pear black spot in a test proportioning range.
TABLE 51 Activity of Individual active Components
Figure BDA0002790774720000641
TABLE 52 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000642
Figure BDA0002790774720000651
Example 26 test for controlling leaf spot disease in peanut 1
Two pairs of potted plant double-leaf flat-growth-period peanut seedlings of 'Baisha' are treated by spraying with aqueous solutions (the concentrations are shown in the table) of active components or compositions, after 24 hours, peanut brown germ spore suspension is inoculated on leaves and cultured in a climate chamber, after the infection of diseases is completed, the leaves are moved into a greenhouse for culture, and after 10-12 days, disease condition investigation is carried out after full control and disease attack.
The data of the activity of each individual active ingredient of the invention for controlling the leaf spot of peanut are shown in table 53.
The activity data and synergistic effect of the composition for preventing and treating peanut leaf spot are shown in table 54.
The results in Table 54 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the peanut leaf spot in the range of the experimental mixture ratio.
TABLE 53 Activity of Individual active Components
Figure BDA0002790774720000652
Figure BDA0002790774720000661
TABLE 54 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000662
Example 27 peanut leaf Spot control test 2
Two pairs of potted plant double-leaf flat-growth-period peanut seedlings of 'Baisha' are treated by spraying with aqueous solutions (the concentrations are shown in the table) of active components or compositions, after 24 hours, peanut brown germ spore suspension is inoculated on leaves and cultured in a climate chamber, after the infection of diseases is completed, the leaves are moved into a greenhouse for culture, and after 10-12 days, disease condition investigation is carried out after full control and disease attack.
The data of the activity of each individual active ingredient for controlling the peanut leaf spot disease are shown in table 55.
The activity data and synergistic effect of the composition for preventing and treating peanut leaf spot are shown in table 56.
The results in Table 56 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on the peanut leaf spot in the range of the experimental mixture ratio.
TABLE 55 Activity of Individual active Components
Figure BDA0002790774720000663
Figure BDA0002790774720000671
TABLE 56 Activity and synergistic Effect of the compositions of the present invention
Figure BDA0002790774720000672
EXAMPLE 28 wheat scab control test
The potted two-leaf period wheat seedling of the variety Liaochun 18 is treated by spraying with aqueous solution (concentration is shown in the table) of each active component or composition, 24 hours later, the suspension of the wheat scab germ spores is inoculated on the leaves and cultured in a greenhouse, and after 5 days, the disease condition is investigated after the control fully attacks the disease.
The activity data of each single active component for preventing and treating wheat scab is shown in a table 57.
The activity data and synergistic effect of the composition for preventing and treating wheat scab are shown in Table 58.
The results in Table 58 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on wheat scab in a test proportioning range.
TABLE 57 Activity of Individual active Components
Figure BDA0002790774720000673
Figure BDA0002790774720000681
TABLE 58 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000682
Example 29 test for controlling Rice sheath blight disease 1
Potted two-leaf stage rice seedlings of the variety "Longdao 18" were treated with spray with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, 24 hours later, suspension of rice sheath blight hypha was inoculated on rice leaves and cultured in a greenhouse, and after 5 days, disease investigation was conducted after full control.
The activity data of each individual active component of the invention for preventing and treating rice sheath blight disease are shown in table 59.
The activity data and synergistic effect of the composition for preventing and treating rice sheath blight disease are shown in Table 60.
The results in Table 60 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on rice sheath blight in a test mixture ratio range.
TABLE 59 Activity of Individual active Components
Figure BDA0002790774720000691
TABLE 60 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000692
Figure BDA0002790774720000701
Example 30 test for controlling Rice sheath blight disease 2
Potted two-leaf stage rice seedlings of the variety "Longdao 18" were treated with spray with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, 24 hours later, suspension of rice sheath blight hypha was inoculated on rice leaves and cultured in a greenhouse, and after 5 days, disease investigation was conducted after full control.
The data of the activity of each individual active ingredient for controlling rice sheath blight disease of the present invention are shown in table 61.
The activity data and synergistic effect of the composition for preventing and treating rice sheath blight disease are shown in Table 62.
The results in Table 62 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on rice sheath blight in a test mixture ratio range.
TABLE 61 Activity of Individual active Components
Figure BDA0002790774720000711
TABLE 62 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000712
Figure BDA0002790774720000721
Example 31 test for controlling bacterial blight of rice
Planting rice (variety is overtight) in the same pot of a greenhouse, 8 plants/pot, spraying water solution of each active component or composition when the rice grows to the four-leaf stage, uniformly spraying the activated rice bacterial leaf blight strain on rice leaves after 24 hours, preserving moisture for 24 hours by artificial gas, and then transferring the rice leaves into the greenhouse for continuous culture. After the control of clear water is sufficiently diseased, the length of the disease spots of each treated leaf is measured, and the disease inhibition rate, namely the observation effect, is calculated by the following formula.
Figure BDA0002790774720000722
The activity data of each individual active component for preventing and treating the bacterial blight of rice are shown in a table 63.
The activity data and synergistic effect of the composition for preventing and treating bacterial blight of rice are shown in Table 64.
The results in Table 64 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on rice bacterial leaf blight in a test mixture ratio range.
TABLE 63 Activity of Individual active Components
Figure BDA0002790774720000723
Figure BDA0002790774720000731
TABLE 64 Activity and synergy of the compositions of the invention
Figure BDA0002790774720000732
Example 32 treatment of pepper anthracnose
Inoculating pepper spore suspension of pepper anthracnose pathogen to potted six-leaf stage pepper seedling of green round pepper, culturing in climate chamber, spraying with water solution (effective component concentration shown in table) of each active component or composition after 24 hr, transferring into greenhouse, culturing for 5-7 days, and performing disease condition investigation after full control disease.
The data on the therapeutic activity of the individual active ingredients and compositions of the invention against anthracnose of capsicum are shown in tables 65 and 66.
The results in tables 65 and 66 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of>1, the composition shows a synergistic effect on pepper anthracnose in a test proportioning range.
TABLE 65 therapeutic efficacy of active ingredients and synergistic effect of the compositions
Figure BDA0002790774720000733
Figure BDA0002790774720000741
TABLE 66 therapeutic efficacy of active ingredients and synergistic effect of the compositions
Figure BDA0002790774720000742
EXAMPLE 33 persistent test for controlling powdery mildew of Capsicum
The pepper seedlings in the six-leaf period of potted plants of the variety 'green round pepper' are treated by spraying with aqueous solutions (the concentration of active ingredients is shown in the table below) of the active components or the compositions, the pepper powdery mildew spores are sprayed on the back surfaces of the leaves by an inoculator after 1 day, 3 days, 5 days, 7 days and 10 days, the pepper powdery mildew spores are cultured in a greenhouse, and disease investigation is carried out after the control fully attacks 20-25 days.
The data on the activity of the individual active ingredients and the compositions according to the invention for controlling powdery mildew of capsicum are shown in table 67.
The results in Table 67 below show that the observed efficacy of the individual components and compositions of the invention on powdery mildew of capsicum also decreased gradually with increasing inoculation time after dosing; at the same concentration, when inoculated 5 days after the drug administration, the observed efficacy of the individual components is 50 percent lower, and the observed efficacy of the composition is higher than 60 percent; after inoculation for 10 days after the application, the observation effect of the single component is not obvious, the observation effect of the composition is about 30 percent, and the obvious control effect is shown. The single components of the invention are used in the form of a composition, which enhances the lasting activity of the medicament on the powdery mildew of hot pepper.
TABLE 67 persistent activity and synergism of the active ingredients
Figure BDA0002790774720000751
Example 34 field test for controlling cucumber powdery mildew
In the middle stage of powdery mildew development of cucumber (variety "fruit cucumber") in a sunlight greenhouse, spray treatment was performed with aqueous solutions (concentrations are shown in the following table) of the respective active ingredients or compositions, and after 15 days, disease investigation was performed.
The activity data of the individual active ingredients of the invention for controlling cucumber powdery mildew are shown in table 68.
The activity data and synergistic effect of the composition for preventing and treating cucumber powdery mildew are shown in Table 69.
The results in Table 69 below show the observed efficacy of the compositions (C)obs) And expected efficacy (C)exp) All ratio of (A to B)>1, the composition shows a synergistic effect on the cucumber powdery mildew in the field within the range of the experimental proportion.
TABLE 68 Activity of Individual active Components
Figure BDA0002790774720000752
Figure BDA0002790774720000761
TABLE 69 Activity and synergy of the compositions of the present invention
Figure BDA0002790774720000762

Claims (4)

1. A germicidal composition, characterized by: the composition comprises A, B two active components, wherein the weight ratio of the active component A to the active component B is 1:20-20: 1;
wherein the active component A is a compound shown as a general formula I-A or a salt formed by the compound and sulfuric acid:
Figure 91972DEST_PATH_IMAGE001
in the formula:
R3selected from hydrogen;
R4、R5are respectively selected from hydrogen;
R6、R7are respectively selected from hydrogen;
R8、R9are respectively selected from hydrogen;
R11selected from 4-chloro;
R14、R15、R16or R17Are respectively selected from hydrogen;
w is selected from hydrogen;
n is 1;
the active component B is selected from bactericides of respiratory inhibitor;
the respiration inhibitor bactericide is selected from benzovindiflupyr (benzovindifiupyr) B1, fluxapyroxad (fluxapyroxad) B4, fluopyram (flupyrad) B5, boscalid (boscalid) B9, thifluzamide (thifluzamide) B13, fluxapyroxad (pydiflumetofen) B14, fluopyram (fluopiolide) B27, ametoctradin (ametoctradin) B31, fluazinam (fluzinam) B32 or fenpicoxamid B33.
2. The germicidal composition of claim 1, wherein: the composition comprises an active component A and an active component B in a weight ratio of 1:10-10: 1.
3. Use of the germicidal composition according to claim 1, characterized in that: the bactericidal composition is used for preparing medicines for preventing and treating plant pathogenic fungi and bacterial diseases.
4. Use of a fungicidal composition according to claim 3, characterized in that: the plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust disease, scab, leaf mold, banded sclerotial blight, damping off, black nevus, smut, powdery mildew, downy mildew, late blight, epidemic disease, downy mildew, black shank, soft rot, damping-off, phytophthora blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, gummy stem blight, gray mold, sclerotinia, rot, root rot, gibberellic disease, soft rot, bacterial leaf blight, angular leaf spot, circular spot, bacterial wilt, ulcer disease or yellow dragon disease.
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